A serotonin transporter gene polymorphism predicts peripartum depressive symptoms in an at-risk psychiatric cohort
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Background Peripartum major depressive disorder (MDD) is a prevalent psychiatric disorder with potential detrimental consequences for both mother and child. Despite its enormous health care relevance, data regarding genetic predictors of peripartum depression are sparse. The aim of this study was to investigate associations of the serotonin-transporter linked polymorphic region (5-HTTLPR) genotype with peripartum MDD in an at-risk population.Methods Two hundred and seventy four women with a prior history of MDD were genotyped for 5-HTTLPR and serially evaluated in late pregnancy (gestational weeks 31-40), early post-partum (week 1-8) and late post-partum (week 9-24) for diagnosis of a current major depressive episode (MDE) and depressive symptom severity.Results 5-HTTLPR S-allele carrier status predicted the occurrence of a MDE in the early post-partum period only (OR=5.13, p=0.017). This association persisted despite continued antidepressant treatment.Conclusions The 5-HTTLPR genotype may be a clinically relevant predictor of early post-partum depression in an at-risk population.Objective Peripartum major depressive disorder is a prevalent psychiatric disorder with potential detrimental consequences for both mother and child. Despite its enormous health care relevance, data regarding genetic predictors of peripartum depression are sparse. The aim of this study was to investigate associations of the serotonin-transporter linked polymorphic region (5-HTTLPR) genotype with peripartum MDD in an at-risk population.
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Post-birth decompensation in women with bipolar disorder is caused by genetic factors and by massive gonadal steroid withdrawal after birth in women who are neurobiologically sensitive to hormonal change.
“The causes of post-birth decompensation in women with bipolar disorder include genetic factors [31–33] and massive gonadal steroid withdrawal after birth in women who are neurobiologically sensitive to hormonal change [34].”
From Perinatal mental illness: Definition, description and aetiology (2014) · cites this paper as [31]
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- Authors
- Binder, E. B., Jeffrey Newport, D., Zach, E. B., Smith, A. K., Deveau, T. C., Altshuler, L. L., Cohen, L. S., Stowe, Z. N., & Cubells, J. F.
- Affiliations
- Emory University (US)
- University of California, Los Angeles (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Binder, Elisabeth B.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 44
- Issue
- 10
- Pages
- 640-646
- ISSN
- 0022-3956 (ISSN-L)
- PMC
- PMC2891911
- OpenAlex
- W2075634070
- Cited by
- 69
- References
- 42
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 5
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Funders
- Doris Duke Charitable Foundation
- National Institute of Mental Health (P50 MH 68036)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- 5-HTTLPR, serotonin transporter gene polymorphism, postpartum depression, genetic predictors, S-alleles, antidepressant treatment, depression severity, pregnancy
- MeSH terms
- Adult, Major Depressive Disorder, Female, Humans, Polymorphism, Genetic, Predictive Value of Tests, Pregnancy, Risk Factors, Severity of Illness Index, Cohort Studies, Odds Ratio, Depression, Postpartum, Genetic Predisposition to Disease, Serotonin Plasma Membrane Transport Proteins
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