The Neurobiology of Postpartum Anxiety and Depression

Pawluski, Jodi L.; Lonstein, Joseph S.; Fleming, Alison S.

doi:10.1016/j.tins.2016.11.009

Cited by 325Maternal Mental Health During Pregnancy and PostpartumNeuroendocrine regulation and behaviorInfant Health and Development

The Neurobiology of Postpartum Anxiety and Depression

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Pawluski, Jodi L., Lonstein, Joseph S., Fleming, Alison S.·2017·Trends in Neurosciences

DOI 10.1016/j.tins.2016.11.009

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Abstract

Ten to twenty percent of postpartum women experience anxiety or depressive disorders, which can have detrimental effects on the mother, child, and family. Little is known about the neural correlates of these affective disorders when they occur in mothers, but they do have unique neural profiles during the postpartum period compared with when they occur at other times in a woman's life. Given that the neural systems affected by postpartum anxiety and depression overlap and interact with the systems involved in maternal caregiving behaviors, mother-infant interactions are highly susceptible to disruption. Thus, there is an intricate interplay among maternal mental health, the mother-infant relationship, and the neurobiological mechanisms mediating them that needs to be the focus of future study.

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Several studies found that mothers who report more anxiety and depression also demonstrate lower levels of oxytocin when breastfeeding than asymptomatic breastfeeding mothers.
“Several studies found that mothers who report more anxiety and depression also demonstrate lower levels of oxytocin when breastfeeding than asymptomatic breastfeeding mothers (Stuebe et al., 2013; Cox et al., 2015; Pawluski et al., 2017).”
From The evolved nest, oxytocin functioning, and prosocial development (2023) · cites this paper as Pawluski et al., 2017
Postpartum conditions might relate to lower oxytocin levels and decreased sensitivity to infant cries.
“Postpartum conditions might relate to lower levels of oxytocin and decreased sensitivity to infant cries9”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [9]

