Cited by 235Per- and polyfluoroalkyl substances researchPeroxisome Proliferator-Activated ReceptorsFluorine in Organic Chemistry

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)

Behr, Anne-Cathrin, Plinsch, Christin, Braeuning, Albert, Buhrke, Thorsten·2020·Toxicology in Vitro

DOI 10.1016/j.tiv.2019.104700

Open this paper in CoChat — free account

Abstract

Perfluoralkylated substances (PFAS) such as perfluorooctanoic acid (PFOA) or perfluorooctanesulfonic acid (PFOS) are used to produce, e.g., surface coatings with water- and dirt-repellent properties. These substances have been shown to be hepatotoxic in rodents, and the mechanism of action is mostly attributed to the PFAS-mediated activation of the peroxisome proliferator-activated receptor alpha (PPARα). In the present study, we investigated by using luciferase-based reporter gene assays whether PFOA, PFOS and six alternative PFAS can activate, in addition to PPARα, eight other human nuclear receptors. All tested PFAS except for perfluorobutanesulfonic acid (PFBS) were able to activate human PPARα. Perfluoro-2-methyl-3-oxahexanoic acid (PMOH) and 3H-perfluoro-3-[(3-methoxypropoxy) propanoic acid] (PMPP) were weak agonists of human PPARγ. The other human nuclear receptors (PPARδ, CAR, PXR, FXR, LXRα, RXRα and RARα) were not affected by any PFAS tested in this study. Although PMOH was more effective than PFOA in stimulating PPARα in the transactivation assay, it was less effective in stimulating PPARα-dependent target gene expression in human HepG2 hepatocarcinoma cells. Notably, any effect observed in this in vitro study only occurred at concentrations higher than 10 μM of the respective PFAS which is in all cases several magnitudes above the average blood concentration in the Western population. Thus, the results suggest that nuclear receptor activation may only play a minor role in potential PFAS-mediated adverse effects in humans.

Integrity signals

Registry

Crossref · 10.1016/j.tiv.2019.104700

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164
Polyfluoroalkyl Chemicals in the U.S. Population: Data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and Comparisons with NHANES 1999–2000
Calafat, A. M., Wong, L.-Y., Kuklenyik, Z., Reidy, J. A., & Needham, L. L. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10598 · Cited by 1,247
Peroxisome Proliferator-Activated Receptor Alpha Target Genes
Rakhshandehroo, M., Knoch, B., Müller, M., & Kersten, S. (2010) · PPAR Research · doi:10.1155/2010/612089 · Cited by 1,020
Perfluorinated compounds – Exposure assessment for the general population in western countries
Fromme, H., Tittlemier, S. A., Völkel, W., Wilhelm, M., & Twardella, D. (2008) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2008.04.007 · Cited by 979
The Developmental Toxicity of Perfluoroalkyl Acids and Their Derivatives
Lau, C., Butenhoff, J. L., & Rogers, J. M. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.11.031 · Cited by 867
Trends in Exposure to Polyfluoroalkyl Chemicals in the U.S. Population: 1999−2008
Kato, K., Wong, L.-Y., Jia, L. T., Kuklenyik, Z., & Calafat, A. M. (2011) · Environmental Science & Technology · doi:10.1021/es1043613 · Cited by 777
The toxicology of perfluorooctanoate
Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seacat, A. M., Perkins, R. G., Biegel, L. B., Murphy, S. R., & Farrar, D. G. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490464705 · Cited by 742
Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in surface waters, sediments, soils and wastewater – A review on concentrations and distribution coefficients
Zareitalabad, P., Siemens, J., Hamer, M., & Amelung, W. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.02.024 · Cited by 642

Show all 53 references

Sorted by citations

Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research
Fenton, S. E., Ducatman, A., Boobis, A., DeWitt, J. C., Lau, C., Ng, C., Smith, J. S., & Roberts, S. M. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4890 · Cited by 2,445
Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests
Masoodi, M., Gastaldelli, A., Hyötyläinen, T., Arretxe, E., Alonso, C., Gaggini, M., Brosnan, J., Anstee, Q. M., Millet, O., Ortiz, P., et al. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00502-9 · Cited by 451
Exposure to per- and polyfluoroalkyl substances and markers of liver injury: a systematic review and meta-analysis
Costello, E., Rock, S., Stratakis, N., Eckel, S. P., Walker, D. I., Valvi, D., Cserbik, D., Jenkins, T., Xanthakos, S. A., Kohli, R., et al. (2022) · Environmental Health Perspectives · doi:10.1289/ehp10092 · Cited by 420
Consideration of pathways for immunotoxicity of per-and polyfluoroalkyl substances (PFAS)
Ehrlich, V., Bil, W., Vandebriel, R., Granum, B., Luijten, M., Lindeman, B., Grandjean, P., Kaiser, A.-M., Hauzenberger, I., Hartmann, C., et al. (2023) · Environmental Health · doi:10.1186/s12940-022-00958-5 · Cited by 318
Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury
Roth, K., Yang, Z., Agarwal, M., Liu, W. J., Peng, Z., Long, Z., Birbeck, J. A., Westrick, J. A., Liu, W., & Petriello, M. C. (2021) · Environment International · doi:10.1016/j.envint.2021.106843 · Cited by 322
Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease
Sen, P., Qadri, S. U., Luukkonen, P. K., Ragnarsdóttir, O., McGlinchey, A. J., Jäntti, S. E., Juuti, A., Arola, J. T., Schlezinger, J. J., Webster, T. F., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.09.039 · Cited by 299
Insight into the binding model of per- and polyfluoroalkyl substances to proteins and membranes
Zhao, L., Teng, M., Zhao, X., Li, Y., Sun, J., Zhao, W., Ruan, Y., Leung, K., & Wu, F. (2023) · Environment International · doi:10.1016/j.envint.2023.107951 · Cited by 236
In Vitro Activity of a Panel of Per- and Polyfluoroalkyl Substances (PFAS), Fatty Acids, and Pharmaceuticals in Peroxisome Proliferator-Activated Receptor (PPAR) Alpha, PPAR Gamma, and Estrogen Receptor Assays
Evans, N., Conley, J. M., Cardon, M., Hartig, P., Medlock-Kakaley, E., & Gray, L. E. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116136 · Cited by 208
PPARα/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per- and polyfluoroalkyl substances: An integrated approach
Wang, Y., Ling, X., He, S., Cui, H., Yang, Z., An, H., Wang, L., Zou, P., Chen, Q., Liu, J., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108138 · Cited by 210
Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?
Fragki, S., Dirven, H. A. A. M., Fletcher, T., Grasl‐Kraupp, B., Gützkow, K. B., Hoogenboom, L. A. P., Kersten, S., Lindeman, B., Louisse, J., Peijnenburg, A., et al. (2021) · Critical Reviews in Toxicology · doi:10.1080/10408444.2021.1888073 · Cited by 196
The exposome and liver disease - how environmental factors affect liver health
Barouki, R., Samson, M., Blanc, É., Colombo, M. G., Zucman‐Rossi, J., Lazaridis, K. N., Miller, G. W., & Coumoul, X. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.034 · Cited by 189
A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior
Starnes, H. M., Rock, K. D., Jackson, T. W., & Belcher, S. M. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.881584 · Cited by 166
Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure
Houck, K. A., Patlewicz, G. Y., Richard, A. M., Williams, A. J., Shobair, M., Smeltz, M. G., Clifton, M. S., Wetmore, B. A., Medvedev, A. V., & Makarov, S. S. (2021) · Toxicology · doi:10.1016/j.tox.2021.152789 · Cited by 149
Environmental exposure to perfluoroalkyl substances in early pregnancy, maternal glucose homeostasis and the risk of gestational diabetes: A prospective cohort study
Yu, G., Jin, M., Huang, Y., Aimuzi, R., Zheng, T., Nian, M., Tian, Y., Wang, W., Luo, Z., Shen, L., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106621 · Cited by 141
Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells
Louisse, J., Rijkers, D., Stoopen, G. M., Janssen, A. W. F., Staats, M., Hoogenboom, L. A. P., Kersten, S., & Peijnenburg, A. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02808-0 · Cited by 143
Short-chain per- and polyfluoralkyl substances (PFAS) effects on oxidative stress biomarkers in human liver, kidney, muscle, and microglia cell lines
