The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Engineered exosomes targeting MYC reverse the proneural-mesenchymal transition and extend survival of glioblastoma
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In the citing paper
“This inhibition results in slower tumor progression and extends the survival of the mice.”
From Emerging role of exosomes in cancer therapy: progress and challenges (2025) · cites this paper as [208]
In the citing paper
“Specifically, iExo-Myc successfully localizes to GB tumors in mice, significantly inhibiting tumor proliferation and angiogenesis.”
From Emerging role of exosomes in cancer therapy: progress and challenges (2025) · cites this paper as [208]
In the citing paper
“These results confirm the promise of Myc as a therapeutical target for GB and demonstrate that delivering Myc siRNA via exosomes is an effective strategy for extending the survival of GB-bearing mice.”
From Emerging role of exosomes in cancer therapy: progress and challenges (2025) · cites this paper as [208]
In the citing paper
“This approach not only overcomes the limitations posed by the blood-brain barrier but also provides a new avenue for targeting difficult-to-inhibit oncogenes [208].”
From Emerging role of exosomes in cancer therapy: progress and challenges (2025) · cites this paper as [208]
In the citing paper
“Further single-cell RNA sequencing showed that iExo-Myc induced a shift in GB cells from a mesenchymal to a proneural state and downregulated genes related to cell proliferation and inflammation.”
From Emerging role of exosomes in cancer therapy: progress and challenges (2025) · cites this paper as [208]
In the citing paper
“Transcriptomic analysis revealed that Myc inhibition induces transcriptional changes in tumor cells, suppressing pathways associated with tumor invasion and promoting a transition from a mesenchymal to a proneural phenotype.”
From Emerging role of exosomes in cancer therapy: progress and challenges (2025) · cites this paper as [208]
In the citing paper
“The study consequences indicate that siRNA targeting the Myc gene, delivered via exosomes derived from human bone marrow mesenchymal stem cells (iExo-Myc), exhibits significant anti-tumor effects against GB.”
From Emerging role of exosomes in cancer therapy: progress and challenges (2025) · cites this paper as [208]
In the citing paper
“| Glioblastoma | iExo-Myc | Significantly inhibited tumor proliferation and angiogenesis | [208] |”
From Emerging role of exosomes in cancer therapy: progress and challenges (2025) · cites this paper as [208]
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Citations
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
The single-cell transcriptional landscape of mammalian organogenesis
Cao, J., Spielmann, M., Qiu, X., Huang, X., Ibrahim, D. M., Hill, A. J., Zhang, F., Mundlos, S., Christiansen, L., Steemers, F. J., et al. (2019) · Nature · doi:10.1038/s41586-019-0969-x · Cited by 4,490
A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
Gilbert, M. R., Dignam, J. J., Armstrong, T. S., Wefel, J. S., Blumenthal, D. T., Vogelbaum, M. A., Colman, H., Chakravarti, A., Pugh, S., Won, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1308573 · Cited by 2,834
The current state and future directions of RNAi-based therapeutics
Setten, R. L., Rossi, J. J., & Han, S.-P. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0017-4 · Cited by 1,443
Massively parallel single-nucleus RNA-seq with DroNc-seq
Habib, N., Avraham-Davidi, I., Basu, A., Burks, T., Shekhar, K., Hofree, M., Choudhury, S. R., Aguet, F., Gelfand, E., Ardlie, K., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4407 · Cited by 1,069
Self-citationMYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
Shachaf, C. M., Kopelman, A. M., Arvanitis, C., Karlsson, Å., Beer, S., Mandl, S., Bachmann, M. H., Borowsky, A. D., Ruebner, B., Cardiff, R. D., et al. (2004) · Nature · doi:10.1038/nature03043 · Cited by 874
Therapeutically harnessing extracellular vesicles
Cheng, L., & Hill, A. F. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00410-w · Cited by 737
Single-nucleus and single-cell transcriptomes compared in matched cortical cell types
Bakken, T. E., Hodge, R. D., Miller, J. A., Yao, Z., Nguyen, T. N., Aevermann, B., Barkan, E., Bertagnolli, D., Casper, T., Dee, N., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209648 · Cited by 608
Guo, S., Perets, N., Betzer, O., Ben-Shaul, S., Sheinin, A., Michaelevski, I., Popovtzer, R., Offen, D., & Levenberg, S. (2019) · ACS Nano · doi:10.1021/acsnano.9b01892 · Cited by 424
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Cited by
Sorted by citations
Emerging role of exosomes in cancer therapy: progress and challenges
Li, J., Wang, J., & Chen, Z. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02215-4 · Cited by 297
Metadata
- Authors
- Haltom, A. R., Hassen, W. E., Hensel, J., Kim, J., Sugimoto, H., Li, B., McAndrews, K. M., Conner, M. R., Kirtley, M. L., Luo, X., Xie, B., Volpert, O. V., Olalekan, S., Maltsev, N., Basu, A., LeBleu, V. S., & Kalluri, R.
- Venue
- Extracellular Vesicle
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 1
- Pages
- 100014
- ISSN
- 2773-0417
- PMC
- PMC10373511
- Cited by
- 36
- References
- 11
- Language
- en
- Licence
- Funders
- Musella Foundation For Brain Tumor Research and Information
- National Cancer Institute (P30CA016672)
- University of Texas MD Anderson Cancer Center
- National Institutes of Health (R35CA263815)
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- The paper
- Haltom, A. R., Hassen, W. E., Hensel, J., Kim, J., Sugimoto, H., Li, B., McAndrews, K. M., Conner, M. R., Kirtley, M. L., Luo, X., Xie, B., Volpert, O. V., Olalekan, S., Maltsev, N., Basu, A., LeBleu, V. S., & Kalluri, R. (2022). Engineered exosomes targeting MYC reverse the proneural-mesenchymal transition and extend survival of glioblastoma. Extracellular Vesicle. https://doi.org/10.1016/j.vesic.2022.100014