Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse
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Planar cell polarity (PCP) signaling is well known to play a critical role during prenatal brain development; whether it plays specific roles at postnatal stages remains rather unknown. Here, we investigated the role of a key PCP-associated gene scrib in CA1 hippocampal structure and function at postnatal stages. We found that Scrib is required for learning and memory consolidation in the Morris water maze as well as synaptic maturation and NMDAR-dependent bidirectional plasticity. Furthermore, we unveiled a direct molecular interaction between Scrib and PP1/PP2A phosphatases whose levels were decreased in postsynaptic density of conditional knock-out mice. Remarkably, exposure to enriched environment (EE) preserved memory formation in CaMK-Scrib-/- mice by recovering synaptic plasticity and maturation. Thus, Scrib is required for synaptic function involved in memory formation and EE has beneficiary therapeutic effects. Our results demonstrate a distinct new role for a PCP-associated protein, beyond embryonic development, in cognitive functions during adulthood.
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Postnatal Scribble knockout in hippocampal neurons revealed only subtle roles in learning and memory consolidation, suggesting that the effects are time and context dependent.
“Postnatal Scribble knockout in hippocampal neurons revealed only subtle roles in learning and memory consolidation, suggesting that the effects are time and context dependent (Hilal et al., 2017).”
From Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation (2019) · cites this paper as Hilal et al., 2017
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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works
The contribution of de novo coding mutations to autism spectrum disorder
Iossifov, I., O’Roak, B. J., Sanders, S. J., Ronemus, M., Krumm, N., Levy, D., Stessman, H. A., Witherspoon, K. T., Vives, L., Patterson, K. E., et al. (2014) · Nature · doi:10.1038/nature13908 · Cited by 2,585 · see citing works
Neural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works
Functional impact of global rare copy number variation in autism spectrum disorders
Pinto, D., Pagnamenta, A. T., Klei, L., Anney, R., Merico, D., Regan, R., Conroy, J., Magalhaes, T. R., Correia, C., Abrahams, B. S., et al. (2010) · Nature · doi:10.1038/nature09146 · Cited by 2,013 · cited 1× · see citing works
“3 encompassing five genes, including SCRIB (the human orthologue of scrib) (Hu et al. 2015) and two with a missense mutation in SCRIB (c.1114C>T, c.1774C>T) (Pinto et al. 2010; Neale et al. 2012; Iossifov et al. 2014).”
BackgroundTranscriptomic Analysis of Autistic Brain Reveals Convergent Molecular Pathology
Voineagu, I., Wang, X., Johnston, P., Lowe, J. K., Tian, Y., Horvath, S., Mill, J., Cantor, R. M., Blencowe, B. J., & Geschwind, D. H. (2011) · Nature · doi:10.1038/nature10110 · Cited by 1,874 · see citing works
Patterns and rates of exonic de novo mutations in autism spectrum disorders
Neale, B. M., Kou, Y., Liu, L., Ma’ayan, A., Samocha, K. E., Sabo, A., Lin, C.-F., Stevens, C., Wang, L.-S., Makarov, V., et al. (2012) · Nature · doi:10.1038/nature11011 · Cited by 1,734 · see citing works
Liao, D., Hessler, N. A., & Malinow, R. (1995) · Nature · doi:10.1038/375400a0 · Cited by 1,365 · see citing works
Evidence for silent synapses: Implications for the expression of LTP
Isaac, J. T. R., Nicoll, R. A., & Malenka, R. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90046-2 · Cited by 1,233 · see citing works
Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
Mulkey, R. M., Endo, S., Shenolikar, S., & Malenka, R. C. (1994) · Nature · doi:10.1038/369486a0 · Cited by 1,083 · see citing works
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals
Montcouquiol, M., Rachel, R. A., Lanford, P. J., Copeland, N. G., Jenkins, N. A., & Kelley, M. W. (2003) · Nature · doi:10.1038/nature01618 · Cited by 705 · see citing works
