Menstrual cycle effects on cortisol responsivity and emotional retrieval following a psychosocial stressor
Open accessAbstract
Laboratory-induced stress produces elevations in cortisol and deficits in memory, especially when stress is induced immediately before retrieval of emotionally valent stimuli. Sex and sex steroids appear to influence these stress-induced outcomes, though no study has directly compared the effects of laboratory-induced stress on cortisol and emotional retrieval across the menstrual cycle. We examined the effect of psychosocial stress on cortisol responsivity and emotional retrieval in women tested during either the follicular phase (low estradiol and progesterone) or the luteal phase (higher estradiol and progesterone). Forty women (50%White; age 18–40 years) participated in the study; 20 completed the task during the luteal phase and 20 during the follicular phase. Psychosocial stress was induced with the Trier Social Stress Test (TSST). On the day before the TSST, participants learned two lists of word pairs to 100% criterion. The next day, participants recalled one list after the control condition and the other after the TSST. Women in the follicular phase, but not the luteal phase, demonstrated a significant cortisol response to the TSST. There was a stress-induced decrease in emotional retrieval following the TSST, but this effect was not modified by menstrual phase. However, regression and correlational analyses showed that individual differences in stress-induced cortisol levels were associated with impaired emotional retrieval in the follicular phase only. The present…
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Claims the paper makes
2 of 22 cited sources checked · 1 supported · 0 flagged · accuracy not yet measured
- Premisecitation
People with prior emotional trauma have blunted cortisol reactions to the TSST.
“Individuals with a history of emotional trauma show blunted cortisol responses to the TSST (Carpenter et al., 2007).”
Quote in the paperSubstantial claim1 of 1 sources checked- cites Carpenter et al., 2007 source
The Discussion reports a blunted cortisol response to the TSST in healthy adults who reported significant childhood maltreatment, particularly emotional neglect. The citing sentence captures that finding but broadens it to people with any history of emotional trauma, without the study’s childhood-exposure and healthy-adult limits. (LLM, conf=0.86)
Experimental — accuracy not yet measured
- Findingown data
Individual differences in stress-induced cortisol levels were associated with impaired emotional retrieval in the follicular phase only.
“However, regression and correlational analyses showed that individual differences in stress-induced cortisol levels were associated with impaired emotional retrieval in the follicular phase only.”
Quote in the paperSubstantial claim- Rests on an assumption: The 20-minute control condition used in the study was non-stressful.
- Findingown data
The TSST caused a decrease in emotional retrieval.
“There was a stress-induced decrease in emotional retrieval following the TSST, but this effect was not modified by menstrual phase.”
Quote in the paperSubstantial claim- Rests on an assumption: The 20-minute control condition used in the study was non-stressful.
- Findingown data
Menstrual phase did not modify the stress-induced decrease in emotional retrieval.
“There was a stress-induced decrease in emotional retrieval following the TSST, but this effect was not modified by menstrual phase.”
Quote in the paperSubstantial claim- Rests on an assumption: The 20-minute control condition used in the study was non-stressful.
- Findingown data
A Valence × Phase interaction showed a trend toward significance for emotional memory.
“However, there was a trend for a Valence × Phase interaction, F(2, 76) = 2.77, p = 0.07.”
Quote in the paperNot a substantial claim
- Findingown data
Within each phase, estradiol and progesterone variation was not related to memory performance.
“Individual differences in estradiol and progesterone levels within each menstrual phase were unrelated to memory performance.”
Quote in the paperNot a substantial claim - Findingown data
There was a significant Condition × Phase interaction on cortisol levels.
“The test of the primary hypothesis—the two-way Condition × Phase interaction was also significant, F(1, 32) = 7.87, p = 0.008.”
Quote in the paperSubstantial claim - Findingown data
Memory for positive words was better than memory for neutral words.
“This valence effect was driven by better memory for positive words (M = 2.90, SE = 0.20) compared to neutral words (M = 2.25, SE = 0.20), F(1, 76) = 7.82, p < 0.05.”
Quote in the paperNot a substantial claim - Findingown data
Cortisol trajectories across time points varied by condition.
“Additionally, the Condition × Time interaction was significant indicating that the change in cortisol levels over time (i.e., between the rest, challenge, and memory phases) differed by Condition, F(2, 64) = 14.54, p < 0.001.”
Quote in the paperSubstantial claim - Findingown data
Cortisol rose significantly from control to TSST among follicular-phase women.
“The Follicular group showed a significant increase in cortisol levels from the non-stress control to the TSST condition, F(1, 32) = 5.61, p = 0.02”
Quote in the paperSubstantial claim - Findingown data
STAI anxiety ratings were higher in the stress condition than in the control condition.
“On the STAI, subjective ratings of anxiety were higher during the stress (M = 10.58, SE = 0.51) compared to the control condition (M = 8.31, SE = 0.34), F(1, 38) = 41.31, p < 0.001.”
Quote in the paperNot a substantial claim - Findingown data
Cortisol levels were higher in the TSST condition than in the non-stress control condition.
“As expected, there was a main effect of Condition with cortisol levels being higher in the TSST (M = 0.61, SE = 0.06) versus the non-stress control condition (M = 0.49, SE = 0.05), F(1, 32) = 11.12, p = 0.002.”
Quote in the paperSubstantial claim - Findingown data
There was a main effect of word valence on emotional memory.
“There was also a main effect of Valence, F(2, 76) = 8.24, p = 0.001.”
Quote in the paperNot a substantial claim - Findingown data
Negative-word memory did not differ from positive- or neutral-word memory.
“Memory for negative words (M = 2.52, SE = 0.19) did not differ from memory for positive or neutral words, F(1, 76) = 2.60, ns and F(1, 76) = 1.40, ns, respectively.”
Quote in the paperNot a substantial claim - Findingown data
In the TSST condition, cortisol was higher at challenge and memory than at rest.
“During the TSST condition, cortisol levels were higher during challenge and memory phase compared to rest (ps < 0.05).”
Quote in the paperNot a substantial claim - Findingown data
Memory for negative words was better in the follicular group than in the luteal group.
“That interaction was driven by significantly better memory for negative words in the follicular group (M = 2.87, SE = 0.27) compared to the luteal group (M = 2.17, SE = 0.27), F(1, 76) = 4.54, p < 0.01.”
Quote in the paperSubstantial claim - Findingown data
Emotional memory was worse during the TSST than during the non-stress control condition.
“Overall, there was a main effect of Condition with worse memory during the TSST (M = 2.38, SE = 0.21) compared with the non-stress control condition (M = 2.73, SE = 0.17), F(1, 38) = 4.29, p = 0.045.”
Quote in the paperSubstantial claim - Findingown data
Luteal-phase women did not have a significant cortisol rise between conditions.
“whereas the Luteal group did not show a significant increase in cortisol levels across conditions, F(1, 32) = 0.05, p = 0.81.”
Quote in the paperSubstantial claim - Findingown data
There was no significant Condition × Phase interaction for emotional memory.
“Unexpectedly, there was no support for a significant interaction between Condition and Phase, F(1, 38) = 1.91, p = 0.17.”
- Also stated in: § Discussion · plain
“However, this effect did not differ by menstrual phase.”
Quote in the paperSubstantial claim - Also stated in: § Discussion · plain
- Findingown data
In the control condition, cortisol was higher at rest than at challenge or memory.
“Conversely, in the non-stress control condition, cortisol levels were higher during rest compared to challenge and memory (ps < 0.05).”
Quote in the paperNot a substantial claim - Findingown data
A greater proportion of follicular-phase women were cortisol responders (73%) than luteal-phase women (32%).
“A significant Phase effect in cortisol response to the stressor was found, where 73% of women in the follicular group were cortisol responders, compared to only 32% of women in the luteal group, χ2 (df = 1, 34) = 8.59, p = 0.016.”
Quote in the paperSubstantial claim - Premisecitation
Men generally show elevated cortisol responses to the TSST compared to women.
“In general men show elevated cortisol responses to the TSST compared to women (Kudielka and Kirschbaum, 2005), but not all studies find a sex difference (Kudielka et al., 2004).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Kudielka and Kirschbaum, 2005 source
- Premisecitation
The extent to which the TSST impairs emotional retrieval differs between sexes, with greater impairing effects in men than women.
