Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection

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Dimers of mitochondrial ATP synthase form the permeability transition pore

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An uncoupling channel within the c-subunit ring of the F 1 F O ATP synthase is the mitochondrial permeability transition pore

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New roles for mitochondrial proteases in health, ageing and disease

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Postconditioning Inhibits Mitochondrial Permeability Transition

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The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

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Cyclophilin‐D binds strongly to complexes of the voltage‐dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

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Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel

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The Mitochondrial Permeability Transition, Release of Cytochrome c and Cell Death

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Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.

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Role of the c subunit of the F O ATP synthase in mitochondrial permeability transition

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Structure and Mechanisms of F-Type ATP Synthases

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Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

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The SLC25 Mitochondrial Carrier Family: Structure and Mechanism

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Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection

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Ischaemic Preconditioning Inhibits Opening of Mitochondrial Permeability Transition Pores in the Reperfused Rat Heart

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Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28

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Action of cyclosporine on mitochondrial calcium fluxes

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Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

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The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

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The Mitochondrial Phosphate Carrier Interacts with Cyclophilin D and May Play a Key Role in the Permeability Transition

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Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria.

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Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti‐apoptotic effects of melatonin

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Cyclophilin D Modulates Mitochondrial F0F1-ATP Synthase by Interacting with the Lateral Stalk of the Complex

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Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM

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Inhibition of the Mitochondrial Permeability Transition by the Nonimmunosuppressive Cyclosporin Derivative NIM811

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Loss of m-AAA protease in mitochondria causes complex I deficiency and increased sensitivity to oxidative stress in hereditary spastic paraplegia

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The non‐immunosuppressive cyclosporin DEBIO‐025 is a potent inhibitor of hepatitis C virus replication in vitro†

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The mitochondrial megachannel is the permeability transition pore

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Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology

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Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

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Modulation of the mitochondrial megachannel by divalent cations and protons.

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The inner mitochondrial membrane contains ion‐conducting channels similar to those found in bacteria

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The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

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Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP

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The cyclophilin inhibitor Debio 025 combined with PEG IFNα2a significantly reduces viral load in treatment-naïve hepatitis C patients #

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Chemical Modification of Arginines by 2,3-Butanedione and Phenylglyoxal Causes Closure of the Mitochondrial Permeability Transition Pore

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Protective Effects of NIM811 in Transient Focal Cerebral Ischemia Suggest Involvement of the Mitochondrial Permeability Transition

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Estrogen receptor beta modulates permeability transition in brain mitochondria

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Arginine 107 of yeast ATP synthase subunit g mediates sensitivity of the mitochondrial permeability transition to phenylglyoxal

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Why F-ATP Synthase Remains a Strong Candidate as the Mitochondrial Permeability Transition Pore

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Discovery, Synthesis, and Optimization of Diarylisoxazole‐3‐carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

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lncRNA Structure: Message to the Heart

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Patch clamp investigation into the phosphate carrier from Saccharomyces cerevisiae mitochondria

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Structural Basis for the Non-Immunosuppressive Character of the Cyclosporin A Analogue Debio 025

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Arg-8 of yeast subunit e contributes to the stability of F-ATP synthase dimers and to the generation of the full-conductance mitochondrial megachannel

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N‐Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

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NMR studies of an immunomodulatory benzodiazepine binding to its molecular target on the mitochondrial F1F0‐ATPase

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Novel mitochondrial transition pore inhibitor N‐methyl‐4‐isoleucine cyclosporin is a new therapeutic option in acute pancreatitis

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Modification of Permeability Transition Pore Arginine(s) by Phenylglyoxal Derivatives in Isolated Mitochondria and Mammalian Cells

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Is there a common binding center in the ADP, ATP carrier for substrate and inhibitors?

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SPG7 targets the m-AAA protease complex to process MCU for uniporter assembly, Ca2+ influx, and regulation of mitochondrial permeability transition pore opening

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Mechanisms for Ca 2+ -dependent permeability transition in mitochondria

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Deletion of Amino Acids 261−269 in the Brown Fat Uncoupling Protein Converts the Carrier into a Pore

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A novel class of cardioprotective small-molecule PTP inhibitors

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Mutations in the β-Subunit Thr159 and Glu184 of the Rhodospirillum rubrumF0F1 ATP Synthase Reveal Differences in Ligands for the Coupled Mg2+- and Decoupled Ca2+-dependent F0F1 Activities

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Second‐Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability

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Ligand-selective Modulation of the Permeability Transition Pore by Arginine Modification

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Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

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Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions

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Mitochondrial pores at the crossroad between cell death and inflammatory signaling

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Mitochondrial dysfunction in cardiovascular disease: Current status of translational research/clinical and therapeutic implications

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Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration

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The mitochondrial permeability transition: Nexus of aging, disease and longevity

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The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

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The mitochondrial permeability transition: Recent progress and open questions

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Mitochondrial Permeability Transition Pore Opening as a Promising Therapeutic Target in Cardiac Diseases

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The role of the mitochondrial permeability transition pore in heart disease

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From ATP to PTP and Back

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