Self-citationA Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains
Irimia, M., Weatheritt, R. J., Ellis, J. D., Parikshak, N. N., Gonatopoulos-Pournatzis, T., Babor, M., Quesnel-Vallières, M., Tapial, J., Raj, B., O’Hanlon, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.035 · Cited by 693 · see citing works
Different modes of expression of AMPA and NMDA receptors in hippocampal synapses
Takumi, Y., Ramírez-León, V., Laake, P., Rinvik, E., & Ottersen, O. P. (1999) · Nature Neuroscience · doi:10.1038/10172 · Cited by 675 · see citing works
PDZ domains and their binding partners: structure, specificity, and modification
Lee, H., & Zheng, J. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-8 · Cited by 584 · see citing works
A developmental change in NMDA receptor-associated proteins at hippocampal synapses
Sans, N., Petralia, R. S., Wang, Y.-X., Blahos, J., Hell, J. W., & Wenthold, R. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01260.2000 · Cited by 537 · see citing works
Self-citationCharacterization of the proteome, diseases and evolution of the human postsynaptic density
Bayés, À., van de Lagemaat, L. N., Collins, M. O., Croning, M. D. R., Whittle, I. R., Choudhary, J. S., & Grant, S. G. N. (2011) · Nature Neuroscience · doi:10.1038/nn.2719 · Cited by 499 · see citing works
Lisman (2001) · doi:10.1016/s0896-6273(01)00364-6 · Cited by 480 · see citing works
Tissue/planar cell polarity in vertebrates: new insights and new questions
Wang, Y., & Nathans, J. (2007) · Development · doi:10.1242/dev.02772 · Cited by 442 · see citing works
The role of calmodulin as a signal integrator for synaptic plasticity
Xia, Z., & Storm, D. R. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1647 · Cited by 441 · see citing works
Synapse-specific regulation of AMPA receptor function by PSD-95.
Béïque, J.-C., Lin, D.-T., Kang, M.-G., Aizawa, H., Takamiya, K., & Huganir, R. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608492103 · Cited by 398 · see citing works
Diversity in NMDA Receptor Composition
Sanz-Clemente, A., Nicoll, R. A., & Roche, K. W. (2012) · The Neuroscientist · doi:10.1177/1073858411435129 · Cited by 397 · see citing works
Stein, V., House, D. R. C., Bredt, D. S., & Nicoll, R. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05503.2003 · Cited by 341 · see citing works
NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex
Sans, N., Prybylowski, K., Petralia, R. S., Chang, K., Wang, Y.-X., Racca, C., Vicini, S., & Wenthold, R. J. (2003) · Nature Cell Biology · doi:10.1038/ncb990 · Cited by 327 · see citing works
Self-citationMontcouquiol, M., Sans, N., Huss, D., Kach, J., Dickman, J. D., Forge, A., Rachel, R. A., Copeland, N. G., Jenkins, N. A., Bogani, D., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4680-05.2006 · Cited by 322 · see citing works
Self-citationCukier, H. N., Dueker, N., Slifer, S. H., Lee, J. M., Whitehead, P. L., Lalanne, E., Leyva, N., Konidari, I., Gentry, R. C., Hulme, W. F., et al. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-1 · Cited by 316 · see citing works
Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice
Frick, K. M., & Fernandez, S. M. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00138-0 · Cited by 303 · see citing works
A CamKIIα iCre BAC allows brain‐specific gene inactivation
Casanova, E., Fehsenfeld, S., Mantamadiotis, T., Lemberger, T., Greiner, E. F., Stewart, A. F., & Schütz, G. (2001) · genesis · doi:10.1002/gene.1078 · Cited by 293 · see citing works
Hippocampal long-term depression is required for the consolidation of spatial memory
Ge, Y., Dong, Z., Bagot, R. C., Howland, J. G., Phillips, A. G., Wong, T. P., & Wang, Y. T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008200107 · Cited by 280 · see citing works
Planar Cell Polarity and the Developmental Control of Cell Behavior in Vertebrate Embryos