“Mirroring the cortisol response, the extent to which the TSST induces impairments in emotional retrieval differs between the sexes, with greater impairing effects in men compared to women (Wolf et al., 2001).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Wolf et al., 2001 source
- Premisecitation
The TSST and cortisone administration differentially impair retrieval of emotional compared to neutral stimuli.
“The TSST and cortisone administration differentially impair retrieval of emotional stimuli compared to neutral stimuli (Kuhlmann et al., 2005a, 2005b; Wolf, 2009).”
Quote in the paperSubstantial claim0 of 2 sources checked- cites Kuhlmann et al., 2005a, 2005b
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites Wolf, 2009 source
- Interpretationown data
The correlational results are consistent with reduced glucocorticoid sensitivity in the luteal phase.
“Our correlation findings would support this interpretation since there was a significant stress-induced increase in cortisol in the luteal phase (albeit significantly lower than in the follicular phase), but no correlation was observed between cortisol levels and retrieval impairment.”
Quote in the paperSubstantial claim0 of 2 sources checked - Premisecitation
A second TSST administration produces a significantly smaller cortisol response.
“a notable advantage of the between-subjects design is that cortisol responsivity to the TSST decreases significantly on the second administration (Kirschbaum et al., 1995).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Kirschbaum et al., 1995 source
- Premisecitation
Glucocorticoid administration before memory retrieval produces a reliable impairing effect in rodents and humans.
“Similarly, glucocorticoid administration before memory retrieval produces a reliable, impairing effect in rodents (Roozendaal, 2002) and humans (de Quervain et al., 2000).”
Quote in the paperNot a substantial claim0 of 2 sources checked - Study design and conductown data
Learning speed for the word lists did not differ significantly by menstrual phase.
“There was no significant effect of menstrual cycle phase on the rate of learning of the word lists (all ps > .39); on average it took about 4.20 trials to learn List A and about 4.37 trials to learn List B.”
Quote in the paperNot a substantial claim - Study design and conductown data
The luteal and follicular groups did not differ on demographic or psychological measures.
“There were no group differences in any demographic or psychological outcomes (See Table 1).”
Quote in the paperNot a substantial claim - Study design and conductown data
Phase and order did not interact significantly.
“Similarly, there was no significant Phase by Order interaction, p = 0.75.”
Quote in the paperNot a substantial claim - Interpretationown data
The lack of significant luteal-phase correlations between cortisol and emotional retrieval is unsurprising because luteal cortisol responses were much smaller.
“The finding that there were no significant correlations during the luteal phase is not surprising given that the cortisol response during that phase was considerably attenuated.”
Quote in the paperSubstantial claim - Interpretationreasoning
Luteal-phase cortisol reactivity was blunted enough that small individual differences in cortisol did not predict emotional retrieval.
“Conversely, cortisol responsivity is dampened during the luteal phase to a level at which small individual differences in cortisol levels are not related to emotional retrieval.”
Quote in the paperSubstantial claim - Study design and conductown data
Estradiol and progesterone were higher in the luteal group than in the follicular group.
“Levels of estradiol and progesterone were significantly higher in the luteal group compared to the follicular group, p < 0.001.”
Quote in the paperSubstantial claim - Premisecitation
A reliable deficit in memory retrieval occurs when participants learn words and then, hours to days later, are exposed to the TSST and immediately asked to retrieve them.
“A reliable deficit in memory retrieval is observed when participants learn a list of words under normal conditions, and then several hours to days later are exposed to the TSST and are immediately asked to retrieve the words (Het et al., 2005).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Het et al., 2005 source
- Premisecitation
A second study found that luteal-phase women had a smaller cortisol increase to the TSST compared to men.
“Conversely, a second study found that women tested in the luteal phase had a smaller increase in cortisol response to the TSST compared to men (Schoofs and Wolf, 2009).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Schoofs and Wolf, 2009 source
- Study design and conductreasoning
The control condition always came before the TSST on the same day, rather than on separate days, to keep ovarian hormone status controlled.
“We consistently administered the non-stress control condition before the TSST in the same day rather than on separate days to control for the main factor of interest, ovarian hormone status during tightly controlled menstrual cycle phases.”
Quote in the paperSubstantial claim - Interpretationown data
Higher cortisol increases were linked to poorer emotional retrieval only among follicular-phase women.
“Thus in addressing our third aim – examination of individual differences in cortisol response with regression and correlational analyses – we found that increases in cortisol were significantly associated with decreases in emotional retrieval during the follicular phase only.”
- Also stated in: § Conclusions · plain
“Furthermore, it is only when ovarian hormone levels are low that cortisol levels are associated with impaired retrieval.”
Quote in the paperSubstantial claim - Also stated in: § Conclusions · plain
- Interpretationown data
Stress impairs emotional retrieval.
“Retrieval performance in the emotional memory test was significantly worse following the TSST compared to the non-stress control, confirming that stress impairs emotional retrieval.”
Quote in the paperSubstantial claim - Premisecitation
No impairing effect of stress or cortisol on emotional retrieval was observed in women tested during the luteal phase when estradiol and progesterone are high.
“In contrast to men, no impairing effect of stress or cortisol on emotional retrieval was observed in women tested during the luteal phase of the menstrual cycle when levels of estradiol and progesterone are high (Schoofs and Wolf, 2009).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Schoofs and Wolf, 2009 source
- Interpretationown data
Women in the luteal phase had smaller cortisol reactions to the TSST than women in the follicular phase.
“Specifically, cortisol responses to the TSST were lower in women tested during the luteal phase when levels of the ovarian hormones estradiol and progesterone are high compared to a group of women tested in the follicular phase when hormone levels are low.”
- Also stated in: § Conclusions · plain
“Specifically, cortisol responsivity is lower in the luteal phase when levels of estradiol and progesterone are high compared to the follicular phase when levels are low.”
Quote in the paperSubstantial claim - Also stated in: § Conclusions · plain
- May combine two claims. 17
- The quote only partly states this claim. 1
- Classified as probably not a substantial claim. 13
May combine two claims.
Study design and conductreasoningAn undocumented trauma history might have influenced the results and could not be ruled out.
“Therefore, we cannot rule out the possible influence of an undocumented history of trauma on the present findings.”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites Carpenter et al., 2007 source
May combine two claims.
Findingown dataWomen in the follicular phase, but not the luteal phase, showed a significant cortisol response to the TSST.
“Women in the follicular phase, but not the luteal phase, demonstrated a significant cortisol response to the TSST.”
Quote in the paperSubstantial claim- Rests on an assumption: The 20-minute control condition used in the study was non-stressful.
May combine two claims.
Findingown dataCortisol levels correlated with emotion memory performance in the follicular phase only, and this held for neutral, positive, and negative words.
“As shown in Table 2, performance on the emotion memory task was significantly associated with cortisol levels in the follicular but not the luteal phase, and these correlations were significant for neutral, positive and negative words.”
Quote in the paperSubstantial claimThe quote only partly states this claim.
Findingown dataMenstrual phase did not affect VAS anxiety or VAS stress ratings.
“but no effect of menstrual phase. On the VAS measures of stress, there was also a significant main effect of Condition, F(1, 38) = 36.20, p < 0.001, and Time F(2, 76) = 30.25, p < 0.001, and a significant Condition × Time interaction, F(2, 76) = 16.69, p < 0.001, but no effect of menstrual phase.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataAmong follicular-phase women, stress-related memory decline correlated with cortisol increases but not with anxiety increases.
“Regression analyses of outcomes in the follicular group showed that the negative effect of stress on overall memory performance was associated with increases in cortisol (β = −0.37, p = 0.04) but not increases in self-reported anxiety on the STAI (β = −0.09, p = 0.59).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataPositive- and neutral-word memory did not differ between the follicular and luteal groups.
“Luteal and follicular groups did not differ in memory for positive or neutral words, F(1, 76) = 0.09 and F(1, 76) = 0, respectively.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataMenstrual phase did not affect subjective anxiety ratings on the STAI, nor did it interact with condition or time.
“There was no effect of menstrual phase on anxiety ratings, nor did phase interact with condition or time on this outcome.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationIn an early study, women tested in the luteal phase showed TSST-induced cortisol elevations similar to men and higher than follicular-phase women and oral contraceptive users.
“For example, in an early study, women tested in the luteal phase of the menstrual cycle (higher estradiol and progesterone), showed TSST-induced elevations in cortisol that were similar in magnitude to men and higher than both women in the follicular phase (low estradiol and progesterone) and women using oral contraceptives (low endogenous estradiol and progesterone; high exogenous levels of estro”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Kirschbaum et al., 1999 source
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThe cortisol assay had intra-assay coefficients of variation of 1.9%, 2.8%, and 4.8% at high, medium, and low concentrations.
