The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans
Open accessAbstract
We have evaluated the serum response to seasonal influenza vaccination in subjects of different ages and associated this with the specific B cell response to the vaccine in vitro. Although the serum response has previously been shown to decrease with age, this has largely been associated to decreased T cell functions. Our results show that in response to the vaccine, the specific response of B cells in vitro, as measured by AID (activation-induced cytidine deaminase), the in vivo serum HI (hemagglutination inhibition) response, and the in vivo generation of switch memory B cells are decreased with age, as evaluated in the same subjects. This is the first report to demonstrate that intrinsic B cell defects with age contribute to reduced antibody responses to the influenza vaccine. The level of AID in response to CpG before vaccination can also predict the robustness of the vaccine response. These results could contribute to developing more effective vaccines to protect the elderly as well as identifying those most at risk.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“For example, the serum antibody response to both seasonal and pandemic influenza vaccines, as well as the in vitro B-cell response after vaccination, are both decreased with increasing age and are significantly correlated [114, 124, 125].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [125]
Experimental — accuracy not yet measuredIn the citing paper
“AID expression is also significantly correlated with antibody affinity maturation for the HA1 globular domain of the pandemic (p)H1N1 HA, as measured by antibody-antigen complex dissociation rates and Surface Plasmon Resonance [125].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [125]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States
Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J., & Fukuda, K. (2003) · JAMA · doi:10.1001/jama.289.2.179 · Cited by 3,673
Influenza-Associated Hospitalizations in the United States
Thompson, W. W. (2004) · JAMA · doi:10.1001/jama.292.11.1333 · Cited by 2,213
Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells
Bernasconi, N. L., Traggiai, E., & Lanzavecchia, A. (2002) · Science · doi:10.1126/science.1076071 · Cited by 1,304
Duration of Humoral Immunity to Common Viral and Vaccine Antigens
Amanna, I. J., Carlson, N. E., & Slifka, M. K. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066092 · Cited by 1,286
The Efficacy of Influenza Vaccine in Elderly Persons: A Meta-Analysis and Review of the Literature
Gross, P. A., Hermogenes, A. W., Sacks, H. S., Lau, J., & Levandowski, R. A. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-123-7-199510010-00008 · Cited by 1,100
Antibody response to influenza vaccination in the elderly: A quantitative review
GOODWIN, K., VIBOUD, C., & SIMONSEN, L. (2006) · Vaccine · doi:10.1016/j.vaccine.2005.08.105 · Cited by 1,064
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
Wrammert, J., Smith, K., Miller, J., Langley, W. A., Kokko, K. E., Larsen, C. P., Zheng, N., Mays, I., Garman, L., Helms, C., et al. (2008) · Nature · doi:10.1038/nature06890 · Cited by 1,026
Cytotoxic T-Cell Immunity to Influenza
McMichael, A. J., Gotch, F. M., Noble, G. R., & Beare, P. A. (1983) · New England Journal of Medicine · doi:10.1056/nejm198307073090103 · Cited by 931
Pandemic versus Epidemic Influenza Mortality: A Pattern of Changing Age Distribution
Simonsen, L., Clarke, M. J., Schonberger, L. B., Arden, N. H., Cox, N. J., & Fukuda, K. (1998) · The Journal of Infectious Diseases · doi:10.1086/515616 · Cited by 705
Mortality benefits of influenza vaccination in elderly people: an ongoing controversy
Simonsen, L., Taylor, R. J., Viboud, C. G., Miller, M. A., & Jackson, L. A. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70236-0 · Cited by 520
Cited by
Sorted by citations
Items 101–143 of 143
Antibody Responsiveness to Influenza: What Drives It?
