Cited by 192Chromatin Remodeling and CancerGenomics and Chromatin DynamicsEpigenetics and DNA Methylation

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The nucleosome remodeling and deacetylase complex in development and disease

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Basta, Jeannine, Rauchman, Michael·2015·Translational Research

DOI 10.1016/j.trsl.2014.05.003PMC PMC4793962

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Abstract

The nucleosome remodeling and deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity, and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.

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Regulating the Regulators: The Post‐Translational Code of Class I HDAC1 and HDAC2
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Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis
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New Regulators of Wnt/β-Catenin Signaling Revealed by Integrative Molecular Screening
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Epigenetic reprogramming induces the expansion of cord blood stem cells
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Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: Role in epithelial cancer cell invasion, proliferation and nuclear regulation
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Serological detection of cutaneous T-cell lymphoma-associated antigens
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The dMi‐2 chromodomains are DNA binding modules important for ATP‐dependent nucleosome mobilization
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p66α–MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2–NuRD complex
Gnanapragasam, M. N., Scarsdale, J. N., Amaya, M. L., Webb, H. D., Desai, M. A., Walavalkar, N. M., Wang, S. Z., Zu Zhu, S., Ginder, G. D., & Williams, D. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015341108 · Cited by 148
The structure of the core NuRD repression complex provides insights into its interaction with chromatin
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ATM Engages Autodegradation of the E3 Ubiquitin Ligase COP1 After DNA Damage
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Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice
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A Conserved 12-Amino Acid Motif in Sall1 Recruits the Nucleosome Remodeling and Deacetylase Corepressor Complex
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Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences
Günther, K., Rust, M., Leers, J., Boettger, T., Scharfe, M., Jarek, M., Bartkuhn, M., & Renkawitz, R. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt035 · Cited by 136
ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State
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SALL4, the missing link between stem cells, development and cancer
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NuRD–ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination
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MTA1, a transcriptional activator of breast cancer amplified sequence 3
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Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications
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MBD3, a Component of the NuRD Complex, Facilitates Chromatin Alteration and Deposition of Epigenetic Marks
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Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein
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Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression
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Chromodomain Helicase DNA-binding Protein 4 (CHD4) Regulates Homologous Recombination DNA Repair, and Its Deficiency Sensitizes Cells to Poly(ADP-ribose) Polymerase (PARP) Inhibitor Treatment
Pan, M., Hsieh, H.-J., Dai, H., Hung, W.-C., Li, K., Peng, G., & Lin, S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.287037 · Cited by 118
A new non‐catalytic role for ubiquitin ligase RNF8 in unfolding higher‐order chromatin structure
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Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain
Yamada, T., Yang, Y., Hemberg, M., Yoshida, T., Cho, H. Y., Murphy, J. P., Fioravante, D., Regehr, W. G., Gygi, S. P., Georgopoulos, K., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.039 · Cited by 116
MBD3 Localizes at Promoters, Gene Bodies and Enhancers of Active Genes
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Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14
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Metastasis-Associated Protein 1/Nucleosome Remodeling and Histone Deacetylase Complex in Cancer
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Insights into Association of the NuRD Complex with FOG-1 from the Crystal Structure of an RbAp48·FOG-1 Complex
Lejon, S., Thong, S. Y., Murthy, A., AlQarni, S., Murzina, N. V., Blobel, G. A., Laue, E. D., & Mackay, J. P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.195842 · Cited by 106
NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells
Luo, M., Ling, T., Xie, W., Sun, H., Zhou, Y., Zhu, Q., Shen, M., Zong, L., Lyu, G., Zhao, Y., et al. (2013) · Stem Cells · doi:10.1002/stem.1374 · Cited by 104
SALL4 is a new target in endometrial cancer
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Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells
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Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex
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Metastasis Tumor Antigen Family Proteins during Breast Cancer Progression and Metastasis in a Reliable Mouse Model for Human Breast Cancer
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CHD5 is required for spermiogenesis and chromatin condensation
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CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy now
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The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation
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Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor
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The chromatin remodeler Mi-2β is required for establishment of the basal epidermis and normal differentiation of its progeny
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A network of epigenetic regulators guides developmental haematopoiesis in vivo
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E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1
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Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin
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Role of CHD5 in Human Cancers: 10 Years Later
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Identification of Conserved Pathways of DNA-Damage Response and Radiation Protection by Genome-Wide RNAi
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Insight into the Architecture of the NuRD Complex
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The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis
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A Core Chromatin Remodeling Factor Instructs Global Chromatin Signaling through Multivalent Reading of Nucleosome Codes
