Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans
Open accessAbstract
The life span of the nematode Caenorhabditis elegans is under control of sensory signals detected by the amphid neurons. In these neurons, C. elegans expresses at least 13 Galpha subunits and a Ggamma subunit, which are involved in the transduction and modulation of sensory signals. Here, we show that loss-of-function mutations in the Galpha subunits odr-3, gpa-1 and gpa-9, in the Ggamma subunit gpc-1 and the introduction of extra copies of the Galpha subunit gpa-11 extend the life span of C. elegans. Loss-of-function of odr-3 and extra copies of gpa-11 act synergistically and can together extend life span more than two-fold, indicating that sensory signals play an important role in regulating life span. We show that gpa-1, gpa-11, odr-3 and gpc-1 all signal via the daf-16 FOXO family transcription factor. In addition, odr-3 and gpa-11 might suppress life span extension partially independent of the insulin/IGF-1 like receptor homologue daf-2. Our results suggest that the previously unanticipated nociceptive ASH and/or ADL neurons regulate longevity. We expect that the implication of specific G proteins will eventually contribute to the identification of the sensory cues that determine the rate of aging in C. elegans.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
C. elegans CFAP-20 participates in several sensory and physiological processes that depend on various types of non-motile cilia: gustatory plasticity, lifespan control, locomotion (roaming), and body size determination.
“Yet, C. elegans CFAP-20 participates in several sensory and physiological processes that depend on various types of non-motile cilia: ability to sense and learn to avoid salt in the absence of food (gustatory plasticity); lifespan control; locomotion (roaming); and, body size determination40,42,47–51.”
From The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision (2022) · cites this paper as [47]
The Introduction and the section ‘Multiple sensory G proteins modulate longevity in C. elegans’ discuss sensory cilia, gustatory plasticity, and lifespan control, but do not identify CFAP-20 as participating in them. Searches for CFAP-20, roaming, and body size found no passage connecting that protein to any of the claimed processes. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 14,985 · see citing works
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works
Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250 · see citing works
Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935 · see citing works
Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,496 · see citing works
The plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338 · see citing works
Riddle, D. L., Blumenthal, T., Meyer, B. J., & Priess, J. R. (1998) · Cited by 1,047 · see citing works
Lin, K., Hsin, H., Libina, N., & Kenyon, C. J. (2001) · Nature Genetics · doi:10.1038/88850 · Cited by 1,027 · see citing works
Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans
Troemel, E. R., Chou, J. H., Dwyer, N. D., Colbert, H. A., & Bargmann, C. I. (1995) · Cell · doi:10.1016/0092-8674(95)90162-0 · Cited by 684 · see citing works
Pierce, S. B., Costa, M. A., Wisotzkey, R. G., Devadhar, S., Homburger, S. A., Buchman, A. R., Ferguson, K. C., Heller, J., Platt, D., Pasquinelli, A. E., et al. (2001) · Genes & Development · doi:10.1101/gad.867301 · Cited by 639 · see citing works
The Caenorhabditis elegans dauer larva: Developmental effects of pheromone, food, and temperature
Golden, J. W., & Riddle, D. L. (1984) · Developmental Biology · doi:10.1016/0012-1606(84)90201-x · Cited by 602 · see citing works
Regulation of lifespan by sensory perception in Caenorhabditis elegans
Apfeld, J., & Kenyon, C. (1999) · Nature · doi:10.1038/45544 · Cited by 573 · see citing works
Genetic and Environmental Regulation of Dauer Larva DevelopmentPreprint
Riddle, D. L., & Albert, P. S. (1997) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969532.33.739 · Cited by 453 · see citing works
Komatsu, H., Mori, I., Rhee, J.-S., Akaike, N., & Ohshima, Y. (1996) · Neuron · doi:10.1016/s0896-6273(00)80202-0 · Cited by 446 · see citing works
Coburn, C. M., & Bargmann, C. I. (1996) · Neuron · doi:10.1016/s0896-6273(00)80201-9 · Cited by 441 · see citing works
Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons
Alcedo, J., & Kenyon, C. (2004) · Neuron · doi:10.1016/s0896-6273(03)00816-x · Cited by 388 · see citing works
Li, W., Kennedy, S. G., & Ruvkun, G. (2003) · Genes & Development · doi:10.1101/gad.1066503 · Cited by 368 · see citing works
Roayaie, K., Crump, J. G., Sagasti, A., & Bargmann, C. I. (1998) · Neuron · doi:10.1016/s0896-6273(00)80434-1 · Cited by 308 · see citing works