Lin, X., Lin, F., Liang, T., Ducatez, M., Zanin, M., & Wong, S. (2021) · Viruses · doi:10.3390/v13071400 · Cited by 16
Rodríguez‐Zhurbenko, N., Rabade‐Chediak, M., Bedoya, D. M., Griñán, T., & Hernández, A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12827 · Cited by 14
Cortegano, I., Rodríguez, M., Martín, I., Prado, C., Ruíz, C., Hortigüela, R., Alía, M., Vilar, M., Mira, H., Cano, E., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.351 · Cited by 14
Gary, E. N., Tursi, N. J., Warner, B. M., Cuismano, G., Connors, J. R., Parzych, E. M., Griffin, B. D., Bell, M. R., Ali, A., Frase, D. M., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1138609 · Cited by 13
Ionov, S., & Lee, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.832533 · Cited by 12
Leon, L. A. A., Coelho, W. L. D. C. N. P., Alves, A. D. R., Carneiro, V. C. D. S., Moreira, O. C., de Paula, V. S., Salvio, A. L., Duarte, L. A., Gutman, E. G., Fontes-Dantas, F. L., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12072568 · Cited by 11
Lang, P.-O., Govind, S., & Aspinall, R. (2012) · NPG. Neurologie, psychiatrie, gériatrie/NPG · doi:10.1016/j.npg.2012.04.005 · Cited by 12
AID in aging and autoimmune diseases
Frasca, D., Andrisani, G., Diaz, A., Felice, C., Guidi, L., & Blomberg, B. B. (2012) · Autoimmunity · doi:10.3109/08916934.2012.750300 · Cited by 12
Self-citationCookenham, T. S., Lanzer, K. G., Tighe, M., Ward, J. M., Reiley, W. W., & Blackman, M. A. (2021) · ImmunoHorizons · doi:10.4049/immunohorizons.2100032 · Cited by 11
Vanderven, H. A., Barr, I., Reynaldi, A., Wheatley, A. K., Wines, B. D., Davenport, M. P., Hogarth, P. M., & Kent, S. J. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.01.066 · Cited by 10
Divithotawela, C., Pham, A., Bell, P. T., Ledger, E. L., Tan, M. E., Yerkovich, S. T., Grant, M., Hopkins, P. M.-A., Wells, T. J., & Chambers, D. C. (2021) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2021.05.016 · Cited by 10
E47 retroviral rescue of intrinsic B‐cell defects in senescent mice
Landin, A. M., Frasca, D., Harrison, P. T., Scallan, M. F., Riley, R. L., & Blomberg, B. B. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00673.x · Cited by 10
Self-citationHarder, O. E., & Niewiesk, S. (2022) · Advances in Virology · doi:10.1155/2022/8637545 · Cited by 9
Hara, M., Hanaoka, T., Mizushima, T., Honma, J., Maeda, K., Ohfuji, S., Tanaka, K., & Hirota, Y. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.08.097 · Cited by 9
Wang, W., Qiong, C., Ford-Siltz, L. A., Katzelnick, L. C., Parra, G. I., Song, H. S., Vassell, R. A., & Weiss, C. D. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy818 · Cited by 7
Vaccine responses in ageing and chronic viral infection
Rees-Spear, C., & McCoy, L. E. (2021) · Oxford Open Immunology · doi:10.1093/oxfimm/iqab007 · Cited by 8
Investigating population-level immunosenescence: From bench to bedside
Cunha, L. L., Valsecchi, V. A. D. S., & Ward, L. S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.949928 · Cited by 7
Petrović, V., Vuković, V., Patić, A., Marković, M., & Ristić, M. (2022) · Vaccines · doi:10.3390/vaccines11010056 · Cited by 6
Napolioni, V., Serone, E., Iacoacci, V., Carpi, F. M., Giambra, V., & Frezza, D. (2014) · Gene · doi:10.1016/j.gene.2014.08.057 · Cited by 6
Frasca, D., & Blomberg, B. B. (2016) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2017020113 · Cited by 6
Self-citationChen, P.-L., Richardson, R. A., Rovito, S. W., Yang, G., Writt, H. N., Ojha, C. R., DeBeauchamp, J., Crumpton, J. C., Woodard, K., Penaflor, M. K., et al. (2025) · Vaccine · doi:10.1016/j.vaccine.2025.127090 · Cited by 5
Frasca, D., Diaz, A., & Blomberg, B. B. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2963-4_9 · Cited by 5
Self-citationHashan, M. R., Smoll, N. R., Chapman, G., King, C. L., Walker, J., Kirk, M., Akbar, D., Booy, R., & Khandaker, G. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-073555 · Cited by 5
Ishimura, D. T. M. E. (2015) · Journal of Aging Science · doi:10.4172/2329-8847.1000132 · Cited by 3
Herati, R. S., Silva, L. V., Vella, L. A., Muselman, A., Alanio, C., Bengsch, B., Kurupati, R. K., Kannan, S., Manne, S., Kossenkov, A. V., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/711911 · Cited by 4
Human B Cell Senescence in Pulmonary Infections
Blomberg, B. B. (2012) · Open Longevity Science · doi:10.2174/1876326x01206010047 · Cited by 3