Solan, M. E., Koperski, C. P., Senthilkumar, S., & Lavado, R. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115424 · Cited by 126
Treatment technologies for removal of per- and polyfluoroalkyl substances (PFAS) in biosolids
Garg, A., Shetti, N. P., Basu, S., Nadagouda, M. N., & Aminabhavi, T. M. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.139964 · Cited by 132
Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells
Behr, A., Kwiatkowski, A., Ståhlman, M., Schmidt, F. F., Luckert, C., Braeuning, A., & Buhrke, T. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02732-3 · Cited by 125
Self-citation
Associations between Per- and Polyfluoroalkyl Substances Exposures and Blood Lipid Levels among Adults—A Meta-Analysis
Liu, B., Zhu, L., Wang, M., & Sun, Q. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11840 · Cited by 129
Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet
Schlezinger, J. J., Puckett, H. M., Oliver, J., Nielsen, G. H., Heiger‐Bernays, W., & Webster, T. F. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115204 · Cited by 122
Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice
Attema, B. J., Janssen, A. W. F., Rijkers, D., van Schothorst, E. M., Hooiveld, G. J. E. J., & Kersten, S. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101602 · Cited by 109
Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms
Andersen, M. E., Hagenbuch, B., Apte, U. M., Corton, J. C., Fletcher, T., Lau, C. S., Roth, W. L., Staels, B., Vega, G. L., M.A., H. J. C. I., et al. (2021) · Toxicology · doi:10.1016/j.tox.2021.152845 · Cited by 104
Changes in plasma levels of per- and polyfluoroalkyl substances (PFAS) are associated with changes in plasma lipids - A longitudinal study over 10 years
Dunder, L., Lind, P., Salihović, S., Stubleski, J., Kärrman, A., & Lind, L. (2022) · Environmental Research · doi:10.1016/j.envres.2022.112903 · Cited by 101
Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts
Papadopoulou, E., Stratakis, N., Basagaña, X., Brantsæter, A. L., Casas, M., Fossati, S., Gražulevičienė, R., Haug, L. S., Heude, B., Maître, L., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106853 · Cited by 98
Neurotoxicity of per- and polyfluoroalkyl substances: Evidence and future directions
Bharal, B., Ruchitha, C., Kumar, P., Pandey, R., Rachamalla, M., Niyogi, S., Naidu, R., & Kaundal, R. K. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176941 · Cited by 94
PFAS and Potential Adverse Effects on Bone and Adipose Tissue through Interactions with PPARγ
Kirk, A. B., Michelsen-Correa, S., Rosen, C., Martin, C. F., & Blumberg, B. (2021) · Endocrinology · doi:10.1210/endocr/bqab194 · Cited by 90
Perfluoroalkyl Acid Binding with Peroxisome Proliferator-Activated Receptors α, γ, and δ, and Fatty Acid Binding Proteins by Equilibrium Dialysis with a Comparison of Methods
Khazaee, M., Christie, E. C., Cheng, W., Michalsen, M. M., Field, J. A., & Ng, C. A. (2021) · Toxics · doi:10.3390/toxics9030045 · Cited by 86
Perfluoroalkyl substances and lipid concentrations in the blood: A systematic review of epidemiological studies
Ho, S. H., Soh, S. X. H., Wang, M. X., Ong, J., Seah, A., Wong, Y., Fang, Z., Sim, S., & Lim, J. T. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158036 · Cited by 84
Per‐ and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells
Qi, Q., Niture, S. K., Gadi, S. V., Arthur, E., Moore, J. T., Levine, K. E., & Kumar, D. (2022) · Environmental Toxicology · doi:10.1002/tox.23680 · Cited by 79
The EU’s Per- and Polyfluoroalkyl Substances (PFAS) Ban: A Case of Policy over Science
Spyrakis, F., & Dragani, T. A. (2023) · Toxics · doi:10.3390/toxics11090721 · Cited by 78
Batch and fixed bed sorption of low to moderate concentrations of aqueous per- and poly-fluoroalkyl substances (PFAS) on Douglas fir biochar and its Fe3O4 hybrids
Rodrigo, P. M., Navarathna, C. M., Pham, M. T. H., McClain, S. J., Stokes, S. L., Zhang, X., Perez, F. A., Gunatilake, S. R., Karunanayake, A. G., Anderson, R., et al. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.136155 · Cited by 78