The complete family of genes encoding G proteins of Caenorhabditis elegans
Jansen, G., Thijssen, K. L., Werner, P., van derHorst, M., Hazendonk, E., & Plasterk, R. H. A. (1999) · Nature Genetics · doi:10.1038/7753 · Cited by 302 · see citing works
Self-citationSerotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans
Loer, C., & Kenyon, C. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-12-05407.1993 · Cited by 273 · see citing works
Chao, M. Y., Komatsu, H., Fukuto, H. S., Dionne, H. M., & Hart, A. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403369101 · Cited by 244 · see citing works
Hilliard, M. A., Bergamasco, C., Arbucci, S., Plasterk, R. H. A., & Bazzicalupo, P. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600107 · Cited by 189 · see citing works
Dauer Formation Induced by High Temperatures in Caenorhabditis elegans
Ailion, M., & Thomas, J. H. (2000) · Genetics · doi:10.1093/genetics/156.3.1047 · Cited by 169 · see citing works
Healthy Animals with Extreme Longevity
Arantes-Oliveira, N., Berman, J. R., & Kenyon, C. J. (2003) · Science · doi:10.1126/science.1089169 · Cited by 169 · see citing works
Zwaal, R. R., Mendel, J., Sternberg, P. W., & Plasterk, R. H. A. (1997) · Genetics · doi:10.1093/genetics/145.3.715 · Cited by 131 · see citing works
Neurosecretory control of aging in <i>Caenorhabditis</i> <i>elegans</i>
Ailion, M., Inoue, T., Weaver, C. I., Holdcraft, R. W., & Thomas, J. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7394 · Cited by 121 · see citing works
Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans
Hukema, R. K., Rademakers, S., Dekkers, M. P., Burghoorn, J., & Jansen, G. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600940 · Cited by 111 · see citing works
Self-citationThe G‐protein γ subunit gpc‐1 of the nematode C.elegans is involved in taste adaptation
Jansen, G., Weinkove, D., & Plasterk, R. H. A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.5.986 · Cited by 99 · see citing works
Self-citationA Network of Stimulatory and Inhibitory Gα-Subunits Regulates Olfaction in Caenorhabditis elegans
Lans, H., Rademakers, S., & Jansen, G. (2004) · Genetics · doi:10.1534/genetics.103.024786 · Cited by 97 · see citing works
Self-citationAilion, M., & Thomas, J. H. (2003) · Genetics · doi:10.1093/genetics/165.1.127 · Cited by 74 · see citing works
Yau, D. M., Yokoyama, N., Goshima, Y., Siddiqui, Z. K., Siddiqui, S. S., & Kozasa, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2533143100 · Cited by 46 · see citing works
Proteins interacting with Caenorhabditis elegans Gα subunits
Cuppen, E. P. J. G., van der Linden, A. M., Jansen, G., & Plasterk, R. H. A. (2003) · Comparative and Functional Genomics · doi:10.1002/cfg.318 · Cited by 41 · see citing works
Self-citationExtending Life-Span in C. elegans
Houthoofd, K., Braeckman, B. P., Johnson, T. E., & Vanfleteren, J. R. (2004) · Science · doi:10.1126/science.305.5688.1238c · Cited by 21 · see citing works
Lans, H., & Jansen, G. (2006) · Genetics · doi:10.1534/genetics.106.058750 · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
C. elegans dauer formation and the molecular basis of plasticityPreprint
Fielenbach, N., & Antebi, A. (2008) · Genes & Development · doi:10.1101/gad.1701508 · Cited by 556 · see citing works
Ascaroside signaling in C. elegans
Ludewig, A. (2013) · WormBook · doi:10.1895/wormbook.1.155.1 · Cited by 204 · see citing works
Plant basal resistance to nematodes: an update
Holbein, J., Grundler, F. M. W., & Siddique, S. (2016) · Journal of Experimental Botany · doi:10.1093/jxb/erw005 · Cited by 193 · see citing works
Genetics of Aging in Caenorhabditis elegans
Antebi, A. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030129 · Cited by 188 · see citing works
Butcher, R. A., Ragains, J. R., Kim, E., & Clardy, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806676105 · Cited by 156 · see citing works
Smith, E. D., Kaeberlein, T. L., Lydum, B. T., Sager, J. E., Welton, K. L., Kennedy, B. K., & Kaeberlein, M. R. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-49 · Cited by 133 · see citing works
Hypothalamic microinflammation: a common basis of metabolic syndrome and aging
Tang, Y., Purkayastha, S., & Cai, D. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.10.002 · Cited by 109 · see citing works
A TRPV Channel Modulates C. elegans Neurosecretion, Larval Starvation Survival, and Adult Lifespan
Lee, B. H., & Ashrafi, K. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000213 · Cited by 94 · see citing works
The genetics of pathogen avoidance inCaenorhabditis elegans
Hinrich Schulenburg, Y., & Ewbank, J. J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05946.x · Cited by 96 · see citing works
Some highlights of research on aging with invertebrates, 2010