“At high (4.09 mg/dL), medium (1.41 mg/dL) and low (0.47 mg/dL) concentrations of cortisol, the intra-assay coefficients of variation (CV) were 1.9%, 2.8% and, 4.8% respectively.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductcitationThe two word lists were balanced on valence, arousal, word frequency, and word length.
“The two word lists were balanced on overall ratings of valence, arousal, word frequency, and word length based on Affective Norms for English Words (Bradley and Lang, 1999).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Bradley and Lang, 1999
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThe cortisol assay had a sensitivity of 0.011 μg/d.
“Assay sensitivity for cortisol was 0.011 µg/d.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenSalivary cortisol samples for each participant were run on the same assay plate.
“Each of the samples for each participant was run on the same assay plate.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductown dataParticipants were randomized to be tested during either the follicular or luteal phase.
“Women were then randomized to be tested on two consecutive days during either the follicular or luteal phase of the menstrual cycle as follows.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationThe TSST is a valid laboratory stressor; social evaluative threat combined with uncontrollability produces the largest cortisol increases in the laboratory.
“The validity of the TSST as a laboratory stressor was demonstrated in a meta-analysis which found that social evaluative threat combined with uncontrollability produces the largest cortisol increases in the laboratory (Dickerson and Kemeny, 2004).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Dickerson and Kemeny, 2004 source
May combine two claims.
Interpretationown dataCortisol responsivity and the impairing effects of cortisol on emotional memory are lower when estradiol and progesterone levels are high compared to when they are low.
“The present findings indicate that cortisol responsivity and the impairing effects of cortisol on emotional memory are lower when levels of estradiol and progesterone are high compared to when levels are low.”
Quote in the paperSubstantial claim- Rests on an assumption: The 20-minute control condition used in the study was non-stressful.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataSix women were missing cortisol levels due to a malfunctioning freezer.
“Six women were missing cortisol levels (5 follicular, 1 luteal) due to a malfunctioning freezer.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationNot all studies find a sex difference in cortisol response to the TSST.
“In general men show elevated cortisol responses to the TSST compared to women (Kudielka and Kirschbaum, 2005), but not all studies find a sex difference (Kudielka et al., 2004).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Kudielka et al., 2004 source
Classified as probably not a substantial claim. May combine two claims.
Study design and conductreasoningLearning the word lists to 100% criterion ensured equivalent learning across groups, avoided floor effects at recall, and ensured that recall errors the next day were not due to unsuccessful encoding.
“The list was taught to 100% criterion to ensure equivalent learning across groups, avoid floor effects at recall, and ensure that any errors in recall on the next day were not due to unsuccessful encoding.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenPresentation of lists was counterbalanced across conditions and groups.
“The presentation of lists was counter-balanced across conditions (TSST or control) and groups (follicular, luteal).”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductnone givenBlood was drawn at the beginning of the session for hormone assays to confirm menstrual phase.
“Blood was drawn at the beginning of the session for hormone assays to confirm menstrual phase.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenThe examiner was blinded to menstrual status.
“During the first of the two consecutive test sessions, participants met one-on-one with an examiner who was blinded to menstrual status.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationMenstrual cycle effects on stress responsivity have been reported, but results are inconsistent.
“Menstrual cycle effects on stress responsivity have also been reported and compared to findings in men, but results have been somewhat inconsistent (Kirschbaum et al., 1999; Schoofs and Wolf, 2009).”
Quote in the paperNot a substantial claim0 of 2 sources checkedMay combine two claims.
InterpretationreasoningThe results raise the possibility that ovarian hormones protect memory from cortisol's impairing effects, or that luteal-phase glucocorticoid sensitivity is lower.
“These findings suggest a possible protective effect of ovarian hormones against the impairing effects of cortisol on memory, or given previous findings (Schoofs and Wolf, 2009), they may reflect reduced glucocorticoid sensitivity during the luteal phase.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Schoofs and Wolf, 2009 source
May combine two claims.
Interpretationown dataFollicular-phase women showed stronger cortisol reactivity, and within that phase higher cortisol went with worse memory performance.
“Generally then, these findings indicate that cortisol responsivity is heightened in the follicular phase and that heightened cortisol levels during that phase negatively relate to memory performance.”
Quote in the paperSubstantial claimMay combine two claims.
Study design and conductown dataEven with the missing cortisol data, menstrual cycle effects remained detectable in the continuous primary analysis and the categorical responder analysis.
“Despite this loss, we were able to detect significant menstrual cycle effects both in our primary analysis of continuous cortisol outcomes and in our secondary analysis of categorical outcomes (i.e., responders versus non-responders).”
Quote in the paperSubstantial claim- Rests on an assumption: Missing cortisol values caused by the freezer malfunction are missing at random and do not bias the cortisol findings.
May combine two claims.
Interpretationown dataMenstrual phase affects cortisol responses to a lab stressor, while it does not affect self-reported anxiety or stress.
“The present findings indicate that menstrual phase influences cortisol levels following a laboratory stressor, but does not influence subjective ratings of anxiety or stress.”
- Also stated in: § Conclusions · hedged
“The present findings indicate that menstrual phase influences cortisol responsivity to a laboratory stressor, but does not influence subjective ratings of anxiety or stress.”
Quote in the paperSubstantial claim- Also stated in: § Conclusions · hedged
Classified as probably not a substantial claim.
PremisecitationOvarian steroid hormones might protect against stress-induced impairments in emotional retrieval.
“Menstrual cycle studies suggest that ovarian steroid hormones might protect against stress-induced impairments in emotional retrieval (Schoofs and Wolf, 2009).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Schoofs and Wolf, 2009 source
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenA freezer malfunction caused missing cortisol data for six women: one luteal and five follicular.
“Due to a malfunctioning freezer, cortisol levels were missing on six women, including one woman in the luteal group and five women in the follicular group.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductown dataWomen reporting mood or anxiety disorders were excluded, and questionnaire scores for mood and anxiety were in the normal range.
“In the present study, we screened out women with a reported history of mood and anxiety disorders, and questionnaires indicated that mood and anxiety levels were within normal limits.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataBecause cortisol and emotional memory were negatively correlated in the follicular phase, the authors argue stress rather than fatigue or low motivation caused the post-stress retrieval impairment.
“However, the fact that there was a significant negative correlation between cortisol and emotional memory performance during the follicular phase, when most women showed a cortisol response, suggests that it was the stress and not those other factors that accounted for the impaired emotional retrieval after stress.”
Quote in the paperSubstantial claim
The paper relies on this without support.
The 20-minute control condition used in the study was non-stressful.
“A 20-minute non-stressful control condition was employed in this study in which participants completed a series of questionnaires relating to mood, symptoms and lifestyle habits.”
The paper relies on this without support.
Cortisol levels vary minimally between 1:00 pm and 5:00 pm.
“The two consecutive test sessions for all participants were scheduled between 1:00 pm and 5:00 pm due to the minimal variation in cortisol during that time of day.”
The paper relies on this without support.
Having the control condition always precede the stress condition does not confound the comparison between conditions.
“The control condition always preceded the stress condition.”
The paper relies on this without support.
Missing cortisol values caused by the freezer malfunction are missing at random and do not bias the cortisol findings.
“Due to a malfunctioning freezer, cortisol levels were missing on six women, including one woman in the luteal group and five women in the follicular group.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Maki et al. (2015) found that menstrual cycle phases influenced cortisol response to laboratory psychosocial stress, with women in the luteal phase having higher progesterone and estradiol and lower cortisol reactivity to the stressor than follicular phase women.
“Maki et al. (2015) also found that menstrual cycle phases influenced cortisol response to laboratory psychosocial stress, however, in their study, compared to women in the follicular phase, women in the luteal phase had higher levels of progesterone and estradiol and lower cortisol reactivity to the stressor.”
From The relationship between the menstrual cycle and cortisol secretion: Daily and stress-invoked cortisol patterns (2018) · cites this paper as Maki et al. (2015)
Statistics that don’t add up
Each reported p-value recomputed from its test statistic and degrees of freedom.
Inconsistent p-value: F(1, 76) = 4.54, p < .01
MinorThe paper reports p < .01 here; recomputing from the test statistic and its degrees of freedom gives p = .036. The check cannot tell whether the statistic or the p-value is the misprint.
