Cited by 82Developmental Biology and Gene RegulationAxon Guidance and Neuronal SignalingHippo pathway signaling and YAP/TAZ

The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors

Open access
Courbard, Jean-Remy, Djiane, Alexandre, Wu, Jun, Mlodzik, Marek·2009·Developmental Biology

Abstract

Most tissues display several features of cellular polarization. Besides the ubiquitous epithelial polarization in the Apical-Basal (A/B) axis, many epithelia (and associated organs) display a Planar Cell Polarization (PCP). Recently, a crosstalk between the PCP and A/B polarity determinants has been suggested, i.e. the activity or stability of the PCP factor Frizzled is regulated by the A/B determinants aPKC and Bazooka in the Drosophila eye. We have systematically investigated genetic and physical interactions between the Drosophila A/B factors and the core PCP component Strabismus (Stbm)/Van Gogh (Vang). The A/B determinant Scribble was found to interact both genetically and physically with Stbm/Vang. We demonstrate that Scribble binds Stbm/Vang through its PDZ domain 3 and that it cooperates with Stbm/Vang in PCP establishment. Our data indicate that Scribble, in addition to its role in A/B polarity, has a distinct requirement in PCP establishment in the Drosophila eye and wing. We define a scribble allele that is largely PCP specific. Our data show that Scribble is part of the Stbm/Vang PCP complex and further suggest that it might act as an effector of Stbm/Vang during PCP establishment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.ydbio.2009.06.024

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A very similar mechanism links Drosophila Vang and Scribble in planar polarization of the wing hairs and photoreceptor cells.

    “Intriguingly, a very similar mechanism appears to link Drosophila Vang and Scribble in planar polarization of the wing hairs and photoreceptor cells (Courbard et al., 2009).”

    From Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation (2019) · cites this paper as Courbard et al., 2009

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Courbard, J.-R., Djiane, A., Wu, J., & Mlodzik, M.
Affiliations
Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Mlodzik, Marek
Venue
Developmental Biology
Publisher
Elsevier BV
Published
2009-09
Volume
333
Issue
1
Pages
67-77
ISSN
0012-1606 (ISSN-L)
OpenAlex
W2047339425
Cited by
82
References
46
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 1 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 10
FWCI
4.16
Type
journal article
Language
en
Open access
Locations
  • Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Eye Institute (EY 13256, R01EY013256)
  • National Institute of General Medical Sciences (R01GM062917, GM 62917)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords
Scribble, strabismus, Vincent van Gogh, planar cell polarity, apical-basal polarity, PDZ domain, protein-protein interaction, Drosophila eye, Drosophila wing, epithelial polarization
MeSH terms
Animals, Drosophila, Membrane Proteins, Mutation, Protein Binding, Wings, Animal, Cell Polarity, Body Patterning, Drosophila Proteins, Compound Eye, Arthropod

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review