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The human papillomavirus type 16 E5 oncoprotein synergizes with EGF-receptor signaling to enhance cell cycle progression and the down-regulation of p27Kip1

Pedroza-Saavedra, Adolfo, Lam, Eric W-F, Esquivel-Guadarrama, Fernando, Gutierrez-Xicotencatl, Lourdes·2010·Virology
DOI 10.1016/j.virol.2010.01.009
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  1. Abukhdeir, 2008, p21 and p27: roles in carcinogenesis and drug resistance, Expert Rev. Mol. Med., 10, e19, 10.1017/S1462399408000744 · DOI
  2. Adam, 2000, A mutagenic analysis of the E5 protein of human papillomavirus type 16 reveals that E5 binding to the vacuolar H+-ATPase is not sufficient for biological activity, using mammalian and yeast expression systems, Virology, 272, 315, 10.1006/viro.2000.0376 · DOI
  3. Akerman, 2001, Human papillomavirus type 16 E6 and E7 cooperate to increase epidermal growth factor receptor (EGFR) mRNA levels, overcoming mechanisms by which excessive EGFR signaling shortens the life span of normal human keratinocytes, Cancer Res., 61, 3837
  4. Ashby, 2001, E5 transforming proteins of human papillomaviruses do not disturb the activity of the vacuolar H+-ATPase, J. Gen. Virol., 82, 2353, 10.1099/0022-1317-82-10-2353 · DOI
  5. Bahnassy, 2007, The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma, BMC Clin. Pathol., 7, 4, 10.1186/1472-6890-7-4 · DOI
  6. Belle, 2006, Quantification of protein half-lives in the budding yeast proteome, Proc. Natl. Acad. Sci. U.S.A., 103, 13004, 10.1073/pnas.0605420103 · DOI · Paper page
  7. Berezutskaya, 1997, Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16 E7 oncoprotein, Cell Growth Differ., 8, 1277
  8. Bloom, 2003, Deregulated degradation of the cdk inhibitor p27 and malignant transformation, Semin. Cancer Biol., 13, 41, 10.1016/S1044-579X(02)00098-6 · DOI
  9. Borriello, 2007, p27Kip1 metabolism: a fascinating labyrinth, Cell Cycle, 6, 1053, 10.4161/cc.6.9.4142 · DOI
  10. Bouvard, 1994, The human papillomavirus type 16 E5 gene cooperates with the E7 gene to stimulate proliferation of primary cells and increases viral gene expression, Virology, 203, 73, 10.1006/viro.1994.1456 · DOI · Paper page
  11. Briggs, 2001, The human papillomavirus type 16 E5 protein alters vacuolar H(+)-ATPase function and stability in Saccharomyces cerevisiae, Virology, 280, 169, 10.1006/viro.2000.0783 · DOI
  12. Cánepa, 2007, INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions, IUBMB Life, 59, 419, 10.1080/15216540701488358 · DOI
  13. Carraway, 1994, A neu acquaintance for erbB3 and erbB4: a role for receptor hetero-dimerization in growth signaling, Cell, 78, 5, 10.1016/0092-8674(94)90564-9 · DOI
  14. Catzavelos, 1997, Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer, Nat. Med., 3, 227, 10.1038/nm0297-227 · DOI
  15. Chan, 1995, Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4, Mol. Cell. Biol., 15, 2682, 10.1128/MCB.15.5.2682 · DOI
  16. Chen, 1990, Transforming activity of E5a protein of human papillomavirus type 6 in NIH 3T3 and C127 cells, J. Virol., 64, 3226, 10.1128/jvi.64.7.3226-3233.1990 · DOI · Paper page
  17. Chen, 1994, Antisense oligodeoxynucleotides to c-jun inhibits proliferation of transformed NIH 3T3 cells induced by E5a of HPV11, Cancer Lett., 85, 119, 10.1016/0304-3835(94)90247-X · DOI