Reported p < .01 · recomputed p = .036
“F(1, 76) = 4.54, p < 0.01”
Inconsistent p-value: F(1, 32) = 0.05, p = .81
MinorThe paper reports p = .81 here; recomputing from the test statistic and its degrees of freedom gives p = .824. The check cannot tell whether the statistic or the p-value is the misprint.
Reported p = .81 · recomputed p = .824
“F(1, 32) = 0.05, p = 0.81”
Statistics recomputed
Every reported test result, recomputed from its test statistic and degrees of freedom. A result shows as not adding up only once an independent check has confirmed it.
- Doesn’t add upF(1, 32) = 0.05reported p = .81 · recomputed p = .824
“F(1, 32) = 0.05, p = .81”
- Doesn’t add upF(1, 76) = 4.54reported p < .01 · recomputed p = .036
“F(1, 76) = 4.54, p < .01”
- ConsistentF(1, 32) = 11.12reported p = .002 · recomputed p = .002
“F(1, 32) = 11.12, p = .002”
- ConsistentF(1, 32) = 7.87reported p = .008 · recomputed p = .008
“F(1, 32) = 7.87, p = .008”
- ConsistentF(1, 32) = 5.61reported p = .02 · recomputed p = .024
“F(1, 32) = 5.61, p = .02”
- ConsistentF(2, 64) = 14.54reported p < .001 · recomputed p < .001
“F(2, 64) = 14.54, p < .001”
- ConsistentF(2, 64) = 2.79reported p = .09 · recomputed p = .069
“F(2, 64) = 2.79, p = .09”
The paper states a sphericity correction
- ConsistentF(1, 38) = 41.31reported p < .001 · recomputed p < .001
“F(1, 38) = 41.31, p < .001”
- ConsistentF(2, 76) = 25.05reported p < .001 · recomputed p < .001
“F(2, 76) = 25.05, p < .001”
- ConsistentF(2, 76) = 24.89reported p < .001 · recomputed p < .001
“F(2, 76) = 24.89, p < .001”
- ConsistentF(2, 76) = 84.74reported p < .001 · recomputed p < .001
“F(2, 76) = 84.74, p < .001”
- ConsistentF(2, 76) = 0.2reported n.s. · recomputed p = .819
“F(2, 76) = 0.20, ns.”
- ConsistentF(1, 76) = 110.01reported p < .001 · recomputed p < .001
“F(1, 76) = 110.01, p < .001”
- ConsistentF(1, 76) = 25.09reported p < .001 · recomputed p < .001
“F(1, 76) = 25.09, p < .001”
- ConsistentF(1, 38) = 24.2reported p < .001 · recomputed p < .001
“F(1, 38) = 24.20, p < .001”
- ConsistentF(2, 76) = 23reported p < .001 · recomputed p < .001
“F(2, 76) = 23.00, p < .001”
- ConsistentF(2, 76) = 16.81reported p < .001 · recomputed p < .001
“F(2, 76) = 16.81, p < .001”
- ConsistentF(1, 38) = 36.2reported p < .001 · recomputed p < .001
“F(1, 38) = 36.20, p < .001”
- ConsistentF(2, 76) = 30.25reported p < .001 · recomputed p < .001
“F(2, 76) = 30.25, p < .001”
- ConsistentF(2, 76) = 16.69reported p < .001 · recomputed p < .001
“F(2, 76) = 16.69, p < .001”
- ConsistentF(1, 38) = 4.29reported p = .045 · recomputed p = .045
“F(1, 38) = 4.29, p = .045”
- ConsistentF(2, 76) = 8.24reported p = .001 · recomputed p < .001
“F(2, 76) = 8.24, p = .001”
- ConsistentF(1, 76) = 7.82reported p < .05 · recomputed p = .007
“F(1, 76) = 7.82, p < .05”
- ConsistentF(1, 76) = 2.6reported n.s. · recomputed p = .111
“F(1, 76) = 2.60, ns”
- ConsistentF(1, 76) = 1.4reported n.s. · recomputed p = .240
“F(1, 76) = 1.40, ns”
- ConsistentF(1, 38) = 1.91reported p = .17 · recomputed p = .175
“F(1, 38) = 1.91, p = .17”
- ConsistentF(2, 76) = 2.77reported p = .07 · recomputed p = .069
“F(2, 76) = 2.77, p = .07”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Discussion reverses the reported luteal cortisol result
MajorThe Results state that the luteal group did not have a significant cortisol increase across conditions, but the Discussion describes that increase as significant.
“there was a significant stress-induced increase in cortisol in the luteal phase (albeit significantly lower than in the follicular phase)”
“the Luteal group did not show a significant increase in cortisol levels across conditions, F(1, 32) = 0.05, p = 0.81.”
Discussion reverses the luteal cortisol significance result
MajorThe discussion calls the luteal-phase cortisol increase significant, whereas the results explicitly report that it was not significant (p = 0.81).
“there was a significant stress-induced increase in cortisol in the luteal phase (albeit significantly lower than in the follicular phase)”
“whereas the Luteal group did not show a significant increase in cortisol levels across conditions, F(1, 32) = 0.05, p = 0.81.”
The labeled low cortisol concentration exceeds the high concentration
MinorIn the inter-assay concentration series, the value labeled low is 50 mg/dL, which is greater than the value labeled high, 4.12 mg/dL.
“low (50 mg/dL)”
“high (4.12 mg/dL)”
Maximum VAS rating exceeds the stated scale length
MinorTwo ratings on 10-cm lines can total at most 20 cm, not the stated 80 cm.
Reported 80 · recomputed 20
“At six timepoints concurrent with saliva sampling, participants completed a two-item Visual Analog Scale (VAS) measuring how “anxious” and “stressed” they felt on a 10-cm line (maximum distress rating = 80 cm).”
The labeled low cortisol concentration exceeds the labeled high concentration
MinorThe inter-assay concentration labeled low is 50 mg/dL, which is greater than the 4.12 mg/dL concentration labeled high.
“low (50 mg/dL) concentrations of cortisol”
“high (4.12 mg/dL), medium (1.51 mg/dL)”
Maximum visual-analog rating exceeds the scale length
MinorA two-item scale with each item marked on a 10-cm line has a maximum combined length of 20 cm, not 80 cm.
Reported 80 · recomputed 20
“participants completed a two-item Visual Analog Scale (VAS) measuring how “anxious” and “stressed” they felt on a 10-cm line (maximum distress rating = 80 cm).”
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BackgroundMethodResultInfluentialSex differences in HPA axis responses to stress: a review
Kudielka, B. M., & Kirschbaum, C. (2005) · Biological Psychology · doi:10.1016/j.biopsycho.2004.11.009 · Cited by 1,624 · cited 2× · see citing works
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“In general men show elevated cortisol responses to the TSST compared to women (Kudielka and Kirschbaum, 2005), but not all studies find a sex difference (Kudielka et al., 2004).”
BackgroundStress and memory: opposing effects of glucocorticoids on memory consolidation and memory retrieval
Roozendaal, B. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4080 · Cited by 838 · cited 2× · see citing works
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BackgroundAcute cortisone administration impairs retrieval of long-term declarative memory in humans
de Quervain, D. J.-F., Roozendaal, B., Nitsch, R. M., McGaugh, J. L., & Hock, C. (2000) · Nature Neuroscience · doi:10.1038/73873 · Cited by 745 · cited 1× · see citing works
“Similarly, glucocorticoid administration before memory retrieval produces a reliable, impairing effect in rodents (Roozendaal, 2002) and humans (de Quervain et al., 2000).”
BackgroundImpaired Memory Retrieval after Psychosocial Stress in Healthy Young Men
Kuhlmann, S., Piel, M., & Wolf, O. T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5139-04.2005 · Cited by 680 · cited 2× · see citing works
“In contrast, a more recent study found that women tested in the luteal phase (n = 36) showed a smaller increase in cortisol to the TSST compared to men (n = 19) (Kuhlmann et al., 2005b; Schoofs and Wolf, 2009).”
BackgroundResultKirschbaum, C., Prussner, J. C., Stone, A. A., Federenko, I., Gaab, J., Lintz, D., Schommer, N., & Hellhammer, D. H. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199509000-00009 · Cited by 666 · cited 1× · see citing works
“Although a within-subject design allows for greater control over individual differences in cortisol responsivity, a notable advantage of the between-subjects design is that cortisol responsivity to the TSST decreases significantly on the second administration (Kirschbaum et al., 1995).”