Wallingford, J. B. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154208 · Cited by 251 · see citing works
Regulation of Synaptic Strength by Protein Phosphatase 1
Morishita, W., Connor, J. H., Xia, H., Quinlan, E. M., Shenolikar, S., & Malenka, R. C. (2001) · Neuron · doi:10.1016/s0896-6273(01)00554-2 · Cited by 227 · see citing works
Mammalian Scribble Forms a Tight Complex with the βPIX Exchange Factor
Audebert, S., Navarro, C., Nourry, C., Chasserot-Golaz, S., Lécine, P., Bellaiche, Y., Dupont, J.-L., Premont, R. T., Sempéré, C., Strub, J.-M., et al. (2004) · Current Biology · doi:10.1016/j.cub.2004.05.051 · Cited by 218 · see citing works
Self-citationNONCANONICAL WNT SIGNALING AND NEURAL POLARITY
Montcouquiol, M., Crenshaw, E. B., & Kelley, M. W. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112933 · Cited by 191 · see citing works
Self-citationNithianantharajah, J. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.02.002 · Cited by 191 · see citing works
Dow, L. E., Kauffman, J. S., Caddy, J., Peterson, A. S., Jane, S. M., Russell, S. M., & Humbert, P. O. (2007) · Oncogene · doi:10.1038/sj.onc.1210016 · Cited by 187 · see citing works
Glutamate-induced transient modification of the postsynaptic density
Dosemeci, A., Tao-Cheng, J.-H., Vinade, L., Winters, C. A., Pozzo-Miller, L., & Reese, T. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181336998 · Cited by 184 · see citing works
The rodent hippocampus and spatial memory: from synapses to systems
Martin, S. J., & Clark, R. E. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6336-3 · Cited by 165 · see citing works
Role of Serine/Threonine Protein Phosphatase in Alzheimer’s Disease
Tian, Q., & Wang, J. (2002) · Neurosignals · doi:10.1159/000067425 · Cited by 156 · see citing works
Opposing roles in neurite growth control by two seven-pass transmembrane cadherins
Shima, Y., Kawaguchi, S., Kosaka, K., Nakayama, M., Hoshino, M., Nabeshima, Y., Hirano, T., & Uemura, T. (2007) · Nature Neuroscience · doi:10.1038/nn1933 · Cited by 154 · see citing works
GABA depolarization is required for experience-dependent synapse unsilencing in adult-born neurons
Chancey, J. H., Adlaf, E. W., Sapp, M. C., Pugh, P. C., Wadiche, J. I., & Overstreet-Wadiche, L. S. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0781-13.2013 · Cited by 152 · see citing works
Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory
Mansuy, I. M., & Shenolikar, S. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.10.004 · Cited by 151 · see citing works
Dahlqvist, P. M., Rönnbäck, A., Bergström, S., Söderström, I., & Olsson, T. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03248.x · Cited by 140 · see citing works
mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression
Sans, N., Wang, P. Y., Du, Q., Petralia, R., Wang, Y.-X., Nakka, S., Blumer, J., Macara, I., & Wenthold, R. (2005) · Nature Cell Biology · doi:10.1038/ncb1325 · Cited by 131 · see citing works
Self-citationPlanar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A
Hannus, M., Feiguin, F. M., Heisenberg, C., & Eaton, S. (2002) · Development · doi:10.1242/dev.129.14.3493 · Cited by 130 · see citing works
Shaping the nervous system: role of the core planar cell polarity genes
Tissir, F., & Goffinet, A. M. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3525 · Cited by 126 · see citing works
Pointing in the right direction: new developments in the field of planar cell polarity
Bayly, R. D., & Axelrod, J. D. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2956 · Cited by 122 · see citing works
Young, L. C., Hartig, N., Muñoz-Alegre, M., Osés-Prieto, J. A., Durdu, S., Bender, S., Vijayakumar, V., Rudan, M. V., Gewinner, C. A., Henderson, S. R., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.004 · Cited by 118 · see citing works
Asher, I. M., & Aghajanian, G. K. (1974) · Brain Research · doi:10.1016/0006-8993(74)90888-9 · Cited by 117 · see citing works
Mechanism for increased hippocampal synaptic strength following differential experience.