Functional Neuroimaging of Anxiety: A Meta-Analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia
Etkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391 · cited 2× · see citing works
“Although there are exceptions, a number of functional imaging studies on GAD outside the postpartum period show significant hypoactivity in prefrontal cortical areas (DLPFC, DMPFC, ACC) and hyperactivity in the AMG and insula in response to emotional cues [83].”
Background
Perinatal Depression: A Systematic Review of Prevalence and Incidence
Gavin, N. I., Gaynes, B. N., Lohr, K. N., Meltzer-Brody, S., Gartlehner, G., & Swinson, T. (2005) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000183597.31630.db · Cited by 3,282 · see citing works
Effects of perinatal mental disorders on the fetus and child
Stein, A., Pearson, R. M., Goodman, S. H., Rapa, E., Rahman, A., McCallum, M., Howard, L. M., & Pariante, C. M. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61277-0 · Cited by 2,166 · see citing works
Risks of all-cause and suicide mortality in mental disorders: a meta-review
Chesney, E., Goodwin, G. M., & Fazel, S. (2014) · World Psychiatry · doi:10.1002/wps.20128 · Cited by 2,115 · see citing works
International encyclopedia of the social & behavioral sciences
(2006) · Choice Reviews Online · doi:10.5860/choice.43sup-0452 · Cited by 1,949 · see citing works
Postpartum depression: current status and future directions
O'Hara, M. W., & McCabe, J. E. (2013) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185612 · Cited by 1,750 · see citing works
Neurobiology of emotion perception II: implications for major psychiatric disorders
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00171-9 · Cited by 1,736 · see citing works
Postpartum depression effects on early interactions, parenting, and safety practices: a review
Field, T. (2010) · Infant Behavior and Development · doi:10.1016/j.infbeh.2009.10.005 · Cited by 1,493 · cited 2× · see citing works
“Indeed, a postpartum psychiatric admission is a greater mortality risk for women than almost all other single causes, including heavy smoking [24, 25]! Postpartum anxiety and depression are also each associated with a host of other negative outcomes for mothers and infants including reduced breastfeeding, lack of mate…”
Background
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,448 · see citing works
Screening for Depression in Adults: US Preventive Services Task Force Recommendation Statement
Siu, A. L., and the US Preventive Services Task Force (USPSTF), Bibbins-Domingo, K., Grossman, D. C., Baumann, L. C., Davidson, K. W., Ebell, M., García, F. A. R., Gillman, M., Herzstein, J., et al. (2016) · JAMA · doi:10.1001/jama.2015.18392 · Cited by 1,407 · see citing works
Functional Magnetic Resonance Imaging
Walsh, A. (2014) · Encyclopedia of Criminal Justice Ethics · doi:10.4135/9781452274102.n135 · Cited by 1,225 · see citing works
The course of anxiety and depression through pregnancy and the postpartum in a community sample
Heron, J., O'Connor, T. G., Evans, J., Golding, J., & Glover, V. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2003.08.004 · Cited by 1,151 · see citing works
Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review
Van den Bergh, B. R. H., Mulder, E. J. H., Mennes, M., & Glover, V. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.007 · Cited by 1,104 · see citing works
Psychiatric Disorders in Pregnant and Postpartum Women in the United States
Vesga-López, O., Blanco, C., Keyes, K., Olfson, M., Grant, B. F., & Hasin, D. S. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.7.805 · Cited by 1,065 · see citing works
Antenatal risk factors for postnatal depression: A large prospective study
Milgrom, J., Gemmill, A. W., Bilszta, J. L., Hayes, B., Barnett, B., Brooks, J., Ericksen, J., Ellwood, D., & Buist, A. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.10.014 · Cited by 953 · see citing works
Postpartum Depression Help-Seeking Barriers and Maternal Treatment Preferences: A Qualitative Systematic Review
Dennis, C., & Chung‐Lee, L. (2006) · Birth · doi:10.1111/j.1523-536x.2006.00130.x · Cited by 881 · see citing works
Biological and psychosocial predictors of postpartum depression: systematic review and call for integration
Yim, I. S., Tanner Stapleton, L. R., Guardino, C. M., Hahn-Holbrook, J., & Dunkel Schetter, C. (2015) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-101414-020426 · Cited by 749 · see citing works
Behavior-state matching and synchrony in mother-infant interactions of nondepressed versus depressed dyads.
Field, T., Healy, B. T., Goldstein, S., & Guthertz, M. (1990) · Developmental Psychology · doi:10.1037/0012-1649.26.1.7 · Cited by 715 · see citing works
The Neurobiology of Parental Behavior
(2003) · Hormones, Brain, and Behavior · doi:10.1007/b97533 · Cited by 684 · see citing works
Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression
Drevets, W. C. (2000) · Progress in Brain Research · doi:10.1016/s0079-6123(00)26027-5 · Cited by 659 · see citing works
Controlled prospective study of postpartum mood disorders: comparison of childbearing and nonchildbearing women
O'Hara, M. W., Zekoski, E. M., Philipps, L. H., & Wright, E. J. (1990) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.99.1.3 · Cited by 610 · see citing works
Controlled prospective study of postpartum mood disorders: Comparison of childbearing and nonchildbearing women.
O’Hara, M. W., Zekoski, E. M., Philipps, L. H. C., & Wright, E. J. (1990) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.99.1.3 · Cited by 605 · see citing works
Psychosocial and psychological interventions for preventing postpartum depression
Dennis, C., & Creedy, D. K. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001134.pub2 · Cited by 574 · see citing works
Postpartum depression: Etiology, treatment and consequences for maternal care
Brummelte, S., & Galea, L. A. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.08.008 · Cited by 567 · see citing works
Primary Care Screening for and Treatment of Depression in Pregnant and Postpartum Women: Evidence Report and Systematic Review for the US Preventive Services Task Force
O’Connor, E., Rossom, R. C., Henninger, M., Groom, H. C., & Burda, B. U. (2016) · JAMA · doi:10.1001/jama.2015.18948 · Cited by 563 · see citing works
Neonatal Outcomes After Prenatal Exposure to Selective Serotonin Reuptake Inhibitor Antidepressants and Maternal Depression Using Population-Based Linked Health Data
Oberlander, T. F., Warburton, W., Misri, S., Aghajanian, J., & Hertzman, C. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.898 · Cited by 551 · see citing works
Breastfeeding and depression: A systematic review of the literature
Dias, C. C., & Figueiredo, B. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.09.022 · Cited by 515 · see citing works
Mothers' neural activation in response to pictures of their children and other children
Leibenluft, E., Gobbini, M. I., Harrison, T., & Haxby, J. V. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.05.017 · Cited by 493 · see citing works
How psychotherapy changes the brain – the contribution of functional neuroimaging
Linden, D. E. J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001816 · Cited by 491 · see citing works
Endocrine factors in the etiology of postpartum depression
Bloch, M., Daly, R. C., & Rubinow, D. R. (2003) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(03)00034-8 · Cited by 476 · see citing works
What’s in a smile? Maternal brain responses to infant facial cues
Strathearn, L., Li, J., Fonagy, P., & Montague, P. R. (2008) · Pediatrics · doi:10.1542/peds.2007-1566 · Cited by 460 · see citing works
Psychosocial and psychological interventions for preventing postpartum depression
Dennis, C.-L., & Dowswell, T. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001134.pub3 · Cited by 459 · see citing works
Increasing use of antidepressants in pregnancy
Cooper, W. O., Willy, M. E., Pont, S. J., & Ray, W. A. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.01.033 · Cited by 458 · see citing works
Medication use in pregnancy: a cross-sectional, multinational web-based study
Lupattelli, A., Spigset, O., Twigg, M., Zagorodnikova, K., Mårdby, A., Moretti, M., Drozd, M., Panchaud, A., Hämeen-Anttila, K., Rieutord, A., et al. (2014) · BMJ Open · doi:10.1136/bmjopen-2013-004365 · Cited by 435 · see citing works
Annual Research Review: All mothers are not created equal: neural and psychobiological perspectives on mothering and the importance of individual differences
Barrett, J., & Fleming, A. S. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02306.x · Cited by 433 · see citing works
Self-citation
Committee Opinion No. 630
(2015) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000465192.34779.dc · Cited by 424 · see citing works
A systematic review of the efficacy of cognitive behavioral therapy for treating and preventing perinatal depression
Sockol, L. E. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.01.052 · Cited by 395 · see citing works
Effects of suckling on hypothalamic-pituitary-adrenal axis responses to psychosocial stress in postpartum lactating women
Heinrichs, M., Meinlschmidt, G., Neumann, I., Wagner, S., Kirschbaum, C., Ehlert, U., & Hellhammer, D. H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7919 · Cited by 386 · see citing works
Breastfeeding, brain activation to own infant cry, and maternal sensitivity
Kim, P., Feldman, R., Mayes, L. C., Eicher, V., Thompson, N., Leckman, J. F., & Swain, J. E. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02406.x · Cited by 386 · see citing works
Perinatal anxiety disorder prevalence and incidence
Fairbrother, N., Janssen, P., Antony, M. M., Tucker, E., & Young, A. H. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.12.082 · Cited by 375 · see citing works
Risk factors and course patterns of anxiety and depressive disorders during pregnancy and after delivery: A prospective-longitudinal study
Martini, J., Petzoldt, J., Einsle, F., Beesdo‐Baum, K., Höfler, M., & Wïttchen, H. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.01.012 · Cited by 364 · see citing works
The Functional Neuroanatomy of Maternal Love: Mother’s Response to Infant’s Attachment Behaviors
Noriuchi, M., Kikuchi, Y., & Senoo, A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.018 · Cited by 334 · see citing works
A systematic review of the effects of postnatal maternal anxiety on children
Glasheen, C., Richardson, G. A., & Fabio, A. (2009) · Archives of Women s Mental Health · doi:10.1007/s00737-009-0109-y · Cited by 322 · see citing works
Breastfeeding is negatively affected by prenatal depression and reduces postpartum depression
Figueiredo, B., Canário, C., & Field, T. (2014) · Psychological Medicine · doi:10.1017/s0033291713001530 · Cited by 298 · see citing works
Measurement issues in postpartum depression part 1: Anxiety as a feature of postpartum depression
Ross, L. E., Evans, S. E. G., Sellers, E. M., & Romach, M. K. (2003) · Archives of Women s Mental Health · doi:10.1007/s00737-002-0155-1 · Cited by 296 · see citing works
Association Between Maternal Mood and Oxytocin Response to Breastfeeding
Stuebe, A. M., Grewen, K., & Meltzer-Brody, S. (2013) · Journal of Women's Health · doi:10.1089/jwh.2012.3768 · Cited by 295 · see citing works
No stress please! Mechanisms of stress hyporesponsiveness of the maternal brain
Slattery, D. A., & Neumann, I. D. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.145896 · Cited by 293 · see citing works
Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo
Vrontou, S., Wong, A. M., Rau, K. K., Koerber, H. R., & Anderson, D. J. (2013) · Nature · doi:10.1038/nature11810 · Cited by 289 · see citing works
Gestational stress induces post-partum depression-like behaviour and alters maternal care in rats
Smith, J. W., Seckl, J. R., Evans, A. T., Costall, B., & Smythe, J. W. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00025-8 · Cited by 289 · see citing works
Prevalence, onset and comorbidity of postpartum anxiety and depressive disorders
Reck, C., Struben, K., Backenstrass, M., Stefenelli, U., Reinig, K., Fuchs, T., Sohn, C., & Mundt, C. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01264.x · Cited by 288 · see citing works
Interactions between mothers and infants: Impact of maternal anxiety