Association between per- and polyfluoroalkyl substances exposure and risk of diabetes: a systematic review and meta-analysis
Gui, S., Qiao, J.-C., Xu, K., Li, Z., Chen, Y.-N., Wu, K., Jiang, Z., & Hu, C. (2022) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-022-00464-3 · Cited by 80
Retracted: Exposure to Per- and Polyfluoroalkyl Substances and Mortality in U.S. Adults: A Population-Based Cohort Study
Wen, X., Wang, M., Xu, X., & Li, T. (2022) · Environmental Health Perspectives · doi:10.1289/ehp10393 · Cited by 79
Retracted
Proteomics and lipidomics analyses reveal modulation of lipid metabolism by perfluoroalkyl substances in liver of Atlantic cod (Gadus morhua)
Dale, K., Yadetie, F., Müller, M. B., Pampanin, D. M., Gilabert, A., Zhang, X., Tairova, Z., Haarr, A., Lille‐Langøy, R., Lyche, J. L., et al. (2020) · Aquatic Toxicology · doi:10.1016/j.aquatox.2020.105590 · Cited by 74
Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish
Sun, W., Zhang, X., Qiao, Y., Griffin, N., Zhang, H., Wang, L., & Liu, H. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115020 · Cited by 75
Assessment of unique behavioral, morphological, and molecular alterations in the comparative developmental toxicity profiles of PFOA, PFHxA, and PFBA using the zebrafish model system
Wasel, O., Thompson, K. M., & Freeman, J. L. (2022) · Environment International · doi:10.1016/j.envint.2022.107642 · Cited by 77
Impact of perfluoroalkyl substances (PFAS) and PFAS mixtures on lipid metabolism in differentiated HepaRG cells as a model for human hepatocytes
Sadrabadi, F., Alarcan, J., Sprenger, H., Braeuning, A., & Buhrke, T. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03649-3 · Cited by 74
Self-citation
Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity
Sen, P., Fan, Y., Schlezinger, J. J., Ehrlich, S. D., Webster, T. F., Hyötyläinen, T., Pedersen, O. B., & Orešič, M. (2024) · Environment International · doi:10.1016/j.envint.2024.108569 · Cited by 72
Neurotoxic Effects of Mixtures of Perfluoroalkyl Substances (PFAS) at Environmental and Human Blood Concentrations
Ríos-Bonilla, K. M., Aga, D. S., Lee, J., König, M., Qin, W., Cristobal, J. R., Atilla‐Gokcumen, G. E., & Escher, B. I. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c06017 · Cited by 69
A Comprehensive Statewide Spatiotemporal Stream Assessment of Per- and Polyfluoroalkyl Substances (PFAS) in an Agricultural Region of the United States
Kolpin, D. W., Hubbard, L. E., Cwiertny, D. M., Meppelink, S. M., Thompson, D. A., & Gray, J. L. (2021) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.1c00750 · Cited by 67
A database framework for rapid screening of structure-function relationships in PFAS chemistry
(2021) · doi:10.1038/s41597-021-00798-x · Cited by 67
Interspecies Differences in Activation of Peroxisome Proliferator-Activated Receptor γ by Pharmaceutical and Environmental Chemicals
Garoche, C., Boulahtouf, A., Grimaldi, M., Chiavarina, B., Toporová, L., den Broeder, M. J., Legler, J., Bourguet, W., & Balaguer, P. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c04318 · Cited by 65
Comparative cytotoxicity of seven per- and polyfluoroalkyl substances (PFAS) in six human cell lines
Solan, M. E., Senthilkumar, S., Aquino, G. V., Bruce, E. D., & Lavado, R. (2022) · Toxicology · doi:10.1016/j.tox.2022.153281 · Cited by 65
The association between blood PFAS concentrations and clinical biochemical measures of organ function and metabolism in participants of the Canadian Health Measures Survey (CHMS)
Cakmak, S., Lukina, A. O., Karthikeyan, S., Atlas, E., & Dales, R. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153900 · Cited by 58
Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
Küblbeck, J., Niskanen, J., & Honkakoski, P. (2020) · Cells · doi:10.3390/cells9102306 · Cited by 56
Binding of Per- and Polyfluoro-alkyl Substances to Peroxisome Proliferator-Activated Receptor Gamma
Almeida, N. M. S., Eken, Y., & Wilson, A. K. (2021) · ACS Omega · doi:10.1021/acsomega.1c01304 · Cited by 57