Foster, T. C., & Dumas, T. C. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.4.1377 · Cited by 111 · see citing works
Novel Mode of Ligand Recognition by the Erbin PDZ Domain
Birrane, G., Chung, J., & Ladias, J. A. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200571200 · Cited by 111 · see citing works
Bejar, R. L., Yasuda, R., Krugers, H. J., Hood, K. L., & Mayford, M. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05719.2002 · Cited by 95 · see citing works
Krucker, T., Siggins, G. R., McNamara, R. K., Lindsley, K. A., Dao, A. T. T., Allison, D. W., de Lecea, L., Lovenberg, T. W., Sutcliffe, J. G., & Gerendasy, D. D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05525.2002 · Cited by 95 · see citing works
Sowers, L. P., Loo, L., Wu, Y. C., Campbell, E., Ulrich, J. D., Wu, S., Paemka, L., Wassink, T. H., Meyer, K. J., Bing, X., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.71 · Cited by 94 · see citing works
Revisiting planar cell polarity in the inner ear
Ezan, J., & Montcouquiol, M. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.03.012 · Cited by 85 · see citing works
Self-citationCourbard, J.-R., Djiane, A., Wu, J., & Mlodzik, M. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.06.024 · Cited by 82 · see citing works
Collective nomenclature for LAP proteins
Bilder, D., Birnbaum, D., Borg, J.-P., Bryant, P., Huigbretse, J., Jansen, E., Kennedy, M. B., Labouesse, M., Legouis, R., Mechler, B., et al. (2000) · Nature Cell Biology · doi:10.1038/35017119 · Cited by 81 · see citing works
Self-citationNOS1AP associates with Scribble and regulates dendritic spine development
Richier, L., Williton, K., Clattenburg, L., Colwill, K., O'Brien, M., Tsang, C., Kolar, A., Zinck, N., Metalnikov, P., Trimble, W. S., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3726-09.2010 · Cited by 81 · see citing works
Nagaoka, T., Ohashi, R., Inutsuka, A., Sakai, S., Fujisawa, N., Yokoyama, M., Huang, Y. H., Igarashi, M., & Kishi, M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.044 · Cited by 79 · see citing works
Chronic Inactivation of a Neural Circuit Enhances LTP by Inducing Silent Synapse Formation
Arendt, K. L., Sarti, F., & Chen, L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3880-12.2013 · Cited by 77 · see citing works
Protein phosphatase 1 regulation by inhibitors and targeting subunits
Watanabe, T., Huang, H., Horiuchi, A., Silva, E. F. D. C., Hsieh‐Wilson, L. C., Allen, P. B., Shenolikar, S., Greengard, P., & Nairn, A. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051003898 · Cited by 73 · see citing works
The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function
Moreau, M. M., Piguel, N., Papouin, T., Koehl, M., Durand, C. M., Rubio, M. E., Loll, F., Richard, E. M., Mazzocco, C., Racca, C., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6007-09.2010 · Cited by 69 · see citing works
Self-citationThe Plane Facts of PCP in the CNS
Goodrich, L. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.003 · Cited by 68 · see citing works
The Role of the PDZ Protein GIPC in Regulating NMDA Receptor Trafficking
Yi, Z., Petralia, R. S., Fu, Z., Swanwick, C. C., Wang, Y., Prybylowski, K., Sans, N., Vicini, S., & Wenthold, R. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3252-07.2007 · Cited by 66 · see citing works
Self-citationJouvenceau, A., Billard, J., Haditsch, U., Mansuy, I. M., & Dutar, P. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02831.x · Cited by 64 · see citing works
Planar cell polarity signaling in neural development
Tissir, F., & Goffinet, A. M. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.05.006 · Cited by 61 · see citing works
Kozulin, A., Lebeer, J., Madella-Noja, A., Gonzalez, F., Jeffrey, I. A., Rosenthal, N., & Koslowsky, M. (2010) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2009.12.001 · Cited by 60 · see citing works
Scribble Acts in the Drosophila Fat-Hippo Pathway to Regulate Warts Activity
Verghese, S., Waghmare, I., Kwon, H., Hanes, K., & Kango-Singh, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047173 · Cited by 55 · see citing works
NMDA Receptor-Dependent LTD Is Required for Consolidation But Not Acquisition of Fear Memory
Liu, X., Gu, Q.-H., Duan, K., & Li, Z. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2752-13.2014 · Cited by 52 · see citing works