Nicol-Harper, R., Harvey, A. G., & Stein, A. L. (2006) · Infant Behavior and Development · doi:10.1016/j.infbeh.2006.08.005 · Cited by 285 · see citing works
Anxiety disorders in postpartum women: A systematic review and meta-analysis
Goodman, J. H., Watson, G. R., & Stubbs, B. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.05.033 · Cited by 279 · see citing works
Sensitive periods in human social development: New insights from research on oxytocin, synchrony, and high-risk parenting
Feldman, R. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000048 · Cited by 271 · see citing works
Prevalence and correlates of major depressive episode in pregnant and postpartum women in the United States
Strat, Y. L., Dubertret, C., & Foll, B. L. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.07.004 · Cited by 263 · see citing works
Heterogeneity of postpartum depression: a latent class analysis
† (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)00055-8 · Cited by 257 · see citing works
Breastfeeding cessation and symptoms of anxiety and depression: a longitudinal cohort study
Ystrom, E. (2012) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-12-36 · Cited by 249 · see citing works
Postpartum adjustment in first-time mothers: Relations between mood, maternal attitudes, and mother-infant interactions.
Fleming, A. S., Ruble, D. N., Flett, G. L., & Shaul, D. L. (1988) · Developmental Psychology · doi:10.1037/0012-1649.24.1.71 · Cited by 247 · see citing works
Self-citation
Cortisol, Hedonics, and Maternal Responsiveness in Human Mothers
Fleming, A. S., Steiner, M., & Corter, C. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1407 · Cited by 246 · see citing works
Self-citation
Neurosteroid regulation of GABAA receptors: Focus on the α4 and δ subunits
Smith, S. S., Shen, H., Gong, Q. H., & Zhou, X. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.03.008 · Cited by 241 · see citing works
Sustained Neurobehavioral Effects of Exposure to SSRI Antidepressants During Development: Molecular to Clinical Evidence
Oberlander, T. F., Gingrich, J. A., & Ansorge, M. S. (2009) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2009.201 · Cited by 236 · see citing works
Does the Edinburgh Postnatal Depression Scale measure anxiety?
Brouwers, E. P. M., van Baar, A. L., & Pop, V. J. M. (2001) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00245-8 · Cited by 236 · see citing works
Maternal touch and maternal child-directed speech: effects of depressed mood in the postnatal period
Herrera, E., Reissland, N., & Shepherd, J. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2003.07.001 · Cited by 231 · see citing works
Risk of Obsessive-Compulsive Disorder in Pregnant and Postpartum Women: A Meta-Analysis
Russell, E. J., Fawcett, J. M., & Mazmanian, D. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r07917 · Cited by 229 · see citing works
Regulation of anxiety during the postpartum period
Lonstein, J. S. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.05.002 · Cited by 229 · see citing works
Self-citation
Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch
Liu, Q., Vrontou, S., Rice, F. L., Zylka, M. J., Dong, X., & Anderson, D. J. (2007) · Nature Neuroscience · doi:10.1038/nn1937 · Cited by 227 · see citing works
Depression and anxiety through pregnancy and the early postpartum: An examination of prospective relationships
Skouteris, H., Wertheim, E. H., Rallis, S., Milgrom, J., & Paxton, S. J. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.06.002 · Cited by 226 · see citing works
A cry in the dark: depressed mothers show reduced neural activation to their own infant’s cry
Laurent, H. K., & Ablow, J. C. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq091 · Cited by 224 · see citing works
The ‘resting-state hypothesis’ of major depressive disorder—A translational subcortical–cortical framework for a system disorder
Northoff, G., Wiebking, C., Feinberg, T., & Panksepp, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.007 · Cited by 222 · see citing works
Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam
Brummelte, S., & Galea, L. A. M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.07.012 · Cited by 211 · see citing works
Early parental preoccupations and behaviors and their possible relationship to the symptoms of obsessive–compulsive disorder
Leckman, J. F., Mayes, L. C., Feldman, R., Evans, D. W., King, R. A., & Cohen, D. J. (1999) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1999.tb10951.x · Cited by 207 · see citing works
A systematic review of fMRI studies in generalized anxiety disorder: Evaluating its neural and cognitive basis
Mochcovitch, M. D., da Rocha Freire, R. C., Garcia, R. F., & Nardi, A. E. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.041 · Cited by 206 · cited 1× · see citing works
“GAD has further been associated with decreased connectivity between the AMG and prefrontal cortical areas, but increased connectivity between the AMG and insular cortex in response to emotional cues or an emotional task [84, 85].”
Background
Effect of Mother/Infant Skin‐to‐Skin Contact on Postpartum Depressive Symptoms and Maternal Physiological Stress
Bigelow, A. E., Power, M., MacLellan‐Peters, J., Alex, M. R., & McDonald, C. (2012) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1111/j.1552-6909.2012.01350.x · Cited by 206 · see citing works
Maternal brain response to own baby‐cry is affected by cesarean section delivery
Swain, J. E., Tasgin, E., Mayes, L. C., Feldman, R., Todd Constable, R., & Leckman, J. F. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01963.x · Cited by 206 · see citing works
Gestational exposure to selective serotonin reuptake inhibitors and offspring psychiatric disorders: A national register-based study
Malm, H., Brown, A. S., Gissler, M., Gyllenberg, D., Hinkka-Yli-Salomäki, S., McKeague, I. W., Weissman, M., Wickramaratne, P., Artama, M., Gingrich, J. A., et al. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.02.013 · Cited by 206 · see citing works
Prevalence and risk factors for comorbid postpartum depressive symptomatology and anxiety
Falah‐Hassani, K., Shiri, R., & Dennis, C. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.03.010 · Cited by 204 · see citing works
Incidence of Maternal and Paternal Depression in Primary Care: A Cohort Study Using a Primary Care Database
Davé, S., Petersen, I., Sherr, L., & Nazareth, I. (2010) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2010.184 · Cited by 194 · see citing works
Suicide and other causes of mortality after post-partum psychiatric admission
Appleby, L., Mortensen, P. B., & Faragher, E. B. (1998) · British Journal of Psychiatry · doi:10.1192/bjp.173.3.209 · Cited by 192 · see citing works
Abnormally Reduced Dorsomedial Prefrontal Cortical Activity and Effective Connectivity With Amygdala in Response to Negative Emotional Faces in Postpartum Depression
Moses-Kolko, E. L., Perlman, S. B., Wisner, K. L., James, J., Saul, A. T., & Phillips, M. L. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09081235 · Cited by 190 · see citing works
Parental Care: Evolution, Mechanisms, and Adaptive Significance
(1996) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)x6027-9 · Cited by 185 · see citing works
Somatosensation and Maternal Care in Norway Rats
Stern, J. M. (1996) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)60335-6 · Cited by 181 · see citing works
Rates and risk factors associated with depressive symptoms during pregnancy and with postpartum onset
Verreault, N., Costa, D. D., Marchand, A., Ireland, K., Dritsa, M., & Khalifé, S. (2014) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.3109/0167482x.2014.947953 · Cited by 179 · see citing works
The neural correlates of maternal sensitivity: an fMRI study
Musser, E. D., Kaiser-Laurent, H., & Ablow, J. C. (2012) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2012.04.003 · Cited by 177 · see citing works
The development of maternal touch across the first year of life
Ferber, S. G., Feldman, R., & Makhoul, I. R. (2007) · Early Human Development · doi:10.1016/j.earlhumdev.2007.09.019 · Cited by 177 · see citing works
Maternal affect and quality of parenting experiences are related to amygdala response to infant faces
Barrett, J., Wonch, K. E., Gonzalez, A., Ali, N., Steiner, M., Hall, G. B., & Fleming, A. S. (2012) · Social Neuroscience · doi:10.1080/17470919.2011.609907 · Cited by 177 · see citing works
Self-citation
Fluoxetine during Development Reverses the Effects of Prenatal Stress on Depressive-Like Behavior and Hippocampal Neurogenesis in Adolescence
Rayen, I., van den Hove, D., Prickaerts, J., Steinbusch, H. W. M., & Pawluski, J. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024003 · Cited by 175 · see citing works
Self-citation
Palatable cafeteria diet ameliorates anxiety and depression-like symptoms following an adverse early environment
Maniam, J., & Morris, M. J. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.10.013 · Cited by 173 · see citing works
Antidepressant treatment for postnatal depression
Molyneaux, E., Howard, L. M., McGeown, H. R., Karia, A. M., & Trevillion, K. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002018.pub2 · Cited by 171 · see citing works
Mom Power: preliminary outcomes of a group intervention to improve mental health and parenting among high-risk mothers
Muzik, M., Rosenblum, K. L., Alfafara, E. A., Schuster, M. M., Miller, N. M., Waddell, R. M., & Kohler, E. S. (2015) · Archives of Women s Mental Health · doi:10.1007/s00737-014-0490-z · Cited by 170 · see citing works
Maternal anxiety: course and antecedents during the early postpartum period
Britton, J. R. (2008) · Depression and Anxiety · doi:10.1002/da.20325 · Cited by 167 · see citing works
The neural basis of maternal responsiveness to infants: an fMRI study
Ranote, S., Elliott, R., Abel, K. M., Mitchell, R., Deakin, J. F. W., & Appleby, L. (2004) · NeuroReport · doi:10.1097/01.wnr.0000137078.64128.6a · Cited by 167 · see citing works
Perinatal Major Depression Biomarkers: A systematic review
Serati, M., Redaelli, M., Buoli, M., & Altamura, A. C. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.01.027 · Cited by 166 · see citing works
Mental Health Aspects of Women's Reproductive Health: A Global Review of the Literature
Stotland, N. L. (2010) · Psychiatric Services · doi:10.1176/ps.2010.61.4.421 · Cited by 159 · see citing works
GABAergic neuroactive steroids and resting-state functional connectivity in postpartum depression: A preliminary study
Deligiannidis, K. M., Şıkoğlu, E. M., Shaffer, S. A., Frederick, B. B., Svenson, A., Kopoyan, A., Kosma, C. A., Rothschild, A. J., & Moore, C. M. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.02.010 · Cited by 153 · see citing works
Common and divergent psychobiological mechanisms underlying maternal behaviors in non-human and human mammals
Lonstein, J. S., Lévy, F., & Fleming, A. S. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.011 · Cited by 151 · see citing works
Self-citation
A Longitudinal Study of Maternal Postpartum Depression Symptoms
Horowitz, J. A., & Goodman, J. H. (2004) · Research and theory for nursing practice · doi:10.1891/rtnp.18.2.149.61285 · Cited by 151 · see citing works
Maternal antidepressant use and adverse outcomes: a cohort study of 228,876 pregnancies
Hayes, R. M., Wu, P., Shelton, R. C., Cooper, W. O., Dupont, W. D., Mitchel, E., & Hartert, T. V. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.04.028 · Cited by 149 · see citing works
Frontoparietal Activation During Response Inhibition Predicts Remission to Antidepressants in Patients With Major Depression
Gyurak, A., Patenaude, B., Korgaonkar, M. S., Grieve, S. M., Williams, L. M., & Etkin, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.037 · Cited by 149 · see citing works
Maternal early life experiences and parenting: the mediating role of cortisol and executive function
Gonzalez, A., Jenkins, J. M., Steiner, M., & Fleming, A. S. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.04.003 · Cited by 146 · see citing works
Self-citation
Is subcortical–cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach
Alcaro, A., Panksepp, J., Witczak, J., Hayes, D. J., & Northoff, G. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.023 · Cited by 144 · see citing works
Perinatal Generalized Anxiety Disorder: Assessment and Treatment
Misri, S. K., Abizadeh, J., Sanders, S., & Swift, E. (2015) · Journal of Women s Health · doi:10.1089/jwh.2014.5150 · Cited by 143 · see citing works
