PACRG, a protein linked to ciliary motility, mediates cellular signaling
Open accessAbstract
Cilia are microtubule-based organelles that project from nearly all mammalian cell types. Motile cilia generate fluid flow, whereas nonmotile (primary) cilia are required for sensory physiology and modulate various signal transduction pathways. Here we investigate the nonmotile ciliary signaling roles of parkin coregulated gene (PACRG), a protein linked to ciliary motility. PACRG is associated with the protofilament ribbon, a structure believed to dictate the regular arrangement of motility-associated ciliary components. Roles for protofilament ribbon–associated proteins in nonmotile cilia and cellular signaling have not been investigated. We show that PACRG localizes to a small subset of nonmotile cilia in Caenorhabditis elegans, suggesting an evolutionary adaptation for mediating specific sensory/signaling functions. We find that it influences a learning behavior known as gustatory plasticity, in which it is functionally coupled to heterotrimeric G-protein signaling. We also demonstrate that PACRG promotes longevity in C. elegans by acting upstream of the lifespan-promoting FOXO transcription factor DAF-16 and likely upstream of insulin/IGF signaling. Our findings establish previously unrecognized sensory/signaling functions for PACRG and point to a role for this protein in promoting longevity. Furthermore, our work suggests additional ciliary motility-signaling connections, since EFHC1 (EF-hand containing 1), a potential PACRG interaction partner similarly associated with the protofilament ribbon and ciliary motility, also positively regulates lifespan.
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The C. elegans cfap-20 mutant exhibits structural defects in the specialised mechanosensory cilia of the OLQ neuron similar to the pcrg-1 mutant.
“In addition, the C. elegans cfap-20 mutant exhibits structural defects in the specialised mechanosensory cilia of the OLQ neuron (Supplementary Fig. 7) similar to that observed for the pcrg-1 mutant36.”
From The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision (2022) · cites this paper as [36]
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A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739 · see citing works
Proteomic analysis of a eukaryotic cilium
Pazour, G. J., Agrin, N. S., Leszyk, J., & Witman, G. B. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200504008 · Cited by 1,028 · see citing works
Mutant sensory cilia in the nematode Caenorhabditis elegans
Perkins, L. A., Hedgecock, E. M., Thomson, J. N., & Culotti, J. G. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90314-3 · Cited by 907 · see citing works
Klass, M. R. (1977) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(77)90043-4 · Cited by 793 · see citing works
Bargmann, C. I. (2006) · WormBook · doi:10.1895/wormbook.1.123.1 · Cited by 787 · see citing works
Li, J. B., Gerdes, J. M., Haycraft, C. J., Fan, Y., Teslovich, T. M., May‐Simera, H., Li, H., Blacque, O. E., Li, L., Leitch, C. C., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00450-7 · Cited by 760 · see citing works
Self-citationBargmann, C. I., & Horvitz, H. R. (1991) · Neuron · doi:10.1016/0896-6273(91)90276-6 · Cited by 740 · see citing works
Motile Cilia of Human Airway Epithelia Are Chemosensory
Shah, A. S., Ben‐Shahar, Y., Moninger, T. O., Kline, J. N., & Welsh, M. J. (2009) · Science · doi:10.1126/science.1173869 · Cited by 717 · see citing works
Apfeld, J., O'Connor, G., McDonagh, T., DiStefano, P. S., & Curtis, R. (2004) · Genes & Development · doi:10.1101/gad.1255404 · Cited by 643 · see citing works
Regulation of lifespan by sensory perception in Caenorhabditis elegans
Apfeld, J., & Kenyon, C. (1999) · Nature · doi:10.1038/45544 · Cited by 573 · see citing works
The AID/APOBEC family of nucleic acid mutators
Conticello, S. G. (2008) · Genome biology · doi:10.1186/gb-2008-9-6-229 · Cited by 544 · see citing works
Cilia and Developmental Signaling
Eggenschwiler, J. T., & Anderson, K. V. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123249 · Cited by 530 · see citing works
Lee, R., Hench, J., & Ruvkun, G. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00595-4 · Cited by 508 · see citing works
Avidor‐Reiss, T., Maer, A. M., Koundakjian, E. J., Polyanovsky, A. D., Keil, T. A., Subramaniam, S., & Zuker, C. S. (2004) · Cell · doi:10.1016/s0092-8674(04)00412-x · Cited by 505 · see citing works
A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans.