  18. Chen, 1995, Differential induction and regulation of the c-jun, junB, junD and c-fos by human papillomavirus type 11 E5a oncoprotein, J. Gen. Virol., 76, 2653, 10.1099/0022-1317-76-11-2653 · DOI
  19. Chen, 1996, The regulation mechanism of c-jun and junB by human papillomavirus type 16 E5 oncoprotein, Arch. Virol., 141, 791, 10.1007/BF01718155 · DOI · Paper page
  20. Chen, 1996, E5 proteins of human papillomavirus types 11 and 16 transactivate the c-fos promoter through the NF1 binding element, J. Virol., 70, 8558, 10.1128/jvi.70.12.8558-8563.1996 · DOI · Paper page
  21. Chen, 2007, ErbB4 (JM-b/CYT-1)-induced expression and phosphorylation of c-Jun is abrogated by human papillomavirus type 16 E5 protein, Oncogene, 26, 42, 10.1038/sj.onc.1209768 · DOI
  22. Conrad, 1993, The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein, J. Virol., 67, 6170, 10.1128/jvi.67.10.6170-6178.1993 · DOI
  23. Crusius, 1997, Enhancement of EGF- and PMA-mediated MAP kinase activation in cells expressing the human papillomavirus type 16 E5 protein, Oncogene, 15, 1437, 10.1038/sj.onc.1201312 · DOI · Paper page
  24. Crusius, 1998, The human papillomavirus type 16 E5-protein modulates ligand-dependent activation of the EGF receptor family in the human epithelial cell line HaCat, Exp. Cell Res., 241, 76, 10.1006/excr.1998.4024 · DOI · Paper page
  25. Di Domenico, 2009, Expression of Human papillomavirus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity, J. Exp. Clin. Cancer Res., 28, 4, 10.1186/1756-9966-28-4 · DOI
  26. Dyson, 1992, Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins, J. Virol., 66, 6893, 10.1128/jvi.66.12.6893-6902.1992 · DOI · Paper page
  27. Durand, 1998, p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation, Curr. Biol., 8, 431, 10.1016/S0960-9822(98)70177-0 · DOI
  28. El-Deiry, 1993, WAF1, a potential mediator of p53 tumor suppression, Cell, 75, 817, 10.1016/0092-8674(93)90500-P · DOI · Paper page
  29. Fehrmann, 2003, Human papillomavirus type 31 E5 protein supports cell cycle progression and activates late viral functions upon epithelial differentiation, J. Virol., 77, 2819, 10.1128/JVI.77.5.2819-2831.2003 · DOI
  30. Genther Williams, 2005, Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogene, Cancer Res., 65, 6534, 10.1158/0008-5472.CAN-05-0083 · DOI · Paper page
  31. Gryfe, 1997, Molecular biology of colorectal cancer, Curr. Prob. Cancer, 21, 233, 10.1016/S0147-0272(97)80003-7 · DOI
  32. Gu, 1993, Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit, Nature, 366, 707, 10.1038/366707a0 · DOI
  33. Gu, 1995, Effect of human papillomavirus type 16 oncogenes on MAP kinase activity, J. Virol., 69, 8051, 10.1128/jvi.69.12.8051-8056.1995 · DOI · Paper page
  34. Guan, 1994, Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function, Genes Dev., 8, 2939, 10.1101/gad.8.24.2939 · DOI
  35. Harper, 1993, The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases, Cell, 75, 805, 10.1016/0092-8674(93)90499-G · DOI · Paper page
  36. Hengst, 1996, Translational control of p27Kip1 accumulation during the cell cycle, Science, 271, 1861, 10.1126/science.271.5257.1861 · DOI
  37. Hirai, 1995, Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6, Mol. Cell. Biol., 15, 2672, 10.1128/MCB.15.5.2672 · DOI
  38. Hitomi, 2006, p27Kip1 and cyclin dependent kinase 2 regulate passage through the restriction point, Cell Cycle, 5, 2281, 10.4161/cc.5.19.3318 · DOI
