Cited by 230Inflammatory mediators and NSAID effectsEicosanoids and Hypertension PharmacologyPeroxisome Proliferator-Activated Receptors

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Cyclooxygenase knockout mice

Langenbach, Robert, Loftin, Charles, Lee, Christopher, Tiano, Howard·1999·Biochemical Pharmacology

DOI 10.1016/s0006-2952(99)00158-6

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Abstract

The development of cyclooxygenase (COX) deficient mice has allowed investigation into the individual physiological roles of the COX-1 and COX-2 isoforms. In the following article, the phenotypes of the two Ptgs (genes coding for COX-1 and COX-2) knockouts are summarized, and recent studies to investigate the effects of COX deficiency on cancer susceptibility, inflammatory response, gastric ulceration, and female reproductive processes are discussed. Also, the development and potential uses of mice deficient in both COX isoforms and mice containing only a single copy of one isoform are discussed. Additionally, when the data permit, the effects of genetic ablation of COX activity are compared with those of pharmacological inhibition of COX activity by nonsteroidal anti-inflammatory drugs. The data suggest that prostaglandins derived via the individual COX isoforms have separate as well as common functions. However, for the maintenance of normal physiology, it appears that deficiency of COX-2 has more profound effects than deficiency of COX-1.

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Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs
VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
Eberhart, C. E., Coffey, R. J., Aramandla, R., Giardiello, F. M., Ferrenbach, S., & DuBois, R. N. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90246-1 · Cited by 2,512
Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)
Oshima, M., Dinchuk, J. E., Kargman, S., Oshima, H., Hancock, B. C., Kwong, E. C., Trzăskos, J. M., Evans, J. F., & Taketo, M. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81988-1 · Cited by 2,363
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
Tsujii, M., & DuBois, R. N. (1995) · Cell · doi:10.1016/0092-8674(95)90127-2 · Cited by 2,292
Cyclooxygenase regulates angiogenesis induced by colon cancer cells
Tsujii, M., Kawano, S., Tsuji, S., Sawaoka, H., Hori, M., & DuBois, R. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81433-6 · Cited by 2,272
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2
Smith, W. L., Garavito, R. M., & DeWitt, D. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33157 · Cited by 1,973
TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
Kujubu, D. A., Fletcher, B. S., Varnum, B. C., Lim, R. W., & Herschman, H. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98774-0 · Cited by 1,786
Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.
Xie, W. L., Chipman, J. G., Robertson, D. L., Erikson, R. L., & Simmons, D. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2692 · Cited by 1,707
Aspirin Use and Reduced Risk of Fatal Colon Cancer
Thun, M. J., Namboodiri, M. M., & Heath, C. W. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112053252301 · Cited by 1,685
A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse
Moser, A. R., Pitot, H. C., & Dove, W. F. (1990) · Science · doi:10.1126/science.2296722 · Cited by 1,591
Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice
Lim, H. J., Paria, B. C., Das, S., Dinchuk, J. E., Langenbach, R. I., Trzăskos, J. M., & Dey, S. K. (1997) · Cell · doi:10.1016/s0092-8674(00)80402-x · Cited by 1,426
Self-citation
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.
Meade, E. A., Smith, W. L., & DeWitt, D. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53294-4 · Cited by 1,262
Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
Yamagata, K., Andreasson, K. I., Kaufmann, W. E., Barnes, C. A., & Worley, P. F. (1993) · Neuron · doi:10.1016/0896-6273(93)90192-t · Cited by 1,231
Prostaglandin synthase 2
Herschman, H. R. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00194-8 · Cited by 1,200
Expression of cyclooxygenase-1 and -2 in human colorectal cancer.
Sano, H., Kawahito, Y., Wilder, R. L., Hashiramoto, A., Mukai, S., Asai, K., Kimura, S., Kato, H., Kondo, M., & Hla, T. (1995) · PubMed · Cited by 1,126
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
Langenbach, R. J., Morham, S. G., Tiano, H. F., Loftin, C. D., Ghanayem, B. I., Chulada, P. C., Mahler, J. F., Lee, C. A., Goulding, E. H., Kluckman, K. D., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90126-4 · Cited by 1,120
Self-citation
Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs
Lehmann, J. M., Lenhard, J. M., Oliver, B. B., Ringold, G. M., & Kliewer, S. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3406 · Cited by 1,110
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
Morham, S. G., Langenbach, R. J., Loftin, C. D., Tiano, H. F., Vouloumanos, N., Jennette, J. C., Mahler, J. F., Kluckman, K. D., Ledford, A., Lee, C. A., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90125-6 · Cited by 1,080
Self-citation
Cytoprotection by prostaglandins
Robert, A. (1979) · Gastroenterology · doi:10.1016/0016-5085(79)90235-x · Cited by 1,074
Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.