Kaplan, J. M., & Horvitz, H. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2227 · Cited by 487 · see citing works
Tobin, D. M., Madsen, D. M., Kahn-Kirby, A. H., Peckol, E. L., Moulder, G. L., Barstead, R. J., Maricq, A. V., & Bargmann, C. I. (2002) · Neuron · doi:10.1016/s0896-6273(02)00757-2 · Cited by 455 · see citing works
A Proteomic Analysis of Human Cilia
Ostrowski, L. E., Blackburn, K., Radde, K. M., Moyer, M. B., Schlatzer, D., Moseley, M. A., & Boucher, R. C. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m200037-mcp200 · Cited by 441 · see citing works
Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor
Hart, A. C., Sims, S., & Kaplan, J. M. (1995) · Nature · doi:10.1038/378082a0 · Cited by 426 · see citing works
Functional coordination of intraflagellar transport motors
Ou, G., E. Blacque, O., Snow, J. J., Leroux, M. R., & Scholey, J. M. (2005) · Nature · doi:10.1038/nature03818 · Cited by 411 · see citing works
Self-citationSnow, J. J., Ou, G., Gunnarson, A. L., Walker, M. R. S., Zhou, H. M., Brust-Mascher, I., & Scholey, J. M. (2004) · Nature Cell Biology · doi:10.1038/ncb1186 · Cited by 404 · see citing works
Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons
Alcedo, J., & Kenyon, C. (2004) · Neuron · doi:10.1016/s0896-6273(03)00816-x · Cited by 388 · see citing works
Mutations in EFHC1 cause juvenile myoclonic epilepsy
Suzuki, T., Delgado‐Escueta, A. V., Aguan, K., Alonso, M. E., Shi, J., Hara, Y., Nishida, M., Numata, T., Medina, M. T., Takeuchi, T., et al. (2004) · Nature Genetics · doi:10.1038/ng1393 · Cited by 371 · see citing works
Blacque, O. E., Reardon, M. J., Li, C., McCarthy, J., Mahjoub, M. R., Ansley, S. J., Badano, J. L., Mah, A. K., Beales, P. L., Davidson, W. S., et al. (2004) · Genes & Development · doi:10.1101/gad.1194004 · Cited by 347 · see citing works
Self-citationFujiwara, M., Sengupta, P., & McIntire, S. L. (2002) · Neuron · doi:10.1016/s0896-6273(02)01093-0 · Cited by 344 · see citing works
Proteomic Analysis of Isolated Chlamydomonas Centrioles Reveals Orthologs of Ciliary-Disease Genes
Keller, L. C., Romijn, E. P., Zamora, I., Yates, J. R., & Marshall, W. F. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.024 · Cited by 338 · see citing works
The RFX-Type Transcription Factor DAF-19 Regulates Sensory Neuron Cilium Formation in C. elegans
Swoboda, P., Adler, H. T., & Thomas, J. H. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80436-0 · Cited by 336 · see citing works
Structural and Functional Conservation of the Caenorhabditis elegans Timing Gene clk-1
Ewbank, J. J., Barnes, T. M., Lakowski, B., Lussier, M., Bussey, H., & Hekimi, S. (1997) · Science · doi:10.1126/science.275.5302.980 · Cited by 319 · see citing works
A database of Caenorhabditis elegans behavioral phenotypes
Yemini, E., Jucikas, T., Grundy, L. J., Brown, A. E., & Schafer, W. R. (2013) · Nature Methods · doi:10.1038/nmeth.2560 · Cited by 309 · see citing works
Self-citationRoayaie, K., Crump, J. G., Sagasti, A., & Bargmann, C. I. (1998) · Neuron · doi:10.1016/s0896-6273(00)80434-1 · Cited by 308 · see citing works
The complete family of genes encoding G proteins of Caenorhabditis elegans
Jansen, G., Thijssen, K. L., Werner, P., van derHorst, M., Hazendonk, E., & Plasterk, R. H. A. (1999) · Nature Genetics · doi:10.1038/7753 · Cited by 302 · see citing works
Self-citationSocial feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli
de Bono, M., Tobin, D. M., Davis, M. W., Avery, L., & Bargmann, C. I. (2002) · Nature · doi:10.1038/nature01169 · Cited by 279 · see citing works
Sensory Cilia and Integration of Signal Transduction in Human Health and Disease
Christensen, S. T., Pedersen, L. B., Schneider, L. H., & Satir, P. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00516.x · Cited by 256 · see citing works
Caenorhabditis elegans TRPA-1 functions in mechanosensation
