Efficacy of moxidectin microsphere sustained release formulation for the prevention of subcutaneous filarial (Dirofilaria repens) infection in dogs
Abstract
A study was carried out to assess the efficacy of a moxidectin microsphere sustained release (SR) injectable formulation (Guardian SR Iniettabile, Fort Dodge) for the prevention of Dirofilaria repens infection in experimentally infected dogs. On day 0, 18 Beagle dogs, 9 male dogs and 9 female dogs, weighing 12-16 kg were ranked in ascending order of body weight (b.w.) and blocked into pairs. Within each pair, dogs were allocated to Group 1 or Group 2 at random. On the same day, dogs in Group 1 were injected with 0.05 ml/kg b.w. of saline solution and dogs in Group 2 were injected with moxidectin SR at the label dose 0.17 mg/kg b.w. (0.05 ml/kg b.w.). Six months after moxidectin SR or saline injection, on day 180, each dog in the two groups was challenged with 50 infective larvae of D. repens collected from laboratory-reared, experimentally infected Aedes aegypti. Dogs were humanely euthanized on day 380 of the study, approximately 7 months from D. repens challenge. At necropsy, no worms were found in dogs treated with moxidectin SR (Group 2) while adult worms were found in saline-treated dogs (total 90; 38 males and 52 females; arithmetic mean 10, standard error 0.96, median 9, range 7-15) (Group 1 vs Group 2 P<0.001). In this experimental study, moxidectin SR injectable showed full efficacy (100%) lasting at least 6 months, and is able to prevent subcutaneous D. repens patent infection throughout the entire transmission season in Europe.
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The injectable long-lasting formulation containing moxidectin is effective in controlling Dirofilaria immitis and Dirofilaria repens infestations for a period of 6 months after a single administration.
“The injectable long lasting formulation containing moxidectin showed to be effective in controlling D. immitis and D. repens infestations for a period of 6 months after a single administration [95,96].”
From Vector-borne helminths of dogs and humans in Europe (2013) · cites this paper as [96]
Prevention of patent infections by D. repens with macrocyclic lactones is questionable.
“The prevention of patent infections by D. repens with macrocyclic lactones is questionable”
From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [152]
To date, only continuous-release moxidectin microspheres have demonstrated full efficacy in experimental studies for preventing patent D. repens infections.
“only continuous-release moxidectin microspheres have demonstrated full efficacy in experimental studies (152).”
From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [152]
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- Authors
- Genchi, M., Pengo, G., & Genchi, C.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Genchi, Marco
- ORCID
- Genchi, Marco
- Venue
- Veterinary Parasitology
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 170
- Issue
- 1-2
- Pages
- 167-169
- ISSN
- 0304-4017 (ISSN-L)
- OpenAlex
- W2020578582
- Cited by
- 31
- References
- 30
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Veterinary Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Keywords
- moxidectin, sustained-release formulation, Dirofilaria repens, dogs, anthelmintic efficacy, Aedes aegypti, experimental infection
- MeSH terms
- Animals, Anthelmintics, Delayed-Action Preparations, Dirofilaria, Dirofilariasis, Dog Diseases, Dogs, Female, Male, Random Allocation, Statistics, Nonparametric, Macrolides
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