Cited by 143Influenza Virus Research StudiesImmune responses and vaccinationsT-cell and B-cell Immunology

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Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans

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Frasca, Daniela, Diaz, Alain, Romero, Maria, Landin, Ana Marie, Phillips, Mitch, Lechner, Suzanne C., Ryan, John G., Blomberg, Bonnie B.·2010·Vaccine

DOI 10.1016/j.vaccine.2010.10.023PMC PMC3223387

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Abstract

We have evaluated the serum response to seasonal influenza vaccination in subjects of different ages and associated this with the specific B cell response to the vaccine in vitro. Although the serum response has previously been shown to decrease with age, this has largely been associated to decreased T cell functions. Our results show that in response to the vaccine, the specific response of B cells in vitro, as measured by AID (activation-induced cytidine deaminase), the in vivo serum HI (hemagglutination inhibition) response, and the in vivo generation of switch memory B cells are decreased with age, as evaluated in the same subjects. This is the first report to demonstrate that intrinsic B cell defects with age contribute to reduced antibody responses to the influenza vaccine. The level of AID in response to CpG before vaccination can also predict the robustness of the vaccine response. These results could contribute to developing more effective vaccines to protect the elderly as well as identifying those most at risk.

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Authors: Frasca, D., Diaz, A., Romero, M., Landin, A. M., Phillips, M., Lechner, S. C., Ryan, J. G., & Blomberg, B. B.
Affiliations: University of Miami (US)
Corresponding author: Blomberg, Bonnie B.
ORCID: Frasca, Daniela
Romero, Maria
Ryan, John G.
Blomberg, Bonnie B.
Venue: Vaccine
Publisher: Elsevier BV
Published: 2010-11
Volume: 28
Issue: 51
Pages: 8077-8084
ISSN: 0264-410X (ISSN-L)
DOI: 10.1016/j.vaccine.2010.10.023
PMC: PMC3223387
OpenAlex: W1998709016
Cited by: 143
References: 49
Citations by year: 2026: 5 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 19 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 13 · 2016: 12 · 2015: 11 · 2014: 9 · 2013: 12 · 2012: 12
FWCI: 9.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Vaccine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG032576, AG-17618, R01AG017618, R37AG023717, AG-28586, R01AG023717, AG23717, R21AG028586)
Topics: Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: seasonal influenza vaccine, B cell response, aging, activation-induced cytidine deaminase, hemagglutination inhibition, antibody response, CpG, older adults, vaccine response prediction
MeSH terms: AICDA (Activation-Induced Cytidine Deaminase), Adult, Age Factors, Aged, Aged, 80 and over, Antibodies, Viral, B-Lymphocytes, Cytidine Deaminase, Female, Hemagglutination Inhibition Tests, Humans, Immunologic Memory, Influenza, Human, Influenza Vaccines, Male, Middle Aged

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Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans

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