Low Serum Allopregnanolone Is Associated with Symptoms of Depression in Late Pregnancy
Hellgren, C., Åkerud, H., Skalkidou, A., Bäckström, T. C., & Poromaa, I. S. (2014) · Neuropsychobiology · doi:10.1159/000358838 · Cited by 137 · see citing works
Sociodemographic, pregnancy, obstetric, and postnatal predictors of postpartum stress, anxiety and depression in new mothers
Clout, D., & Brown, R. F. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.08.054 · Cited by 135 · see citing works
Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography study
Moses‐Kolko, E. L., Wisner, K. L., Price, J. C., Berga, S. L., Drevets, W. C., Hanusa, B. H., Loucks, T. L., & MELTZER, C. C. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.03.059 · Cited by 133 · see citing works
Disrupted posterior cingulate–amygdala connectivity in postpartum depressed women as measured with resting BOLD fMRI
Chase, H. W., Moses‐Kolko, E. L., Zevallos, C. R., Wisner, K. L., & Phillips, M. L. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst083 · Cited by 131 · see citing works
Neuroplasticity in the maternal hippocampus: Relation to cognition and effects of repeated stress
Pawluski, J. L., Lambert, K. G., & Kinsley, C. H. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.004 · Cited by 130 · see citing works
Self-citation
In Search of Neural Endophenotypes of Postpartum Psychopathology and Disrupted Maternal Caregiving
Moses‐Kolko, E. L., Horner, M. S., Phillips, M. L., Hipwell, A. E., & Swain, J. E. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12183 · Cited by 129 · see citing works
Interaction between oxytocin receptor DNA methylation and genotype is associated with risk of postpartum depression in women without depression in pregnancy
Bell, A. F., Carter, C. S., Steer, C. D., Golding, J., Davis, J. M., Steffen, A. D., Rubin, L. H., Lillard, T. S., Gregory, S., Harris, J. C., et al. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00243 · Cited by 124 · see citing works
A face a mother could love: Depression-related maternal neural responses to infant emotion faces
Laurent, H. K., & Ablow, J. C. (2013) · Social Neuroscience · doi:10.1080/17470919.2012.762039 · Cited by 124 · see citing works
Étude de l’EPDS (Échelle postnatale d’Edinburgh) chez 859 mères : dépistage des mères à risque de développer une dépression du post-partum
Teissèdre, F., & Chabrol, H. (2004) · L Encéphale · doi:10.1016/s0013-7006(04)95451-6 · Cited by 124 · see citing works
Exposure to Chronic Pregnancy Stress Reverses Peripartum-Associated Adaptations: Implications for Postpartum Anxiety and Mood Disorders
Hillerer, K. M., Reber, S. O., Neumann, I. D., & Slattery, D. A. (2011) · Endocrinology · doi:10.1210/en.2011-1091 · Cited by 122 · see citing works
Selective serotonin reuptake inhibitor prescribing before, during and after pregnancy: a population‐based study in six European regions
Charlton, R., Jordan, S., Pierini, A., Garne, E., Neville, A., Hansen, A., Gini, R., Thayer, D., Tingay, K., Puccini, A., et al. (2015) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.13143 · Cited by 121 · see citing works
Prevalence, nature, severity and correlates of postpartum depressive symptoms in Vietnam
Fisher, J., Morrow, M., Ngoc, N. T. N., & Anh, L. T. (2004) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2004.00394.x · Cited by 121 · see citing works
Postpartum depression and brain response to infants: Differential amygdala response and connectivity
Wonch, K. E., de Medeiros, C. B., Barrett, J. A., Dudin, A., Cunningham, W. A., Hall, G. B., Steiner, M. S., & Fleming, A. S. (2015) · Social Neuroscience · doi:10.1080/17470919.2015.1131193 · Cited by 120 · see citing works
Self-citation
Postpartum depression: A systematic review of the genetics involved
Couto, T. C. E. (2015) · World Journal of Psychiatry · doi:10.5498/wjp.v5.i1.103 · Cited by 119 · see citing works
Selective serotonin reuptake inhibitors (SSRIs) for post-partum depression (PPD): A systematic review of randomized clinical trials
De Crescenzo, F., Perelli, F., Armando, M., & Vicari, S. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.09.019 · Cited by 114 · see citing works
Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression
Deligiannidis, K. M., Kroll‐Desrosiers, A., Mo, S., Nguyen, H. P., Svenson, A., Jaitly, N., Hall, J. E., BARTON, B. A., Rothschild, A. J., & Shaffer, S. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.05.010 · Cited by 114 · see citing works
Repeated long separations from pups produce depression-like behavior in rat mothers
Boccia, M. L., Razzoli, M., Vadlamudi, S. P., Trumbull, W., Caleffie, C., & Pedersen, C. A. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.10.004 · Cited by 109 · see citing works
The effects of maternal depression and maternal selective serotonin reuptake inhibitor exposure on offspring
Olivier, J. D. A., Åkerud, H., Kaihola, H., Pawluski, J. L., Skalkidou, A., Högberg, U., & Poromaa, I. S. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00073 · Cited by 108 · see citing works
Self-citation
Use of SSRI and SNRI Antidepressants during Pregnancy: A Population-Based Study from Denmark, Iceland, Norway and Sweden
Zoëga, H., Kieler, H., Nørgaard, M., Furu, K., Valdimarsdóttir, U. A., Brandt, L., & Haglund, B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144474 · Cited by 108 · see citing works
Stress during gestation induces lasting effects on emotional reactivity of the dam rat
Darnaudéry, M., Dutriez-Casteloot, I., Viltart, O., Morley‐Fletcher, S., & Maccari, S. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.001 · Cited by 104 · see citing works
Chronic fluoxetine treatment and maternal adversity differentially alter neurobehavioral outcomes in the rat dam
Pawluski, J. L., Charlier, T. D., Fillet, M., Houbart, V., Crispin, H. T., Steinbusch, H. W. M., & van den Hove, D. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.11.043 · Cited by 101 · see citing works
Self-citation
Rapid Habituation of Ventral Striatal Response to Reward Receipt in Postpartum Depression
Moses‐Kolko, E. L., Fraser, D., Wisner, K. L., James, J. A., Saul, A. T., Fiez, J. A., & Phillips, M. L. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.021 · Cited by 101 · see citing works
Oxytocin receptor activity in the ventrocaudal periaqueductal gray modulates anxiety-related behavior in postpartum rats.
Figueira, R. J., Peabody, M. F., & Lonstein, J. S. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.3.618 · Cited by 101 · see citing works
Self-citation
Oxytocin in the medial prefrontal cortex regulates maternal care, maternal aggression and anxiety during the postpartum period
Sabihi, S., Dong, S. M., Durosko, N. E., & Leuner, B. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00258 · Cited by 101 · see citing works
Of rodents and humans: A comparative review of the neurobehavioral effects of early life SSRI exposure in preclinical and clinical research
Glover, M. E., & Clinton, S. M. (2016) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2016.04.008 · Cited by 101 · see citing works
Chronic Gestational Stress Leads to Depressive-Like Behavior and Compromises Medial Prefrontal Cortex Structure and Function during the Postpartum Period
Leuner, B., Fredericks, P. J., Nealer, C., & Albin-Brooks, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089912 · Cited by 100 · see citing works
Flexibility and adaptation of the neural substrate that supports maternal behavior in mammals
Olazábal, D. E., Pereira, M., Agrati, D., Ferreira, A., Fleming, A. S., González-Mariscal, G., Lévy, F., Lucion, A. B., Morrell, J. I., Numan, M., et al. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.004 · Cited by 97 · see citing works
Self-citation
Epidemiology of Postpartum Depressive Symptoms among Canadian Women: Regional and National Results from a Cross-Sectional Survey
Dennis, C., Heaman, M. I., & Vigod, S. N. (2012) · The Canadian Journal of Psychiatry · doi:10.1177/070674371205700904 · Cited by 95 · see citing works
Detection of Postpartum Depression and Anxiety in a Large Health Plan
Coates, A. O., Schaefer, C. A., & Alexander, J. L. (2004) · The Journal of Behavioral Health Services & Research · doi:10.1007/bf02287376 · Cited by 94 · see citing works
Neural Dysfunction in Postpartum Depression:<i>An fMRI Pilot Study</i>
Silverman, M. E., Loudon, H., Safier, M., Protopopescu, X., Leiter, G., Liu, X., & Goldstein, M. (2007) · CNS Spectrums · doi:10.1017/s1092852900015595 · Cited by 91 · see citing works
Association study of 44 candidate genes with depressive and anxiety symptoms in post-partum women
Costas, J., Gratacòs, M., Escaramís, G., Martín‐Santos, R., de Diego‐Otero, Y., Baca‐García, E., Cañellas, F., Estivill, X., Guillamat, R., Guitart, M., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.12.012 · Cited by 90 · see citing works
Baby stimuli and the parent brain: functional neuroimaging of the neural substrates of parent-infant attachment.
Swain, J. E. (2008) · Europe PMC (PubMed Central) · Cited by 89 · see citing works
Parenting and mother-infant interactions in the context of maternal postpartum obsessive-compulsive disorder: Effects of obsessional symptoms and mood
Challacombe, F. L., Salkovskis, P. M., Woolgar, M., Wilkinson, E. L., Read, J., & Acheson, R. (2016) · Infant Behavior and Development · doi:10.1016/j.infbeh.2016.04.003 · Cited by 86 · see citing works
Routine psychosocial assessment of women in the antenatal period: frequency of risk factors and implications for clinical services
Matthey, S., Phillips, J., White, T., Glossop, P., Hopper, U., Panasetis, P., Petridis, A., Larkin, M., & Barnett, B. (2004) · Archives of Women s Mental Health · doi:10.1007/s00737-004-0064-6 · Cited by 85 · see citing works
Gestational Stress Leads to Depressive-Like Behavioural and Immunological Changes in the Rat
O’Mahony, S. M., Myint, A.-M., van den Hove, D., Desbonnet, L., Steinbusch, H. W. M., & Leonard, B. E. (2006) · NeuroImmunoModulation · doi:10.1159/000096090 · Cited by 83 · see citing works
Emotion and Mood Adaptations in the Peripartum Female: Complementary Contributions of GABA and Oxytocin
Lonstein, J. S., Maguire, J. L., Meinlschmidt, G., & Neumann, I. D. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12188 · Cited by 83 · see citing works
Self-citation
The Edinburgh Postnatal Depression Scale detects but does not distinguish anxiety disorders from depression in mothers of infants
Rowe, H. J., Fisher, J., & Loh, W. M. (2008) · Archives of Women s Mental Health · doi:10.1007/s00737-008-0003-z · Cited by 82 · see citing works
Neural systems and hormones mediating attraction to infant and child faces
Luo, L. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00970 · Cited by 80 · see citing works
Executive function and mothering: Challenges faced by teenage mothers
Chico, E., González, A., Ali, N., Steiner, M. S., & Fleming, A. S. (2014) · Developmental Psychobiology · doi:10.1002/dev.21185 · Cited by 79 · see citing works
Self-citation
Prevalence of suicide risk and comorbidities in postpartum women in Pelotas
Tavares, D., Quevedo, L., Jansen, K., Souza, L., Pinheiro, R., & Silva, R. (2012) · Revista Brasileira de Psiquiatria · doi:10.1016/j.rbp.2011.12.001 · Cited by 77 · see citing works
Depression Drug Treatment Outcomes in Pregnancy and the Postpartum Period
McDonagh, M. S., Matthews, A. M., Phillipi, C. A., Romm, J., Peterson, K., Thakurta, S., & Guise, J. (2014) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000000410 · Cited by 77 · see citing works
Gestational stress induces persistent depressive‐like behavior and structural modifications within the postpartum nucleus accumbens
Haim, A., Sherer, M., & Leuner, B. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12752 · Cited by 76 · see citing works
Mothers’ depressed mood and anxiety levels are reduced after massaging their preterm infants
Feijó, L., Hernandez‐Reif, M., Field, T. M., Burns, W. J., Valley-Gray, S. A., & Simco, E. R. (2006) · Infant Behavior and Development · doi:10.1016/j.infbeh.2006.02.003 · Cited by 74 · see citing works
Pharmacotherapy of postpartum depression: an update
Kim, D. R., Epperson, C. N., Weiss, A. R., & Wisner, K. L. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.911842 · Cited by 74 · see citing works
Maternal anxiety from pregnancy to 2 years postpartum: transactional patterns of maternal early adversity and child temperament
