Cited by 230Inflammatory mediators and NSAID effectsEicosanoids and Hypertension PharmacologyPeroxisome Proliferator-Activated Receptors

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Cyclooxygenase knockout mice

Langenbach, Robert, Loftin, Charles, Lee, Christopher, Tiano, Howard·1999·Biochemical Pharmacology

DOI 10.1016/s0006-2952(99)00158-6

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Abstract

The development of cyclooxygenase (COX) deficient mice has allowed investigation into the individual physiological roles of the COX-1 and COX-2 isoforms. In the following article, the phenotypes of the two Ptgs (genes coding for COX-1 and COX-2) knockouts are summarized, and recent studies to investigate the effects of COX deficiency on cancer susceptibility, inflammatory response, gastric ulceration, and female reproductive processes are discussed. Also, the development and potential uses of mice deficient in both COX isoforms and mice containing only a single copy of one isoform are discussed. Additionally, when the data permit, the effects of genetic ablation of COX activity are compared with those of pharmacological inhibition of COX activity by nonsteroidal anti-inflammatory drugs. The data suggest that prostaglandins derived via the individual COX isoforms have separate as well as common functions. However, for the maintenance of normal physiology, it appears that deficiency of COX-2 has more profound effects than deficiency of COX-1.

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Authors: Langenbach, R., Loftin, C., Lee, C., & Tiano, H.
Affiliations: National Institutes of Health (US)
National Institute of Environmental Health Sciences (US)
Corresponding author: Langenbach, Robert
ORCID: Lee, Christopher
Venue: Biochemical Pharmacology
Publisher: Elsevier BV
Published: 1999-10
Volume: 58
Issue: 8
Pages: 1237-1246
ISSN: 0006-2952 (ISSN-L)
DOI: 10.1016/s0006-2952(99)00158-6
OpenAlex: W113612665
Cited by: 230
References: 115
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 2 · 2015: 13 · 2014: 5 · 2013: 7 · 2012: 9
FWCI: 12.40
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: cyclooxygenase, cyclooxygenase-1, cyclooxygenase-2, prostaglandins, cancer susceptibility, inflammation, gastric ulcer, nonsteroidal anti-inflammatory drugs, cyclooxygenase inhibition, gene ablation
MeSH terms: Animals, Cell Transformation, Neoplastic, Female, Humans, Inflammation, Isoenzymes, Membrane Proteins, Phenotype, Prostaglandin-Endoperoxide Synthases, Reproduction, Stomach Ulcer, Mice, Knockout, Mice, Cyclooxygenase 1, Cyclooxygenase 2

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