Effects of per- and polyfluoroalkyl substances on the liver: Human-relevant mechanisms of toxicity
Maerten, A., Callewaert, E., Sanz-Serrano, J., Devisscher, L., & Vinken, M. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176717 · Cited by 54
Health and social concerns about living in three communities affected by per- and polyfluoroalkyl substances (PFAS): A qualitative study in Australia
Banwell, C. L., Housen, T., Smurthwaite, K. S., Trevenar, S. M., Walker, L., Todd, K., Rosas, M., & Kirk, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245141 · Cited by 58
How the Structure of Per- and Polyfluoroalkyl Substances (PFAS) Influences Their Binding Potency to the Peroxisome Proliferator-Activated and Thyroid Hormone Receptors—An In Silico Screening Study
Kowalska, D., Sosnowska, A., Buławska, N., Stepnik, M., Behnisch, P., Behnisch, P., & Puzyn, T. (2023) · Molecules · doi:10.3390/molecules28020479 · Cited by 56
Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression
Imir, O. B., Kaminsky, A. Z., Zuo, Q., Liu, Y.-J., Singh, R., Spinella, M. J., Irudayaraj, J., Hu, W., Prins, G. S., & Madak‐Erdogan, Z. (2021) · Nutrients · doi:10.3390/nu13113902 · Cited by 56
Agonistic and potentiating effects of perfluoroalkyl substances (PFAS) on the Atlantic cod (Gadus morhua) peroxisome proliferator-activated receptors (Ppars)
Søderstrøm, S., Lille‐Langøy, R., Yadetie, F., Rauch, M., Milinski, A., Dejaegere, A. P., Stote, R. H., Goksøyr, A., & Karlsen, O. A. (2022) · Environment International · doi:10.1016/j.envint.2022.107203 · Cited by 56
Per- and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids
Addicks, G. C., Rowan‐Carroll, A., Reardon, A. J. F., Leingartner, K., Williams, A., Meier, M. J., Moffat, I. D., Carrier, R., Lorusso, L., Wetmore, B. A., et al. (2023) · Toxicological Sciences · doi:10.1093/toxsci/kfad044 · Cited by 54
Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes
Marques, E., Pfohl, M., Wei, W., Tarantola, G., Ford, L. C., Amaeze, O. U., Alesio, J., Ryu, S., Jia, X., Zhu, H., et al. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.115991 · Cited by 54
Cumulative maternal and neonatal effects of combined exposure to a mixture of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) during pregnancy in the Sprague-Dawley rat
Conley, J. M., Lambright, C. S., Evans, N., Medlock-Kakaley, E., Dixon, A., Hill, D., McCord, J. P., Strynar, M. J., Ford, J., & Gray, L. E. (2022) · Environment International · doi:10.1016/j.envint.2022.107631 · Cited by 50
Environmental toxicants and placental function
Bloom, M. S., Varde, M., & Newman, R. (2022) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2022.09.003 · Cited by 49
Predicting the effects of per- and polyfluoroalkyl substance mixtures on peroxisome proliferator-activated receptor alpha activity in vitro
Nielsen, G. H., Heiger‐Bernays, W., Schlezinger, J. J., & Webster, T. F. (2021) · Toxicology · doi:10.1016/j.tox.2021.153024 · Cited by 53
Effects of In Utero PFOS Exposure on Epigenetics and Metabolism in Mouse Fetal Livers
Ho, T. C., Wan, H. T., Lee, W. K., Lam, T. K. Y., Lin, X., Chan, T., Lai, K. P., & Wong, C. K. C. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c05207 · Cited by 47
Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease
Massart, J., Begriche, K., Corlu, A., & Fromenty, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031062 · Cited by 47
Per- and Polyfluoroalkyl Substances (PFAS) Affect Female Reproductive Health: Epidemiological Evidence and Underlying Mechanisms
Qu, R., Wang, J., Li, X., Zhang, Y., Yin, T., & Yang, P. (2024) · Toxics · doi:10.3390/toxics12090678 · Cited by 49
Comparison of sub-lethal metabolic perturbations of select legacy and novel perfluorinated alkyl substances (PFAS) in Daphnia magna
Labine, L. M., Pereira, E. A. O., Kleywegt, S. M., Jobst, K. J., Simpson, A. J., & Simpson, M. J. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113582 · Cited by 47
Perfluorinated alkyl substances affect the growth, physiology and root proteome of hydroponically grown maize plants