BackgroundCarpenter, L. L., Carvalho, J. P., Tyrka, A. R., Wier, L. M., Mello, A. F., Mello, M. F., Anderson, G. M., Wilkinson, C. W., & Price, L. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.002 · Cited by 564 · cited 1× · see citing works
“Individuals with a history of emotional trauma show blunted cortisol responses to the TSST (Carpenter et al., 2007).”
BackgroundStress and memory in humans: twelve years of progress?
Wolf, O. T. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.013 · Cited by 456 · cited 15× · see citing works
“To allow comparisons to previous work, we also conducted a responder analysis where a stress-related increase of 2.5 nmol/L defines a responder (see Statistical analysis section) (Schoofs and Wolf, 2009).”
BackgroundMethodResultInfluentialA meta-analytic review of the effects of acute cortisol administration on human memory
Het, S., Ramlow, G., & Wolf, O. T. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.03.005 · Cited by 414 · cited 2× · see citing works
“A reliable deficit in memory retrieval is observed when participants learn a list of words under normal conditions, and then several hours to days later are exposed to the TSST and are immediately asked to retrieve the words (Het et al., 2005).”
BackgroundHormonal Cycle Modulates Arousal Circuitry in Women Using Functional Magnetic Resonance Imaging
Goldstein, J. M., Jerram, M., Poldrack, R., Ahern, T., Kennedy, D. N., Seidman, L. J., & Makris, N. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2239-05.2005 · Cited by 368 · cited 2× · see citing works
“The authors attributed this pattern of effects to estradiol and indicated that estradiol assays were needed to definitively demonstrate this relationship (Goldstein et al., 2005).”
BackgroundThe relationship between stress induced cortisol levels and memory differs between men and women
Wolf, O. T., Schommer, N. C., Hellhammer, D. H., McEwen, B. S., & Kirschbaum, C. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00025-7 · Cited by 362 · cited 2× · see citing works
“sexes, with greater impairing effects in men compared to women (Wolf et al., 2001).”
BackgroundDe Quervain, D. J. ‐., Henke, K., Aerni, A., Treyer, V., McGaugh, J. L., Berthold, T., Nitsch, R. M., Buck, A., Roozendaal, B., & Hock, C. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02542.x · Cited by 342 · cited 1× · see citing works
“Cortisone administration before retrieval decreased regional cerebral blood flow in the right posterior medial temporal lobe in men, particularly in the parahippocampal gyrus (de Quervain et al., 2003).”
BackgroundBeta-adrenergic Modulation of Cognitive Flexibility during Stress
Alexander, J. K., Hillier, A., Smith, R. M., Tivarus, M. E., & Beversdorf, D. Q. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.3.468 · Cited by 306 · cited 1× · see citing works
“Both conditions were interrupted at 11, 14, and 16 min into the condition to complete a 1-minute cognitive flexibility task at each interruption (data not shown) (Alexander et al., 2007).”
MethodRoozendaal, B., Hahn, E. L., Nathan, S. V., de Quervain, D. J.-F., & McGaugh, J. L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2574-04.2004 · Cited by 301 · cited 1× · see citing works
“Studies in male rats indicate that cortisone-induced impairments in retrieval are mediated, at least in part, by noradrenergic activity in the hippocampus and basolateral amygdala (Roozendaal et al., 2004a, 2004b).”
BackgroundTask and Content Modulate Amygdala-Hippocampal Connectivity in Emotional Retrieval
Smith, A. P. R., Stephan, K. E., Rugg, M. D., & Dolan, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.025 · Cited by 252 · cited 1× · see citing works
“Neuroimaging studies in humans demonstrate that during emotional retrieval, the hippocampus and amygdala are active, functionally connected, and regulated by the orbitofrontal cortex (Smith et al., 2006).”
BackgroundOrbitofrontal cortex activity related to emotional processing changes across the menstrual cycle
Protopopescu, X., Pan, H., Altemus, M. M., Tüscher, O., Polanecsky, M., McEwen, B. S., Silbersweig, D., & Stern, E. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502818102 · Cited by 221 · cited 1× · see citing works
“Studies in premenopausal women suggest that estrogen may modulate changes in brain circuitry underlying processing of emotionally valent items (Amin et al., 2006; Goldstein et al., 2005; Protopopescu et al., 2005).”
BackgroundKuhlmann, S., Kirschbaum, C., & Wolf, O. T. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.09.001 · Cited by 217 · cited 2× · see citing works
“In contrast, a more recent study found that women tested in the luteal phase (n = 36) showed a smaller increase in cortisol to the TSST compared to men (n = 19) (Kuhlmann et al., 2005b; Schoofs and Wolf, 2009).”
BackgroundResultFluctuations in symptoms and moods during the menstrual cycle
Moos, R. H., Kopell, B. S., Melges, F. T., Yalom, I. D., Lunde, D. T., Clayton, R. B., & Hamburg, D. A. (1969) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(69)90017-8 · Cited by 190 · cited 2× · see citing works
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript behavioral change, arousal, and control (Moos et al., 1969).”
BackgroundPreventive Effect of β-Adrenoceptor Blockade on Glucocorticoid-Induced Memory Retrieval Deficits
de Quervain, D. J. ‐., Aerni, A., & Roozendaal, B. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.6.967 · Cited by 181 · cited 1× · see citing works
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript Quervain et al., 2007).”
BackgroundStress and emotional memory retrieval: Effects of sex and cortisol response
Buchanan, T. W., & Tranel, D. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.07.003 · Cited by 179 · cited 5× · see citing works
“Buchanan TW, Tranel D. Stress and emotional memory retrieval: effects of sex and cortisol response.”
BackgroundMethodResultInfluentialEffects of estrogen variation on neural correlates of emotional response inhibition
Amin, Z., Epperson, C. N., Constable, R. T., & Canli, T. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.03.013 · Cited by 163 · cited 1× · see citing works
“Studies in premenopausal women suggest that estrogen may modulate changes in brain circuitry underlying processing of emotionally valent items (Amin et al., 2006; Goldstein et al., 2005; Protopopescu et al., 2005).”
BackgroundMenstrual cycle modulation of the relationship between cortisol and long-term memory
Andreano, J. M., Arjomandi, H., & Cahill, L. F. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.009 · Cited by 156 · cited 3× · see citing works
“, Days 18–24) compared to the follicular phase (Andreano et al., 2008).”
BackgroundMethodCortisol and memory retrieval in women: influence of menstrual cycle and oral contraceptives
Kuhlmann, S., & Wolf, O. T. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0143-z · Cited by 142 · cited 2× · see citing works
“Like other studies that have examined cortisol effects in the follicular versus luteal phase (Andreano et al., 2008; Kirschbaum et al., 1999; Kuhlmann and Wolf, 2005), we used a between-subjects design.”
BackgroundMethodRoozendaal, B., de Quervain, D. J. ‐., Schelling, G., & McGaugh, J. L. (2003) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2003.10.001 · Cited by 128 · see citing works
Stress effects on declarative memory retrieval are blocked by a β-adrenoceptor antagonist in humans
Schwabe, L., Römer, S., Richter, S., Dockendorf, S., Bilak, B., & Schächinger, H. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.009 · Cited by 96 · cited 1× · see citing works
“Similarly, propranolol blocks the amnestic effects of the TSST on retrieval of emotional words in men (Schwabe et al., 2009).”
BackgroundAltemus, M. M., Redwine, L. S., Leong, Y.-M., MD, D. L. M., Ph.D, T. Y., Detera-Wadleigh, S. D., & Ph.D, R. Y. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00039-0 · Cited by 84 · cited 2× · see citing works
“Their interpretation was that glucocorticoid sensitivity is reduced during the luteal phase, a finding that is consistent with the observation that dexamethasone-induced suppression of plasma cortisol was lower in the luteal phase of the menstrual cycle compared to the follicular phase (Altemus et al., 1997).”
ResultAltemus, M. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00121-8 · Cited by 74 · see citing works
Stress and memory retrieval in women: No strong impairing effect during the luteal phase.
Schoofs, D., & Wolf, O. T. (2009) · Behavioral Neuroscience · doi:10.1037/a0015625 · Cited by 68 · cited 12× · see citing works
“To allow comparisons to previous work, we also conducted a responder analysis where a stress-related increase of 2.5 nmol/L defines a responder (see Statistical analysis section) (Schoofs and Wolf, 2009).”