Vane, J. R., Mitchell, J. A., Appleton, I., Tomlinson, A., Bishop‐Bailey, D., Croxtall, J. D., & Willoughby, D. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2046 · Cited by 1,035
Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
Dinchuk, J. E., Car, B. D., Focht, R. J., Johnston, J. J., JAFFEE, B. D., Covington, M. B., Contel, N. R., Eng, V. M., Collins, R. J., Czerniak, P. M., et al. (1995) · Nature · doi:10.1038/378406a0 · Cited by 967
Aspirin use and risk of fatal cancer.
Thun, M. J., Namboodiri, M. M., Calle, E. E., Flanders, W. D., & Heath, C. W. (1993) · PubMed · Cited by 870
Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.
Harris, R. C., McKanna, J. A., Akai, Y., Jacobson, H. R., DuBois, R. N., & Breyer, M. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117620 · Cited by 856
Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.
Kargman, S., O’Neill, G. P., Vickers, P. J., Evans, J. F., Mancini, J. A., & Jothy, S. (1995) · PubMed · Cited by 831
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
Futaki, N., Takahashi, S., Yokoyama, M., Arai, I., Higuchi, S., & Otomo, S. (1994) · Prostaglandins · doi:10.1016/0090-6980(94)90074-4 · Cited by 821
Pharmacological analysis of cyclooxygenase-1 in inflammation
Smith, C., Zhang, Y., Koboldt, C. M., Muhammad, J., Zweifel, B. S., Shaffer, A. F., Talley, J. J., Masferrer, J. L., Seibert, K., & Isakson, P. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13313 · Cited by 802
The Function and Mechanism of Promoters of Carcinogenesis
Boutwell, R. K., & Sivak, A. J. (1973) · Critical Reviews in Toxicology · doi:10.3109/10408447309025704 · Cited by 743
Mechanism of Action of Nonsteroidal Anti-inflammatory Drugs
Vane, J. R., & Botting, R. M. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)00203-9 · Cited by 723
Prostaglandin Endoperoxide H Synthases-1 and -2
Smith, W. L., & DeWitt, D. L. (1996) · Advances in immunology · doi:10.1016/s0065-2776(08)60430-7 · Cited by 711
Towards a better aspirin
Vane, J. R. (1994) · Nature · doi:10.1038/367215a0 · Cited by 698
Aspirin and the potential role of prostaglandins in colon cancer.
Marnett, L. J. (1992) · PubMed · Cited by 685
Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice
Mizuno, H., Sakamoto, C., Matsuda, K., Wada, K., Uchida, T., Noguchi, H., Akamatsu, T. M., & Kasuga, M. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9024292 · Cited by 637
Failure of Parturition in Mice Lacking the Prostaglandin F Receptor
Sugimoto, Y., Yamasaki, A., Segi, E., Tsuboi, K., Aze, Y., Nishimura, T., Oida, H., Yoshida, N., Tanaka, T., Katsuyama, M., et al. (1997) · Science · doi:10.1126/science.277.5326.681 · Cited by 608
Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene
Shibata, H., Toyama, K., Shioya, H., Ito, M., Hirota, M., Hasegawa, S., Matsumoto, H., Takano, H., Akiyama, T., Toyoshima, K., et al. (1997) · Science · doi:10.1126/science.278.5335.120 · Cited by 605
Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway
Hanif, R., Pittas, A., Feng, Y., Koutsos, M. I., Qiao, L., Staiano‐Coico, L., Shiff, S. I., & Rigas, B. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)00181-5 · Cited by 604
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.
DeWitt, D. L., & Smith, W. L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.5.1412 · Cited by 598
Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2
Morita, I., Schindler, M., Regier, M. K., Otto, J. C., Hori, T., DeWitt, D. L., & Smith, W. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10902 · Cited by 572
Nonsteroidal anti-inflammatory drugs and gastroenteropathy: The second hundred years
Jl, W. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9041264 · Cited by 568
Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment
Funk, C. D., Funk, L. B., Kennedy, M. E., Pong, A. S., & FitzGerald, G. A. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.9.1907252 · Cited by 568
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.
