Cited by 402Heart Rate Variability and Autonomic ControlCardiovascular Function and Risk FactorsCardiovascular Disease and Adiposity

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Heart rate variability in obesity and the effect of weight loss

Karason, Kristjan, Mølgaard, Henning, Wikstrand, John, Sjöström, Lars·1999·The American Journal of Cardiology

DOI 10.1016/s0002-9149(99)00066-1

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Abstract

To investigate the effects of obesity and weight loss on cardiovascular autonomic function, we examined 28 obese patients referred for weight-reducing gastroplasty, 24 obese patients who received dietary recommendations, and 28 lean subjects. Body weight, blood pressure, and 24-hour urinary norepinephrine excretion were measured, and time and frequency domain indexes of heart rate variability (HRV) were obtained from 24-hour Holter recordings. A measure of long-term HRV, the SD of all normal RR intervals (SDANN), was used as an index of sympathetic activity and the high-frequency (HF) component of the frequency domain, reflecting short-term HRV, as an estimate of vagal activity. All 3 study groups were investigated at baseline, and the 2 obese groups were reexamined at 1-year follow-up. Obese patients had higher blood pressure, higher urinary norepinephrine excretion, and attenuated SDANN and HF values than lean subjects (p <0.01). Obese patients treated with surgery had a mean weight loss of 32 kg (28%), whereas the obese group treated with dietary recommendations remained weight stable (p <0.001). At follow-up the weight-loss group displayed decreases in blood pressure and norepinephrine excretion and showed increments in SDANN and HF values. These changes were significantly greater than those observed in the obese control group (p <0.05). Our findings suggest that obese patients have increased sympathetic activity and a withdrawal of vagal activity and that these autonomic disturbances improve after weight loss.

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Authors: Karason, K., Mølgaard, H., Wikstrand, J., & Sjöström, L.
Affiliations: Sahlgrenska University Hospital (SE)
Aarhus University Hospital (DK)
Corresponding author: Karason, Kristjan
ORCID: Karason, Kristjan
Venue: The American Journal of Cardiology
Publisher: Elsevier BV
Published: 1999-04
Volume: 83
Issue: 8
Pages: 1242-1247
ISSN: 0002-9149 (ISSN-L)
DOI: 10.1016/s0002-9149(99)00066-1
OpenAlex: W2086229307
Cited by: 402
References: 31
Citations by year: 2026: 13 · 2025: 12 · 2024: 4 · 2023: 10 · 2022: 15 · 2021: 14 · 2020: 19 · 2019: 23 · 2018: 25 · 2017: 19 · 2016: 24 · 2015: 28 · 2014: 23 · 2013: 17 · 2012: 24
FWCI: 4.12
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The American Journal of Cardiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: heart rate variability, obesity, weight loss, cardiac autonomic function, sympathetic activity, parasympathetic activity, blood pressure, urinary norepinephrine, bariatric surgery, dietary weight loss, SDANN
MeSH terms: Adult, Blood Pressure, Circadian Rhythm, Diet, Female, Follow-Up Studies, Heart Rate, Humans, Male, Middle Aged, Norepinephrine, Obesity, Risk Factors, Gastroplasty, Weight Loss, Electrocardiography, Ambulatory, Body Mass Index

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Heart rate variability in obesity and the effect of weight loss

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