Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)

A new mathematical model for relative quantification in real-time RT-PCR

Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610

Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings

Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164

Polyfluoroalkyl Chemicals in the U.S. Population: Data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and Comparisons with NHANES 1999–2000

Calafat, A. M., Wong, L.-Y., Kuklenyik, Z., Reidy, J. A., & Needham, L. L. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10598 · Cited by 1,247

Peroxisome Proliferator-Activated Receptor Alpha Target Genes

Rakhshandehroo, M., Knoch, B., Müller, M., & Kersten, S. (2010) · PPAR Research · doi:10.1155/2010/612089 · Cited by 1,020

Perfluorinated compounds – Exposure assessment for the general population in western countries

Fromme, H., Tittlemier, S. A., Völkel, W., Wilhelm, M., & Twardella, D. (2008) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2008.04.007 · Cited by 979

The Developmental Toxicity of Perfluoroalkyl Acids and Their Derivatives

Lau, C., Butenhoff, J. L., & Rogers, J. M. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.11.031 · Cited by 867

Trends in Exposure to Polyfluoroalkyl Chemicals in the U.S. Population: 1999−2008

Kato, K., Wong, L.-Y., Jia, L. T., Kuklenyik, Z., & Calafat, A. M. (2011) · Environmental Science & Technology · doi:10.1021/es1043613 · Cited by 777

The toxicology of perfluorooctanoate

Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seacat, A. M., Perkins, R. G., Biegel, L. B., Murphy, S. R., & Farrar, D. G. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490464705 · Cited by 742

Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in surface waters, sediments, soils and wastewater – A review on concentrations and distribution coefficients

Zareitalabad, P., Siemens, J., Hamer, M., & Amelung, W. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.02.024 · Cited by 642

Perfluorooctanoic acid disrupts hepatic metabolism in the developing chicken embryo

Scherbak, N. N., Duberg, D., Kråkström, M., Tikka, P., Dickens, A. M., Engwall, M., Orešič, M., & Hyötyläinen, T. (2025) · Metabolomics · doi:10.1007/s11306-025-02374-5 · Cited by 1

PFOA and co-exposure with PFOS induce AMPK-dependent hypoglycemia in mice: integrated evidence from physiology, multi-omics, and molecular docking

Chang, J., Xiaojuan, X., Shiyan, C., Xiaoli, Y., Yan, Z., Junfang, Z., Zhiliang, Z., Yin, D., & Yanling, Q. (2026) · Environment International · doi:10.1016/j.envint.2026.110076 · Cited by 1

Insights into the Possible Impact of PFAS on Phosphatidylcholine Metabolism and Membranes through Molecular Dynamics Simulations

Pedroni, L., Dall'Asta, C., & Dellafiora, L. (2026) · ACS Environmental Au · doi:10.1021/acsenvironau.5c00299 · Cited by 1

Analysis of transcriptomic alterations induced by 33 different per- and polyfluoroalkyl substances (PFAS) in differentiated HepaRG cells

Sprenger, H., Alker, W., Rocchi, A., Leo, C., Giglio, R., Molaro, G. I., Dondero, F., Braeuning, A., & Buhrke, T. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04429-5 · Cited by 4

Assessment of the obesogenic properties of PFAS using an in vitro-based testing strategy

Lentz, S. B. I., Bil, W., Bokkers, B. G. H., van Merode, K., Kamstra, J. H., & Legler, J. (2026) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2026.106142 · Cited by 1

PFAS Exposure and Metabolic Disorders: Mechanistic Insights into Lipid and Glucose Homeostasis

Chen, X., Wen, W., Gu, S., Guo, F., Mo, Z., Chen, Z., Yan, S., & Wang, X. F. (2026) · Biomolecules · doi:10.3390/biom16071056 · Cited by 1

Differential Activation of Peroxisome Proliferator-Activated Receptor Alpha by Per- and Polyfluoroalkyl Substances

Kanitz, M. H., & Striley, C. (2025) · International Journal of Toxicology · doi:10.1177/10915818251393212 · Cited by 1

How the Structure of Per- and Polyfluoroalkyl Substances (Pfas) Influences Their Binding Potency to the Peroxisome Proliferator-Activated and Thyroid Hormone Receptors – an in Silico Screening StudyPreprint

Jurkiewicz, D., Sosnowska, A., Buławska, N., Stepnik, M., Behnisch, P., Besselink, H. T., & Puzyn, T. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4173912 · Cited by 1

Analysis of PFAS Levels and Associations with Adolescent Anthropometric Outcomes in NHANES