Agrati, D., Browne, D. T., Jonas, W., Meaney, M. J., Atkinson, L. R., Steiner, M. S., & Fleming, A. S. (2015) · Archives of Women s Mental Health · doi:10.1007/s00737-014-0491-y · Cited by 74 · see citing works
Self-citation
Mood and anxiety disorders in a sample of Canadian perinatal women referred for psychiatric care
Grigoriadis, S., Meschino, D. D. C., Barrons, E., Bradley, L., Eady, A., Fishell, A., Mamisachvili, L., Cook, G. S., O’Keefe, M., Romans, S. E., et al. (2011) · Archives of Women s Mental Health · doi:10.1007/s00737-011-0223-5 · Cited by 73 · see citing works
Is Postpartum Depression a Distinct Disorder?
Florio, A. D., & Meltzer-Brody, S. E. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0617-6 · Cited by 72 · see citing works
The neural processing of negative emotion postpartum: a preliminary study of amygdala function in postpartum depression
Silverman, M. E., Loudon, H., Liu, X., Mauro, C., Leiter, G., & Goldstein, M. A. (2011) · Archives of Women s Mental Health · doi:10.1007/s00737-011-0226-2 · Cited by 72 · see citing works
Neuroanatomical and neurochemical basis of parenting: Dynamic coordination of motivational, affective and cognitive processes
Pereira, M., & Ferreira, A. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.08.005 · Cited by 68 · see citing works
Socioeconomic disadvantages and neural sensitivity to infant cry: role of maternal distress
Kim, P., Capistrano, C. G., & Congleton, C. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw063 · Cited by 68 · see citing works
Neural correlates of hypothalamic–pituitary–adrenal regulation of mothers with their infants
Laurent, H. K., Stevens, A., & Ablow, J. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.011 · Cited by 67 · see citing works
Stress and the pregnant female: Impact on hippocampal cell proliferation, but not affective-like behaviors
Pawluski, J. L., van den Hove, D., Rayen, I., Prickaerts, J., & Steinbusch, H. W. M. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.02.012 · Cited by 66 · see citing works
Self-citation
Affective changes during the postpartum period: Influences of genetic and experiential factors
Agrati, D., & Lonstein, J. S. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.07.016 · Cited by 65 · see citing works
Self-citation
Amygdala functional connectivity as a longitudinal biomarker of symptom changes in generalized anxiety
Makovac, E., Watson, D. R., Meeten, F., Garfinkel, S. N., Cercignani, M., Critchley, H., & Ottaviani, C. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw091 · Cited by 65 · see citing works
Hypoactivation of CRF Receptors, Predominantly Type 2, in the Medial-Posterior BNST Is Vital for Adequate Maternal Behavior in Lactating Rats
Klampfl, S. M., Brunton, P. J., Bayerl, D. S., & Bosch, O. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4220-13.2014 · Cited by 63 · see citing works
POSTPARTUM GAD IS A RISK FACTOR FOR POSTPARTUM MDD: THE COURSE AND LONGITUDINAL RELATIONSHIPS OF POSTPARTUM GAD AND MDD
Prenoveau, J., Craske, M., Counsell, N., West, V., Davies, B., Cooper, P., Rapa, E., & Stein, A. (2013) · Depression and Anxiety · doi:10.1002/da.22040 · Cited by 62 · see citing works
The Neurobiological Impact of Postpartum Maternal Depression
Drury, S. S., Scaramella, L. V., & Zeanah, C. H. (2016) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2015.11.001 · Cited by 62 · see citing works
Lactation-induced reduction in rats' acoustic startle is associated with changes in noradrenergic neurotransmission.
Toufexis, D. J., Rochford, J. M., & Walker, C. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.1.176 · Cited by 58 · see citing works
Lactation-induced reduction in rats' acoustic startle is associated with changes in noradrenergic neurotransmission.
Toufexis, D. J., Rochford, J., & Walker, C.-D. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.1.176 · Cited by 58 · see citing works
Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study
Gingnell, M., Bannbers, E., Moes, H. R., Engman, J., Sylvén, S. M., Skalkidou, A., Kask, K., Wikström, J., & Poromaa, I. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128964 · Cited by 57 · see citing works
Gestational stress and fluoxetine treatment differentially affect plasticity, methylation and serotonin levels in the PFC and hippocampus of rat dams
Gemmel, M., Rayen, I., van Donkelaar, E. L., Loftus, T., Steinbusch, H. W. M., Kokras, N., Dalla, C., & Pawluski, J. L. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.068 · Cited by 56 · see citing works
Self-citation
The effects of gestational stress and Selective Serotonin reuptake inhibitor antidepressant treatment on structural plasticity in the postpartum brain — A translational model for postpartum depression
Haim, A., Albin-Brooks, C., Sherer, M. L., Mills, E., & Leuner, B. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.005 · Cited by 52 · see citing works
Pregnancy or stress decrease complexity of CA3 pyramidal neurons in the hippocampus of adult female rats
Pawluski, J. L., Valença, A., Santos, A. I., Costa-Nunes, J. P., Steinbusch, H. W. M., & Strekalova, T. V. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.059 · Cited by 51 · see citing works
Self-citation
Breastfeeding and mother-infant interactions
Kuzela, A. L., Stifter, C. A., & Worobey, J. (1990) · Journal of Reproductive and Infant Psychology · doi:10.1080/02646839008403623 · Cited by 49 · see citing works
Developmental fluoxetine and prenatal stress effects on serotonin, dopamine, and synaptophysin density in the PFC and hippocampus of offspring at weaning
Gemmel, M., Rayen, I., Lotus, T., van Donkelaar, E. L., Steinbusch, H. W. M., Lacalle, S. D., Kokras, N., Dalla, C., & Pawluski, J. L. (2015) · Developmental Psychobiology · doi:10.1002/dev.21372 · Cited by 48 · see citing works
Self-citation
Antidepressant Treatment for Postnatal Depression
Molyneaux, E., Trevillion, K., & Howard, L. M. (2015) · JAMA · doi:10.1001/jama.2015.2276 · Cited by 45 · see citing works
Offspring-exposure reduces depressive-like behaviour in the parturient female rat
Pawluski, J. L., Lieblich, S. E., & Galea, L. A. M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.08.001 · Cited by 45 · see citing works
Self-citation
Mental Health Aspects of Women's Reproductive Health: A Global Review of the Literature
Stotland, N. L. (2010) · Psychiatric Services · doi:10.1176/appi.ps.61.4.421 · Cited by 45 · see citing works
Selective serotonin reuptake inhibitor exposure during early pregnancy and the risk of birth defects
Gentile, S. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01673.x · Cited by 41 · see citing works
Differential effects of repeated long and brief maternal separation on behaviour and neuroendocrine parameters in Wistar dams
Eklund, M. B., Johansson, L., Uvnäs‐Moberg, K., & Arborelius, L. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.017 · Cited by 41 · see citing works
The course of anxiety and depressive symptoms in Nigerian postpartum women
Adewuya, A. O., & Afolabi, O. T. (2005) · Archives of Women s Mental Health · doi:10.1007/s00737-005-0089-5 · Cited by 40 · see citing works
Differential postpartum sensitivity to the anxiety-modulating effects of offspring contact is associated with innate anxiety and brainstem levels of dopamine beta-hydroxylase in female laboratory rats
Ragan, C. M., & Lonstein, J. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.014 · Cited by 37 · see citing works
Self-citation
Increased Posterior Cingulate, Medial Frontal and Decreased Temporal Regional Homogeneity in Depressed Mothers. A Resting-State Functional Magnetic Resonance Study
Wang, X., Jian, W., Zhi-hong, L., Yan, M., & Shi-wei, Z. (2011) · Procedia Environmental Sciences · doi:10.1016/j.proenv.2011.10.112 · Cited by 35 · see citing works
Magnetic Resonance Imaging Studies of Postpartum Depression: An Overview
Fiorelli, M., Aceti, F., Marini, I., Giacchetti, N., Macci, E., Tinelli, E., Calistri, V., Meuti, V., Caramia, F., & Biondi, M. (2015) · Behavioural Neurology · doi:10.1155/2015/913843 · Cited by 31 · see citing works
Reduced Progesterone Metabolites Are Not Critical for Plus-Maze Performance of Lactating Female Rats
Kellogg, C. K., & Barrett, K. A. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00041-6 · Cited by 31 · see citing works
Perinatal Selective Serotonin Reuptake Inhibitor Exposure: Impact on Brain Development and Neural Plasticity
Pawluski, J. L. (2011) · Neuroendocrinology · doi:10.1159/000329293 · Cited by 30 · see citing works
Self-citation
Noradrenergic alpha-2 receptor modulators in the ventral bed nucleus of the stria terminalis: Effects on anxiety behavior in postpartum and virgin female rats.
Smith, C. D., Piasecki, C. C., Weera, M. M., Olszewicz, J., & Lonstein, J. S. (2013) · Behavioral Neuroscience · doi:10.1037/a0032776 · Cited by 27 · see citing works
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Increased blood serotonin concentrations are correlated with reduced tension/anxiety in healthy postpartum lactating women
Sekiyama, T., Nakatani, Y., Yu, X., Seki, Y., Sato‐Suzuki, I., & Arita, H. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.03.009 · Cited by 25 · see citing works
Factors associated with post‐natal anxiety among primiparous mothers in N epal
Shrestha, S., Adachi, K., Petrini, M. A., & Shrestha, S. (2014) · International Nursing Review · doi:10.1111/inr.12118 · Cited by 23 · see citing works
Extensive juvenile “babysitting” facilitates later adult maternal responsiveness, decreases anxiety, and increases dorsal raphe tryptophan hydroxylase‐2 expression in female laboratory rats
Harding, K. M., & Lonstein, J. S. (2016) · Developmental Psychobiology · doi:10.1002/dev.21392 · Cited by 23 · see citing works
Self-citation
GABAA receptor antagonism in the ventrocaudal periaqueductal gray increases anxiety in the anxiety-resistant postpartum rat
Miller, S. M., Piasecki, C. C., Peabody, M. F., & Lonstein, J. S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.03.007 · Cited by 22 · see citing works
Self-citation
Brain CRF-binding protein modulates aspects of maternal behavior under stressful conditions and supports a hypo-anxious state in lactating rats
Klampfl, S. M., Schramm, M. M., Stinnett, G. S., Bayerl, D. S., Seasholtz, A. F., & Bosch, O. J. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.06.009 · Cited by 18 · see citing works
Propagation of maternal behavior across generations is associated with changes in non-maternal cognitive and behavioral processes
Lovic, V., & Fleming, A. S. (2015) · Behavioural Processes · doi:10.1016/j.beproc.2015.02.016 · Cited by 17 · see citing works
Self-citation
Functional Magnetic Resonance Imaging
Keller, K. (2008) · Encyclopedia of Obesity · doi:10.4135/9781412963862.n193 · Cited by 17 · see citing works
Pregnancy, childbirth and the postpartum period
von Sydow, K. (2005) · CRC Press eBooks · doi:10.1201/b14618-39 · Cited by 9 · see citing works
Global Histone H4 Acetylation in the Olfactory Bulb of Lactating Rats with Different Patterns of Maternal Behavior
de Moura, A. C., da Silva, I. R. V., Reinaldo, G. P., Dani, C., Elsner, V. R., & Giovenardi, M. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0306-3 · Cited by 8 · see citing works
Very-low-birth-weight infants in South Africa.
Cooper, P. A. (1999) · PubMed · Cited by 7 · see citing works
The influence of motherhood on neural systems for reward processing in low income, minority, young women
Moses-Kolko, E. L., Forbes, E. E., Stepp, S., Fraser, D., Keenan, K. E., Guyer, A. E., Chase, H. W., Phillips, M. L., Zevallos, C. R., Guo, C., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.009 · Cited by 6 · see citing works
Role of pelvic sensory signalling during delivery in postpartum mental health
Hayes, U. L., Balaban, S., Smith, J. Z., Perry‐Jenkins, M., & Powers, S. I. (2010) · Journal of Reproductive and Infant Psychology · doi:10.1080/02646831003630039 · Cited by 4 · see citing works
Depressed Mothers Show Increased Anxiety and Negativity and Differential Salivary Cortisol in Response to Infant Cries
Akbari, E., & Gonzalez, A. (2015) · Journal of Depression & Anxiety · doi:10.4172/2167-1044.s3-005 · Cited by 4 · see citing works
Very-Low-Birth-Weight Infants in South Africa
Cooper, P. A. (2000) · DigitalGeorgetown (Georgetown University Library) · Cited by 2 · see citing works