Self-citationGonzalez, K. J., & Strauch, E. (2021) · Journal of Clinical Investigation · doi:10.1172/jci151732 · Cited by 3
Allogeneic Mesenchymal Stem Cells as a Treatment for Aging Frailty
Tompkins, B. A., Landin, A. M., Florea, V., Natsumeda, M., Rieger, A. C., Balkan, W., Schulman, I. H., & Hare, J. M. (2017) · InTech eBooks · doi:10.5772/intechopen.69194 · Cited by 3
Self-citationDifferences in Alloimmune Response Between Elderly and Young Mice
Book, B. K., Volz, M. A., Ward, E. K., Eckert, G. J., Pescovitz, M. D., & Wiebke, E. A. (2013) · Transplantation Proceedings · doi:10.1016/j.transproceed.2013.01.006 · Cited by 2
Hashemi, S. A., & Madani, S. A. (2013) · Research in Endocrinology · doi:10.5171/2013.401901 · Cited by 1
Immune cell subsets in young kidney transplant recipients: Mechanistic and clinical perspectives
Corr, M., Khan, N., Malinova, D., Maxwell, A. P., McKay, G. J., & Griffin, M. D. (2025) · Transplantation Reviews · doi:10.1016/j.trre.2025.100971 · Cited by 1
Bartolucci, M., Utyro, O., Muraglia, A., Repetto, A., Agostini, V. W., Pizzonia, M., Ottaviani, S., Tripodi, G., Filaci, G., Cancedda, R., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1695213 · Cited by 1
Liu, J., Zhang, Z., Zhang, J., & Nian, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1919049 · Cited by 1
Development of a broadly reactive vaccine for highly pathogenic H5N1 influenza
Giles, B. M. (2011) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1
Brown, S.-A. W., & Braman, S. S. (2023) · Springer eBooks · doi:10.1007/978-3-030-01782-8_55-1 · Cited by 1
Brown, S.-A. W., & Braman, S. S. (2024) · Springer eBooks · doi:10.1007/978-3-030-74720-6_55 · Cited by 1
Antiviral CD4+ T and myeloid cell responses to influenza vaccines are attenuated in older adults
Oakes, J. M., Simmons, J., Nochowicz, C. H., Kirk, L. A., Eason, J., Halasa, N., Talbot, H. K., Bailin, S. S., Castilho, J. L., & Kalams, S. A. (2026) · Communications Medicine · doi:10.1038/s43856-026-01586-7 · Cited by 1
Hashan, M. R., Smoll, N. R., Chapman, G., King, C. L., Walker, J., Kirk, M., Akbar, D., Booy, R., & Khandaker, G. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4181714 · Cited by 1
Blomberg, B. B., & Frasca, D. (2011) · Revista Brasileira de Hematologia e Hemoterapia · doi:10.5581/1516-8484.20110093
Self-citationImmune system changes and immunosenescence
Pawelec, G., Müller, L., Fülöp, T., & Dunn‐Walters, D. K. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198701590.003.0045
ВОЗРАСТНЫЕ ИЗМЕНЕНИЯ В ИММУННОЙ СИСТЕМЕ ПРИ СТАРЕНИИ ОРГАНИЗМА
Movsisyan, M. R. (2024) · MEDICINE SCIENCE AND EDUCATION · doi:10.56936/18291775-2024.37-43
Influenza vaccine-specific CD4+ T cell responses are impaired in older adults
Saint-Charles, P., Hagen, M., Autaa, G., Bijvank, E., Beckers, L., van Beek, J., van Baarle, D., Weinberger, B., & Appay, V. (2026) · npj Vaccines · doi:10.1038/s41541-026-01437-5
Miller, K., Gelsomini, A., Romero, M., Garcia, D., Diaz, A., Bueno, V., Hansen, J., Jurecic, R., Antoni, M. H., & Frasca, D. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1944615
Self-citation
Metadata
- Authors
- Frasca, D., Diaz, A., Romero, M., Landin, A. M., Phillips, M., Lechner, S. C., Ryan, J. G., & Blomberg, B. B.
- Affiliations
- University of Miami (US)
- Corresponding author
- Blomberg, Bonnie B.
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 28
- Issue
- 51
- Pages
- 8077-8084
- ISSN
- 0264-410X (ISSN-L)
- PMC
- PMC3223387
- OpenAlex
- W1998709016
- Cited by
- 143
- References
- 49
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 19 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 13 · 2016: 12 · 2015: 11 · 2014: 9 · 2013: 12 · 2012: 12
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG032576, AG-17618, R01AG017618, R37AG023717, AG-28586, R01AG023717, AG23717, R21AG028586)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- seasonal influenza vaccine, B cell response, aging, activation-induced cytidine deaminase, hemagglutination inhibition, antibody response, CpG, older adults, vaccine response prediction
- MeSH terms
- AICDA (Activation-Induced Cytidine Deaminase), Adult, Age Factors, Aged, Aged, 80 and over, Antibodies, Viral, B-Lymphocytes, Cytidine Deaminase, Female, Hemagglutination Inhibition Tests, Humans, Immunologic Memory, Influenza, Human, Influenza Vaccines, Male, Middle Aged
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
