The DOI matches its Crossref record; 110 of the 115 references it cites were found in a registry or an index.
Cyclooxygenase knockout mice
Abstract
The development of cyclooxygenase (COX) deficient mice has allowed investigation into the individual physiological roles of the COX-1 and COX-2 isoforms. In the following article, the phenotypes of the two Ptgs (genes coding for COX-1 and COX-2) knockouts are summarized, and recent studies to investigate the effects of COX deficiency on cancer susceptibility, inflammatory response, gastric ulceration, and female reproductive processes are discussed. Also, the development and potential uses of mice deficient in both COX isoforms and mice containing only a single copy of one isoform are discussed. Additionally, when the data permit, the effects of genetic ablation of COX activity are compared with those of pharmacological inhibition of COX activity by nonsteroidal anti-inflammatory drugs. The data suggest that prostaglandins derived via the individual COX isoforms have separate as well as common functions. However, for the maintenance of normal physiology, it appears that deficiency of COX-2 has more profound effects than deficiency of COX-1.
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“First, the prolonged gestation interval observed in the ERKdko females was reminiscent of phenotype described for the cyclooxygenase 1 (PGHS1/COX1) knockout animal34–39.”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [37]
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Metadata
- Authors
- Langenbach, R., Loftin, C., Lee, C., & Tiano, H.
- Affiliations
- National Institutes of Health (US)
- National Institute of Environmental Health Sciences (US)
- Corresponding author
- Langenbach, Robert
- ORCID
- Lee, Christopher
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 58
- Issue
- 8
- Pages
- 1237-1246
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W113612665
- Cited by
- 230
- References
- 115
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 2 · 2015: 13 · 2014: 5 · 2013: 7 · 2012: 9
- FWCI
- 12.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- cyclooxygenase, cyclooxygenase-1, cyclooxygenase-2, prostaglandins, cancer susceptibility, inflammation, gastric ulcer, nonsteroidal anti-inflammatory drugs, cyclooxygenase inhibition, gene ablation
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Female, Humans, Inflammation, Isoenzymes, Membrane Proteins, Phenotype, Prostaglandin-Endoperoxide Synthases, Reproduction, Stomach Ulcer, Mice, Knockout, Mice, Cyclooxygenase 1, Cyclooxygenase 2
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