Partridge, L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00649.x · Cited by 74 · see citing works
Modulation of Longevity by Environmental Sensing
Libert, S., & Pletcher, S. D. (2007) · Cell · doi:10.1016/j.cell.2007.12.002 · Cited by 56 · see citing works
Hypothalamic and dietary control of temperature-mediated longevity
Tabarean, I. V., Morrison, B. E., Marcondes, M. C. G., Bartfai, T., & Conti, B. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.07.004 · Cited by 56 · see citing works
Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis
Maglioni, S., Schiavi, A., Runci, A., Shaik, A., & Ventura, N. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.026 · Cited by 52 · see citing works
Jeong, D., Artan, M., Seo, K., & Lee, S. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00218 · Cited by 53 · see citing works
Soo, S. K., Rudich, Z. D., Ko, B., Moldakozhayev, A., AlOkda, A., & Raamsdonk, J. M. V. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101941 · Cited by 57 · see citing works
Sensory Perception and Aging in Model Systems: From the Outside In
Linford, N. J., Kuo, T.-H., Chan, T. P., & Pletcher, S. D. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154240 · Cited by 43 · see citing works
The Anticonvulsant Ethosuximide Disrupts Sensory Function to Extend C. elegans Lifespan
Collins, J. J., Evason, K. J., Pickett, C. L., Schneider, D. L., & Kornfeld, K. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000230 · Cited by 44 · see citing works
Lans, H., Lindvall, J. M., Thijssen, K. L., Karambelas, A. E., Cupac, D., Fensgård, Ø., Jansen, G., Hoeijmakers, J. H. J., Nilsen, H. L., & Vermeulen, W. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.126 · Cited by 42 · see citing works
Self-citationThe role of food odor in invertebrate foraging
Zjacic, N., & Scholz, M. (2022) · Genes Brain & Behavior · doi:10.1111/gbb.12793 · Cited by 39 · see citing works
Role of the hypothalamus in mediating protective effects of dietary restriction during aging
Dacks, P. A., Moreno, C. L., Kim, E. S., Marcellino, B. K., & Mobbs, C. V. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.12.001 · Cited by 37 · see citing works
Hahm, J., Kim, S., & Paik, Y. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00495.x · Cited by 38 · see citing works
Wide‐scale comparative analysis of longevity genes and interventions
Yanai, H., Budovsky, A., Barzilay, T., Tăcutu, R., & Fraifeld, V. E. (2017) · Aging Cell · doi:10.1111/acel.12659 · Cited by 37 · see citing works
Chrystal, P. W., Lambacher, N. J., Doucette, L. P., Bellingham, J., Schiff, E. R., Noel, N. C. L., Li, C., Tsiropoulou, S., Casey, G. A., Zhai, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33820-w · Cited by 31 · see citing works
Self-citationM(o)TOR of aging: MTOR as a universal molecular hypothalamus
Blagosklonny, M. V. (2013) · Aging · doi:10.18632/aging.100580 · Cited by 28 · see citing works
Healthy aging: what can we learn from Caenorhabditis elegans?
Torgovnick, A., Schiavi, A., Maglioni, S., & Ventura, N. (2013) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-013-0533-5 · Cited by 27 · see citing works
Liu, T., & Cai, D. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.75 · Cited by 27 · see citing works
Kaplan, R. E. W., Webster, A. K., Chitrakar, R., Dent, J. A., & Baugh, L. R. (2018) · BMC Biology · doi:10.1186/s12915-018-0579-3 · Cited by 24 · see citing works
Genes and Pathways That Influence Longevity in Caenorhabditis elegans
Lee, Y., An, S. W. A., Artan, M., Seo, M., Hwang, A. B., Jeong, D., Son, H. G., Hwang, W., Lee, D.-Y., Seo, K., et al. (2015) · Springer eBooks · doi:10.1007/978-4-431-55763-0_8 · Cited by 24 · see citing works
PACRG, a protein linked to ciliary motility, mediates cellular signaling
Loucks, C. M., Bialas, N. J., Dekkers, M. P. J., Walker, D. S., Grundy, L. J., Li, C., Inglis, P. N., Kida, K., Schafer, W. R., Blacque, O. E., et al. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-07-0490 · Cited by 23 · see citing works
Self-citationHahm, J., Kim, S., & Paik, Y. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00655.x · Cited by 22 · see citing works
Choi, W., Ryu, S. E., Cheon, Y., Park, Y.-J., Kim, S., Kim, E., Koo, J., Choi, H., Moon, C., & Kim, K. (2021) · Current Biology · doi:10.1016/j.cub.2021.11.035 · Cited by 18 · see citing works
Endogenous RNAi Pathways Are Required in Neurons for Dauer Formation in Caenorhabditis elegans
Bharadwaj, P. S., & Hall, S. E. (2017) · Genetics · doi:10.1534/genetics.116.195438 · Cited by 17 · see citing works
GPCR Signaling in C. elegans and Its Implications in Immune Response
Gupta, A., & Singh, V. (2017) · Advances in immunology · doi:10.1016/bs.ai.2017.05.002 · Cited by 16 · see citing works