  39. Hubbert, 1992, Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes, J. Virol., 66, 6237, 10.1128/jvi.66.10.6237-6241.1992 · DOI
  40. Johnston, 1999, Elevation of the epidermal growth factor receptor and dependent signaling in human papillomavirus-infected laryngeal papillomas, Cancer Res., 59, 968
  41. Kato, 1994, Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation, Cell, 79, 487, 10.1016/0092-8674(94)90257-7 · DOI
  42. Kato, 1997, Inactivation of the cyclin D-dependent kinase in the rat fibroblast cell line, 3Y1, induced by contact inhibition, J. Biol. Chem., 272, 8065, 10.1074/jbc.272.12.8065 · DOI
  43. Kim, 2006, Human papillomavirus 16 E5 up-regulates the expression of vascular endothelial growth factor through the activation of epidermal growth factor receptor, MEK/ERK1, 2 and PI3K/Akt, Cell. Mol. Life Sci., 63, 930, 10.1007/s00018-005-5561-x · DOI
  44. Kivi, 2008, Genes involved in cell adhesion, cell motility and mitogenic signaling are altered due to HPV 16 E5 protein expression, Oncogene, 27, 2532, 10.1038/sj.onc.1210916 · DOI
  45. Lee, 1995, Cloning of p57Kip2 a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution, Genes Dev., 9, 639, 10.1101/gad.9.6.639 · DOI
  46. Leechanachai, 1992, The E5 gene from human papillomavirus type 16 is an oncogene which enhances growth factor-mediated signal transduction to the nucleus, Oncogene, 7, 19
  47. Leptak, 1991, Tumorigenic transformation of murine keratinocytes by the E5 gene of bovine papillomavirus type 1 and human papillomavirus type 16, J. Virol., 65, 7078, 10.1128/jvi.65.12.7078-7083.1991 · DOI · Paper page
  48. Lewis, 2008, The first hydrophobic region of the HPV16 E5 protein determines protein cellular location and facilitates anchorage-independent growth, Virol. J., 5, 30, 10.1186/1743-422X-5-30 · DOI
  49. Li, 2001, Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling, EMBO J., 20, 6793, 10.1093/emboj/20.23.6793 · DOI
  50. Martin, 1989, The bovine papillomavirus E5 transforming protein can stimulate the transforming activity of EGF and CSF-1 receptors, Cell, 59, 21, 10.1016/0092-8674(89)90866-0 · DOI
  51. Matsuoka, 1995, p57Kip2 a structurally distinct member of the p21Cip1 Cdk inhibitor family, is a candidate tumor suppressor gene, Genes Dev., 9, 650, 10.1101/gad.9.6.650 · DOI
  52. Maufort, 2007, Human papillomavirus 16 E5 oncogene contributes to two stages of skin carcinogenesis, Cancer Res., 67, 6106, 10.1158/0008-5472.CAN-07-0921 · DOI
  53. Moeller, 2003, p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation, Mol. Cell. Biol., 23, 3735, 10.1128/MCB.23.11.3735-3752.2003 · DOI
  54. Morgan, 1995, Principles of CDK regulation, Nature, 374, 131, 10.1038/374131a0 · DOI
  55. Mori, 1997, p27 expression and gastric carcinoma, Nat. Med., 3, 593, 10.1038/nm0697-593 · DOI
  56. Muñoz, 1994, The role of HPV in the etiology of cervical cancer, Mutat. Res., 305, 293, 10.1016/0027-5107(94)90249-6 · DOI
  57. Muraoka, 2002, Erb2/Neu-induced cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells, Mol. Cell. Biol., 22, 2204, 10.1128/MCB.22.7.2204-2219.2002 · DOI
  58. Nath, 2006, Analyses of variant human papillomavirus type-16 E5 proteins for their ability to induce mitogenesis of murine fibroblasts, Cancer Cell Int., 6, 19, 10.1186/1475-2867-6-19 · DOI