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Pathophysiological mechanisms implicated in postpartum depression
Payne, J. L., & Maguire, J. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.12.001 · Cited by 459 · see citing works
Postpartum psychiatric disorders
Meltzer-Brody, S., Howard, L. M., Bergink, V., Vigod, S., Jones, I., Munk-Olsen, T., Honikman, S., & Milgrom, J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.22 · Cited by 357 · see citing works
The transition to parenthood as a critical window for adult health.
Saxbe, D., Rossin-Slater, M., & Goldenberg, D. (2018) · American Psychologist · doi:10.1037/amp0000376 · Cited by 315 · see citing works
Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond
Zorumski, C. F., Paul, S. M., Covey, D. F., & Mennerick, S. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100196 · Cited by 305 · see citing works
Brain plasticity in pregnancy and the postpartum period: links to maternal caregiving and mental health
Barba‐Müller, E., Craddock, S., Carmona, S., & Hoekzema, E. A. (2018) · Archives of Women s Mental Health · doi:10.1007/s00737-018-0889-z · Cited by 240 · see citing works
Neuroanatomical changes observed over the course of a human pregnancy
Pritschet, L., Taylor, C. M., Cossio, D. M., Faskowitz, J., Santander, T., Handwerker, D. A., Grotzinger, H., Layher, E., Chrastil, E. R., & Jacobs, E. G. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01741-0 · Cited by 178 · see citing works
Education level and risk of postpartum depression: results from the Japan Environment and Children’s Study (JECS)
the Japan Environment and Children’s Study (JECS) Group, Matsumura, K., Hamazaki, K., Tsuchida, A., Kasamatsu, H., & Inadera, H. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2401-3 · Cited by 150 · see citing works
The HPA Axis During the Perinatal Period: Implications for Perinatal Depression
Dickens, M. J., & Pawluski, J. L. (2018) · Endocrinology · doi:10.1210/en.2018-00677 · Cited by 148 · see citing works
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High-Dietary Fiber Intake Alleviates Antenatal Obesity-Induced Postpartum Depression: Roles of Gut Microbiota and Microbial Metabolite Short-chain Fatty Acid Involved
Liu, Z., Li, L., Ma, S., Jin, Y., Zhang, H., Li, Y., Sair, A. T., Pan, J., Liu, X., Li, X., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04290 · Cited by 128 · see citing works
It Is Time for Routine Screening for Perinatal Mood and Anxiety Disorders in Obstetrics and Gynecology Settings
Accortt, E. E., & Wong, M. S. (2017) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000477 · Cited by 122 · see citing works
Neural circuitry for maternal oxytocin release induced by infant cries
Valtcheva, S., Issa, H. A., Bair-Marshall, C. J., Martin, K. A., Jung, K., Zhang, Y., Kwon, H.-B., & Froemke, R. C. (2023) · Nature · doi:10.1038/s41586-023-06540-4 · Cited by 115 · see citing works
Estrogen receptor α drives pro-resilient transcription in mouse models of depression
Lorsch, Z. S., Loh, Y.-H. E., Purushothaman, I., Walker, D. M., Parise, E. M., Salery, M., Cahill, M. E., Hodes, G. E., Pfau, M. L., Kronman, H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03567-4 · Cited by 104 · see citing works
Serotonin and motherhood: From molecules to mood
Pawluski, J. L., Li, M., & Lonstein, J. S. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.03.001 · Cited by 98 · see citing works
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Brexanolone, a GABAA Modulator, in the Treatment of Postpartum Depression in Adults: A Comprehensive Review
Edinoff, A. N., Odisho, A. S., Lewis, K., Kaskas, A. M., Hunt, G., Cornett, E. M., Kaye, A. D., Kaye, A. M., Morgan, J. H., Barrilleaux, P. S., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.699740 · Cited by 95 · see citing works
Automated Detection of Major Depressive Disorder With EEG Signals: A Time Series Classification Using Deep Learning
Rafiei, A., Zahedifar, R., Sitaula, C., & Marzbanrad, F. (2022) · IEEE Access · doi:10.1109/access.2022.3190502 · Cited by 88 · see citing works
Inhibition of Autophagy in Microglia Alters Depressive-Like Behavior via BDNF Pathway in Postpartum Depression
Tan, X., Du, X., Jiang, Y., Botchway, B. O. A., Hu, Z., & Fang, M. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00434 · Cited by 80 · see citing works
The maternal reward system in postpartum depression
Goodpaster, C. M., & Leuner, B. (2018) · Archives of Women s Mental Health · doi:10.1007/s00737-018-0926-y · Cited by 73 · see citing works
How stress can influence brain adaptations to motherhood
Kim, P. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100875 · Cited by 73 · see citing works
The Parental Brain
Numan, M. (2020) · doi:10.1093/oso/9780190848675.001.0001 · Cited by 101 · see citing works
Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and the epigenome
Gemmel, M., Bögi, E., Ragan, C. M., Hazlett, M. F., Dubovický, M., van den Hove, D., Oberlander, T. F., Charlier, T. D., & Pawluski, J. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.023 · Cited by 65 · see citing works
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Neurophysiological and cognitive changes in pregnancy
Grattan, D. R., & Ladyman, S. R. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64239-4.00002-3 · Cited by 63 · see citing works
Characterizing the Brain Structural Adaptations Across the Motherhood Transition
Martínez‐Garcia, M., Paternina-Die, M., Desco, M., Vilarroya, Ó., & Carmona, S. (2021) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2021.742775 · Cited by 59 · see citing works
Perinatal fluoxetine effects on social play, the HPA system, and hippocampal plasticity in pre-adolescent male and female rats: Interactions with pre-gestational maternal stress
Gemmel, M., Hazlett, M. F., Bögi, E., Lacalle, S. D., Hill, L. A., Kokras, N., Hammond, G. L., Dalla, C., Charlier, T. D., & Pawluski, J. L. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.07.480 · Cited by 56 · see citing works
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Black Perinatal Mental Health: Prioritizing Maternal Mental Health to Optimize Infant Health and Wellness
Estriplet, T., Morgan, I. A., Davis, K. D., Perry, J. C., & Matthews, K. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.807235 · Cited by 56 · see citing works
Association between particulate air pollution exposure during pregnancy and postpartum maternal psychological functioning
Sheffield, P. E., Speranza, R. J., Chiu, Y.-H. M., Hsu, H. L., Curtin, P. C. P., Renzetti, S., Pajak, A., Coull, B. A., Schwartz, J. D., Kloog, I., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195267 · Cited by 54 · see citing works
Mom doesn’t care: When increased brain CRF system activity leads to maternal neglect in rodents
Klampfl, S. M., & Bosch, O. J. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.01.001 · Cited by 51 · see citing works
Postpartum Anxiety
Zappas, M. P., BECKER, K. L., & Walton‐Moss, B. (2020) · The Journal for Nurse Practitioners · doi:10.1016/j.nurpra.2020.08.017 · Cited by 51 · see citing works
Barriers to Help-Seeking Behavior Among Women With Postpartum Depression
Grissette, B. G., Spratling, R. G., & Aycock, D. M. (2018) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1016/j.jogn.2018.09.006 · Cited by 50 · see citing works
Abnormal dynamics of resting-state functional activity and couplings in postpartum depression with and without anxiety
Cheng, B., Wang, X., Roberts, N., Zhou, Y., Wang, S., Deng, P., Meng, Y., Deng, W., & Wang, J. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac038 · Cited by 48 · see citing works
Variations in Neurodevelopmental Outcomes in Children with Prenatal SSRI Antidepressant Exposure
Rotem‐Kohavi, N., & Oberlander, T. F. (2017) · Birth Defects Research · doi:10.1002/bdr2.1076 · Cited by 47 · see citing works
Trajectories of maternal distress and risk of child developmental delays: Findings from the All Our Families (AOF) pregnancy cohort
Mughal, M. K., Giallo, R., Arnold, P. D., Kehler, H. L., Bright, K. S., Benzies, K., Wajid, A., & Kingston, D. E. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.12.132 · Cited by 47 · see citing works
AutoDep: automatic depression detection using facial expressions based on linear binary pattern descriptor
Tadalagi, M., & Joshi, A. M. (2021) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-021-02358-2 · Cited by 47 · see citing works
Mothering revisited: A role for cortisol?
Almanza-Sepúlveda, M. L., Fleming, A. S., & Jonas, W. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104679 · Cited by 48 · see citing works
Self-citation
Postpartum stress and protective factors in women who gave birth in the United States during the COVID-19 pandemic
Mollard, E., Kupzyk, K., & Moore, T. (2021) · Women's Health · doi:10.1177/17455065211042190 · Cited by 46 · see citing works
Factor structure of the Edinburgh Postnatal Depression Scale in the Japan Environment and Children’s Study
Matsumura, K., Hamazaki, K., Tsuchida, A., Kasamatsu, H., Inadera, H., The Japan Environment and Children’s Study (JECS) Group, Kamijima, M., Yamazaki, S., Ohya, Y., Kishi, R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67321-x · Cited by 44 · see citing works
Effects of a psychological nursing intervention on prevention of anxiety and depression in the postpartum period: a randomized controlled trial
Liu, H., & Yang, Y. (2021) · Annals of General Psychiatry · doi:10.1186/s12991-020-00320-4 · Cited by 44 · see citing works
Subconstructs of the Edinburgh Postnatal Depression Scale in a multi-ethnic inner-city population in the U.S.
Chiu, Y.-H. M., Sheffield, P. E., Hsu, H. L., Goldstein, J. M., Curtin, P. C. P., & Wright, R. J. (2017) · Archives of Women s Mental Health · doi:10.1007/s00737-017-0765-2 · Cited by 43 · see citing works
Effect of Selected Antidepressants on Placental Homeostasis of Serotonin: Maternal and Fetal Perspectives
Horackova, H., Karahoda, R., Červený, L., Váchalová, V., Ebner, R., Abad, C., & Štaud, F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081306 · Cited by 40 · see citing works
Severity of anxiety moderates the association between neural circuits and maternal behaviors in the postpartum period
Guo, C., Moses‐Kolko, E. L., Phillips, M. L., Swain, J. E., & Hipwell, A. E. (2018) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-017-0516-x · Cited by 40 · see citing works
Testing the social investment principle around childbirth: little evidence for personality maturation before and after becoming a parent
Asselmann, E., & Specht, J. (2020) · European Journal of Personality · doi:10.1002/per.2269 · Cited by 40 · see citing works
Aberrant resting-state interhemispheric functional connectivity in patients with postpartum depression.
Zhang, S., Wang, W., Wang, G., Li, B., Chai, L., Guo, J., & Gao, X. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112483 · Cited by 35 · see citing works
Perinatal selective serotonin reuptake inhibitor (SSRI) and other antidepressant exposure effects on anxiety and depressive behaviors in offspring: A review of findings in humans and rodent models
Hutchison, S. M., Mâsse, L. C., Pawluski, J. L., & Oberlander, T. F. (2020) · Reproductive Toxicology · doi:10.1016/j.reprotox.2020.11.013 · Cited by 38 · see citing works
Self-citation
Prenatal maternal sleep and trajectories of postpartum depression and anxiety symptoms
Gueron‐Sela, N., Shahar, G., Volkovich, E., & Tikotzky, L. (2020) · Journal of Sleep Research · doi:10.1111/jsr.13258 · Cited by 38 · see citing works
Maternal experience and adult neurogenesis in mammals: Implications for maternal care, cognition, and mental health
Medina, J., & Workman, J. L. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24311 · Cited by 37 · see citing works
Effects of opioids on the parental brain in health and disease
Swain, J. E., Ho, S.-H. S., Fox, H. C., Garry, D. J., & Brummelte, S. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100766 · Cited by 37 · see citing works
Altered functional connectivity density and couplings in postpartum depression with and without anxiety
Cheng, B.-C., Zhou, Y.-S., Kwok, V. P. Y., Li, Y.-Y., Wang, S., Zhao, Y.-J., Meng, Y., Deng, W., & Wang, J.-J. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab127 · Cited by 32 · see citing works
Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond: A review of animal and human studies
Hutchison, S. M., Mâsse, L. C., Pawluski, J. L., & Oberlander, T. F. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.02.004 · Cited by 37 · see citing works
Self-citation
A longitudinal study of women's depression symptom profiles during and after the postpartum phase
Fox, M. M., Sandman, C. A., Davis, E. P., & Glynn, L. M. (2018) · Depression and Anxiety · doi:10.1002/da.22719 · Cited by 35 · see citing works
Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non‐perinatal depression