Effect of fluensulfone on different functional genes of root-knot nematode Meloidogyne incognita
Hada, A., Singh, D., Satyanarayana, K. K. V. V., Chatterjee, M., Phani, V., & Rao, U. (2021) · Journal of Nematology · doi:10.21307/jofnem-2021-073 · Cited by 15 · see citing works
Thijssen, K. L., van der Woude, M., Davó-Martínez, C., Dekkers, D. H. W., Sabatella, M., Demmers, J., Vermeulen, W., & Lans, H. (2021) · Communications Biology · doi:10.1038/s42003-021-02875-8 · Cited by 13 · see citing works
Self-citationRodrigues, P. R., Kaul, T. K., Ho, J., Lucanic, M., Burkewitz, K., Mair, W. B., Held, J. M., Bohn, L., & Gill, M. S. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.026997 · Cited by 11 · see citing works
BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice
Cattaneo, M., Aleksova, A., Malovini, A. L., Avolio, E., Thomas, A. C., Alvino, V. V., Kilcooley, M., Pieronne-Deperrois, M., Ouvrard‐Pascaud, A., Maciag, A. E., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06011-8 · Cited by 9 · see citing works
Longevity Regulation by Insulin/IGF-1 Signalling
An, S. W. A., Artan, M., Park, S., Altıntaş, Ö., & Lee, S. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_4 · Cited by 8 · see citing works
Membrane ion Channels and Receptors in Animal lifespan Modulation
Sheng, Y., Tang, L., Kang, L., & Xiao, R. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25824 · Cited by 9 · see citing works
Some highlights of research on aging with invertebrates, 2006–2007
Partridge, L. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00334.x · Cited by 8 · see citing works
Dixit, A., & Bhattacharya, B. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24910 · Cited by 7 · see citing works
Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans
Matei, I. V., Samukange, V. N. C., Bunu, G., Toren, D., Ghenea, S., & Tăcutu, R. (2021) · Aging · doi:10.18632/aging.203518 · Cited by 6 · see citing works
Sutphin, G. L., & Kaeberlein, M. R. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00010-5 · Cited by 4 · see citing works
Notch signaling in germ line stem cells controls reproductive aging in C. elegansPreprint
Kocsisova, Z., Bagatelas, E. D., Santiago-Borges, J. M., Lei, H. C., Egan, B. M., Mosley, M. C., Schneider, D. L., Schedl, T., & Kornfeld, K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.04.482923 · Cited by 4 · see citing works
Signaling Proteins that Regulate NaCL Chemotaxis Responses Modulate Longevity in C. elegans
Lans, H., Dekkers, M. P. J., Hukema, R. K., Bialas, N. J., Leroux, M. R., & Jansen, G. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04362.x · Cited by 3 · see citing works
Self-citationSolovev, I. A., Shaposhnikov, M. V., & Moskalev, A. (2018) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj18.429 · Cited by 2 · see citing works
Hsueh, Y., Leighton, D. H. W., & Sternberg, P. W. (2013) · Springer eBooks · doi:10.1007/978-94-007-7414-8_21 · Cited by 2 · see citing works
Identifying Critical Genes, Neurotransmitters, and Circuits for Social Behavior in Invertebrates
Certel, S. J. (2017) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190456757.013.28
Kaplan, R. E. W., Webster, A. K., Chitrakar, R., Dent, J. A., & Baugh, L. R. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/341883
Wibisono, P., Liu, Y., & Sun, J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.08.723815
- Authors
- Lans, H., & Jansen, G.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Jansen, Gert
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 303
- Issue
- 2
- Pages
- 474-482
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2152177859
- Cited by
- 50
- References
- 34
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 3 · 2021: 5 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 6 · 2012: 2
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2366 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Funders
- Koninklijke Nederlandse Akademie van Wetenschappen
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (805-48-009)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Nematode management and characterization studies
- Keywords
- G proteins, G protein alpha subunit, Gγ subunit, odr-3, gpc-1, lifespan extension, longevity, aging, sensory neurons, olfactory sensory neurons, gustatory neurons, nociceptors, ASH neurons, DAF-16, FOXO transcription factors, daf-2, insulin/IGF-1 signaling, Caenorhabditis elegans
- MeSH terms
- Animals, Longevity, Mutation, Neurons, Afferent, Receptor, Insulin, Transcription Factors, Signal Transduction, Caenorhabditis elegans, Genes, Helminth, GTP-Binding Proteins, GTP-Binding Protein alpha Subunits, Gi-Go, Caenorhabditis elegans Proteins, Animals, Genetically Modified, GTP-Binding Protein gamma Subunits, Forkhead Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
