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Cited by 111Dietary Effects on HealthDiet and metabolism studiesDiet, Metabolism, and Disease

Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial

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He, Mingqian, Wang, Jingya, Liang, Qian, Li, Meng, Guo, Hui, Wang, Yue, Deji, Cuomu, Sui, Jing +17 more·2022·Cell Reports Medicine
DOI 10.1016/j.xcrm.2022.100777PMC PMC9589024
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Abstract

Overconsumption of carbohydrate-rich food combined with adverse eating patterns contributes to the increasing incidence of metabolic syndrome (MetS) in China. Therefore, we conducted a randomized trial to determine the effects of a low-carbohydrate diet (LCD), an 8-h time-restricted eating (TRE) schedule, and their combination on body weight and abdominal fat area (i.e., primary outcomes) and cardiometabolic outcomes in participants with MetS. Compared with baseline, all 3-month treatments significantly reduce body weight and subcutaneous fat area, but only TRE and combination treatment reduce visceral fat area (VFA), fasting blood glucose, uric acid (UA), and dyslipidemia. Furthermore, compared with changes of LCD, TRE and combination treatment further decrease body weight and VFA, while only combination treatment yields more benefits on glycemic control, UA, and dyslipidemia. In conclusion, without change of physical activity, an 8-h TRE with or without LCD can serve as an effective treatment for MetS (ClinicalTrials.gov: NCT04475822).

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  • Central obesity measures-particularly BRI-are indispensable for accurate risk classification.

    “illustrating the indispensable value of central obesity measures—particularly BRI—in accurate risk classification [35–37].”

    From Machine learning with the body roundness index and associated indicators: a new approach to predicting metabolic syndrome (2025) · cites this paper as [37]

    The Results section (page unavailable) calls abdominal fat a pivotal metabolic risk factor and says waist-to-hip ratio is more closely correlated with metabolic syndrome than BMI. That supports the relevance of central-obesity measures, but the paper does not establish that they are indispensable for accurate risk classification or identify BRI as particularly valuable. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Authors
He, M., Wang, J., Liang, Q., Li, M., Guo, H., Wang, Y., Deji, C., Sui, J., Wang, Y.-W., Liu, Y., Zheng, Y., Qian, B., Chen, H., Ma, M., Su, S., Geng, H., Zhou, W.-X., Guo, X., Zhu, W.-Z., Zhang, M., Chen, Z., Rensen, P. C. N., Hui, C.-C., Wang, Y., & Shi, B.
Affiliations
  • First Affiliated Hospital of Xi'an Jiaotong University (CN)
  • Xi'an Jiaotong University (CN)
  • Leiden University Medical Center (NL)
  • University of Toronto (CA)
Corresponding author
  • Wang, Yanan
  • Shi, Bingyin
ORCID
Venue
Cell Reports Medicine
Publisher
Elsevier BV
Published
2022-10
Volume
3
Issue
10
Pages
100777
ISSN
2666-3791 (ISSN-L)
DOI
10.1016/j.xcrm.2022.100777
PMC
PMC9589024
OpenAlex
W4304013994
Cited by
111
References
21
Citations by year
2026: 27 · 2025: 37 · 2024: 25 · 2023: 22
FWCI
13.00
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Reports Medicine (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Leiden Repository (Leiden University) (submittedVersion, cc-by-nc-nd)
  • Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc-nd)
Funders
  • Xi’an Jiaotong University
  • National Key Research and Development Program of China (2018YFC1311501)
Topics
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
time-restricted eating, low-carbohydrate diet, metabolic syndrome, visceral fat, abdominal fat, body weight, glycemic control, uric acid, dyslipidemia, fasting blood glucose, dietary intervention
MeSH terms
Blood Glucose, Body Weight, Humans, Uric Acid, Metabolic Syndrome, Intra-Abdominal Fat, Dyslipidemias, Diet, Carbohydrate-Restricted

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