The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
The influence of intrinsically-photosensitive retinal ganglion cells on the spectral sensitivity and response dynamics of the human pupillary light reflex
Open accessAbstract
Historically, it was assumed that the light-evoked neural signals driving the human pupillary light reflex (PLR) originated exclusively from rod and cone photoreceptors. However, a novel melanopsin-containing photoreceptive cell class has recently been discovered in the mammalian retina. These intrinsically photosensitive retinal ganglion cells (ipRGCs) project to the pretectum, the retinorecipient area of the brain responsible for the PLR. This study was therefore designed to examine the relative contribution of rod, cone and the melanopsin photoresponses of ipRGCs to the human PLR. We establish that the melanopsin photoresponse of ipRGCs contributes significantly to the maintenance of half maximal pupilloconstriction in response to light stimuli of 30 seconds or longer, even at low photopic irradiances. Furthermore, we show that the melanopsin photoresponse contributes significantly to three- quarter maximal pupilloconstriction in response to light stimuli as short as 2 seconds. We also demonstrate that cone photoresponses driving pupilloconstriction adapt considerably and contribute little after 30 seconds, but rod photoresponses adapt less and contribute significantly to the maintenance of pupilloconstriction in response to steady-state light stimuli at irradiance levels which are below the threshold of the melanopsin photoresponse.
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Measuring and using light in the melanopsin age
Lucas, R. J., Peirson, S. N., Berson, D. M., Brown, T. M., Cooper, H. M., Czeisler, C. A., Figueiro, M. G., Gamlin, P. D., Lockley, S. W., O’Hagan, J. B., et al. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.10.004 · Cited by 1,278
Self-citationMcDougal, D. H., & Gamlin, P. D. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c140014 · Cited by 428
Self-citationMelanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior
Do, M. T. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.016 · Cited by 312
Enezi, J. A., Revell, V., Brown, T., Wynne, J., Schlangen, L., & Lucas, R. (2011) · Journal of Biological Rhythms · doi:10.1177/0748730411409719 · Cited by 278
Melanopsin-Based Brightness Discrimination in Mice and Humans
Brown, T. M., Tsujimura, S.-I., Allen, A. E., Wynne, J., Bedford, R., Vickery, G., Vugler, A., & Lucas, R. J. (2012) · Current Biology · doi:10.1016/j.cub.2012.04.039 · Cited by 256
Metadata
- Authors
- McDougal, D. H., & Gamlin, P. D.
- Venue
- Vision Research
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 50
- Issue
- 1
- Pages
- 72-87
- ISSN
- 0042-6989 (ISSN-L)
- OpenAlex
- W1982138519
- Cited by
- 273
- References
- 94
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- McDougal, D. H., & Gamlin, P. D. (2010). The influence of intrinsically-photosensitive retinal ganglion cells on the spectral sensitivity and response dynamics of the human pupillary light reflex. Vision Research. https://doi.org/10.1016/j.visres.2009.10.012
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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