  59. Nourse, 1994, Interleukin-2 mediates elimination of p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin, Nature, 372, 570, 10.1038/372570a0 · DOI
  60. O'Brien, 2001, Cell transformation by the E5/E8 protein of bovine papillomavirus type 4. p27(Kip1), elevated through increased protein synthesis, is sequestered by cyclin D1-CDK4 complexes, J. Biol. Chem., 276, 33861, 10.1074/jbc.M100958200 · DOI
  61. Oetke, 2000, Human papillomavirus type 16 E5 protein localizes to the Golgi apparatus but does not grossly affect cellular glycosylation, Arch. Virol., 145, 2183, 10.1007/s007050070048 · DOI
  62. Ogiso, 1990, Transdominant suppressor mutations of the H-ras oncogene, Cell Growth Differ., 1, 217
  63. Pim, 1992, Human papillomavirus type 16 E5 gene stimulates the transforming activity of the epidermal growth factor receptor, Oncogene, 7, 27
  64. Polyak, 1994, p27Kip1, a cyclin-cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest, Genes Dev., 8, 9, 10.1101/gad.8.1.9 · DOI
  65. Polyak, 1994, Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals, Cell, 78, 59, 10.1016/0092-8674(94)90572-X · DOI
  66. Reynisdottir, 1995, Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β, Genes Dev., 9, 1831, 10.1101/gad.9.15.1831 · DOI · Paper page
  67. Rodriguez, 2000, Binding of human papillomavirus 16 E5 to the 16 kDa subunit c (proteolipid) of the vacuolar H+-ATPase can be dissociated from the E5-mediated epidermal growth factor receptor overactivation, Oncogene, 19, 3727, 10.1038/sj.onc.1203718 · DOI
  68. Scheffner, 1993, The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53, Cell, 75, 495, 10.1016/0092-8674(93)90384-3 · DOI · Paper page
  69. Schwartz, 1997, T cell clonal anergy, Curr. Opin. Immunol., 9, 351, 10.1016/S0952-7915(97)80081-7 · DOI
  70. Seedorf, 1985, Human papillomavirus type 16 DNA sequence, Virology, 145, 181, 10.1016/0042-6822(85)90214-4 · DOI
  71. Serrano, 1993, A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4, Nature, 366, 704, 10.1038/366704a0 · DOI · Paper page
  72. Sherr, 1995, Inhibitors of mammalian G1 cyclin-dependent kinases, Genes Dev., 9, 1149, 10.1101/gad.9.10.1149 · DOI
  73. Sherr, 1999, CDK inhibitors: positive and negative regulators of G1-phase progression, Genes Dev., 13, 1501, 10.1101/gad.13.12.1501 · DOI · Paper page
  74. Straight, 1993, The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and affects the down-regulation of the epidermal growth factor receptor in keratinocytes, J. Virol., 67, 4521, 10.1128/jvi.67.8.4521-4532.1993 · DOI · Paper page
  75. Straight, 1995, The E5 oncoprotein of human papillomavirus type 16 inhibits the acidification of endosomes in human keratinocytes, J. Virol., 69, 3185, 10.1128/jvi.69.5.3185-3192.1995 · DOI
  76. Suprynowicz, 2008, HPV-16 E5 oncoprotein upregulates lipid raft components caveolin-1 and ganglioside GM1 at the plasma membrane of cervical cells, Oncogene, 27, 1071, 10.1038/sj.onc.1210725 · DOI
  77. Swanson, 2000, Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1, Proc. Natl. Acad. Sci. U.S.A., 97, 7796, 10.1073/pnas.97.14.7796 · DOI
  78. Takami, 1995, Multistep carcinogenesis in colorectal cancers, Southeast Asian J. Trop. Med. Public Health, 26, 190
  79. Takuwa, 1997, Ras activity late in G1 phase required for p27Kip1 down-regulation, passage through the restriction point, and entry into S phase in growth factor stimulated NIH3T3 fibroblasts, Mol. Cell. Biol., 17, 5348, 10.1128/MCB.17.9.5348 · DOI