Scribble1/AP2 complex coordinates NMDA receptor endocytic recycling
Piguel, N. H., Fievre, S., Blanc, J.-M., Carta, M., Moreau, M. M., Moutin, E., Pinheiro, V. L., Medina, C., Ezan, J., Lasvaux, L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.017 · Cited by 52 · see citing works
Self-citationYamben, I. F., Rachel, R. A., Shatadal, S., Copeland, N. G., Jenkins, N. A., Warming, S., & Griep, A. E. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.09.027 · Cited by 50 · see citing works
Self-citationHe, J., Yamada, K., Zou, L. B., & Nabeshima, T. (2001) · Journal of Neural Transmission · doi:10.1007/s007020100018 · Cited by 49 · see citing works
Planar cell polarity genes, Celsr1-3, in neural development
Feng, J., Han, Q., & Zhou, L. (2012) · Neuroscience Bulletin · doi:10.1007/s12264-012-1232-8 · Cited by 41 · see citing works
Regulation of CaMKII by α4/PP2Ac contributes to learning and memory
Yamashita, T., Inui, S., Maeda, K., Hua, D. R., Takagi, K., Fukunaga, K., & Sakaguchi, N. (2006) · Brain Research · doi:10.1016/j.brainres.2006.01.101 · Cited by 41 · see citing works
Nagasaka, K., Seiki, T., Yamashita, A., Massimi, P., Subbaiah, V. K., Thomas, M., Kranjec, C., Kawana, K., Nakagawa, S., Yano, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053752 · Cited by 35 · see citing works
A Role for Atypical CadherinCelsr3in Hippocampal Maturation and Connectivity
Feng, J., Xu, Y., Wang, M., Ruan, Y., So, K., Tissir, F., Goffinet, A. M., & Zhou, L. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1965-12.2012 · Cited by 32 · see citing works
Morelli, E., Ghiglieri, V., Pendolino, V., Bagetta, V., Pignataro, A., Fejtová, A., Costa, C., Ammassari‐Teule, M., Gundelfinger, E. D., Picconi, B., et al. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.05.010 · Cited by 31 · see citing works
Bennett, P. C., Zhao, W., & Ng, K. T. (2001) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1999.3959 · Cited by 26 · see citing works
Need, A. C., Irvine, E. E., & Giese, K.-P. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02889.x · Cited by 26 · see citing works
Hagiwara, A., Yasumura, M., Hida, Y., Inoue, E., & Ohtsuka, T. (2014) · Molecular Brain · doi:10.1186/s13041-014-0079-5 · Cited by 23 · see citing works
Hu, J., Sathanoori, M., Kochmar, S. J., Azage, M., Mann, S., Madan‐Khetarpal, S., Goldstein, A. C., & Surti, U. (2015) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.37110 · Cited by 17 · see citing works
Sans, N., Ezan, J., Moreau, M. M., & Montcouquiol, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00013-3 · Cited by 15 · see citing works
Self-citationSize matters at the blood–brain barrier
Green, E. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1160 · Cited by 5 · see citing works
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Bonello, T. T., & Peifer, M. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201810103 · Cited by 127 · see citing works
Linking Cell Polarity to Cortical Development and Malformations
Hakanen, J., Ruiz-Reig, N., & Tissir, F. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00244 · Cited by 65 · see citing works
Applied strategies of neuroplasticity
Johnson, B. P., & Cohen, L. G. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-323-98817-9.00011-9 · Cited by 37 · see citing works
Bayat, M., Kohlmeier, K. A., Haghani, M., Borhani‐Haghighi, A., Khalili, A., Bayat, G., Hooshmandi, E., & Shabani, M. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05853-4 · Cited by 24 · see citing works
Regulation of cellular and PCP signalling by the Scribble polarity module
Milgrom-Hoffman, M., & Humbert, P. O. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.11.021 · Cited by 22 · see citing works
Fass, D. M., Lewis, M. C., Ahmad, R., Szucs, M. J., Zhang, Q., Fleishman, M., Wang, D., Kim, M. J., Biag, J. D., Carr, S. A., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01557-z · Cited by 19 · see citing works
Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion
Robert, B. J. A., Moreau, M. M., Carvalho, S. D. S., Barthet, G., Racca, C., Bhouri, M., Quiedeville, A., Garret, M., Atchama, B., Abed, A. S. A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107743 · Cited by 15 · see citing works
Self-citationThe polarity protein Angiomotin p130 controls dendritic spine maturation
