The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans
Open accessAbstract
We have evaluated the serum response to seasonal influenza vaccination in subjects of different ages and associated this with the specific B cell response to the vaccine in vitro. Although the serum response has previously been shown to decrease with age, this has largely been associated to decreased T cell functions. Our results show that in response to the vaccine, the specific response of B cells in vitro, as measured by AID (activation-induced cytidine deaminase), the in vivo serum HI (hemagglutination inhibition) response, and the in vivo generation of switch memory B cells are decreased with age, as evaluated in the same subjects. This is the first report to demonstrate that intrinsic B cell defects with age contribute to reduced antibody responses to the influenza vaccine. The level of AID in response to CpG before vaccination can also predict the robustness of the vaccine response. These results could contribute to developing more effective vaccines to protect the elderly as well as identifying those most at risk.
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“For example, the serum antibody response to both seasonal and pandemic influenza vaccines, as well as the in vitro B-cell response after vaccination, are both decreased with increasing age and are significantly correlated [114, 124, 125].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [125]
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“AID expression is also significantly correlated with antibody affinity maturation for the HA1 globular domain of the pandemic (p)H1N1 HA, as measured by antibody-antigen complex dissociation rates and Surface Plasmon Resonance [125].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [125]
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Cites
Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States
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Influenza-Associated Hospitalizations in the United States
Thompson, W. W. (2004) · JAMA · doi:10.1001/jama.292.11.1333 · Cited by 2,213
Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells
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Antibody response to influenza vaccination in the elderly: A quantitative review
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Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
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Cytotoxic T-Cell Immunity to Influenza
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Pandemic versus Epidemic Influenza Mortality: A Pattern of Changing Age Distribution
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Real-world effectiveness of COVID-19 vaccines: a literature review and meta-analysis
Zheng, C., Shao, W., Chen, X., Zhang, B., Wang, G., & Zhang, W. (2021) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2021.11.009 · Cited by 719
Aging of the immune system: Focus on inflammation and vaccination
Pinti, M., Appay, V., Campisi, J., Frasca, D., Fülöp, T., Sauce, D., Larbi, A., Weinberger, B., & Cossarizza, A. (2016) · European Journal of Immunology · doi:10.1002/eji.201546178 · Cited by 439
Self-citationVaccination in the elderly: The challenge of immune changes with aging
Ciabattini, A., Nardini, C., Santoro, F., Garagnani, P., Franceschi, C., & Medaglini, D. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.10.010 · Cited by 411
Aging and the immune system: An overview
Akha, A. A. S. (2018) · Journal of Immunological Methods · doi:10.1016/j.jim.2018.08.005 · Cited by 403
Inflammaging decreases adaptive and innate immune responses in mice and humans
Frasca, D., & Blomberg, B. B. (2016) · Biogerontology · doi:10.1007/s10522-015-9578-8 · Cited by 357
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Metadata
- Authors
- Frasca, D., Diaz, A., Romero, M., Landin, A. M., Phillips, M., Lechner, S. C., Ryan, J. G., & Blomberg, B. B.
- Affiliations
- University of Miami (US)
- Corresponding author
- Blomberg, Bonnie B.
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 28
- Issue
- 51
- Pages
- 8077-8084
- ISSN
- 0264-410X (ISSN-L)
- PMC
- PMC3223387
- OpenAlex
- W1998709016
- Cited by
- 143
- References
- 49
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 19 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 13 · 2016: 12 · 2015: 11 · 2014: 9 · 2013: 12 · 2012: 12
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG032576, AG-17618, R01AG017618, R37AG023717, AG-28586, R01AG023717, AG23717, R21AG028586)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- seasonal influenza vaccine, B cell response, aging, activation-induced cytidine deaminase, hemagglutination inhibition, antibody response, CpG, older adults, vaccine response prediction
- MeSH terms
- AICDA (Activation-Induced Cytidine Deaminase), Adult, Age Factors, Aged, Aged, 80 and over, Antibodies, Viral, B-Lymphocytes, Cytidine Deaminase, Female, Hemagglutination Inhibition Tests, Humans, Immunologic Memory, Influenza, Human, Influenza Vaccines, Male, Middle Aged
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