The DOI matches its Crossref record; 168 of the 170 references it cites were found in a registry or an index.
The nucleosome remodeling and deacetylase complex in development and disease
Open accessAbstract
The nucleosome remodeling and deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity, and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.
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“At the biochemical level, the NuRD complex, with nucleosome remodeling and deacetylase roles, is epigenetically involved in gene regulation, with DNA fixed via binding where the damage occurs on multiple loci spots [110].”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [110]
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Metadata
- Authors
- Basta, J., & Rauchman, M.
- Affiliations
- John Cochran VA Medical Center (US)
- Corresponding author
- Rauchman, Michael
- Venue
- Translational Research
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 165
- Issue
- 1
- Pages
- 36-47
- ISSN
- 1878-1810 (ISSN-L)
- 1931-5244
- PMC
- PMC4793962
- OpenAlex
- W1973871665
- Cited by
- 191
- References
- 170
- Citations by year
- 2026: 14 · 2025: 26 · 2024: 26 · 2023: 20 · 2022: 11 · 2021: 14 · 2020: 20 · 2019: 19 · 2018: 17 · 2017: 11 · 2016: 8 · 2015: 3
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Translational research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases
- American Heart Association
- March of Dimes
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- NuRD complex, chromatin remodeling, histone deacetylase, transcriptional regulation, genome stability, cell cycle progression, developmental defects, carcinogenesis, aging, congenital malformations, cancer therapy
- MeSH terms
- Aging, Animals, Female, Humans, Neoplasms, Pregnancy, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Embryonic Development, Embryonic Stem Cells, Mi-2 Nucleosome Remodeling and Deacetylase Complex, Translational Research, Biomedical
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