Full season efficacy of moxidectin microsphere sustained release formulation for the prevention of heartworm (Dirofilaria immitis) infection in dogs
Abstract
The authors report the efficacy of an injectable, moxidectin sustained release (SR) formulation for the prevention of canine heartworm infection in endemic areas in northern and central Italy. Three field trials were carried out on a total of 324 dogs. Two hundred forty-three dogs were treated with moxidectin SR 6 months apart and 81 dogs (positive controls) with moxidectin tablets given monthly for 5 consecutive months during the risk season each year throughout the study. Results of testing for microfilariae and circulating adult female antigens were negative for all the experimentally treated dogs at the 6, 7, 11 and 19 months after the last injection. No adverse reactions to moxidectin SR were observed but a moderate pain at palpation and swelling (5-6 cm) at the injection site after the first treatment. In the study areas, prevalence of Dirofilaria immitis infection calculated by testing dogs which had no preventive treatment in the previous transmission season ranged from 33 to 63%. This study confirms the efficacy and safety of injectable, moxidectin SR formulation in the prevention of heartworm infection in dogs and demonstrates that the prophylactic efficacy lasts for the full season and strongly suggests that the product gives 1-year protection.
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The injectable long-lasting formulation containing moxidectin is effective in controlling Dirofilaria immitis and Dirofilaria repens infestations for a period of 6 months after a single administration.
“The injectable long lasting formulation containing moxidectin showed to be effective in controlling D. immitis and D. repens infestations for a period of 6 months after a single administration [95,96].”
From Vector-borne helminths of dogs and humans in Europe (2013) · cites this paper as [95]
Cites
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Chapter 4 Heartworm Disease in Animals and Humans
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Self-citationCanine and feline cardiopulmonary parasitic nematodes in Europe: emerging and underestimated
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- Authors
- Genchi, C., Rossi, L., Cardini, G., Kramer, L. H., Venco, L., Casiraghi, M., Genchi, M., & Agostini, A.
- Affiliations
- University of Milan (IT)
- University of Pisa (IT)
- University of Parma (IT)
- Corresponding author
- Genchi, Claudio
- Venue
- Veterinary Parasitology
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 110
- Issue
- 1-2
- Pages
- 85-91
- ISSN
- 0304-4017 (ISSN-L)
- OpenAlex
- W1969965688
- Cited by
- 24
- References
- 5
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2017: 2 · 2015: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Veterinary Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Keywords
- moxidectin, sustained-release formulation, canine heartworm disease, Dirofilaria immitis, heartworm prevention, dogs, microfilariae, adverse effects
- MeSH terms
- Administration, Oral, Animals, Anthelmintics, Anti-Bacterial Agents, Antigens, Helminth, Delayed-Action Preparations, Dirofilaria immitis, Dirofilariasis, Dog Diseases, Dogs, Female, Injections, Subcutaneous, Italy, Male, Microfilariae, Microspheres, Macrolides, Endemic Diseases
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