Kindt, K. S., Viswanath, V., Macpherson, L. J., Quast, K. B., Hu, H., Patapoutian, A., & Schafer, W. R. (2007) · Nature Neuroscience · doi:10.1038/nn1886 · Cited by 238 · see citing works
Self-citationŠtolc, V., Samanta, M. P., Tongprasit, W., & Marshall, W. F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408358102 · Cited by 218 · see citing works
Sensory reception is an attribute of both primary cilia and motile cilia
Bloodgood, R. A. (2010) · Journal of Cell Science · doi:10.1242/jcs.066308 · Cited by 218 · see citing works
The sensory cilia of Caenorhabditis elegans_Revised
Scholey, J. M. (2007) · WormBook · doi:10.1895/wormbook.1.126.2 · Cited by 209 · see citing works
Wicks, S. R., de Vries, C. J., van Luenen, H. G. A. M., & Plasterk, R. H. A. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9686 · Cited by 203 · see citing works
Analysis of xbx genes in C. elegans
Efimenko, E., Bubb, K. L., Mak, H. Y., Holzman, T., Leroux, M. R., Ruvkun, G., Thomas, J. H., & Swoboda, P. (2005) · Development · doi:10.1242/dev.01775 · Cited by 191 · see citing works
Self-citationThe roles of evolutionarily conserved functional modules in cilia-related trafficking
Sung, C.-H., & Leroux, M. R. (2013) · Nature Cell Biology · doi:10.1038/ncb2888 · Cited by 186 · see citing works
Self-citationTanaka, H., Iguchi, N., Toyama, Y., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.7958-7964.2004 · Cited by 179 · see citing works
Cilia in vertebrate development and disease
Oh, E. C. T., & Katsanis, N. (2012) · Development · doi:10.1242/dev.050054 · Cited by 158 · see citing works
Zhu, D., Shi, S., Wang, H., & Liao, K. (2009) · Journal of Cell Science · doi:10.1242/jcs.046276 · Cited by 156 · see citing works
The primary cilium as a cellular signaling center: lessons from disease
Lancaster, M. A., & Gleeson, J. G. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.04.008 · Cited by 153 · see citing works
G Proteins Are Required for Spatial Orientation of Early Cell Cleavages in C. elegans Embryos
Zwaal, R. R., Ahringer, J., van Luenen, H. G. A. M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80135-x · Cited by 153 · see citing works
Smith, J. C., Northey, J. G. B., Garg, J., Pearlman, R. E., & Siu, K. W. M. (2005) · Journal of Proteome Research · doi:10.1021/pr050013h · Cited by 120 · see citing works
Winkelbauer, M. E., Schafer, J. C., Haycraft, C. J., Swoboda, P., & Yoder, B. K. (2005) · Journal of Cell Science · doi:10.1242/jcs.02665 · Cited by 118 · see citing works
The tektin family of microtubule-stabilizing proteins
Amos, L. (2008) · Genome biology · doi:10.1186/gb-2008-9-7-229 · Cited by 118 · see citing works
Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans
Hukema, R. K., Rademakers, S., Dekkers, M. P., Burghoorn, J., & Jansen, G. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600940 · Cited by 111 · see citing works
Self-citationYeh, C., Li, A., Chuang, J.-Z., Saito, M., Cáceres, A., & Sung, C.-H. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.07.014 · Cited by 105 · see citing works
The WD Repeat-containing Protein IFTA-1 Is Required for Retrograde Intraflagellar Transport
Blacque, O. E., Li, C., Inglis, P. N., Esmail, M. A., Ou, G., Mah, A. K., Baillie, D. L., Scholey, J. M., & Leroux, M. R. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-06-0571 · Cited by 103 · see citing works
Self-citationThe G‐protein γ subunit gpc‐1 of the nematode C.elegans is involved in taste adaptation
Jansen, G., Weinkove, D., & Plasterk, R. H. A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.5.986 · Cited by 99 · see citing works
Self-citationDawe, H. R., Farr, H., Portman, N., Shaw, M. K., & Keith Gull, B. (2005) · Journal of Cell Science · doi:10.1242/jcs.02659 · Cited by 95 · see citing works
