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Cited by 281

The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.

Impacts of environmental toxicants on male reproductive dysfunction

Open access
Wong, Elissa W.P., Cheng, C. Yan·2011·Trends in Pharmacological Sciences
DOI 10.1016/j.tips.2011.01.001
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Abstract

Male infertility caused by exposure to environmental toxicants, such as cadmium, mercury, bisphenol A (BPA) and dioxin, is a global problem, particularly in industrialized countries. Studies in the testis and other organs have illustrated the importance of environmental toxicant-induced oxidative stress in mediating disruption to cell junctions. This, in turn, is regulated by the activation of PI3K/c-Src/FAK and MAPK signaling pathways, with the involvement of polarity proteins, leading to reproductive dysfunction, such as reduced sperm count and semen quality in men. In this review, we discuss how these findings can improve understanding of the modes of action of environmental toxicants in –testicular dysfunction. Thus, specific inhibitors and/or antagonists against signaling molecules in these pathways can possibly reverse and/or block the disruptive effects of toxicant-induced damage. Additional studies comparing high level acute exposure versus low level chronic exposure to environmental toxicants are also needed to elucidate fully the underlying molecular mechanism(s) by which these toxicants disrupt male reproductive function.

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Metadata

Authors
Wong, E. W. P., & Cheng, C. Y.
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2011-05
Volume
32
Issue
5
Pages
290-299
ISSN
0165-6147 (ISSN-L)
DOI
10.1016/j.tips.2011.01.001
OpenAlex
W1987338052
Cited by
281
References
107
FWCI
2.93
Type
journal article
Language
en
Open access
green

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