Oshima, M., Oshima, H., Kitagawa, K., Kobayashi, M., Itakura, C., & Taketo, M. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4482 · Cited by 558
A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.
O’Banion, M. K., Sadowski, H. B., Winn, V. D., & Young, D. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54491-4 · Cited by 557
Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.
Boolbol, S. K., Dannenberg, A. J., Chadburn, A., Martucci, C., Guo, X., Ramonetti, J. T., Abreu-Goris, M., Newmark, H. L., Lipkin, M. L., DeCosse, J. J., et al. (1996) · PubMed · Cited by 545
The mechanism of action of nonsteroidal antiinflammatory drugs.
Brandt, K. D. (1991) · PubMed · Cited by 518
A Hypothesis: Nonsteroidal Anti-Inflammatory Drugs Reduce the Incidence of Large-Bowel Cancer
Rosenberg, L. A., Palmer, J. R., Zauber, A. G., Warshauer, M. E., Stolley, P. D., & Shapiro, S. (1991) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/83.5.355 · Cited by 500
Differential activation of adipogenesis by multiple PPAR isoforms.Preprint
Brun, R. P., Tontonoz, P., FORMAN, B. M., Ellis, R., Chen, J., Evans, R. M., & Spiegelman, B. M. (1996) · Genes & Development · doi:10.1101/gad.10.8.974 · Cited by 480
The mechanisms of action of nonsteroidal antiinflammatory drugs
Abramson, S. B., & Weissmann, G. (1989) · Arthritis & Rheumatism · doi:10.1002/anr.1780320102 · Cited by 469
Conditional gene targeting.
Rajewsky, K., Gu, H., Kühn, R., Betz, U. A. K., Müller, W., Roes, J., & Schwenk, F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118828 · Cited by 461
Prostaglandin endoperoxide synthase: why two isoforms?
Williams, C. S., & DuBois, R. N. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.270.3.g393 · Cited by 459
Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).
Merlie, J. P., Fagan, D., Mudd, J. L., & Needleman, P. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68959-8 · Cited by 429
Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors
Dubois, R. N., Radhika, A., Reddy, B., & Entingh, A. J. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8613017 · Cited by 425
Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.
Rao, C. V., Rivenson, A., Simi, B., Zang, E. A., Kelloff, G. V., Steele, V. E., & Reddy, B. S. (1995) · PubMed · Cited by 402
Molecular mechanisms of diverse actions of prostanoid receptors
Negishi, M., Sugimoto, Y., & Ichikawa, A. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00146-4 · Cited by 388
Cyclooxygenase-2: Regulation and relevance in inflammation
Mitchell, J. A., Larkin, S. W., & Williams, T. J. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00212-x · Cited by 375
Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.
Elder, D. J. E., Halton, D. E., Hague, A., & Paraskeva, C. (1997) · PubMed · Cited by 366
The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth
Nguyen, M., Camenisch, T. D., Snouwaert, J. N., Hicks, E., Coffman, T. M., Anderson, P. A. W., Malouf, N. N., & Koller, B. H. (1997) · Nature · doi:10.1038/36342 · Cited by 361
Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.
Piazza, G. A., Alberts, D. S., Hixson, L. J., Paranka, N. S., Li, H., Finn, T., Bogert, C. L., Guillen, J. M., Brendel, K., Gross, P. H., et al. (1997) · PubMed · Cited by 361
Anovulation in Cyclooxygenase-2-Deficient Mice Is Restored by Prostaglandin E2 and Interleukin-1β*
Davis, B. J., Lennard, D. E., Lee, C. A., Tiano, H. F., Morham, S. G., Wetsel, W. C., & Langenbach, R. J. (1999) · Endocrinology · doi:10.1210/endo.140.6.6715 · Cited by 352
Self-citation
Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction.