Deletion of the Parkin coregulated gene causes male sterility in the quaking viable mouse mutant
Lorenzetti, D., Bishop, C. E., & Justice, M. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401832101 · Cited by 93 · see citing works
Hukema, R. K., Rademakers, S., & Jansen, G. (2008) · Learning & Memory · doi:10.1101/lm.994408 · Cited by 90 · see citing works
Self-citationInsights into the Structure and Function of Ciliary and Flagellar Doublet Microtubules
Linck, R. W., Fu, X., Lin, J., Ouch, C., Schefter, A. M., Steffen, W., Warren, P. G., & Nicastro, D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.568949 · Cited by 81 · see citing works
Bialas, N. J., Inglis, P. N., Li, C., Robinson, J. F., Parker, J., Healey, M. P., Davis, E. E., Inglis, C. D., Toivonen, T., Cottell, D. C., et al. (2009) · Journal of Cell Science · doi:10.1242/jcs.028621 · Cited by 78 · see citing works
Self-citationSchafer, J. C., Winkelbauer, M. E., Williams, C. L., Haycraft, C. J., Desmond, R. A., & Yoder, B. K. (2006) · Journal of Cell Science · doi:10.1242/jcs.03187 · Cited by 76 · see citing works
Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility
Suzuki, T., Miyamoto, H., Nakahari, T., Inoue, I., Suemoto, T., Jiang, B., Hirota, Y., Itohara, S., Saido, T. C., Tsumoto, T., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp006 · Cited by 76 · see citing works
Ikeda, K., Brown, J. A., Yagi, T., Norrander, J. M., Hirono, M., Eccleston, E., Kamiya, R., & Linck, R. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210751200 · Cited by 75 · see citing works
cAMP and cGMP signaling: sensory systems with prokaryotic roots adopted by eukaryotic cilia
Johnson, J.-L., & Leroux, M. R. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.05.005 · Cited by 74 · see citing works
Self-citationSensory roles of neuronal cilia: Cilia development, morphogenesis, and function in C. elegans
Bae, Y. (2008) · Frontiers in bioscience · doi:10.2741/3129 · Cited by 72 · see citing works
Wilson, G. R. A., Wang, H. X., Egan, G. F., Robinson, P. J., Delatycki, M. B., O’Bryan, M. K., & Lockhart, P. J. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq031 · Cited by 65 · see citing works
Ikeda, T., Ikeda, K., Enomoto, M., et al. (2005) · FEBS Letters · doi:10.1016/j.febslet.2004.12.070 · Cited by 62 · see citing works
Lans, H., & Jansen, G. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.11.028 · Cited by 50 · see citing works
Self-citationA Gap Junction Circuit Enhances Processing of Coincident Mechanosensory Inputs
Rabinowitch, I., Chatzigeorgiou, M., & Schafer, W. R. (2013) · Current Biology · doi:10.1016/j.cub.2013.04.030 · Cited by 50 · see citing works
Self-citationEvolution and persistence of the cilium
Satir, P., Guerra, C., & Bell, A. J. (2007) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20238 · Cited by 47 · see citing works
Tektin interactions and a model for molecular functions
Setter, P. W., Malvey-Dorn, E., Steffen, W., Stephens, R. E., & Linck, R. W. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.05.014 · Cited by 46 · see citing works
Wolf, M. T. F., Lee, J., Panther, F., Otto, E. A., Guan, K., & Hildebrandt, F. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2003121025 · Cited by 45 · see citing works
Ikeda, K., Ikeda, T., Morikawa, K., & Kamiya, R. (2007) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20225 · Cited by 38 · see citing works
Sequential expression of Efhc1/myoclonin1 in choroid plexus and ependymal cell cilia
Suzuki, T., Inoue, I., Yamagata, T., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.126 · Cited by 36 · see citing works
Parkin‐co‐regulated gene (PACRG) product interacts with tubulin and microtubules
Ikeda, T. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.02.081 · Cited by 29 · see citing works
Protofilament Ribbon Compartments of Ciliary and Flagellar Microtubules