BackgroundMethodResultInfluential
Flagged first, then by citations
2 of the 37 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Trier Social Stress Test: Principles and practice
Allen, A. P., Kennedy, P. J., Dockray, S., Cryan, J. F., Dinan, T. G., & Clarke, G. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.11.001 · Cited by 525 · see citing works
“…increase in cortisol in response to the TSST, and cortisol levels were only associated with impaired emotional retrieval during the follicular phase (Maki et al., 2015) The changes in stress response across the menstrual cycle were not significant in another study (Herbison et al., 2016).”
ResultSimultaneous measurement of salivary cortisol and alpha-amylase: Application and recommendations
Strahler, J., Skoluda, N., Kappert, M. B., & Nater, U. M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.015 · Cited by 254 · see citing works
“Women’s sCort responses to acute stress might be altered throughout the menstrual cycle, with lower responses in the luteal phase [74-76].”
BackgroundMethodStephens, M. A. C., Mahon, P. B., McCaul, M. E., & Wand, G. S. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.12.021 · Cited by 245 · see citing works
Heo, J.-Y., Kim, K., Fava, M., Mischoulon, D., Papakostas, G. I., Kim, M.-J., Kim, D. J., Chang, K.-A. J., Oh, Y., Yu, B.-H., et al. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.12.010 · Cited by 192 · see citing works
Poromaa, I. S., Comasco, E., Sumner, R. L., & Eileen Luders, A. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100856 · Cited by 199 · see citing works
Childhood adversity impact on gut microbiota and inflammatory response to stress during pregnancy
Hantsoo, L., Jašarević, E., Criniti, S., McGeehan, B., Tanes, C., Sammel, M. D., Elovitz, M. A., Compher, C., Wu, G., & Epperson, C. N. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.11.005 · Cited by 156 · see citing works
“Cortisol responder status was also calculated as a secondary measure of HPA axis response (Herbison et al., 2016; Maki et al., 2015; Schommer et al., 2003); cortisol responders were defined as those participants with a positive change from baseline to peak.”
Linares, N. F. N., Charron, V., Ouimet, A. J., Labelle, P., & Plamondon, H. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100235 · Cited by 146 · see citing works
An Introductory Guide to Conducting the Trier Social Stress Test.
Labuschagne, I., Grace, C., Rendell, P., Terrett, G., & Heinrichs, M. (2019) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.032 · Cited by 121 · see citing works
“, 2018), although this finding was in contrast to that of another study (Maki et al., 2015).”
ResultSex differences in stress regulation of arousal and cognition
Bangasser, D. A., Eck, S. R., Telenson, A. M., & Salvatore, M. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.09.025 · Cited by 133 · see citing works
Sex differences in stress effects on emotional learning
Merz, C. J., & Wolf, O. T. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23811 · Cited by 122 · see citing works
“In addition, exposure to stress also reduces memory retrieval in women examined in the follicular or luteal phase, even though the association between cortisol increase and memory was evident only in the follicular phase (Maki et al., 2015).”
BackgroundMontero-López, E., Santos-Ruiz, A., García-Ríos, M. C., Rodríguez-Blázquez, M., Rogers, H. L., & Peralta-Ramírez, M. I. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.03.021 · Cited by 113 · see citing works
Hamidovic, A., Karapetyan, K., Serdarevic, F., Choi, S. H., Eisenlohr-Moul, T., & Pinna, G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00311 · Cited by 99 · see citing works
Sex differences in the functional connectivity of the amygdalae in association with cortisol
Kogler, L., Müller, V. I., Seidel, E.-M., Boubela, R., Kalcher, K., Moser, E., Habel, U., Gur, R. C., Eickhoff, S. B., & Derntl, B. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.03.064 · Cited by 78 · see citing works
“…current study we did not induce a stressful, arousing situation and the missing difference between sexes and also between menstrual cycle phases in baseline cortisol are consistent with previous reports (Chung et al., 2016; Duchesne and Pruessner, 2013; Kirschbaum et al., 1999; Maki et al., 2015).”
Gervasio, J., Zheng, S., Skrotzki, C., & Pachete, A. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105626 · Cited by 79 · see citing works
The Menstrual Cycle Influences Emotion but Has Limited Effect on Cognitive Function.
Sundström-Poromaa, I. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.01.016 · Cited by 62 · see citing works
Nillni, Y. I., Rasmusson, A. M., Paul, E., & Pineles, S. L. (2021) · Current Psychiatry Reports · doi:10.1007/s11920-020-01221-9 · Cited by 60 · see citing works
Yamanaka, Y., Motoshima, H., & Uchida, K. (2018) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12042 · Cited by 49 · see citing works
“For seven female subjects, the TSST was only done during their follicular phase, since the significant cortisol response to the TSST was only demonstrated during the follicular phase but not the luteal phase.(25)”
MethodNey, L. J., Gogos, A., Hsu, C. K., & Felmingham, K. L. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104416 · Cited by 47 · see citing works
Hillerer, K. M., Slattery, D. A., & Pletzer, B. A. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100796 · Cited by 47 · see citing works
“, 2018), but also – most importantly – women’s hormonal status (Maki et al., 2015).”
Herbison, C. E., Henley, D., Marsh, J. A., Atkinson, H. C., Newnham, J. P., Matthews, S. G., Lye, S. J., & Pennell, C. E. (2016) · Stress · doi:10.3109/10253890.2016.1146672 · Cited by 49 · see citing works
“E-mail carly.herbison@uwa.edu.au Kirschbaum et al., 1999), in the follicular phase (Huang et al., 2015; Maki et al., 2015) or show no change (Childs et al., 2010; Duchesne & Pruessner, 2013).”
BackgroundCortisol reactivity and emotional memory after psychosocial stress in oral contraceptive users
Mordecai, K. L., Rubin, L. H., Eatough, E. M., Sundermann, E. E., Drogos, L. L., Savarese, A. M., & Maki, P. M. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23904 · Cited by 44 · see citing works
“…obtained in 40 naturally cycling women tested either in the follicular (n 5 20; low estradiol/low progesterone; Days 2–4) or midluteal phase (n 5 20; high estradiol/high progesterone; Days 22–24) where we demonstrated both a salivary cortisol and subjective response to the TSST (Maki et al., 2015).”
BackgroundResultInfluentialSelf-citationPsychosocial Stress Before a Nap Increases Sleep Latency and Decreases Early Slow-Wave Activity
Ackermann, S., Cordi, M. J., Marca, R. L., Seifritz, E., & Rasch, B. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00020 · Cited by 40 · see citing works
The Influence of Menstrual Cycle and Androstadienone on Female Stress Reactions: An fMRI Study
Chung, K., Peisen, F., Kogler, L., Radke, S., Turetsky, B., Freiherr, J., & Derntl, B. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00044 · Cited by 42 · see citing works
“Maki et al. (2015) demonstrated that the stress effect of the TSST on emotional retrieval was further related to individual differences in cortisol response in females during the follicular but not luteal phase (see also Het et al., 2005).”
BackgroundA Longitudinal Examination of Military Veterans’ Invictus Games Stress Experiences
Roberts, G. A., Arnold, R., Turner, J. E., Colclough, M., & Bilzon, J. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01934 · Cited by 35 · see citing works
Ethridge, P., Ali, N., Racine, S. E., Pruessner, J. C., & Weinberg, A. (2020) · Clinical Psychological Science · doi:10.1177/2167702620917463 · Cited by 32 · see citing works
“This was a design decision made in light of evidence that menstrual phase and hormonal contraceptive use have been shown to significantly influence physiological responses to stress (Duchesne & Pruessner, 2013; Maki et al., 2015; Roche et al., 2013; Villada et al., 2014).”
BackgroundMethodHlaváčová, N., Soláriková, P., Marko, M., Brezina, I., & Ježová, D. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.01.007 · Cited by 27 · see citing works
Steins‐Loeber, S., Lörsch, F., Seiferth, C., Müller, A., Brand, M., Duka, T., & Wolf, O. T. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05534-8 · Cited by 26 · see citing works
Gamsakhurdashvili, D., Antov, M. I., & Stockhorst, U. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.641250 · Cited by 26 · see citing works
Impact of endogenous and exogenous progesterone exposure on stress biomarkers: a systematic review
Stadler, A., Weidlinger, S., & Stute, P. (2019) · Climacteric · doi:10.1080/13697137.2019.1622085 · Cited by 23 · see citing works
Cook, C. J., Fourie, P. J., & Crewther, B. T. (2020) · Stress · doi:10.1080/10253890.2020.1860937 · Cited by 23 · see citing works
“…Trier Social Stress Test) on acute HPA dynamics, often indexed by cortisol, across the follicular and luteal phases (Childs et al., 2010; Hlavacova et al., 2008; Kirschbaum et al., 1996, 1999; Lane et al., 2015; Maki et al., 2015; Nakamura et al., 2011; Roca et al., 2003; Tersman et al., 1991).”