Piazza, G. A., Rahm, A. K., Finn, T. S., Fryer, B., Li, H., Stoumen, A. L., Pamukcu, R., & Ahnen, D. J. (1997) · PubMed · Cited by 351
Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats
Reddy, B. S., Rao, C. V., Rivenson, A., & Kelloff, G. V. (1993) · Carcinogenesis · doi:10.1093/carcin/14.8.1493 · Cited by 344
Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity
Wallace, J. L., Bak, A., McKnight, W., Asfaha, S., Sharkey, K. A., & MacNaughton, W. K. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70370-1 · Cited by 336
Patent Ductus Arteriosus and Neonatal Death in Prostaglandin Receptor EP4-Deficient Mice
Segi‐Nishida, E., Sugimoto, Y., Yamasaki, A., Aze, Y., Oida, H., Nishimura, T., Murata, T., Matsuoka, T., Ushikubi, F., Hirose, M., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8461 · Cited by 311
Induction of cyclo‐oxygenase‐2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone
Mitchell, J. A., Belvisi, M. G., Akarasereenont, P., Robbins, R., Kwon, O. J., Croxtall, J. J., Barnes, P. J., & Vane, J. R. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb17093.x · Cited by 308
Mitogen‐inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs
Xie, W., Robertson, D. L., & Simmons, D. L. (1992) · Drug Development Research · doi:10.1002/ddr.430250402 · Cited by 306
Renal Toxicity of the Nonsteroidal Anti-Inflammatory Drugs
Murray, M. D., & Brater, D. C. (1993) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.33.040193.002251 · Cited by 295
Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.
Verma, A. K., Ashendel, C. L., & Boutwell, R. K. (1980) · PubMed · Cited by 271
Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2
Kalgutkar, A. S. S., Crews, B. C., Rowlinson, S. W., Garner, C., Seibert, K., & Marnett, L. J. (1998) · Science · doi:10.1126/science.280.5367.1268 · Cited by 257
Hormonal regulation of messenger ribonucleic acid encoding a novel isoform of prostaglandin endoperoxide H synthase in rat preovulatory follicles. Induction in vivo and in vitro.
Sirois, J., Simmons, D. L., & Richards, J. S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49951-1 · Cited by 256
Opposing actions of prostaglandins and oxytocin determine the onset of murine labor
Gross, G. A., Imamura, T., Luedke, C., Vogt, S. K., Olson, L. M., Nelson, D. M., Sadovsky, Y., & Muglia, L. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11875 · Cited by 238
Nonsteroidal antiinflammatory drugs and the gastrointestinal tract the double-edged sword
Lichtenstein, D. R., Syngal, S., & Wolfe, M. M. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380103 · Cited by 220
Distinct isoforms (COX‐1 and COX‐2) of cyclooxygenase: possible physiological and therapeutic implications
Pairet, M., & Engelhardt, G. (1996) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1996.tb00144.x · Cited by 218
The Pharmacology of the Ductus Arteriosus
Smith, G. C. S. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01348-6 · Cited by 212
Self-Promotion? Intimate Connections Between APC and Prostaglandin H Synthase-2
Prescott, S. M., & White, R. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81983-2 · Cited by 198
Effect of advancing gestational age on the frequency of fetal ductal constriction in association with maternal indomethacin use
Moise, K. J. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(11)90763-7 · Cited by 189
Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis.
Chiu, C. H., McEntee, M. F., & Whelan, J. (1997) · PubMed · Cited by 174
Prostaglandin Synthase-1 and Prostaglandin Synthase-2 Are Coupled to Distinct Phospholipases for the Generation of Prostaglandin D2 in Activated Mast Cells
Reddy, S. T., & Herschman, H. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3231 · Cited by 171
CYCLOOXYGENASE-2 INHIBITORS
Masferrer, J. L., Isakson, P. C., & Seibert, K. (1996) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70252-1 · Cited by 165
Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation
Futaki, N., Arai, I., Hamasaka, Y., Takahashi, S., Higuchi, S., & Otomo, S. (1993) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1993.tb07103.x · Cited by 154
Studies of neoplasia in the Min mouse1C57BL/6J Min/+ mice are available worldwide from The Jackson Laboratory, Bar Harbor, ME 04609, USA.1
Shoemaker, A. R., Gould, K. A., Luongo, C., Moser, A. R., & Dove, W. F. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(96)00041-8 · Cited by 151
Differential expression of prostaglandin h synthase isozymes during multistage carcinogenesis in mouse epidermis
Müller‐Decker, K., Scholz, K., Marks, F., & Fürstenberger, G. (1995) · Molecular Carcinogenesis · doi:10.1002/mc.2940120106 · Cited by 146
Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin.
