Basal cortisol is positively correlated to threat vigilance in patients with psychogenic nonepileptic seizures
Open accessAbstract
Previous studies have provided evidence for a vigilant attentional bias toward threat stimuli and increased basal diurnal cortisol levels in patients with psychogenic nonepileptic seizures (PNES). Because cortisol levels may be predictive of threat vigilance, we reanalyzed previous data on threat vigilance in 19 unmedicated patients with PNES and found a positive correlation between baseline cortisol levels and attentional bias scores for threat stimuli (r=0.49, P=0.035). There was no such relationship in healthy matched controls (n=20) or in patients with epileptic seizures (n=17). These findings provide the first evidence linking an endocrine stress marker to increased threat sensitivity in PNES and support new integrated psychoneurobiological models of PNES.
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- Authors
- Bakvis, P., Spinhoven, P., & Roelofs, K.
- Affiliations
- Leiden University (NL)
- ORCID
- Spinhoven, Philip
- Venue
- Epilepsy & Behavior
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 16
- Issue
- 3
- Pages
- 558-560
- ISSN
- 1525-5050 (ISSN-L)
- OpenAlex
- W2049621745
- Semantic Scholar
- 2b70e5eabfd91ff4933fde31ef33d25638aa0bf5
- Cited by
- 73
- References
- 18
- Citations by year
- 2025: 1 · 2024: 5 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 4 · 2013: 3 · 2012: 4
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epilepsy & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Universiteit Leiden
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (#452-07-008)
- Leids Universitair Medisch Centrum
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Keywords
- psychogenic non-epileptic seizures, basal cortisol, threat vigilance, threat sensitivity, stress hormones, diurnal cortisol, epileptic seizures
- MeSH terms
- Analysis of Variance, Attention, Emotions, Epilepsy, Humans, Hydrocortisone, Neuropsychological Tests, Psychophysiologic Disorders, Saliva, Statistics as Topic, Bias
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