Sutherland, D., Lebeau, A., Bourgeois, M., & Harbison, R. D. (2021) · Occupational Diseases and Environmental Medicine · doi:10.4236/odem.2021.93008

Range of the perfluorooctanoate (PFOA) safe dose for human health: an international collaboration

M.A., H. J. C. I. (2025) · Journal of Toxicology and Regulatory Policy · doi:10.69982/jtrp-24-0005

Chemical hazard characterisation of PFAS : current approaches in dose-response assessments and the lipidomic disruption in human cell models

Brunken, L. (2025) · doi:10.69622/28473254.v1

Factors influencing chemical relative potency in mixture toxicity risk assessment

Widjaja, F. (2025) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2025.100541 · Cited by 1

Potential effect of co-exposure to Per- and polyfluoroalkyl substances on the risk of insomnia

Zhang, Z., Li, N., Yang, Z., Jin, M., Liu, X., Zhang, Y., Lin, N., Li, Z., Zhuang, L., Bao, H., et al. (2025) · Hygiene and Environmental Health Advances · doi:10.1016/j.heha.2025.100163

A Genome-Wide CRISPR Screen Identifies C18orf32 as a Novel Modulator of PFOA-Induced Cytotoxicity and Lipid Dysregulation

Kim, C., Tagmount, A., Zhu, Z., Wilson, F., Barbazuk, B., Bacher, R., & Vulpe, C. D. (2026) · Environmental Health Perspectives · doi:10.64898/2025.12.23.696201

Perfluorooctanesulfonate Induces an Atypical Adipocyte Phenotype: Promoting Adipogenesis and Thermogenesis via PPARγ Signaling and m6A RNA Modifications in 3T3-L1 Cells

Wan, H. T., Lee, W. K., & Wong, C. K. C. (2026) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.5c01286

Role of constitutive androstane receptor in developmental toxicology: linking chemical exposure, nutrition, and disease susceptibility

Shizu, R., & Yoshinari, K. (2026) · Critical Reviews in Toxicology · doi:10.1080/10408444.2026.2623026

Exposure to PFOA and GenX elicits cell typespecific impacts on p53 and TGF-β signaling pathways

Ding, H., Slack, M., McClure, H., Gu, W., Gu, H., Kappes, F., Schultz, T. F., Somarelli, J. A., & Tsigkou, A. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11571-x

Integrated Multi-Omics Reveals Synergistic Hepatotoxicity of Ethanol and PFOS Co-Exposure

Stem, A. D., Alayyoub, M., Aalizadeh, R., Nikolopoulou, V., Lisgara, A., Shvartsman, A., Anitha, M., Patterson, A., Coble, R., Rushing, B., et al. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112101 · Cited by 1

Health benefit considerations for the development of fish advisory guidelines for PFOS

Spliethoff, H. M., Palmer, M. C., Marquez‐Bravo, L. G., Marks, T., & Ginsberg, G. (2026) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2026.2665431 · Cited by 1

Perfluorooctanoic acid (PFOA) induces lipid accumulation, oxidative stress, and reduced neurogenesis in primary human neuronal progenitor cells

Marinello, W. P., & Zylka, M. J. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1814052

Ubiquitously occurring perfluoroalkyl and polyfluoroalkyl substances: An overview of food and environmental contamination and implications for human health

Jaglan, P., Buttar, H. S., Wilson, D. W., & Ig, T. (2026) · Scripta Medica · doi:10.5937/scriptamed57-64908

Intermolecular interactions of perfluoroalkyl acids with human heart-type fatty acid-binding protein

Maekawa, S., Takamiya, N., Terawaki, H., Kondo, N., Hayashi, F., Shimoaka, T., Matsuoka, S., Matsumori, N., Murata, M., Sonoyama, M., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152710

Per- and polyfluoroalkyl substances are associated with gestational diabetes and perturb hepatic metabolic regulatory networks: Convergent epidemiological, computational, and experimental evidence

Liu, W., Zhao, Z. C., Han, J. Y., Li, H., Cheng, G., Li, Y., Lu, Y., Zhai, Y., & Cao, Z. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120313

Alliance between the thyroid hormone receptor and obesogens: Current apprehensions and emerging perspectives on the endocrine origins of obesity

Mahla, S., Chhabra, A., Bano, F., Yadav, U. C. S., & Tyagi, R. K. (2026) · Food and Chemical Toxicology · doi:10.1016/j.fct.2026.116284

Structural conservation of peroxisome proliferator–activated receptor isoforms reveals potential of perfluorooctanesulfonic acid to disrupt mammalian and avian lipid signaling