Ebinezer, L. B., Battisti, I., Sharma, N., Ravazzolo, L., Ravi, L., Trentin, A. R., Barion, G., Panozzo, A., Dall’Acqua, S., Vamerali, T., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129512 · Cited by 43
Effects of legacy and emerging per- and polyfluoroalkyl substances on PPARα/β/γ regulation and osteogenic/adipogenic differentiation
Qin, H., Niu, Y., Luan, H., Li, M., Zheng, L., Pan, Y., & Liu, W. (2022) · Environment International · doi:10.1016/j.envint.2022.107584 · Cited by 46
Exposure to per- and polyfluoroalkyl substances in early pregnancy, risk of gestational diabetes mellitus, potential pathways, and influencing factors in pregnant women: A nested case-control study
Zang, L., Liu, X., Xie, X., Zhou, X., Pan, Y., & Dai, J. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121504 · Cited by 42
Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification
Fritsche, K., Ziková, A., Marx‐Stoelting, P., & Braeuning, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032686 · Cited by 42
Self-citation
Paired Liver:Plasma PFAS Concentration Ratios from Adolescents in the Teen-LABS Study and Derivation of Empirical and Mass Balance Models to Predict and Explain Liver PFAS Accumulation
Baumert, B. O., Fischer, F. C., Nielsen, F., Grandjean, P., Bartell, S. M., Stratakis, N., Walker, D. I., Valvi, D., Kohli, R., Inge, T. H., et al. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c02765 · Cited by 44
Role of bioavailability and protein binding of four anionic perfluoroalkyl substances in cell-based bioassays for quantitative in vitro to in vivo extrapolations
Qin, W., Henneberger, L., Huchthausen, J., König, M., & Escher, B. I. (2023) · Environment International · doi:10.1016/j.envint.2023.107857 · Cited by 40
Association between exposure to perfluoroalkyl substances and metabolic syndrome and related outcomes among older residents living near a Science Park in Taiwan
Lin, T.-W., Chen, M., Lin, C., Chen, M., Tsai, M., Chan, D., Hung, K., & Chen, P. (2020) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2020.113607 · Cited by 40
Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease
Sinisalu, L., Sen, P., Salihović, S., Virtanen, S. M., Hyöty, H., Ilonen, J., Toppari, J., Veijola, R., Orešič, M., Knip, M., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109864 · Cited by 36
Serum concentrations of per-/polyfluoroalkyl substances and risk of type 2 diabetes: A case-control study
Duan, Y., Sun, H., Yao, Y., Li, Y., Meng, Y. D., Lü, Y., Han, L., & Chen, L. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.147476 · Cited by 36
Close association of PFASs exposure with hepatic fibrosis than steatosis: evidences from NHANES 2017–2018
Cheng, W., Li, M., Zhang, L., Zhou, C., Zhang, X., Zhu, C., Tan, L., Lin, H., Zhang, W., & Zhang, W. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2216943 · Cited by 38
Association between serum per- and polyfluoroalkyl substances concentrations and common cold among children and adolescents in the United States
Zhang, Y., Mustieles, V., Sun, Y., Oulhote, Y., Wang, Y.-X., & Messerlian, C. (2022) · Environment International · doi:10.1016/j.envint.2022.107239 · Cited by 39
Per- and polyfluoroalkyl substances (PFAS) and male reproductive function in young adulthood; a cross-sectional study
Petersen, K. U., Hærvig, K. K., Flachs, E. M., Bonde, J. P., Lindh, C. H., Hougaard, K. S., Toft, G. V., Ramlau‐Hansen, C. H., & Tøttenborg, S. S. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113157 · Cited by 36
A novel molecular pathway of lipid accumulation in human hepatocytes caused by PFOA and PFOS
Gou, X., Tian, M., Yan, L., Xia, P., Ji, H., Tan, H., Shi, W. M., Yu, H., & Zhang, X. (2024) · Environment International · doi:10.1016/j.envint.2024.108962 · Cited by 37
Effects of mixed exposure to PFAS on adolescent non-alcoholic fatty liver disease: Integrating evidence from human cohorts, toxicogenomics, and animal models to uncover mechanisms and potential target sites
Du, X., Li, D., Xu, X., Wu, Y., Du, Z., Liang, G., Li, Y.-Z., Zheng, Y.-J., Qin, Y., Qian, K., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136854 · Cited by 34
