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Cited by 40Protein Kinase Regulation and GTPase SignalingNeuroscience and Neuropharmacology ResearchCellular transport and secretion

Regulating Rac in the Nervous System: Molecular Function and Disease Implication of Rac GEFs and GAPs

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Bai, Yanyang, Xiang, Xiaoliang, Liang, Chunmei, Shi, Lei·2015·BioMed Research International
DOI 10.1155/2015/632450PMC PMC4388020
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Abstract

Rho family GTPases, including RhoA, Rac1, and Cdc42 as the most studied members, are master regulators of actin cytoskeletal organization. Rho GTPases control various aspects of the nervous system and are associated with a number of neuropsychiatric and neurodegenerative diseases. The activity of Rho GTPases is controlled by two families of regulators, guanine nucleotide exchange factors (GEFs) as the activators and GTPase-activating proteins (GAPs) as the inhibitors. Through coordinated regulation by GEFs and GAPs, Rho GTPases act as converging signaling molecules that convey different upstream signals in the nervous system. So far, more than 70 members of either GEFs or GAPs of Rho GTPases have been identified in mammals, but only a small subset of them have well-known functions. Thus, characterization of important GEFs and GAPs in the nervous system is crucial for the understanding of spatiotemporal dynamics of Rho GTPase activity in different neuronal functions. In this review, we summarize the current understanding of GEFs and GAPs for Rac1, with emphasis on the molecular function and disease implication of these regulators in the nervous system.

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200 of 201 shown

Cited by

Sorted by citations

Authors
Bai, Y., Xiang, X., Liang, C., & Shi, L.
Affiliations
Jinan University (CN)
Corresponding author
Shi, Lei
ORCID
Venue
BioMed Research International
Publisher
Wiley
Published
2015
Volume
2015
Pages
1-17
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
DOI
10.1155/2015/632450
PMC
PMC4388020
OpenAlex
W1978395024
Cited by
40
References
8
Citations by year
2025: 2 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 4
FWCI
0.58
Type
journal article
Language
en
Open access
Licence
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Natural Science Foundation of China (81422012, 31471046)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
Rac1, Rho GTPases, guanine nucleotide exchange factor, GTPase-activating protein, actin cytoskeleton regulation, nervous system, neuropsychiatric disorders, neurodegenerative diseases, neuronal signaling, RhoA, Cdc42
MeSH terms
Humans, Nervous System, Signal Transduction, Guanine Nucleotide Exchange Factors, GTPase-Activating Proteins, rhoA GTP-Binding Protein, cdc42 GTP-Binding Protein, rac1 GTP-Binding Protein

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