Cyclooxygenase knockout mice

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

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Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

Eberhart, C. E., Coffey, R. J., Aramandla, R., Giardiello, F. M., Ferrenbach, S., & DuBois, R. N. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90246-1 · Cited by 2,512

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

Oshima, M., Dinchuk, J. E., Kargman, S., Oshima, H., Hancock, B. C., Kwong, E. C., Trzăskos, J. M., Evans, J. F., & Taketo, M. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81988-1 · Cited by 2,363

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

Tsujii, M., & DuBois, R. N. (1995) · Cell · doi:10.1016/0092-8674(95)90127-2 · Cited by 2,292

Cyclooxygenase regulates angiogenesis induced by colon cancer cells

Tsujii, M., Kawano, S., Tsuji, S., Sawaoka, H., Hori, M., & DuBois, R. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81433-6 · Cited by 2,272

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

Smith, W. L., Garavito, R. M., & DeWitt, D. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33157 · Cited by 1,973

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

Kujubu, D. A., Fletcher, B. S., Varnum, B. C., Lim, R. W., & Herschman, H. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98774-0 · Cited by 1,786

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

Xie, W. L., Chipman, J. G., Robertson, D. L., Erikson, R. L., & Simmons, D. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2692 · Cited by 1,707

Prostaglandins and Inflammation

Ricciotti, E., & FitzGerald, G. A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207449 · Cited by 4,035

Cyclooxygenases: Structural, cellular, and molecular biology

Smith, W. L., DeWitt, D. L., & Garavito, R. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.145 · Cited by 2,925

Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

Simmons, D. L., Botting, R. M., & Hla, T. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.3.3 · Cited by 1,718

Nonsteroidal Anti-inflammatory Drugs as Anticancer Agents: Mechanistic, Pharmacologic, and Clinical Issues

Thun, M. J., Henley, S. J., & Patrono, C. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.4.252 · Cited by 1,430

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

North, T. E., Goessling, W., Walkley, C. R., Lengerke, C., Kopani, K. R., Lord, A. M., Weber, G. J., Bowman, T. V., Jang, I. H., Großer, T., et al. (2007) · Nature · doi:10.1038/nature05883 · Cited by 1,095

Cyclooxygenases: structural and functional insights

Rouzer, C. A., & Marnett, L. J. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800042-jlr200 · Cited by 690

Synopsis of arachidonic acid metabolism: A review

Hanna, V. S., & HAFEZ, E. A. A. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2018.03.005 · Cited by 614

Cyclooxygenase-2—10 Years Later

Hinz, B., & Brune, K. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.2.367 · Cited by 517

Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice.

Chulada, P. C., Thompson, M. B., Mahler, J. F., Doyle, C. M., Gaul, B. W., Lee, C., Tiano, H. F., Morham, S. G., Smithies, O., & Langenbach, R. J. (2000) · PubMed · Cited by 496

Signalling networks regulating cyclooxygenase-2

Tsatsanis, C., Androulidaki, A., Venihaki, M., & Margioris, A. N. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.03.021 · Cited by 496

Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders

Phillis, J. W., Horrocks, L. A., & Farooqui, A. A. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.02.002 · Cited by 470

Knockouts model the 100 best-selling drugs—will they model the next 100?

Zambrowicz, B., & Sands, A. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd987 · Cited by 398

Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway

Murakami, M., & Kudo, I. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00037-7 · Cited by 376

The COX-2 pathway is essential during early stages of skeletal muscle regeneration

Bondesen, B. A., Mills, S. T., Kegley, K. M., & Pavlath, G. K. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00088.2004 · Cited by 300

Biochemistry of Cyclooxygenase (COX)-2 Inhibitors and Molecular Pathology of COX-2 in Neoplasia

Fosslien, E. (2000) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360091174286 · Cited by 294

Cyclooxygenase in normal human tissues – is COX‐1 really a constitutive isoform, and COX‐2 an inducible isoform?

Zidar, N., Odar, K., Glavač, D., Jerše, M., Zupanc, T., & Štajer, D. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00430.x · Cited by 255

Cyclooxygenase inhibitors: From pharmacology to clinical read-outs

Patrignani, P., & Patrono, C. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.016 · Cited by 244

NSAIDs and Chemoprevention

Rao, C. V., & Reddy, B. S. (2004) · Current Cancer Drug Targets · doi:10.2174/1568009043481632 · Cited by 226

Raging the War Against Inflammation With Natural Products

Attiq, A., Jalil, J., Husain, K., & Ahmad, W. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00976 · Cited by 222

In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats

Brideau, C., van Staden, C., & Chan, C. (2001) · American Journal of Veterinary Research · doi:10.2460/ajvr.2001.62.1755 · Cited by 210

Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin

Neufang, G., Fürstenberger, G., Heidt, M., Marks, F., & Müller‐Decker, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121574098 · Cited by 204

CCAAT/enhancer binding protein-β is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling

Zhu, S., Yoon, K., Sterneck, E., Johnson, P. F., & Smart, R. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012437299 · Cited by 199

Allergic lung responses are increased in prostaglandin H synthase–deficient mice

Gavett, S. H., Madison, S. L., Chulada, P. C., Scarborough, P. E., Qu, W., Boyle, J. E., Tiano, H. F., Lee, C. A., Langenbach, R. J., Roggli, V. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6890 · Cited by 196

Distribution and function of prostanoid receptors: studies from knockout mice

Sugimoto, Y., Narumiya, S., & Ichikawa, A. (2000) · Progress in Lipid Research · doi:10.1016/s0163-7827(00)00008-4 · Cited by 192

p38/NF‐kB‐dependent expression of COX‐2 during differentiation and inflammatory response of chondrocytes

Ulivi, V., Giannoni, P., Gentili, C., Cancedda, R., & Descalzi, F. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21717 · Cited by 188

Vomitoxin-Induced Cyclooxygenase-2 Gene Expression in Macrophages Mediated by Activation of ERK and p38 but Not JNK Mitogen-Activated Protein Kinases

Moon, Y. (2002) · Toxicological Sciences · doi:10.1093/toxsci/69.2.373 · Cited by 161

NSAID–Gut Microbiota Interactions

Maseda, D., & Ricciotti, E. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01153 · Cited by 174

Genetic deletion or pharmacological inhibition of cyclooxygenase‐1 attenuate lipopolysaccharide‐ induced inflammatory response and brain injury

Choi, S., Langenbach, R. I., & Bosetti, F. (2007) · The FASEB Journal · doi:10.1096/fj.07-9411com · Cited by 159

Cyclooxygenase-2 in oncogenesis

Rizzo, M. T. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.12.026 · Cited by 155

Highly Unsaturated (n-3) Fatty Acids, but Not α-Linolenic, Conjugated Linoleic or γ-Linolenic Acids, Reduce Tumorigenesis in Apc Mice

Petrik, M. B. H., Johnson, B. T., Whelan, J. N., McEntee, M. F., & Obukowicz, M. G. (2000) · Journal of Nutrition · doi:10.1093/jn/130.10.2434 · Cited by 142

Multiple NSAID-Induced Hits Injure the Small Intestine: Underlying Mechanisms and Novel Strategies

Boelsterli, U. A., Redinbo, M. R., & Saitta, K. S. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs310 · Cited by 143

Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation

Tootle, T. L., & Spradling, A. C. (2008) · Development · doi:10.1242/dev.017590 · Cited by 142

Cyclooxygenase enzymes and prostaglandins in pathology of the endometrium

Sales, K. J., & Jabbour, H. N. (2003) · Reproduction · doi:10.1530/rep.0.1260559 · Cited by 177

Cyclooxygenase-2 and inflammation in atherosclerosis

Linton, M. F. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.12.003 · Cited by 133

Targeting COX-2 expression by natural compounds: A promising alternative strategy to synthetic COX-2 inhibitors for cancer chemoprevention and therapy

Cerella, C., Sobolewski, C., Dicato, M., & Diederich, M. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.050 · Cited by 129

Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation

Weinberg, J. B. (2000) · Immunologic Research · doi:10.1385/ir:22:2-3:319 · Cited by 121

Bioactive lysolipids in cancer and angiogenesis

Hisano, Y., & Hla, T. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.07.006 · Cited by 121

Prostaglandins and bone metabolism

Choudhary, S., & Pilbeam, C. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00051-8 · Cited by 116

Dual Effect of Platelet Lysate on Human Articular Cartilage: A Maintenance of Chondrogenic Potential and a Transient Proinflammatory Activity Followed by an Inflammation Resolution

Pereira, R. C., Scaranari, M., Benelli, R., Strada, P., Reis, R. L., Cancedda, R., & Gentili, C. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0225 · Cited by 116

Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function

Wang, D., Patel, V. V., Ricciotti, E., Zhou, R., Levin, M. D., Gao, E., Zhou, Y., Ferrari, V. A., Lu, M. M., Xu, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805806106 · Cited by 117

Prostanoids and inflammatory pain.

Chen, L.-H., Yang, G.-R., & Grosser, T. (2013) · Prostaglandins & other lipid mediators · doi:10.1016/j.prostaglandins.2012.08.006 · Cited by 117

Susceptibility of Cyclooxygenase-2-Deficient Mice to Pulmonary Fibrogenesis

Bonner, J. C., Rice, A. B., Ingram, J. L., Moomaw, C. R., Nyska, A., Bradbury, A., Sessoms, A. R., Chulada, P. C., Morgan, D. L., Zeldin, D. C., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64202-2 · Cited by 113

MPP + ‐induced COX‐2 activation and subsequent dopaminergic neurodegeneration

Wang, T., Pei, Z., Zhang, W., Liu, B., Langenbach, R. I., Lee, C., Wilson, B. C., Reece, J. M., Miller, D. S., & Hong, J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2457fje · Cited by 113

Healthy animals and animal models of human disease(s) in safety assessment of human pharmaceuticals, including therapeutic antibodies

Dixit, R., & Boelsterli, U. A. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.02.018 · Cited by 112

Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2

Loftin, C. D., Tiano, H. F., & Langenbach, R. J. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00028-x · Cited by 111

Prostaglandin synthases: Molecular characterization and involvement in prostaglandin biosynthesis

Seo, M., & Oh, D. (2017) · Progress in Lipid Research · doi:10.1016/j.plipres.2017.04.003 · Cited by 110

Cyclooxygenase and prostaglandin synthases in atherosclerosis: Recent insights and future perspectives

Cipollone, F., Cicolini, G., & Bucci, M. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.01.002 · Cited by 112

The “Aspirin” of the New Millennium: Cyclooxygenase-2 Inhibitors

Buttar, N. S., & Wang, K. K. (2000) · Mayo Clinic Proceedings · doi:10.4065/75.10.1027 · Cited by 105

Stretch-induced myoblast proliferation is dependent on the COX2 pathway

Otis, J. S., Burkholder, T. J., & Pavlath, G. K. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.08.009 · Cited by 102

The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout mice

Darling, R. L., Romero, J. J., Dial, E. J., Akunda, J. K., Langenbach, R. J., & Lichtenberger, L. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.003 · Cited by 101

Prostaglandin receptors are mediators of vascular function in endometrial pathologies

Jabbour, H. N., Sales, K. J., Smith, O. P. M., Battersby, S., & Boddy, S. C. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.03.025 · Cited by 97

Effects of eccentric treadmill exercise on inflammatory gene expression in human skeletal muscle

Buford, T. W., Cooke, M. B., Shelmadine, B., Hudson, G. M., Redd, L., & Willoughby, D. S. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-067 · Cited by 91

Identification of CYP4F8 in Human Seminal Vesicles as a Prominent 19-Hydroxylase of Prostaglandin Endoperoxides

Bylund, J., Hidestrand, M., Ingelman‐Sundberg, M., & Oliw, E. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001712200 · Cited by 88

Cyclooxygenase enzymes and prostaglandins in reproductive tract physiology and pathology

Sales, K. J., & Jabbour, H. N. (2003) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s1098-8823(03)00050-9 · Cited by 85

Prostaglandins and Inflammation: The Cyclooxygenase Controversy

Morteau, O. (2001) · Springer eBooks · doi:10.1007/978-94-015-9702-9_6 · Cited by 85

Cyclooxygenase-2 Inhibits UVB-Induced Apoptosis in Mouse Skin by Activating the Prostaglandin E2 Receptors, EP2 and EP4

Chun, K., Akunda, J. K., & Langenbach, R. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3617 · Cited by 84

Role of cyclic AMP responsive element in the UVB induction of cyclooxygenase-2 transcription in human keratinocytes

Tang, Q., Chen, W., Gonzales, M. S., Finch, J. S., Inoue, H., & Bowden, G. T. (2001) · Oncogene · doi:10.1038/sj.onc.1204667 · Cited by 83

Roles of Akt and glycogen synthase kinase 3beta in the ultraviolet B induction of cyclooxygenase-2 transcription in human keratinocytes.

Tang, Q., Gonzales, M., Inoue, H., & Bowden, G. T. (2001) · PubMed · Cited by 84

PGE2-induced hypertrophy of cardiac myocytes involves EP4 receptor-dependent activation of p42/44 MAPK and EGFR transactivation

Méndez, M., & LaPointe, M. C. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00838.2004 · Cited by 80

PGE2 vs PGF2α in human parturition

Li, W.-J., Lu, J.-W., Zhang, C.-Y., Wang, W., Ying, H., Myatt, L., & Sun, K. (2020) · Placenta · doi:10.1016/j.placenta.2020.12.012 · Cited by 80

Cyclooxygenase-2 gene expression and regulation in human retinal pigment epithelial cells.

Chin, M. S., Nagineni, C. N., Hooper, L. C., Detrick, B., & Hooks, J. J. (2001) · PubMed · Cited by 80

Effects of MF-tricyclic, a selective cyclooxygenase-2 inhibitor, on atherosclerosis progression and susceptibility to cytomegalovirus replication in apolipoprotein-E knockout mice

Rott, D., Zhu, J., Burnett, M. S., Zhou, Y., Zalles-Ganley, A., Ogunmakinwa, J., & Epstein, S. E. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00304-8 · Cited by 79

Pretreatment with melatonin exerts anti‐inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model

Pei, Z., & Cheung, R. T. F. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00138.x · Cited by 79

Pharmacologic Inhibition of COX-1 and COX-2 in Influenza A Viral Infection in Mice

Carey, M. A., Bradbury, J. A., Rebolloso, Y. D., Graves, J. P., Zeldin, D. C., & Germolec, D. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011610 · Cited by 77

Anti-Inflammatory and Anticancer Properties of Birch Bark-Derived Betulin: Recent Developments

Tuli, H. S., Sak, K., Gupta, D., Kaur, G., Aggarwal, D., Parashar, N. C., Choudhary, R., Yerer, M. B., Kaur, J., Kumar, M., et al. (2021) · Plants · doi:10.3390/plants10122663 · Cited by 81

Role of cyclooxygenases COX-1 and COX-2 in modulating adipogenesis in 3T3-L1 cells

Yan, H., Kermouni, A., Abdel-Hafez, M., & Lau, D. C. W. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200357-jlr200 · Cited by 76

Expression of Messenger RNA for Prostaglandin E Receptor Subtypes EP4/EP2 and Cyclooxygenase Isozymes in Mouse Periovulatory Follicles and Oviducts During Superovulation1

Segi‐Nishida, E., Haraguchi, K., Sugimoto, Y., Tsuji, M., Tsunekawa, H., Tamba, S., Tsuboi, K., Tanaka, S., & Ichikawa, A. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.003590 · Cited by 76

Genetic and Genomic Approaches to Identify and Study the Targets of Bioactive Small Molecules

Zheng, X., Chan, T., & Zhou, H. H. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2003.08.011 · Cited by 74

The role of nitric oxide in prostaglandin biology; update

Kim, S. F. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.07.002 · Cited by 73

COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing

Xie, C. L., Ming, X., Wang, Q., Schwarz, E. M., Guldberg, R. E., O’Keefe, R. J., & Zhang, X. (2008) · Bone · doi:10.1016/j.bone.2008.08.109 · Cited by 70

Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro

Zhang, D., Hu, X., Li, Q., Wilson, B. C., Lee, C., Flood, P. M., Langenbach, R. J., & Hong, J. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.04.015 · Cited by 69

Obesity is induced in mice heterozygous for cyclooxygenase-2

Fain, J. N., Ballou, L. R., & Bahouth, S. W. (2001) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(01)00136-8 · Cited by 69

Combination of a Poxvirus-Based Vaccine with a Cyclooxygenase-2 Inhibitor (Celecoxib) Elicits Antitumor Immunity and Long-Term Survival in CEA.Tg/MIN Mice

Zeytin, H. E., Patel, A. C., Rogers, C. J., Canter, D. J., Hursting, S. D., Schlom, J., & Greiner, J. W. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3878 · Cited by 67

Evaluation of Dendrimer Safety and Efficacy through Cell Line Studies

Kesharwani, P., Gajbhiye, V., Tekade, R. K., & Jain, N. K. (2011) · Current Drug Targets · doi:10.2174/138945011796818135 · Cited by 66

Distinct Roles for Cyclooxygenases 1 and 2 in Interleukin-1-Induced Behavioral Changes

Swiergiel, A. H., & Dunn, A. J. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.036640 · Cited by 66

Sperm and oocyte communication mechanisms controlling C. elegans fertility

Han, S. M., Cottee, P. A., & Miller, M. A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22202 · Cited by 63

COX-2-deficient mice are less prone to MPTP-neurotoxicity than wild-type mice

Feng, Z., Li, D., Fung, P. C. W., Pei, Z., Ramsden, D. B., & Ho, S. (2003) · Neuroreport · doi:10.1097/00001756-200310270-00009 · Cited by 65

Endoplasmic reticulum stress (ER-stress) by 2-deoxy-D-glucose (2DG) reduces cyclooxygenase-2 (COX-2) expression and N-glycosylation and induces a loss of COX-2 activity via a Src kinase-dependent pathway in rabbit articular chondrocytes

Yu, S., & Kim, S. J. (2010) · Experimental & Molecular Medicine · doi:10.3858/emm.2010.42.11.079 · Cited by 62

Progesterone: a pivotal hormone at menstruation

Maybin, J. A., & Critchley, H. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.05953.x · Cited by 63

Potential Role of Aspirin in the Prevention of Aneurysmal Subarachnoid Hemorrhage

Starke, R. M., Chalouhi, N., Ding, D., & Hasan, D. M. (2015) · Cerebrovascular Diseases · doi:10.1159/000381137 · Cited by 59

General Method for the 11C‐Labeling of 2‐Arylpropionic Acids and Their Esters: Construction of a PET Tracer Library for a Study of Biological Events Involved in COXs Expression

Takashima‐Hirano, M., Shukuri, M., Takashima, T., Goto, M., Wada, Y., Watanabe, Y., Onoe, H., Doi, H., & Suzuki, M. (2010) · Chemistry - A European Journal · doi:10.1002/chem.200903044 · Cited by 58

Androgen Control of Cyclooxygenase Expression in the Rat Epididymis1

Cheuk, B. L. Y., Leung, P. S., Lo, A. C. T., & Wong, P. Y. D. (2000) · Biology of Reproduction · doi:10.1093/biolreprod/63.3.775 · Cited by 56

The Immunophysiology of Male Reproduction

Hedger, M. P. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00019-3 · Cited by 61

Protein Kinase C-α Coordinately Regulates Cytosolic Phospholipase A2Activity and the Expression of Cyclooxygenase-2 through Different Mechanisms in Mouse Keratinocytes

Wang, H. Q., Kim, M. P., Tiano, H. F., Langenbach, R. I., & Smart, R. C. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.860 · Cited by 55

The tissue-specific, compensatory expression of cyclooxygenase-1 and -2 in transgenic mice

Zhang, J., Goorha, S., Raghow, R., & Ballou, L. R. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(01)00177-0 · Cited by 54

Effects of Selective and Nonselective Nonsteroidal Anti-inflammatory Drugs on Antibiotic Efficacy of Experimental Group A Streptococcal Myonecrosis

Hamilton, S. M., Bayer, C. R., Stevens, D. L., & Bryant, A. E. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit594 · Cited by 51

Embryonic prostaglandin H synthase‐2 (PHS‐2) expression and benzo[ α ]pyrene teratogenicity in PHS‐2 knockout mice 1

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Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice

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