Cited by 192Chromatin Remodeling and CancerGenomics and Chromatin DynamicsEpigenetics and DNA Methylation

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The nucleosome remodeling and deacetylase complex in development and disease

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Basta, Jeannine, Rauchman, Michael·2015·Translational Research

DOI 10.1016/j.trsl.2014.05.003PMC PMC4793962

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Abstract

The nucleosome remodeling and deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity, and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.

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Authors: Basta, J., & Rauchman, M.
Affiliations: John Cochran VA Medical Center (US)
Corresponding author: Rauchman, Michael
ORCID: Basta, Jeannine
Rauchman, Michael
Venue: Translational Research
Publisher: Elsevier BV
Published: 2015-01
Volume: 165
Issue: 1
Pages: 36-47
ISSN: 1878-1810 (ISSN-L)
1931-5244
DOI: 10.1016/j.trsl.2014.05.003
PMC: PMC4793962
OpenAlex: W1973871665
Cited by: 191
References: 170
Citations by year: 2026: 14 · 2025: 26 · 2024: 26 · 2023: 20 · 2022: 11 · 2021: 14 · 2020: 20 · 2019: 19 · 2018: 17 · 2017: 11 · 2016: 8 · 2015: 3
FWCI: 0.75
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Translational research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases
American Heart Association
March of Dimes
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: NuRD complex, chromatin remodeling, histone deacetylase, transcriptional regulation, genome stability, cell cycle progression, developmental defects, carcinogenesis, aging, congenital malformations, cancer therapy
MeSH terms: Aging, Animals, Female, Humans, Neoplasms, Pregnancy, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Embryonic Development, Embryonic Stem Cells, Mi-2 Nucleosome Remodeling and Deacetylase Complex, Translational Research, Biomedical

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The nucleosome remodeling and deacetylase complex in development and disease

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