Estrogen and environmental estrogenic chemicals exert developmental effects on rat hypothalamic neurons and glias
Abstract
We investigated effects of 17beta-estradiol (E(2)) and endocrine disrupters, nonylphenol (NP) and bisphenol-A (BPA), focusing on the neuronal development in cultures of fetal rat hypothalamic cells. We applied different concentrations of E(2), NP or BPA to the cultured hypothalamic cells and observed their effects on dendritic and synaptic development by immunocytochemistry using anti-microtubule associated protein-2 (MAP2) and anti-synapsin I antibodies, respectively. Administration of E(2) for 7 days affected MAP2-positive area as well as synapsin I-positive area. NP and BPA also influenced neuronal developments. The significant increase both in MAP2- and synapsin I-positive areas was observed at 10 and/or 100 nM of them, while 1 microM of them reduced the positive areas. Synaptic densities calculated from synapsin I-positive area/MAP2-positive area were not constant among different doses of three chemicals, but increased at 10 and/or 100 nM and decreased at 1 microM. Furthermore, immunostaining of NP-treated cells with the antibody against glial fibrillary acidic protein (GFAP) revealed that glial development was similarly influenced by NP. Therefore, the present results demonstrated that not only E(2) but also the environmental estrogenic chemicals, NP and BPA, affect development of fetal rat hypothalamic cells in vitro.
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Micromolar concentrations of BPA are capable of decreasing synaptic density in cultured rat hypothalamic neurons.
“This is an interesting observation considering micromolar concentrations of BPA are also capable of decreasing synaptic density in cultured rat hypothalamic neurons [ 142 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [142]
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Sadowski, R. N. (2013) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Wang, X., Yin, Z., Chen, L., Hua, L., Ren, F., Wang, S., Li, R., Ning, H., & Ge, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1157527/v1
Yazğan, B., Tatar, M., Yazğan, Y., & Tüfekci̇, K. K. (2026) · Journal of Applied Toxicology · doi:10.1002/jat.70245
- Authors
- Yokosuka, M., Ohtani-Kaneko, R., Yamashita, K., Muraoka, D., Kuroda, Y., & Watanabe, C.
- Affiliations
- Nippon Veterinary and Life Science University (JP)
- St. Marianna University School of Medicine (JP)
- The University of Tokyo (JP)
- Venue
- Toxicology in Vitro
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 22
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0887-2333 (ISSN-L)
- OpenAlex
- W2085350360
- Cited by
- 62
- References
- 49
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 6 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 7 · 2013: 7 · 2012: 7
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology in Vitro (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- estradiol, endocrine disruptors, nonylphenol, bisphenol A, hypothalamic neurons, neuronal development, dendritic development, synaptic development, MAP2, synapsin I, glial fibrillary acidic protein, glial development, fetal brain, xenoestrogens
- MeSH terms
- Bisphenol A Compounds, Animals, Benzhydryl Compounds, Cells, Cultured, Dendrites, Dose-Response Relationship, Drug, Estradiol, Hypothalamus, Immunohistochemistry, Microtubule-Associated Proteins, Neuroglia, Neurons, Phenols, Synapses, Synapsins, Rats, Sprague-Dawley, Rats, Endocrine Disruptors
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