Kiewa, J., Meltzer-Brody, S. E., Milgrom, J., Guintivano, J., Hickie, I. B., Whiteman, D. C., Olsen, C. M., Colodro‐Conde, L., Medland, S. E., Martin, N. G., et al. (2022) · Depression and Anxiety · doi:10.1002/da.23232 · Cited by 36 · see citing works
Perinatal fluoxetine increases hippocampal neurogenesis and reverses the lasting effects of pre-gestational stress on serum corticosterone, but not on maternal behavior, in the rat dam
Gemmel, M., Harmeyer, D., Bögi, E., Fillet, M., Hill, L. A., Hammond, G. L., Charlier, T. D., & Pawluski, J. L. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.11.038 · Cited by 33 · see citing works
Self-citation
A neural circuit for the suppression of feeding under persistent pain
Tang, H.-D., Dong, W., Hu, R. M., Huang, J.-Y., Huang, Z., Xiong, W., Xue, T., Liu, J., Yu, J., Zhu, X., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00688-5 · Cited by 33 · see citing works
Brief postpartum separation from offspring promotes resilience to lipopolysaccharide challenge-induced anxiety and depressive-like behaviors and inhibits neuroinflammation in C57BL/6J dams
Wu, Z., Zhou, L., Sun, L., Xie, Y., Xiao, L., Wang, H., & Wang, G. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.03.016 · Cited by 31 · see citing works
Challenges with Breastfeeding
Mahurin‐Smith, J. (2023) · MCN The American Journal of Maternal/Child Nursing · doi:10.1097/nmc.0000000000000909 · Cited by 30 · see citing works
Postpartum Specific Anxiety Scale (PSAS): Reliability and validity of the Turkish version
Duran, S. (2019) · Perspectives In Psychiatric Care · doi:10.1111/ppc.12385 · Cited by 30 · see citing works
Increased depression-related behavior during the postpartum period in inbred BALB/c and C57BL/6 strains
Shoji, H., & Miyakawa, T. (2019) · Molecular Brain · doi:10.1186/s13041-019-0490-z · Cited by 30 · see citing works
Perinatal fluoxetine prevents the effect of pre-gestational maternal stress on 5-HT in the PFC, but maternal stress has enduring effects on mPFC synaptic structure in offspring
Gemmel, M., Kokras, N., Dalla, C., & Pawluski, J. L. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.10.009 · Cited by 29 · see citing works
Self-citation
Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance
Guintivano, J., Åberg, K. A., Clark, S. L., Rubinow, D. R., Sullivan, P. F., Meltzer-Brody, S. E., & van den Oord, E. J. C. G. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01525-7 · Cited by 28 · see citing works
Neuroendocrinology and Adaptive Physiology of Maternal Care
Smiley, K. O., Ladyman, S. R., Gustafson, P. E., Grattan, D. R., & Brown, R. S. E. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_122 · Cited by 28 · see citing works
Symptoms of postpartum anxiety and depression among women in Canada: findings from a national cross-sectional survey
Gheorghe, M. C., Varin, M., Wong, S. L., Baker, M. M., Grywacheski, V., & Orpana, H. (2020) · Canadian Journal of Public Health · doi:10.17269/s41997-020-00420-4 · Cited by 28 · see citing works
Abnormalities of cortical structures in patients with postpartum depression: A surface-based morphometry study
Li, Y., Chu, T., Che, K., Dong, F., Shi, Y., Ma, H., Zhao, F., Mao, N., & Xie, H. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113340 · Cited by 28 · see citing works
Understanding the Online Social Support Dynamics for Postpartum Depression
Progga, F. T., Kumar, A. S., & Rubya, S. (2023) · CHI Conference on Human Factors in Computing Systems · doi:10.1145/3544548.3581311 · Cited by 28 · see citing works
Neurobiology of maternal mental illness
Maguire, J., McCormack, C., Mitchell, A., & Monk, C. E. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64239-4.00005-9 · Cited by 27 · see citing works
Immune System Alterations and Postpartum Mental Illness: Evidence From Basic and Clinical Research
Dye, C. N., Lenz, K. M., & Leuner, B. (2022) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2021.758748 · Cited by 28 · see citing works
The evolved nest, oxytocin functioning, and prosocial development
Tarsha, M. S., & Narvaez, D. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1113944 · Cited by 25 · see citing works
“Several studies found that mothers who report more anxiety and depression also demonstrate lower levels of oxytocin when breastfeeding than asymptomatic breastfeeding mothers (Stuebe et al., 2013; Cox et al., 2015; Pawluski et al., 2017).”
Background
Bridging Neurobiological Insights and Clinical Biomarkers in Postpartum Depression: A Narrative Review
Zhang, K., He, L., Li, Z. B., Ding, R., Han, X., Chen, B., Cao, G., Ye, J.-H., Li, T., & Fu, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168835 · Cited by 33 · see citing works
Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats
Pawluski, J. L., Paravatou, R., Even, A., Cobraiville, G., Fillet, M., Kokras, N., Dalla, C., & Charlier, T. D. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107950 · Cited by 26 · see citing works
Self-citation
Predicting Risk of Antenatal Depression and Anxiety Using Multi-Layer Perceptrons and Support Vector Machines
Javed, F., Gilani, S. O., Latif, S., Waris, A., Jamil, M., & Waqas, A. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11030199 · Cited by 28 · see citing works
A tumultuous transition to motherhood: Altered brain and hormonal responses in mothers with postpartum depression
Nguyen, A. J., Hoyer, E. A., Rajhans, P., Strathearn, L., & Kim, S. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12794 · Cited by 27 · see citing works
Precision medicine in perinatal depression in light of the human microbiome
Bernabé, B. P., Maki, P. M., Dowty, S. M., Salas, M. L. C., Cralle, L. E., Shah, Z., & Gilbert, J. A. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05436-4 · Cited by 25 · see citing works
Sleep, circadian activity patterns and postpartum depression: A systematic review and meta‐analysis of actigraphy studies
Sobol, M., Błachnio, A., Meisner, M., Szyszkowska, J., & Jankowski, K. S. (2023) · Journal of Sleep Research · doi:10.1111/jsr.14116 · Cited by 25 · see citing works
Understanding the maternal brain in the context of the mental load of motherhood
Callaghan, B. L., McCormack, C. A., Kim, P., & Pawluski, J. L. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00268-4 · Cited by 25 · see citing works
Self-citation
Postpartum changes in affect-related behavior and VTA dopamine neuron activity in rats
Rincón‐Cortés, M., & Grace, A. A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109768 · Cited by 24 · see citing works
Chronic Pb Exposure Induces Anxiety and Depression-like Behaviors in Mice via Excitatory Neuronal Hyperexcitability in Ventral Hippocampal Dentate Gyrus
Zhou, R., Huang, C., Bi, N., Li, L., Li, C., Gu, X., Song, Y., & Wang, H. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c03426 · Cited by 25 · see citing works
Neural processing of infant and adult face emotion and maternal exposure to childhood maltreatment
Olsavsky, A. K., Stoddard, J., Erhart, A., Tribble, R. C., & Kim, P. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz069 · Cited by 25 · see citing works
Screening for postpartum anxiety: A quality improvement project to promote the screening of women suffering in silence
Toler, S., Stapleton, S. R., Kertsburg, K., Callahan, T. J., & Hastings‐Tolsma, M. (2018) · Midwifery · doi:10.1016/j.midw.2018.03.016 · Cited by 24 · see citing works
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Dimén, D., Puska, G., Szendi, V., Sipos, E., Zelena, D., & Dobolyi, Á. (2021) · iScience · doi:10.1016/j.isci.2021.103090 · Cited by 20 · see citing works
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Mundorf, A., Bölükbas, I., & Freund, N. (2022) · Developmental Psychobiology · doi:10.1002/dev.22219 · Cited by 23 · see citing works
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Dessì, A., Pianese, G., Mureddu, P., Fanos, V., & Bosco, A. (2024) · Nutrients · doi:10.3390/nu16142285 · Cited by 32 · see citing works
The early postpartum period – Differences between women with and without a history of depression
Schnakenberg, P., Jo, H., Stickel, S., Habel, U., Eickhoff, S. B., Brodkin, E. S., Goecke, T. W., Votinov, M., & Chechko, N. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.01.056 · Cited by 22 · see citing works
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Bolton, J. L., Wiley, M. G., Ryan, B., Truong, S., Strait, M., Baker, D. C., Yang, N. Y., Ilkayeva, O., O’Connell, T. M., Wroth, S. W., et al. (2017) · Brain and Behavior · doi:10.1002/brb3.828 · Cited by 22 · see citing works
Depression‐related disturbances in rat maternal behaviour are associated with altered monoamine levels within mesocorticolimbic structures
Winokur, S. B., Lopes, K. L., Moparthi, Y., & Pereira, M. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12766 · Cited by 21 · see citing works
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Porto, J. A., Bick, J. R., Perdue, K. L., Richards, J. E., Nunes, M. L., & Nelson, C. A. (2020) · Infant Behavior and Development · doi:10.1016/j.infbeh.2020.101447 · Cited by 23 · see citing works
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Yatziv, T., Vancor, E. A., Bunderson, M., & Rutherford, H. J. V. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.043 · Cited by 21 · see citing works
Long-term association of pregnancy and maternal brain structure: the Rotterdam Study
Aleknavičiūtė, J., Evans, T. E., Aribas, E., de Vries, M. W., Steegers, E. A. P., Ikram, M. A., Tiemeier, H. W., Kavousi, M., Vernooij, M. W., & Kushner, S. A. (2022) · European Journal of Epidemiology · doi:10.1007/s10654-021-00818-5 · Cited by 25 · see citing works
Effects of fast-acting antidepressant drugs on a postpartum depression mice model
García-Baos, A., Gallego‐Landin, I., Ferreres-Álvarez, I., Puig-Reyné, X., Castro‐Zavala, A., Valverde, O., & Martín‐Sánchez, A. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113598 · Cited by 19 · see citing works
Perinatal SSRI medications and offspring hippocampal plasticity: interaction with maternal stress and sex
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Self-citation
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Hutchison, S. M., Mâsse, L. C., Brain, U. M., & Oberlander, T. F. (2018) · Early Human Development · doi:10.1016/j.earlhumdev.2018.10.009 · Cited by 21 · see citing works
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Grieb, Z. A., & Ragan, C. M. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.07.239 · Cited by 21 · see citing works
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Wu, R., Dong, X. Y., Shan, X., Dong, Y. J., & Tao, W. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00022 · Cited by 21 · see citing works
SULFATION PATHWAYS: The steroid sulfate axis and its relationship to maternal behaviour and mental health.
Davies, W. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0219 · Cited by 18 · see citing works
Bibliometrics and Visual Analysis of the Research Status and Trends of Postpartum Depression From 2000 to 2020
Bai, X., Song, Z., Zhou, Y., Wang, X.-X., Wang, Y., & Zhang, D. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.665181 · Cited by 21 · see citing works
Impact of maternal depressive symptoms on the development of infant temperament: Cascading effects during the first year of life
Rigato, S., Stets, M., Bonneville‐Roussy, A., & Holmboe, K. (2020) · Social Development · doi:10.1111/sode.12448 · Cited by 20 · see citing works
Oxytocin receptors in the midbrain dorsal raphe are essential for postpartum maternal social and affective behaviors
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Self-citation
When mothers neglect their offspring: an activated CRF system in the BNST is detrimental for maternal behavior
Klampfl, S. M., & Bosch, O. J. (2018) · Archives of Women s Mental Health · doi:10.1007/s00737-018-0897-z · Cited by 19 · see citing works
Postpartum anxiety: a state-of-the-art review
Feldman, N., Hibara, A., Ye, J., Macaranas, A. R., Larkin, P., Hendrix, E., Aydinian, T., Mittal, L. P., Wiegartz, P. S., Silbersweig, D., et al. (2025) · The Lancet Psychiatry · doi:10.1016/s2215-0366(25)00197-x · Cited by 18 · see citing works
Altered gray matter structural covariance networks in postpartum depression: a graph theoretical analysis
Li, Y., Chu, T., Che, K., Dong, F., Shi, Y., Ma, H., Zhao, F., Mao, N., & Xie, H. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.05.018 · Cited by 18 · see citing works
Postpartum depression in rats causes poor maternal care and neurochemical alterations on dams and long-lasting impairment in sociability on the offspring
Zaccarelli‐Magalhães, J., Abreu, G. R., Fukushima, A. R., Pantaleon, L. D. P., Ribeiro, B. B., Munhoz, C., Manes, M., de Lima, M. A., Miglioli, J., Flório, J. C., et al. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114082 · Cited by 17 · see citing works