Perfluorooctane sulfonate (PFOS) exposure of bovine oocytes affects early embryonic development at human-relevant levels in an in vitro model
Hallberg, I., Persson, S., Olovsson, M. H., Sirard, M., Damdimopoulou, P., Rüegg, J., & Sjunnesson, Y. C. B. (2021) · Toxicology · doi:10.1016/j.tox.2021.153028 · Cited by 31
Prenatal Exposure to an EDC Mixture, NeuroMix: Effects on Brain, Behavior, and Stress Responsiveness in Rats
Gore, A. C., Moore, T., Groom, M. J., & Thompson, L. M. (2022) · Toxics · doi:10.3390/toxics10030122 · Cited by 30
Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst
Phelps, D. W., Palekar, A. I., Conley, H. E., Ferrero, G., Driggers, J. H., Linder, K. E., Kullman, S. W., Reif, D. M., Sheats, M. K., DeWitt, J. C., et al. (2023) · Journal of Immunotoxicology · doi:10.1080/1547691x.2023.2176953 · Cited by 34
Effects of short-chain per- and polyfluoroalkyl substances (PFAS) on human cytochrome P450 (CYP450) enzymes and human hepatocytes: An in vitro study
Solan, M. E., & Lavado, R. (2023) · Current Research in Toxicology · doi:10.1016/j.crtox.2023.100116 · Cited by 33
Baseline Toxicity Model to Identify the Specific and Nonspecific Effects of Per- and Polyfluoroalkyl Substances in Cell-Based Bioassays
Qin, W., Henneberger, L., Glüge, J., König, M., & Escher, B. I. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c09950 · Cited by 32
Perfluorooctanesulfonic Acid (PFOS) Thwarts the Beneficial Effects of Calorie Restriction and Metformin
Salter, D. M., Wei, W., Nahar, P. P., Marques, E., & Slitt, A. L. (2021) · Toxicological Sciences · doi:10.1093/toxsci/kfab043 · Cited by 28
The use of in vitro methods in assessing human health risks associated with short‐chain perfluoroalkyl and polyfluoroalkyl substances (PFAS)
Solan, M. E., & Lavado, R. (2021) · Journal of Applied Toxicology · doi:10.1002/jat.4270 · Cited by 36
The interference between effects of PFAS exposure on thyroid hormone disorders and cholesterol levels: an NHANES analysis
Zheng, L., Wang, Z., Yang, R., Chen, W., Zhang, J., Li, R., Lv, W., Lin, B., & Luo, J. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-28739-8 · Cited by 29
Lipidomics and environmental toxicology: Recent trends
Aristizabal‐Henao, J. J., Ahmadireskety, A., Griffin, E. K., da Silva, B. F., & Bowden, J. A. (2020) · Current Opinion in Environmental Science & Health · doi:10.1016/j.coesh.2020.04.004 · Cited by 29
Exposure to Perfluoroalkyl Substances During Pregnancy and Fetal BDNF Level: A Prospective Cohort Study
Yu, G., Luo, F., Nian, M., Li, S., Liu, B., Feng, L., & Zhang, J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.653095 · Cited by 31
EI/IOT of PFCs: Environmental impacts/interactions, occurrences, and toxicities of perfluorochemicals
Nganda, A., Kumar, M., Uday, V., Srivastava, P. K., Deka, B. J., Zitouni, F., & Mahlknecht, J. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114707 · Cited by 29
Alteration of hepato-lipidomic homeostasis in A/J mice fed an environmentally relevant PFAS mixture
Khan, E. A., Grønnestad, R., Krøkje, Å., Bartosov, Z., Johanson, S. M., Müller, M. H. B., & Arukwe, A. (2023) · Environment International · doi:10.1016/j.envint.2023.107838 · Cited by 31
Endocrine disrupting compounds in the baby's world - A harmful environment to the health of babies
Płotka‐Wasylka, J., Mulkiewicz, E., Lis, H., Godlewska, K., Kurowska‐Susdorf, A., Sajid, M., Lambropoulou, D. A., & Jatkowska, N. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.163350 · Cited by 28
Endocrine disrupting chemicals: A promoter of non-alcoholic fatty liver disease
Chen, Y., Wang, Y., Cui, Z., Liu, W., Liu, B., Zeng, Q., Zhao, X., Dou, J., & Cao, J. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1154837 · Cited by 33
Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study)
Pálešová, N., Maître, L., Stratakis, N., Řiháčková, K., Pindur, A., Kohoutek, J., Šenk, P., Polcrova, A. B., Gregor, P., Vrijheid, M., et al. (2023) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2023.114215 · Cited by 34
Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio
Venezia, O. L., Islam, S. T., Cho, C., Timme‐Laragy, A. R., & Sant, K. E. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115653 · Cited by 27
Lipidomic Analyses Reveal Modulation of Lipid Metabolism by the PFAS Perfluoroundecanoic Acid (PFUnDA) in Non-Obese Diabetic Mice
Hyötyläinen, T., Bodin, J., Duberg, D., Dirven, H. A. A. M., Nygaard, U. C., & Orešič, M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.721507 · Cited by 27
Unbiased approach for the identification of molecular mechanisms sensitive to chemical exposures
Suvorov, A., Salemme, V., McGaunn, J. P., Poluyanoff, A., Teffera, M., & Amir, S. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128362 · Cited by 24
Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays
Murase, W., Kubota, A., Araki, A., Terasaki, M., Nakagawa, K., Shizu, R., Yoshinari, K., & Kojima, H. (2023) · Toxicology · doi:10.1016/j.tox.2023.153577 · Cited by 26
Pharmacokinetic profile of Perfluorobutane Sulfonate and activation of hepatic nuclear receptor target genes in mice
Lau, C. S., Rumpler, J., Das, K. P., Wood, C. R., Schmid, J. E., Strynar, M. J., & Wambaugh, J. F. (2020) · Toxicology · doi:10.1016/j.tox.2020.152522 · Cited by 26
Exploring the sources, occurrence, transformation, toxicity, monitoring, and remediation strategies of per- and polyfluoroalkyl substances: a review
Elgarahy, A. M., Eloffy, M. G., Saber, A. N., Abouzid, M., Rashad, E., Ghorab, M. A., El‐Sherif, D. M., & Elwakeel, K. Z. (2024) · Environmental Monitoring and Assessment · doi:10.1007/s10661-024-13334-2 · Cited by 28
Epigenetic and Genotoxic Mechanisms of PFAS-Induced Neurotoxicity: A Molecular and Transgenerational Perspective
Kebieche, N., Yim, S., Lambert, C., & Soulimani, R. (2025) · Toxics · doi:10.3390/toxics13080629 · Cited by 29
Evaluation of Transcriptomic Responses in Livers of Mice Exposed to the Short-Chain PFAS Compound HFPO-DA
Heintz, M. M., Chappell, G. A., Thompson, C. M., & Haws, L. C. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.937168 · Cited by 25
Association of per- and polyfluoroalkyl substance exposure with metabolic syndrome and its components in adults and adolescents
Zheng, H., Yin, Z., Luo, X., Zhou, Y., Fei, Z., & Guo, Z. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-30317-x · Cited by 25
Binding of Per- and Polyfluoroalkyl Substances (PFAS) to the PPARγ/RXRα–DNA Complex
Almeida, N. M. S., Bali, S. K., James, D., Wang, C., & Wilson, A. K. (2023) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.3c01384 · Cited by 25
In vitro screening of understudied PFAS with a focus on lipid metabolism disruption
Kashobwe, L., Sadrabadi, F., Braeuning, A., Leonards, P. E. G., Buhrke, T., & Hamers, T. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03814-2 · Cited by 24
Self-citation

Authors: Behr, A.-C., Plinsch, C., Braeuning, A., & Buhrke, T.
Affiliations: German Federal Institute for Risk Assessment (BfR) (DE)
Corresponding author: Buhrke, Thorsten
ORCID: Behr, Anne-Cathrin
Braeuning, Albert
Buhrke, Thorsten
Venue: Toxicology in Vitro
Publisher: Elsevier BV
Published: 2020-02
Volume: 62
Pages: 104700
ISSN: 0887-2333 (ISSN-L)
DOI: 10.1016/j.tiv.2019.104700
OpenAlex: W2982329931
Cited by: 235
References: 53
Citations by year: 2026: 36 · 2025: 41 · 2024: 32 · 2023: 40 · 2022: 43 · 2021: 32 · 2020: 11
FWCI: 9.36
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Toxicology in Vitro (publishedVersion)
PubMed (publishedVersion)
OpenAgrar (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Physical Sciences › Chemistry › Organic Chemistry › Fluorine in Organic Chemistry
Keywords: perfluorooctanoic acid, PFOS, PFBS, PPARα, PPARγ, nuclear receptor activation, hepatotoxicity, PPARα agonist, PFAS alternatives, HepG2 cells, endocrine disruption
MeSH terms: Caprylates, Fluorocarbons, Humans, Sulfonic Acids, Transcriptional Activation, Gene Expression, Alkanesulfonic Acids, Genes, Reporter, Receptors, Cytoplasmic and Nuclear, Cell Line, Tumor, PPAR alpha, Hep G2 Cells, HEK293 Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks