The DOI matches its Crossref record; 48 of the 50 references it cites were found in a registry or an index.
β-Secretase Activity Increases with Aging in Human, Monkey, and Mouse Brain
Open accessAbstract
Amyloid beta protein (A beta) accumulates in the brains of aging humans, amyloid precursor protein (APP) transgenic mouse lines, and rhesus monkeys. We tested the hypothesis that aging was associated with increased activity of the beta-site amyloid precursor protein cleaving enzyme (beta-secretase, BACE) in brain. We evaluated BACE activity, BACE protein, and formic acid-extractable A beta levels in cohorts of young (4 months old) and old (14 to 18 months old) nontransgenic mice (n = 16) and Tg2576 APP transgenic mice (n = 17), young (4.4 to 12.7 years old) and old (20.9 to 30.4 years old) rhesus monkeys (n = 17), and a wide age range (18 to 92 years old) of nondemented human brains (n = 25). Aging was associated with increased brain A beta levels in each cohort. Furthermore BACE activity increased significantly with age in mouse, monkey, and human brains, independent of brain region. BACE protein levels, however, were unchanged with age. BACE activity correlated with formic acid-extractable A beta levels in transgenic mouse, nontransgenic mouse, and human cortex, but not in monkey brain. These data suggest that an age-related increase of BACE activity contributes to the increased production and accumulation of brain A beta, and potentially predisposes to Alzheimer's disease in humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Previous studies consistently reported that expression and activity of BACE1 are increased during aging in the brains mice, rats and humans (Boissonneault et al. 2009, Che et al. 2014, Fukumoto et al. 2004, Rossner et al. 2006), raising the possibility of a link between aging-associated alterations in BACE1 and the increased risk for AD.”
From miR‐186 is decreased in aged brain and suppresses BACE 1 expression (2016) · cites this paper as Fukumoto et al. 2004
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876
Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516
HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542
Self-citationTwo amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507
Suzuki, N., Cheung, T. T., Cai, X.-D., Odaka, A., Otvos, L., Eckman, C., Golde, T. E., & Younkin, S. G. (1994) · Science · doi:10.1126/science.8191290 · Cited by 1,471
The prevalence of dementia: A quantitative integration of the literature
Jorm, A. F., Korten, A. E., & Henderson, A. S. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb02906.x · Cited by 1,301
Luo, Y., Bolon, B., Kahn, S., Bennett, B. D., Babu-Khan, S., Denis, P., Fan, W., Kha, H., Zhang, J., Gong, Y., et al. (2001) · Nature Neuroscience · doi:10.1038/85059 · Cited by 1,001
Price, J. L., Davis, P. B., Morris, J. C., & White, D. L. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90006-6 · Cited by 818
Cited by
Sorted by citations
Items 101–200 of 297
BACE2 Expression Increases in Human Neurodegenerative Disease
Holler, C. J., Webb, R. L., Laux, A. L., Beckett, T. L., Niedowicz, D. M., Ahmed, R. R., Liu, Y., Simmons, C. R., Dowling, A. L. S., Spinelli, A., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.09.034 · Cited by 66
Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome
Sun, X., Tong, Y., Qing, H., Chen, C.-H., & Song, W. (2006) · The FASEB Journal · doi:10.1096/fj.05-5628com · Cited by 64
Mukda, S., Panmanee, J., Boontem, P., & Govitrapong, P. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.04.013 · Cited by 62
miR-124 downregulates BACE 1 and alters autophagy in APP/PS1 transgenic mice
Du, X., Huo, X., Yang, Y., Hu, Z., Botchway, B. O. A., Jiang, Y., & Fang, M. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.08.082 · Cited by 64
BACE1 as a Potential Biomarker for Alzheimer's Disease
Decourt, B., & Sabbagh, M. N. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110017 · Cited by 62
BACE1 as a Therapeutic Target in Alzheimer’s Disease: Rationale and Current Status
Evin, G. M., & Hince, C. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0099-3 · Cited by 60
Biochemical deficits and cognitive decline in brain aging: Intervention by dietary supplements
Poddar, J., Pradhan, M., Ganguly, G., & Chakrabarti, S. (2018) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2018.04.002 · Cited by 63
Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer’s Disease
Song, W.-J., Son, M.-Y., Lee, H.-W., Seo, H., Kim, J. H., & Chung, S.-H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0136950 · Cited by 50
Protease inhibitors as potential disease-modifying therapeutics for Alzheimer’s disease
Beher, D., & Graham, S. L. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.11.1385 · Cited by 61
Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism
Lukiw, W. J., Pappolla, M., Pelaez, R. P., & Bazan, N. G. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-4010-6 · Cited by 59
Suzuki, T., Araki, Y., Yamamoto, T., & Nakaya, T. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj121 · Cited by 60
Naushad, M., Durairajan, S. S. K., Bera, A. K., Senapati, S., & Li, M. (2019) · Planta Medica · doi:10.1055/a-1019-9819 · Cited by 59
Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss
Burrinha, T., Martinsson, I., Gomes, R., Terrasso, A. P., Gouras, G. K., & Almeida, C. G. (2021) · Journal of Cell Science · doi:10.1242/jcs.255752 · Cited by 64
Functions of the Alzheimer’s Disease Protease BACE1 at the Synapse in the Central Nervous System
Munro, K. M., Nash, A., Pigoni, M., Lichtenthaler, S. F., & Gunnersen, J. M. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0800-1 · Cited by 59
Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models
Maia, L. F., Kaeser, S. A., Reichwald, J., Lambert, M., Obermüller, U., Schelle, J., Odenthal, J., Martus, P., Staufenbiel, M., & Jucker, M. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201505026 · Cited by 55
Youn, K., Lee, J., Ho, C., & Jun, M. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.10.036 · Cited by 53
Leuba, G., Wernli, G., Vernay, A., Kraftsik, R., Mohajeri, M. H., & Saini, K. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000083496 · Cited by 52
Gender dependent APP processing in a transgenic mouse model of Alzheimer’s disease
Schäfer, S., Wirths, O., Multhaup, G., & Bayer, T. A. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0580-9 · Cited by 52
Consequences of Pharmacological BACE Inhibition on Synaptic Structure and Function
Zhu, K., Peters, F., Filser, S., & Herms, J. W. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.04.022 · Cited by 52
New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease
Medina, M., & Ávila, J. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.843670 · Cited by 50
Ohno, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.007 · Cited by 51
Parsons, R. B., Price, G. C., Farrant, J. K., Subramaniam, D., Adeagbo-Sheikh, J., & Austen, B. (2006) · Biochemical Journal · doi:10.1042/bj20060655 · Cited by 50
APPandBACE1miRNA genetic variability has no major role in risk for Alzheimer disease
Bettens, K., Brouwers, N., Engelborghs, S., Miegroet, H. V., Deyn, P. P. D., Theuns, J., Sleegers, K., & Broeckhoven, C. V. (2009) · Human Mutation · doi:10.1002/humu.21027 · Cited by 50
Wang, H., He, J., Zhang, R., Zhu, S., Wang, J., Kong, L., Tan, Q., & Li, X. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.007 · Cited by 50
Early Molecular Changes in Alzheimer Disease: Can We Catch the Disease in its Presymptomatic Phase?
Wirz, K. T. S., Keitel, S., Swaab, D. F., Verhaagen, J., & Bossers, K. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130920 · Cited by 47
Li, Q.-Y., Wang, H.-M., Wang, Z., Ma, J., Ding, J., & Chen, S.-D. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.06.076 · Cited by 45
Wang, J., Ohno‐Matsui, K., & Morita, I. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.05.085 · Cited by 46
Leukotriene D4 induces amyloid-β generation via CysLT1R-mediated NF-κB pathways in primary neurons
Wang, X. Y., Tang, S. S., Hu, M. Y., Long, Y., Li, Y. Q., Liao, M. X., Ji, H., & Hong, H. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.01.002 · Cited by 46
Biomarkers of ageing of humans and non-human primates
Wu, Z., Qu, J. T., Zhang, W., Bao, Z., Bi, Y., Cai, J.-P., Cai, S.-Q., Cao, C.-M., Cao, F., Cao, Z., et al. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-025-00883-8 · Cited by 52
Peters, F., Salihoglu, H., Pratsch, K., Herzog, É., Pigoni, M., Sgobio, C., Lichtenthaler, S. F., Neumann, U., & Herms, J. W. (2019) · The EMBO Journal · doi:10.15252/embj.2019102345 · Cited by 44
Prion Protein is Reduced in Aging and in Sporadic but not in Familial Alzheimer's Disease
Whitehouse, I. J., Jackson, C. D., Turner, A. J., & Hooper, N. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101071 · Cited by 43
Alsaqati, M., Thomas, R. S., & Kidd, E. J. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx135 · Cited by 43
Whitehouse, I. J., Miners, J. S., Glennon, E. B. C., Kehoe, P. G., Love, S., Kellett, K. A. B., & Hooper, N. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059554 · Cited by 43
Cognitive aging and Alzheimer’s disease
Vandenberghe, R. R., & Tournoy, J. (2005) · Postgraduate Medical Journal · doi:10.1136/pgmj.2004.028290 · Cited by 45
The silence of the fats: A MAM’s story about Alzheimer
Agrawal, R. R., Montesinos, J., Larrea, D., Área-Gómez, E., & Pera, M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105062 · Cited by 42
BACE1 Inhibitors for Alzheimer’s Disease: Current Challenges and Future Perspectives
Coimbra, J. R. M., Resende, R., Custódio, J. B. A., Salvador, J. A. R., & Santos, A. E. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240146 · Cited by 43
Helmond, Z. V., Miners, J. S., Kehoe, P. G., & Love, S. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00374.x · Cited by 42
Mani, S., Dubey, R., Lai, I., Babu, M. A., Tyagi, S., Swargiary, G., Mody, D., Singh, M., Agarwal, S., Iqbal, D., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220700 · Cited by 43
Oxidation of ion channels in the aging nervous system
Patel, R., & Sesti, F. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.046 · Cited by 41
Kang, I., Jang, B. G., In, S., Choi, B., Kim, M., & Kim, M.-J. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.09.013 · Cited by 39
Zhang, H., Wang, P., Xue, Y., Liu, L., Li, Z., & Liu, Y. (2017) · Tissue and Cell · doi:10.1016/j.tice.2017.11.002 · Cited by 39
Fan, Y., Luo, R., Su, L., Xiang, Q., Yu, D., Xu, L., Chen, J., Bi, R., Wu, D., Zheng, P., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170594 · Cited by 37
Memory and learning impairment induced by dexamethasone in senescent but not young mice
Yao, Y., Liu, D., Xu, D.-F., & Li, W. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.07.021 · Cited by 40
Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease
He, J., Luo, H., Yan, B., Yu, Y., Wang, H., Wei, Z., Zhang, Y., Xu, H., Tempier, A., Li, X., et al. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.001 · Cited by 37
Filling the void: a role for exercise-induced BDNF and brain amyloid precursor protein processing
MacPherson, R. E. K. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00255.2017 · Cited by 41
Svedružić, Ž. M., Popović, K., & Jengić, V. Š. (2013) · PLoS ONE · doi:10.1371/journal.pone.0050759 · Cited by 35
Biological basis for amyloidogenesis in Alzheimer’S disease
Андреева, Т. В., Lukiw, W. J., & Rogaev, E. I. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917020043 · Cited by 38
Banerjee, P., Sahoo, A., Anand, S., Bir, A., & Chakrabarti, S. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150514 · Cited by 37
Che, H., Sun, L.-H., Guo, F., Niu, H.-F., Su, X.-L., Bao, Y.-N., Fu, Z. D., Liu, H.-L., Hou, X., Yang, B.-F., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356646 · Cited by 35
Qin, X., Wang, Y., & Paudel, H. K. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.738849 · Cited by 33
Kim, J. H., Jung, H., Lee, Y., & Sohn, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.658860 · Cited by 33
Şatır, T. M., Agholme, L., Karlsson, A., Karlsson, M., Karila, P., Illes, S., Bergström, P., & Zetterberg, H. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00635-0 · Cited by 33
Vergallo, A., Houot, M., Cavedo, E., Lemercier, P., Vanmechelen, E., De Vos, A., Habert, M., Potier, M., Dubois, B., Lista, S., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.07.001 · Cited by 32
Yan, X., Xiong, K., Luo, X., Struble, R. G., & Clough, R. W. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21239 · Cited by 31
MAM and C99, key players in the pathogenesis of Alzheimer’s disease
Pera, M., Montesinos, J., Larrea, D., Agrawal, R. R., VELASCO, K. R., Stavrovskaya, I. G., Yun, T. D., & Área-Gómez, E. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.03.016 · Cited by 35
Shwe, T., Bo‐Htay, C., Ongnok, B., Chunchai, T., Jaiwongkam, T., Kerdphoo, S., Kumfu, S., Pratchayasakul, W., Pattarasakulchai, T., Chattipakorn, N., et al. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111465 · Cited by 32
Ghenimi, N., Alfos, S., Redonnet, A., Higueret, P., Pallet, V., & Enderlin, V. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02002.x · Cited by 31
Li, Z.-H., 650223,中国, 中. 昆., He, X., Li, H., He, R., Hu, X., 650204,中国, 中. 昆., 671000,中国, 大. 大., 200031,中国, 中., 650223,中国, 中. 昆., et al. (2020) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2020.088 · Cited by 32
Miners, J., Morris, S., Love, S., & Kehoe, P. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-101395 · Cited by 32
Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders
Marks, N., & Berg, M. J. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.06.020 · Cited by 30
Trafficking in neurons: Searching for new targets for Alzheimer's disease future therapies
Musardo, S., Saraceno, C., Pelucchi, S., & Marcello, E. E. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.07.019 · Cited by 29
Is It the Twilight of BACE1 Inhibitors?
Hrabinova, M., Pejchal, J., Kucera, T., Jun, D., Schmidt, M., & Soukup, O. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200503023323 · Cited by 28
Widespread distribution of reticulon-3 in various neurodegenerative diseases
Heath, J. E., Siedlak, S. L., Zhu, X., Lee, H., Thakur, A., Yan, R., Perry, G. L., Smith, M. A., & Castellani, R. J. (2010) · Neuropathology · doi:10.1111/j.1440-1789.2010.01107.x · Cited by 29
Cytokines and Cytokine Receptors Involved in the Pathogenesis of Alzheimers Disease
Nagae, T., & Araki, K. (2016) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000441 · Cited by 28
Syeda, T., & Cannon, J. R. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22694 · Cited by 30
Unmasking BACE1 in aging and age-related diseases
Bao, H., & Shen, Y. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.11.008 · Cited by 28
Tolédano, A., Álvarez, M. I., López-Rodríguez, A. B., Toledano‐Díaz, A., & Fernández, C. I. (2012) · Neurología (English Edition) · doi:10.1016/j.nrleng.2012.07.002 · Cited by 29
Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines
Pop, V., Head, E., Berchtold, N. C., Glabe, C. G., Studzinski, C. M., Weidner, A. M., Murphy, M. P., & Cotman, C. W. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.02.008 · Cited by 31
Aging impact on amyloid precursor protein neuronal trafficking
Burrinha, T., & Guimas Almeida, C. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102524 · Cited by 26
Cui, J., Ait‐Ghezala, G., Sambamurti, K., Gao, F., Shen, Y., & Li, R. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0864-20.2021 · Cited by 26
Design and characterization of a new cell‐permeant inhibitor of the β‐secretase BACE1
Lefranc‐Jullien, S., Lisowski, V., Hernandez, J., Martínez, J., & Checler, F. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706183 · Cited by 26
Gandy, S., & Walker, L. C. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.08.002 · Cited by 27
Impaired autophagy in amyloid-beta pathology: A traditional review of recent Alzheimer's research
Yuan, M., Wang, Y., Huang, Z., Jing, F., Qiao, P., Zou, Q., Li, J., & Cai, Z. (2022) · Journal of Biomedical Research · doi:10.7555/jbr.36.20220145 · Cited by 26
Amyloid futures in the expanding pathology of brain aging and dementia
Thorwald, M. A., Silva, J. A., Head, E., & Finch, C. E. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12896 · Cited by 24
BACE Inhibitors for the Treatment of Alzheimer's Disease
Baxter, E. W., & Reitz, A. B. (2005) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(05)40003-2 · Cited by 25
β -Secretases, Alzheimer’s Disease, and Down Syndrome
Webb, R. L., & Murphy, M. P. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/362839 · Cited by 26
Pharmacological evaluation of bromelain in mouse model of Alzheimer’s disease
Kumar, R., Kumar, R., Sharma, N., Khurana, N., Singh, S. K., Satija, S., Mehta, M., & Vyas, M. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.02.009 · Cited by 24
Takasugi, N., Komai, M., Kaneshiro, N., Ikeda, A., Kamikubo, Y., & Uehara, T. (2023) · Cells · doi:10.3390/cells12030454 · Cited by 29
BACE 2 degradation mediated by the macroautophagy–lysosome pathway
Liu, X., Wang, Z., Wu, Y., Wang, J., & Song, W. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12204 · Cited by 24
Differential regulation of insulin signalling by monomeric and oligomeric amyloid beta-peptide
Molina-Fernández, R., Picón-Pagès, P., Barranco-Almohalla, A., Crepin, G., Herrera-Fernández, V., García-Elías, A., Fanlo-Ucar, H., Fernàndez‐Busquets, X., García‐Ojalvo, J., Oliva, B., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac243 · Cited by 23
Study on Aβ34 biology and detection in transgenic mice brains.
Caillava, C., Ranaldi, S., Lauritzen, I., Bauer, C., Fareh, J., Abraham, J.-D., & Checler, F. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.011 · Cited by 22
Age-associated changes of cerebrospinal fluid amyloid-β and tau in cynomolgus monkeys
Yue, F., Lu, C., Ai, Y., Chan, P., & Zhang, Z. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.139 · Cited by 23
Age‐dependent NMDA receptor function is regulated by the amyloid precursor protein
Rajão‐Saraiva, J., Dunot, J., Ribera, A., Temido‐Ferreira, M., Coelho, J. E., König, S., Moréno, S., Enguita, F. J., Willem, M., Kins, S., et al. (2023) · Aging Cell · doi:10.1111/acel.13778 · Cited by 25
Sinha, M. S., Bir, A., Banerjee, A., Bhowmick, P., & Chakrabarti, S. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.10.003 · Cited by 22
Parsons, R. B., & Austen, B. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350974 · Cited by 22
Rieche, F., Carmine-Simmen, K., Poeck, B., Kretzschmar, D., & Strauß, R. (2018) · Current Biology · doi:10.1016/j.cub.2018.01.077 · Cited by 25
Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer’s disease
Xia, Y., Wang, Z.-H., Zhang, Z., Liu, X., Yu, S. P., Wang, J., Wang, X., & Ye, K. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102113 · Cited by 21
Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease
Bettegazzi, B., Monasor, L. S., Bellani, S., Codazzi, F., Restelli, L. M., Colombo, A. V., Deigendesch, N., Frank, S., Saito, T., Saido, T. C., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04062-3 · Cited by 20
Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta
Zhang, C., Jia, Q., Zhu, L., Hou, J., Wang, X., Li, D., Zhang, J., Zhang, Y., Su, Y., Tu, Z., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14122 · Cited by 19
Regulation of amyloid-β production by the prion protein
Jarosz-Griffiths, H., Whitehouse, I. J., & Hooper, N. M. (2012) · Prion · doi:10.4161/pri.18988 · Cited by 23
Chatterjee, G., Roy, D., Khemka, V. K., Chattopadhyay, M., & Chakrabarti, S. (2015) · Aging and Disease · doi:10.14336/ad.2015.0327 · Cited by 20
Upregulation of Aβ42 in the Brain and Bodily Fluids of Rhesus Monkeys with Aging
Zhao, Q., Lü, J., Yao, Z., Wang, S., Zhu, L., Wang, J., & Chen, B. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0840-6 · Cited by 20
New players in old amyloid precursor protein‐processing pathways
Roßner, S. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.07.004 · Cited by 20
Cholesterol and 24S-hydroxycholesterol trafficking in Alzheimer’s disease
Lukiw, W. J. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.5.683 · Cited by 20
Li, X., Wang, F., Chen, G., Li, X., Yang, Q., Cao, L., & Yan, W.-W. (2016) · AGE · doi:10.1007/s11357-016-9920-3 · Cited by 20
Svedružić, Ž. M., Popović, K., Smoljan, I., & Jengić, V. Š. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032293 · Cited by 18
Ulku, I., Leung, R., Herre, F., Walther, L., Shobo, A., Säftig, P., Hancock, M. A., Liebsch, F., & Multhaup, G. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107510 · Cited by 20
Increased BACE1 activity inhibits peripheral nerve regeneration after injury
Tallon, C., Rockenstein, E. M., Masliah, E., & Farah, M. H. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.07.003 · Cited by 18
Expression Analysis of BDNF, BACE1, and Their Natural Occurring Antisenses in Autistic Patients
Ghafouri-Fard, S., Namvar, A., Arsang-Jang, S., Komaki, A., & Taheri, M. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01432-7 · Cited by 17
From reaction kinetics to dementia: A simple dimer model of Alzheimer’s disease etiology
Lindstrom, M. R., Chavez, M. B., Gross-Sable, E. A., Hayden, E. Y., & Teplow, D. B. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009114 · Cited by 19
Metadata
- Authors
- Fukumoto, H., Rosene, D. L., Moss, M. B., Raju, S., Hyman, B. T., & Irizarry, M. C.
- Affiliations
- Massachusetts General Hospital (US)
- Boston University (US)
- Corresponding author
- Irizarry, Michael C.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 164
- Issue
- 2
- Pages
- 719-725
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC1602259
- OpenAlex
- W2076868543
- Cited by
- 294
- References
- 50
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 11 · 2023: 13 · 2022: 13 · 2021: 11 · 2020: 12 · 2019: 10 · 2018: 10 · 2017: 13 · 2016: 16 · 2015: 16 · 2014: 8 · 2013: 23 · 2012: 18
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal Of Pathology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Boston University (RR00165, PHS MH/NS 31862)
- National Institutes of Health (AG05134, AG15453, AG00001)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- beta-secretase, brain aging, amyloid-beta deposition, amyloid precursor protein, Alzheimer's disease, rhesus monkeys, human brain, cerebral cortex
- MeSH terms
- Aging, Animals, Brain, Enzyme-Linked Immunosorbent Assay, Humans, Macaca mulatta, Mice, Transgenic, Blotting, Western, Amyloid beta-Peptides, Aspartic Acid Endopeptidases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review