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The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4
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The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules
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FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment
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Methyl binding domain protein 2 mediates γ-globin gene silencing in adult human βYAC transgenic mice
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dMec: a novel Mi‐2 chromatin remodelling complex involved in transcriptional repression
Kunert, N., Wagner, E., Murawska, M., Klinker, H., Kremmer, E., & Brehm, A. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.3 · Cited by 72
FOG‐1‐mediated recruitment of NuRD is required for cell lineage re‐enforcement during haematopoiesis
Gao, Z., Huang, Z., Olivey, H. E., Gurbuxani, S. K., Crispino, J. D., & Svensson, E. C. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.368 · Cited by 72
A PTBA small molecule enhances recovery and reduces postinjury fibrosis after aristolochic acid-induced kidney injury
Novitskaya, T., McDermott, L. A., Zhang, K. X., Chiba, T., Paueksakon, P., Hukriede, N. A., & de Caestecker, M. P. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00534.2013 · Cited by 72
Structural and Functional Insights into the Human Börjeson-Forssman-Lehmann Syndrome-associated Protein PHF6
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GATAD2B loss-of-function mutations cause a recognisable syndrome with intellectual disability and are associated with learning deficits and synaptic undergrowth in Drosophila
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Repression of Six3 by a corepressor regulates rhodopsin expression
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The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose)
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Sall1 balances self-renewal and differentiation of renal progenitor cells
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Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex
Gao, C., Dimitrov, T., Yong, K. J., Tatetsu, H., Jeong, H.-W., Luo, H. R., Bradner, J. E., Tenen, D. G., & Chai, L. (2013) · Blood · doi:10.1182/blood-2012-04-424275 · Cited by 65
HDAC inhibitors in kidney development and disease
Brilli, L. L., Swanhart, L. M., de Caestecker, M. P., & Hukriede, N. A. (2012) · Pediatric Nephrology · doi:10.1007/s00467-012-2320-8 · Cited by 64
Inactivation of NuRD Component Mta2 Causes Abnormal T Cell Activation and Lupus-like Autoimmune Disease in Mice
Lu, X., Kovalev, G. I., Chang, H., Kallin, E. M., Knudsen, G., Li, X., Mishra, N., Ruiz, P., Li, E., Su, L., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801275200 · Cited by 63
Estrogen Regulates the Tumour Suppressor MiRNA-30c and Its Target Gene, MTA-1, in Endometrial Cancer
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Metastatic tumor antigen 3 is a direct corepressor of the Wnt4 pathwayPreprint
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CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex
Spruijt, C. G., Bartels, S. J. J., Brinkman, A. B., Tjeertes, J., Poser, I., Stunnenberg, H. G., & Vermeulen, M. (2010) · Molecular BioSystems · doi:10.1039/c004108d · Cited by 58
SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules
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The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex
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The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex
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Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos
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β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation
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Role of the GATA-1/FOG-1/NuRD Pathway in the Expression of Human β-Like Globin Genes
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Inhibition of histone binding by supramolecular hosts
Allen, H. F., Daze, K. D., Shimbo, T., Lai, A. Y., Musselman, C. A., Sims, J. K., Wade, P. A., Hof, F. A., & Kutateladze, T. G. (2014) · Biochemical Journal · doi:10.1042/bj20140145 · Cited by 47
A Phosphomimetic Mutation in the Sall1 Repression Motif Disrupts Recruitment of the Nucleosome Remodeling and Deacetylase Complex and Repression of Gbx2
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SALL1 truncated protein expression in Townes-Brocks syndrome leads to ectopic expression of downstream genes
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Fusion of ZMYND8 and RELA Genes in Acute Erythroid Leukemia
Panagopoulos, I., Micci, F., Thorsen, J., Haugom, L., Buechner, J., Kerndrup, G. B., Tierens, A. M., Zeller, B., & Heim, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063663 · Cited by 45
Requirement of MTA1 in ATR-mediated DNA Damage Checkpoint Function
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Protein Kinase C-Mediated Phosphorylation of BCL11B at Serine 2 Negatively Regulates Its Interaction with NuRD Complexes during CD4+ T-Cell Activation
Dubuissez, M., Loison, I., Paget, S., Vorng, H., Yahia, S. A., Rohr, O., Tsicopoulos, A., & Leprince, D. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00062-16 · Cited by 44
The Caenorhabditis elegans LET ‐418/ M i2 plays a conserved role in lifespan regulation
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Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development
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The function of chromatin modifiers in lineage commitment and cell fate specification
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An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation
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Authors: Basta, J., & Rauchman, M.
Affiliations: John Cochran VA Medical Center (US)
Corresponding author: Rauchman, Michael
ORCID: Basta, Jeannine
Rauchman, Michael
Venue: Translational Research
Publisher: Elsevier BV
Published: 2015-01
Volume: 165
Issue: 1
Pages: 36-47
ISSN: 1878-1810 (ISSN-L)
1931-5244
DOI: 10.1016/j.trsl.2014.05.003
PMC: PMC4793962
OpenAlex: W1973871665
Cited by: 191
References: 170
Citations by year: 2026: 14 · 2025: 26 · 2024: 26 · 2023: 20 · 2022: 11 · 2021: 14 · 2020: 20 · 2019: 19 · 2018: 17 · 2017: 11 · 2016: 8 · 2015: 3
FWCI: 0.75
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Translational research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases
American Heart Association
March of Dimes
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: NuRD complex, chromatin remodeling, histone deacetylase, transcriptional regulation, genome stability, cell cycle progression, developmental defects, carcinogenesis, aging, congenital malformations, cancer therapy
MeSH terms: Aging, Animals, Female, Humans, Neoplasms, Pregnancy, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Embryonic Development, Embryonic Stem Cells, Mi-2 Nucleosome Remodeling and Deacetylase Complex, Translational Research, Biomedical

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The nucleosome remodeling and deacetylase complex in development and disease

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