  80. Tomakidi, 2000, Modulation of the epidermal growth factor receptor by the human papillomavirus type 16 E5 protein in raft cultures of human keratinocytes, Eur. J. Cell. Biol., 79, 407, 10.1078/0171-9335-00060 · DOI · Paper page
  81. Towbin, 1979, Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications, Proc. Natl. Acad. Sci. U.S.A., 76, 4350, 10.1073/pnas.76.9.4350 · DOI
  82. Tsao, 1996, Human papillomavirus type 11 and 16 E5 represses p21WafI/SdiI/CipI gene expression in fibroblasts and keratinocytes, J. Virol., 70, 7535, 10.1128/jvi.70.11.7535-7539.1996 · DOI · Paper page
  83. Tungteakkhun, 2008, Cellular binding partners of the human papillomavirus E6 protein, Arch. Virol., 153, 397, 10.1007/s00705-007-0022-5 · DOI
  84. Ungermannova, 2005, Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2, J. Biol. Chem., 280, 30301, 10.1074/jbc.M411103200 · DOI
  85. Velu, 1989, Retroviruses expressing different levels of the normal epidermal growth factor receptor, J. Cell. Biochem., 39, 153, 10.1002/jcb.240390207 · DOI
  86. Vervoorts, 2008, Post-translational regulation of the tumor suppressor p27(KIP1), Cell. Mol. Life Sci., 65, 3255, 10.1007/s00018-008-8296-7 · DOI
  87. Werness, 1990, Association of the human papillomavirus types 16 and 18 E6 proteins with p53, Science, 248, 76, 10.1126/science.2157286 · DOI · Paper page
  88. Wise-Draper, 2008, Papillomavirus E6 and E7 proteins and their cellular targets, Front. Biosci., 13, 1003, 10.2741/2739 · DOI
  89. Yanagisawa, 1999, Opposite regulation of the expression of cyclin-dependent kinase inhibitors during contact inhibition, J. Biochem., 125, 36, 10.1093/oxfordjournals.jbchem.a022265 · DOI
  90. Zhang, 2002, E5 protein of human papillomavirus type 16 protects human foreskin keratinocytes from UV B-irradiation-induced apoptosis, J. Virol., 76, 220, 10.1128/JVI.76.1.220-231.2002 · DOI · Paper page
  91. Zhang, 1996, Transformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2, J. Biol. Chem., 271, 3884, 10.1074/jbc.271.7.3884 · DOI
  92. Zhu, 2001, EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells, Cancer Lett., 169, 27, 10.1016/S0304-3835(01)00547-X · DOI
  93. zur Hausen, 1996, Papillomavirus infections—a major cause of human cancers, Biochim. Biophys. Acta, 1288, F55

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Metadata

Authors
Pedroza-Saavedra, A., Lam, E. W.-F., Esquivel-Guadarrama, F., & Gutierrez-Xicotencatl, L.
Venue
Virology
Publisher
Elsevier BV
Published
2010-04
Volume
400
Issue
1
Pages
44-52
ISSN
0042-6822
DOI
10.1016/j.virol.2010.01.009
Cited by
39
References
6
Language
en
Licence
Funders
  • CONACYT-SEP (38906-M)
  • Miguel Aleman Foundation

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CoChat. (2026). Citation check: The human papillomavirus type 16 E5 oncoprotein synergizes with EGF-receptor signaling to enhance cell cycle progression and the down-regulation of p27Kip1. https://app.cochat.ai/papers/10.1016/j.virol.2010.01.009
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Pedroza-Saavedra, A., Lam, E. W.-F., Esquivel-Guadarrama, F., & Gutierrez-Xicotencatl, L. (2010). The human papillomavirus type 16 E5 oncoprotein synergizes with EGF-receptor signaling to enhance cell cycle progression and the down-regulation of p27Kip1. Virology. https://doi.org/10.1016/j.virol.2010.01.009