Lenz, B. Q., Ankley, G. T., & Etterson, M. A. (2026) · Environmental Toxicology and Chemistry · doi:10.1093/etojnl/vgag203

PFOS exposure is linked to immune-metabolic disruption in MASLD: integrated population, computational, and experimental evidence

Zuo, X., Tan, S., Hou, X., Zhang, C., Zhang, Y., & Zhang, J. (2026) · Molecular Diversity · doi:10.1007/s11030-026-11727-8

Perfluorooctane sulfonate (PFOS) interferes with Cyp1a activity and dysregulates the aryl hydrocarbon receptor pathway in larval zebrafish (Danio rerio)

Miller, D. H., Lachapelle, A., Satbhai, K. M., Chien, P., Borys, K. M., & Timme‐Laragy, A. R. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.129135

L’impact des polluants environnementaux sur le tissu adipeux : liens avec l’obésité 20 ans d’obésogènes : les données s’accumulent

Masaoudi, M., Blanc, É., Coumoul, X., & Kim, M. J. (2026) · Médecine des Maladies Métaboliques · doi:10.1016/j.mmm.2026.09.009

Assessing the impact of mixed exposure to 18 PFASs on dyslipidemia risk: An epidemiological study in middle-aged and elderly adults

Shan, C., Qiu, X., Xiao, Q., Ge, Y., Fu, B., Lin, Y., Guo, A., Li, M., Xu, P., Xu, J., et al. (2026) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2026.105175

New approach methodologies for in vitro detection of chemical-induced cholestatic liver injury

Maerten, A., Avîrvarei, A.-C., & Vinken, M. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04541-6

Evolution of Nuclear Receptors as Environmental Chemical Sensors: Structural Innovation and Signaling Expansion

Goksøyr, S. Ø., Karlsen, O. A., Ruivo, R., Castro, L. F. C., & Goksøyr, A. (2026) · ACS ES&T Toxicology · doi:10.1021/acsesttox.6c00014

Gestational exposure to per- and polyfluoroalkyl substances drives maternal liver dysfunction through lipid dysregulation and NF-κB/EGFR-STAT3 inflammatory activation

Li, S., Li, Y., Wang, Y., Wang, J., Yang, S., Lu, L., 商景阁, Chen, J., & Liu, Y. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.129290

Early-life PFAS exposure induces systemic metabolic alterations in plasma and brain in micePreprint

Hyötyläinen, T., Duberg, D., Evstafev, I., Dickens, A. M., Savontaus, E., & Oresic, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.14.758497

Mechanistic insights into PFAS-induced toxicity: from lipid membrane perturbation to ion channel and transporter dysregulation

Kim, H. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04607-5

Dose- and duration-dependent hepatotoxicity of PFO4DA: Divergent PPARα responses and conserved glucocorticoid receptor suppression

Liu, L., Zhang, Y., Guo, Q., Wang, D., Zhong, X., Wang, C., Zhi, M., & Wang, J. (2026) · Environment International · doi:10.1016/j.envint.2026.110582

In Vitro Activity of a Panel of Per- and Polyfluoroalkyl Substances (PFAS), Fatty Acids, and Pharmaceuticals in Peroxisome Proliferator-Activated Receptor (PPAR) Alpha, PPAR Gamma, and Estrogen Receptor Assays

Evans, N., Conley, J. M., Cardon, M., Hartig, P., Medlock-Kakaley, E., & Gray, L. E. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116136 · Cited by 208

Differential Activation of Nuclear Receptors by Perfluorinated Fatty Acid Analogs and Natural Fatty Acids: A Comparison of Human, Mouse, and Rat Peroxisome Proliferator-Activated Receptor-α, -β, and -γ, Liver X Receptor-β, and Retinoid X Receptor-α

Heuvel, J. P. V., Thompson, J. T., Frame, S. R., & Gillies, P. J. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl014 · Cited by 489

trans-Activation of PPAR and Induction of PPAR Target Genes by Perfluorooctane-Based Chemicals

Shipley, J. M. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh130 · Cited by 168

Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes

Bjork, J. A., Butenhoff, J. L., & Wallace, K. B. (2011) · Toxicology · doi:10.1016/j.tox.2011.06.012 · Cited by 266

Activation of Mouse and Human Peroxisome Proliferator-Activated Receptors (α, β/δ, γ) by Perfluorooctanoic Acid and Perfluorooctane Sulfonate

Takacs, M. L., & Abbott, B. D. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfl135 · Cited by 396