Linck, R. W., & Norrander, J. M. (2003) · Protist · doi:10.1078/143446103322454086 · Cited by 26 · see citing works
Ciliary and non-ciliary expression and function of PACRGduring vertebrate development
Thumberger, T., Hagenlocher, C., Tisler, M., Beyer, T., Tietze, N., Schweickert, A., Feistel, K., & Blum, M. (2012) · Cilia · doi:10.1186/2046-2530-1-13 · Cited by 20 · see citing works
Regional and cellular localisation of Parkin Co-Regulated Gene in developing and adult mouse brain
Brody, K. M., Taylor, J. M., Wilson, G. R. A., et al. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.050 · Cited by 14 · see citing works
Genetic mapping and manipulation: Chapter 2-Two-point mapping with genetic markers
Fay, D. S. (2006) · WormBook · doi:10.1895/wormbook.1.91.2 · Cited by 14 · see citing works
Expression Profile and Distribution of Efhc1 Gene Transcript During Rodent Brain Development
Conte, F. F., Ribeiro, P. A. O., Marchesini, R. B., et al. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9179-6 · Cited by 10 · see citing works
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Genes and molecular pathways underpinning ciliopathies
Reiter, J. F., & Leroux, M. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.60 · Cited by 1,588 · see citing works
Self-citationChrystal, P. W., Lambacher, N. J., Doucette, L. P., Bellingham, J., Schiff, E. R., Noel, N. C. L., Li, C., Tsiropoulou, S., Casey, G. A., Zhai, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33820-w · Cited by 31 · see citing works
Self-citationKhan, N., Pelletier, D., McAlear, T. S., Croteau, N., Veyron, S., Bayne, A. N., Black, C., Ichikawa, M., Khalifa, A. A. Z., Chaaban, S., et al. (2021) · Structure · doi:10.1016/j.str.2021.01.001 · Cited by 24 · see citing works
Loucks, C. M., Park, K., Walker, D. S., McEwan, A. H., Timbers, T. A., Ardiel, E. L., Grundy, L. J., Li, C., Johnson, J.-L., Kennedy, J., et al. (2019) · eLife · doi:10.7554/elife.37271 · Cited by 18 · see citing works
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- Authors
- Loucks, C. M., Bialas, N. J., Dekkers, M. P. J., Walker, D. S., Grundy, L. J., Li, C., Inglis, P. N., Kida, K., Schafer, W. R., Blacque, O. E., Jansen, G., & Leroux, M. R.
- Affiliations
- Simon Fraser University (CA)
- Erasmus MC (NL)
- MRC Laboratory of Molecular Biology (GB)
- Department of Molecular Biology and Biochemistry and Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
- University College Dublin (IE)
- Corresponding author
- Leroux, Michel R.
- ORCID
- Venue
- Molecular Biology of the Cell
- Published
- 2016-07
- Volume
- 27
- Issue
- 13
- Pages
- 2133-2144
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC4927285
- OpenAlex
- W2404354114
- Cited by
- 23
- References
- 77
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 8 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- Molecular Biology of the Cell (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- BORIS (University Library Bern) (submittedVersion, cc-by-nc-sa)
- Open Access CRIS of the University of Bern
- Funders
- Wellcome Trust (WT103784MA, 103784/Z/14/Z)
- Michael Smith Health Research BC
- Science Foundation Ireland (11/PI/1037)
- National Institutes of Health
- Canadian Institutes of Health Research (MOP82870)
- Medical Research Council (MC-A023-5PB91)
- National Center for Research Resources
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- PACRG, primary cilia, ciliary motility, heterotrimeric G protein signaling, longevity, DAF-16/FOXO, insulin/IGF signaling, EFHC1, Caenorhabditis elegans, lifespan regulation, sensory signaling
- MeSH terms
- Animals, Calcium-Binding Proteins, Cilia, Microtubules, Signal Transduction, Caenorhabditis elegans, Molecular Chaperones, Caenorhabditis elegans Proteins, Forkhead Transcription Factors
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