The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Mapping photoautotrophic metabolism with isotopically nonstationary 13C flux analysis
Open accessAbstract
Understanding in vivo regulation of photoautotrophic metabolism is important for identifying strategies to improve photosynthetic efficiency or re-route carbon fluxes to desirable end products. We have developed an approach to reconstruct comprehensive flux maps of photoautotrophic metabolism by computational analysis of dynamic isotope labeling measurements and have applied it to determine metabolic pathway fluxes in the cyanobacterium Synechocystis sp. PCC6803. Comparison to a theoretically predicted flux map revealed inefficiencies in photosynthesis due to oxidative pentose phosphate pathway and malic enzyme activity, despite negligible photorespiration. This approach has potential to fill important gaps in our understanding of how carbon and energy flows are systemically regulated in cyanobacteria, plants, and algae.
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Cites
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Autotrophic carbon fixation in archaea
Berg, I. A., Kockelkorn, D., Ramos-Vera, W. H., Say, R. F., Zarzycki, J., Hügler, M., Alber, B. E., & Fuchs, G. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2365 · Cited by 719
CO2 CONCENTRATING MECHANISMS IN PHOTOSYNTHETIC MICROORGANISMS
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Metabolic networks in motion: 13 C‐based flux analysis
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METABOLIC CHANNELING IN PLANTS
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Elementary metabolite units (EMU): A novel framework for modeling isotopic distributions
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Self-citationFatty acid production in genetically modified cyanobacteria
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Cited by
Synthetic biology of cyanobacteria: unique challenges and opportunities
Berla, B. M., Saha, R., Immethun, C. M., Maranas, C. D., Moon, T. S., & Pakrasi, H. B. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00246 · Cited by 305
Detailing the optimality of photosynthesis in cyanobacteria through systems biology analysis
Nogales, J., Gudmundsson, S., Knight, E. M., Palsson, B. O., & Thiele, I. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117907109 · Cited by 301
Metabolic engineering of cyanobacteria for the synthesis of commodity products
Angermayr, S. A., Gorchs Rovira, A., & Hellingwerf, K. J. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.03.009 · Cited by 273
Cyanobacteria: Promising biocatalysts for sustainable chemical production
Knoot, C. J., Ungerer, J., Wangikar, P. P., & Pakrasi, H. B. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.815886 · Cited by 225
Engineering cyanobacteria for photosynthetic production of 3-hydroxybutyrate directly from CO2
Wang, B., Pugh, S., Nielsen, D. R., Zhang, W., & Meldrum, D. R. (2013) · Metabolic Engineering · doi:10.1016/j.ymben.2013.01.001 · Cited by 170
Metadata
- Authors
- Young, J. D., Shastri, A. A., Stephanopoulos, G., & Morgan, J. A.
- Venue
- Metabolic Engineering
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 13
- Issue
- 6
- Pages
- 656-665
- ISSN
- 1096-7176 (ISSN-L)
- OpenAlex
- W2142111857
- Cited by
- 346
- References
- 42
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