BackgroundHelpman, L. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105211 · Cited by 25 · see citing works
The gonadal response to social stress and its relationship to cortisol
Pletzer, B. A., Poppelaars, E. S., Klackl, J., & Jonas, E. (2021) · Stress · doi:10.1080/10253890.2021.1891220 · Cited by 22 · see citing works
“…cortisol response was observed during the high-hormone luteal phase of the menstrual cycle compared to low hormone phases (Kirschbaum et al., 1999; Altemus et al., 2001; Espin et al., 2013; Montero-L opez et al., 2018; Stephens et al., 2016; but see: Duchesne et al., 2012; Maki et al., 2015).”
BackgroundSex Differences in Aging and Associated Biomarkers
Thomas, N., Gurvich, C., & Kulkarni, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-25650-0_4 · Cited by 21 · see citing works
Sex-hormone status and emotional processing in healthy women
Gamsakhurdashvili, D., Antov, M. I., & Stockhorst, U. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105258 · Cited by 20 · see citing works
Mengelkoch, S., Gassen, J., Slavich, G. M., & Hill, S. E. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.10.033 · Cited by 22 · see citing works
“Though unexpected, others have also found disparate results when investigating women ’ s GC responses to stress (Maki et al., 2015; Sharma et al., 2020).”
Sex differences in stress reactivity after intranasal oxytocin in recreational cannabis users
Reed, S. C., Haney, M., Manubay, J. M., Campagna, B. R., Reed, B., Foltin, R. W., & Evans, S. M. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.11.008 · Cited by 20 · see citing works
“induced stress as indicated by increased negative subjective ratings and cardiovascular effects in recreational cannabis users relative to the NST, replicating previous studies across a range of populations (e.g., Kirschbaum et al., 1993; Dickerson and Kemeny, 2004; Foley and Kirschbaum, 2010; Maki et al., 2015; McQua…”
Active Shooter Training Drill Increases Blood and Salivary Markers of Stress
McAllister, M. J., Martaindale, M. H., & Rentería, L. I. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17145042 · Cited by 18 · see citing works
“Moreover, both males and females were involved in this study, which is also commonly done [9]; however, since menstrual cycle phase can impact cortisol responses to a stressor [24], this could also be viewed as a limitation.”
BackgroundSex differences in HIV effects on visual memory among substance-dependent individuals
Keutmann, M. K., González, R., Maki, P. M., Rubin, L. H., Vassileva, J., & Martin, E. M. (2016) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2016.1250869 · Cited by 17 · see citing works
“Additionally, cortisol levels are high in recently abstinent cocaine-dependent women (Fox, Hong, Siedlarz, & Sinha, 2008), and high levels of cortisol are associated with decreased memory performance, particularly when estrogen levels are low (Maki et al., 2015).”
BackgroundResultSelf-citationImpulsivity and Saliva Cortisol in Patients with Suicide Attempt and Controls
Lewitzka, U., Bauer, M., Ripke, B., Bronisch, T., & Günther, L. (2017) · Neuropsychobiology · doi:10.1159/000484664 · Cited by 16 · see citing works
Acute psychosocial stress modulates neural and behavioral substrates of cognitive control
Spencer, C., Mill, R. D., Bhanji, J. P., Delgado, M. R., Cole, M. W., & Tricomi, E. M. (2024) · Human Brain Mapping · doi:10.1002/hbm.26716 · Cited by 14 · see citing works
“This is an important factor to take into consideration in stress studies using cortisol measurement, given evidence suggesting that cortisol responsivity to acute stress varies based on menstrual cycle phase (Maki et al., 2015; Montero-López et al., 2018).”
BackgroundDziembowska, I., Wójcik, M., Hołyńska-Iwan, I., Litwic-Kamińska, K., Słomka, A., & Żekanowska, E. (2019) · Medicina · doi:10.3390/medicina55060258 · Cited by 16 · see citing works
“High levels of estradiol and progesterone during the luteal phase seem to alter cortisol release in response to socio-evaluative stressors by an easy return to initial values after a stressful situation [19].”
BackgroundCassiers, L., Niemegeers, P., Fransén, E., Morrens, M., Boer, P. D., Nueten, L. V., Claes, S. J., Sabbe, B., & Eede, F. V. D. (2019) · Brain Sciences · doi:10.3390/brainsci9120375 · Cited by 12 · see citing works
“The levels of proinflammatory cytokines [54,55] and HPA axis responsiveness to psychosocial stress [56,57] also vary with the different phases of the menstrual cycle.”
BackgroundSalivary Afternoon Cortisol and Relationship Status in Healthy Women With Regular Menstrual Cycles
Wilson, M. C., Lorenz, T. K., & Heiman, J. R. (2018) · Women s Reproductive Health · doi:10.1080/23293691.2018.1490079 · Cited by 11 · see citing works
“Nonetheless, additional studies have shown either greater salivary cortisol responses to stress in the follicular phase (Maki et al., 2015) or no difference in either phase (Duchesne & Pruessner, 2013; Ossewaarde et al., 2010).”
BackgroundAutomatic Detection of Subjective, Annotated and Physiological Stress Responses from Video Data
Norden, M., Wolf, O. T., Lehmann, L., Langer, K., Lippert, C., & Drimalla, H. (2022) · International Conference on Affective Computing and Intelligent Interaction and workshops · doi:10.1109/acii55700.2022.9953894 · Cited by 10 · see citing works
“As commonly done in stress studies, we only recruited male participants to exclude confounding factors resulting from general sex differences and menstrual cycle effects on cortisol and emotional responsivity [37], [38].”
BackgroundAvoidance Learning Across the Menstrual Cycle: A Conceptual Replication
Diekhof, E. K., Korf, S., Ott, F., Schädlich, C., & Holtfrerich, S. K. C. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00231 · Cited by 11 · see citing works
“Only two studies that assessed changes in stress responsivity across the menstrual cycle intentionally used a between-subjects design and compared the follicular and luteal phase (25) or the early follicular phase and the period around ovulation (26).”
BackgroundSocial Stress during the Estrus or Luteal Phase in Sheep
Freitas‐de‐Melo, A., Rodriguez, M. G. K., Crosa, C., & Ungerfeld, R. (2022) · Journal of Applied Animal Welfare Science · doi:10.1080/10888705.2021.2021408 · Cited by 10 · see citing works
“Therefore, the estrous phase might very well also modulate the sensitivity to stressors in farm species, as happens in humans and rodents (Maki et al. 2015, p. 205; Viau & Meaney, 1991).”
BackgroundWomen demonstrate lower markers of stress and oxidative stress during active shooter training drill
McAllister, M. J., & Martaindale, M. H. (2021) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100046 · Cited by 9 · see citing works
“In addition, menstrual cycle phase as well as oral contraceptive use can impact cortisol responses to stress [24].”
BackgroundRaju, S., Notaras, M. J., Grech, A. M., Schroeder, A., van den Buuse, M., & Hill, R. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105231 · Cited by 9 · see citing works
Kördel, M., Meier, M., Kühnel, A., & Kroemer, N. B. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100764 · Cited by 8 · see citing works
“…follicular and luteal phases of the menstrual cycle (Childs et al., 2010; De Souza et al., 1991; Galliven et al., 1997; Gordon and Girdler, 2014; Maki et al., 2015), and 2 compared women in the early follicular phase with those in the mid-cycle/ovulatory phase (Antov and Stockhorst, 2014;…”
InfluentialHormonal Responses and Jump Performance Across a Season in Collegiate Women Basketball Players
Luebbers, P. E., Andre, M. J., Fry, A. C., Olsen, L. A., Pfannestiel, K. B., & Čabarkapa, D. (2022) · Women in Sport and Physical Activity Journal · doi:10.1123/wspaj.2021-0048 · Cited by 8 · see citing works
Acute stress selectively blunts reward anticipation but not consumption: An ERP study
Yi, W., Chen, Y., Yan, L., Kohn, N., & Wu, J. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100583 · Cited by 8 · see citing works
“Female participants had regular menstrual cycles and were tested during their W. Yi et al. follicular phase (4 – 12 days after the cessation of the last menstrual period) to exclude the impact of the follicular phase (Hamidovic et al., 2020; Maki et al., 2015).”