Mothers’ neural response to valenced infant interactions predicts postpartum depression and anxiety
Finnegan, M. K., Kane, S., Heller, W., & Laurent, H. K. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250487 · Cited by 12 · see citing works
Postpartum Depression and Anxiety: A Literature Review of Neural Mechanisms, Child Outcomes, and Treatment OutcomesPreprint
Esparza, K. A., Armstrong, J. M., & Aupperle, R. L. (2026) · doi:10.31234/osf.io/h4bsu_v1
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Self-citation
Mothers’ neural response to valenced infant interactions predicts postnatal depression and anxiety
Finnegan, M. K. (2020) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Postpartum Depression Is Associated With Altered Neural Connectivity Between Affective and Mentalizing Regions During Mother-Infant Interactions
Morgan, J. K., Santosa, H., Fridley, R. M., Conner, K. K., Hipwell, A. E., Forbes, E. E., & Huppert, T. J. (2021) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2021.744649 · Cited by 17 · see citing works

Authors: Pawluski, J. L., Lonstein, J. S., & Fleming, A. S.
Affiliations: Inserm (FR)
Michigan State University (US)
University of Toronto (CA)
Corresponding author: Pawluski, Jodi L.
Lonstein, Joseph S.
ORCID: Pawluski, Jodi L.
Lonstein, Joseph S.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2017-02
Volume: 40
Issue: 2
Pages: 106-120
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2016.11.009
OpenAlex: W2581908356
Semantic Scholar: 1a04b202342821d315811b033e4fe93b525072d4
Cited by: 325
References: 189
Citations by year: 2026: 29 · 2025: 42 · 2024: 40 · 2023: 28 · 2022: 35 · 2021: 39 · 2020: 46 · 2019: 27 · 2018: 27 · 2017: 9 · 2015: 1 · 2013: 1
FWCI: 4.84
Type: journal article
Language: en
Open access: green
univ-rennes.hal.science
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Funders: Canadian Institutes of Health Research
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD057962)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Health Sciences › Health Professions › Pharmacy › Infant Health and Development
Keywords: postpartum anxiety, postpartum depression, maternal mental health, mother-infant relationship, maternal care, neural correlates, neurobiology of depression, neural correlates of anxiety, mother-infant interaction
MeSH terms: Animals, Anxiety, Depression, Humans, Maternal Behavior, Mother-Child Relations, Mothers, Postpartum Period

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The Neurobiology of Postpartum Anxiety and Depression

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