Wigerius, M., Quinn, D. P., Diab, A. M., Clattenburg, L., Kolar, A., Qi, J., Krueger, S., & Fawcett, J. P. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201705184 · Cited by 15 · see citing works
Ang, M. J., Kang, S., & Moon, C. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24708 · Cited by 13 · see citing works
Ezan, J., Moreau, M. M., Mamo, T. M., Shimbo, M., Decroo, M., Richter, M., Peyroutou, R., Rachel, R. A., Tissir, F., de Anda, F. C., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-88147-1 · Cited by 11 · see citing works
Self-citationTroyanovsky, R. B., Indra, I., Kato, R., Mitchell, B. J., & Troyanovsky, S. M. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101289 · Cited by 11 · see citing works
Identification of a novel de novo PUF60 variant causing Verheij syndrome in a fetus
Miao, M., Wang, J., Guo, C., Su, X., Sun, L., & Lu, S. H. (2023) · Gene · doi:10.1016/j.gene.2023.148092 · Cited by 7 · see citing works
Neuron-Specific Deletion of Scrib in Mice Leads to Neuroanatomical and Locomotor Deficits
Ezan, J., Moreau, M. M., Mamo, T. M., Shimbo, M., Decroo, M., Sans, N., & Montcouquiol, M. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.872700 · Cited by 6 · see citing works
Self-citationScribble Controls Social Motivation Behavior through the Regulation of the ERK/Mnk1 Pathway
Moreau, M. M., Pietropaolo, S., Ezan, J., Robert, B. J. A., Miraux, S., Maître, M., Cho, Y. H., Crusio, W. E., Montcouquiol, M., & Sans, N. (2022) · Cells · doi:10.3390/cells11101601 · Cited by 7 · see citing works
Self-citationLiu, G., Xie, C., Li, J., Jiang, X., Tang, H., Li, C., & Zhang, K. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105806 · Cited by 1 · see citing works
Chen, Y., 宋恩杰, Yu, S., Wan, S., & Zheng, W. (2026) · Journal of Molecular Neuroscience · doi:10.1007/s12031-026-02593-y · Cited by 1 · see citing works
Chouraeshkenazi, M. (2023) · F1000Research · doi:10.12688/f1000research.132840.1
Rôle de la signalisation de la polarité cellulaire planaire dans les processus mnésiques
Robert, B. (2017) · theses.fr (ABES) · doi:10.70675/41013e3fz233az4203zaca1ze75d7d8e28fb
Identification and functional characterization of a novel Scribble phosphorylation site
Wagner, M. S. (2019) · theses.fr (ABES) · doi:10.70675/4042eb4fz7dbfz4465za1bez63d3149b21d5
Revisiting neuronal polarity in the context of PCP
Rivas, A. D. (2021) · theses.fr (ABES) · doi:10.70675/e6c0a489z9417z4ed7z9faaz2b8d89b6869d
- Authors
- Hilal, M. L., Moreau, M. M., Racca, C., Pinheiro, V. L., Piguel, N. H., Santoni, M.-J., Dos Santos Carvalho, S., Blanc, J.-M., Abada, Y.-S. K., Peyroutou, R., Medina, C., Doat, H., Papouin, T., Vuillard, L., Borg, J.-P., Rachel, R., Panatier, A., Montcouquiol, M., Oliet, S. H. R., & Sans, N.
- Affiliations
- Université de Bordeaux (FR)
- INSERM, Neurocentre Magendie, Unité U1215, F-33000 Bordeaux, France
- Newcastle University (GB)
- Centre National de la Recherche Scientifique (FR)
- BioXtal Structural Biology Unit, Campus de Luminy, F-13288 Marseille, France
- National Cancer Institute (US)
- Corresponding author
- Sans, Nathalie
- ORCID
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-11-22
- Volume
- 27
- Issue
- 12
- Pages
- 5635-5651
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC5939200
- OpenAlex
- W2549504385
- Cited by
- 20
- References
- 80
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity) (cc-by-nc)
- Funders
- National Institutes of Health
- National Research Agency (ANR-07-NEUR-031-01, ANR-12-BSV4-0016-01)
- National Institute of Health and Medical Research
- Conseil Régional d'Aquitaine
- La Fondation pour la Recherche Médicale (FDT20120925405, FDT20130928124)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Scribble, planar cell polarity signaling, environmental enrichment, hippocampal CA1, synaptic plasticity, synapse maturation, bidirectional synaptic plasticity, postsynaptic density, cognitive impairment, postnatal brain development, conditional knockout mice
- MeSH terms
- Animals, Chlorocebus aethiops, Environment, Hippocampus, Housing, Animal, Learning Disabilities, Male, Memory Disorders, Models, Molecular, Neuronal Plasticity, Synapses, Receptors, N-Methyl-D-Aspartate, Mice, Knockout, COS Cells, Intracellular Signaling Peptides and Proteins, Post-Synaptic Density, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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