Luo, Y., Li, J., Zhang, Y., & Pan, W. (2023) · Psychophysiology · doi:10.1111/psyp.14462 · Cited by 8 · see citing works
Effect of anticipatory stress on placebo alcohol consumption in a bar laboratory
Bernstein, M. H., & Wood, M. D. (2016) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2016.1209514 · Cited by 7 · see citing works
The Presence of a Pet Dog Is Associated with a More Balanced Response to a Social Stressor
Gandenberger, J., Ledreux, A., Taeckens, A., Murphy, K., Forkin, J., Gilmore, A., & Morris, K. N. (2024) · Stresses · doi:10.3390/stresses4030038 · Cited by 6 · see citing works
“We considered the participant age, gender, race/ethnicity, physical activity, and menstrual cycle phases as covariates, as these factors may have significant impacts on physiological responses to the TSST [44,52].”
Cardiovascular reactivity to acute stress: Attachment styles and invisible stranger support
McMahon, G., Creaven, A., & Gallagher, S. M. (2021) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2021.03.005 · Cited by 6 · see citing works
Maternal Stress Responses and Coping Following a NICU Experience
Doheny, K. K., Gardner, F. C., Ali, S., Fronheiser, B. J., MILLER, C. E., & Brelsford, G. M. (2025) · Children · doi:10.3390/children12060660 · Cited by 5 · see citing works
The effects of acute stress on attentional networks and working memory in females
Stone, C., Ney, L. J., Felmingham, K. L., Nichols, D. S., & Matthews, A. J. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113602 · Cited by 6 · see citing works
Exploration of possible sex bias in acute social stress research: a semi-systematic review
Rrapaj, A., Landau, A. M., & Winterdahl, M. (2023) · Acta Neuropsychiatrica · doi:10.1017/neu.2023.16 · Cited by 5 · see citing works
“Women in the follicular and luteal phases do not have the same salivary-free cortisol response (Maki et al., 2015).”
BackgroundAnno, T., Kawasaki, F., Shigemoto, R., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00751 · Cited by 4 · see citing works
“Moreover, in general, estradiol levels are higher in the luteal phases rather than in the follicular phases, and cortisol levels are higher in the follicular phases rather than in the luteal phases (11, 12).”
BackgroundEffects of menstrual cycle phase and ovulation on the salivary cortisol awakening response
Haase, L., Vehlen, A., Strojny, J., & Domes, G. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106669 · Cited by 4 · see citing works
Goulden, E. H., Gust, C. J., Bryan, A. D., & Knight, E. L. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2025.107579 · Cited by 3 · see citing works
Social evaluation under stress: Does acute stress affect social attributions and eye gaze?
Azulay, H., Guy, N., Shalev, I., Pertzov, Y., & Israel, S. (2021) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100093 · Cited by 3 · see citing works
“Some studies have observed that stressed females in the follicular phase showed a more attenuated cortisol response compared to females in the luteal phase [15], while others showed a stress-induced cortisol increase in the follicular phase, but not in the luteal phase [16].”
BackgroundWalker, J. K., Dillard, C. C., Gonzalez, D. E., Waldman, H. S., & McAllister, M. J. (2025) · Stress · doi:10.1080/10253890.2024.2449098 · Cited by 4 · see citing works
“Most studies have reported changes in cortisol across the MC phases (Hamidovic et al., 2020; Kulzhanova et al., 2023; Maki et al., 2015; Montero-López et al., 2018).”
Thompson, L. A., & White, B. L. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113560 · Cited by 2 · see citing works
Linares, N. F. N., Charron, V., Ouimet, A. J., Labelle, P., & Plamondon, H. (2020) · doi:10.31234/osf.io/9wtre · Cited by 2 · see citing works
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Chong, L. S., Mejia, T., Senich, K. L., Olezeski, C. L., & Gordis, E. B. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115146 · Cited by 1 · see citing works
Effect of Green Tea Amino Acid L-Theanine on Physiological Responses: A Protocol for Clinical Trial
Williams, J., D'Cunha, N. M., Anstice, N. S., McKune, A. J., & Naumovski, N. (2020) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2020.00048 · Cited by 1 · see citing works
The Role of Cortisol in Cognitive Emotion Regulation Failure
Tsumura, H. (2023) · Integrated science · doi:10.1007/978-3-031-15959-6_15 · Cited by 1 · see citing works
Efeito do cortisol e atividade física na qualidade do sono: uma revisão integrativa
da Silva, L. P., Lima, G. D. S. O., Cunha, T. S., Casali, K. R., & do Nascimento, M. A. (2024) · Saúde (Santa Maria) · doi:10.5902/2236583485825 · Cited by 1 · see citing works
Serio, B., Yilmaz, D., Pritschet, L., Grotzinger, H., Jacobs, E. G., Eickhoff, S. B., & Valk, S. L. (2025) · Imaging Neuroscience · doi:10.1162/imag_a_00474 · Cited by 1 · see citing works
“…varying and interacting effects of cortisol levels and perceived stress in females throughout the menstrual cycle ( Duchesne & Pruessner, 2013; Maki et al., 2015), as well as associations between resting functional connectivity and both testosterone and cortisol concentrations in males (…”
Stress, Memory, and Hormonal Influence: Considering Ovarian Hormones in Emotional Memory Intrusions
Daly, K. A., Tsytsurina, A., Mitnick, D. M., & Marshall, A. D. (2025) · Women · doi:10.3390/women5030025 · Cited by 1 · see citing works
Effects of Menstrual Cycle Phase and Stress on Spatial Navigational Strategy Use
McHale, A. L. (2020) · Open University of Cape Town (University of Cape Town) · Cited by 1 · see citing works
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The influence of exercise-induced dehydration on cognitive performance in women
Doohan, M. A. (2024) · Queensland University of Technology · doi:10.5204/thesis.eprints.249218 · Cited by 1 · see citing works
Gleich oder ungleich? Geschlechtsunterschiede hinsichtlich Stress und Stressbewältigung
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The presence of a pet dog is associated with a more balanced response to a social stressorPreprint
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Practical Significance of Rajaswala Paricharya in Modern Era
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“This suggests the possibility of different stress mechanisms between the participants, possibly in line with previous findings of varying psychophysiological effects of cortisol levels and perceived stress throughout the menstrual cycle [39, 40].”
BackgroundResultThe Poet is Speaking: A Case for Studying the Role of Auditory Imagery in Poetry-Elicited Emotions
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“…correlate with subjective reports of emotion, but show marked individual variability (Gendron & Barrett, 2009; Mauss & Robinson, 2009) and are in fl uenced by a wide range of unrelated internal (e.g., menstrual cycle; Maki et al., 2015) and external factors (e.g., temperature; Tang et al., 2021).”
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- Authors
- Maki, P. M., Mordecai, K. L., Rubin, L. H., Sundermann, E., Savarese, A., Eatough, E., & Drogos, L.
- Affiliations
- Rosalind Franklin University of Medicine and Science (US)
- University of Illinois Chicago (US)
- Corresponding author
- Maki, Pauline M.
- ORCID
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 74
- Pages
- 201-208
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC4876953
- OpenAlex
- W898822149
- Semantic Scholar
- 0b3a3888f211840d0da9f23c92082e5f76e883b0
- Cited by
- 87
- References
- 37
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 4 · 2023: 10 · 2022: 4 · 2021: 12 · 2020: 12 · 2019: 10 · 2018: 6 · 2017: 5 · 2016: 9 · 2015: 1
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (NIMH) (1K01MH098798-01)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (K12HD055892)
- National Institutes of Health Office of Research on Women's Health (ORWH)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- menstrual cycle, psychosocial stress, Trier Social Stress Test, estradiol, progesterone, luteal phase, follicular phase, sex hormones, stress-induced memory impairment
- MeSH terms
- Adolescent, Adult, Cognition, Emotions, Estradiol, Female, Humans, Hydrocortisone, Memory, Menstrual Cycle, Progesterone, Mental Recall, Stress, Psychological, Young Adult
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