Bozza, P. T., Payne, J. L., Morham, S. G., Langenbach, R. J., Smithies, O., & Weller, P. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.11091 · Cited by 125
Self-citation
Differentiation of Monocytoid THP-1 Cells with Phorbol Ester Induces Expression of Prostaglandin Endoperoxide Synthase-1 (COX-1)
Smith, C. J., Morrow, J. D., Roberts, L. J., & Marnett, L. J. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1483 · Cited by 124
Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion)
Fürstenberger, G., Gross, M., & Marks, F. (1989) · Carcinogenesis · doi:10.1093/carcin/10.1.91 · Cited by 116
Prostacyclin synthesis in ovine pulmonary artery is developmentally regulated by changes in cyclooxygenase-1 gene expression.
Brannon, T. S., North, A. J., Wells, L. B., & Shaul, P. W. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117220 · Cited by 111
Effects of Transforming Growth Factor β and Interleukin-1β on Expression of Cyclooxygenase 1 and 2 and Phospholipase A2 mRNA in Lung Fibroblasts and Endothelial Cells in Culture
Jackson, B. A., Goldstein, R. H., Roy, R., Cozzani, M., Taylor, L., & POLGAR, P. R. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2642 · Cited by 110
Nonsteroidal antiinflammatory drugs and the gastrointestinal tract.
Hirschowitz, B. I. (1994) · PubMed · Cited by 102
Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?
Alberts, D. S., Hixson, L. J., Ahnen, D. J., Bogert, C. L., Einspahr, J. G., Paranka, N. S., Brendel, K., Gross, P. H., Pamukcu, R., & Burt, R. W. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240590804 · Cited by 100
R-flurbiprofen chemoprevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer.
Wechter, W. J., Kantoci, D., Murray, E. D., Quiggle, D. D., Leipold, D. D., Gibson, K. M., & McCracken, J. D. (1997) · PubMed · Cited by 98
Tumorigenic Transformation of Immortalized ECV Endothelial Cells by Cyclooxygenase-1 Overexpression
Narko, K., Ristimaki, A. P., MacPhee, M. J., Smith, E., Haudenschild, C. C., & Hla, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21455 · Cited by 97
Multiple Controls in Inflammation
Cirino, G. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00215-3 · Cited by 95
Temporal and spatial immunolocalization of cytokines in murine chronic granulomatous tissue. Implications for their role in tissue development and repair processes.
Appleton, I., Tomlinson, A., Colville‐Nash, P., & Willoughby, D. A. (1993) · PubMed · Cited by 87
Induction of growth inhibition of 293 cells by downregulation of the cyclin E and cyclin-dependent kinase 4 proteins due to overexpression of TIS21
Lim, I. K., Lee, M. S., Ryu, M. S., Park, T. J., Fujiki, H., Eguchi, H., & Paik, W. K. (1998) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199809)23:1 · Cited by 75
Prostaglandin-endoperoxide synthase
Schomburg, D., & Stephan, D. (1994) · Springer eBooks · doi:10.1007/978-3-642-57942-4_153 · Cited by 68
Role of Prostaglandins in Gastroduodenal Mucosal Protection
Wilson, D. E. (1991) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199112001-00011 · Cited by 66
Selective Induction of Prostaglandin G/H Synthase I by Stem Cell Factor and Dexamethasone in Mast Cells
Samet, J. M., Fasano, M. B., Fonteh, A. N., & Chilton, F. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.14.8044 · Cited by 59
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS: HOW DO THEY DAMAGE THE GUT?
Levi, S., & Shaw-Smith, C. J. (1994) · Lara D. Veeken · doi:10.1093/rheumatology/33.7.605 · Cited by 55
Constitutive expression of prostaglandin endoperoxide G/H synthetase (PGHS)-2 but not PGHS-1 in hum an tracheal epithelial cells in vitro
Walenga, R. W., KESTER, M. A., Coroneos, E., Butcher, S., Dwivedi, R., & Statt, C. (1996) · Prostaglandins · doi:10.1016/s0090-6980(96)00101-3 · Cited by 51
Mechanisms of NSAID-Induced Gastroenteropathy
Price, A. H., & Fletcher, M. (1990) · Drugs · doi:10.2165/00003495-199000405-00003 · Cited by 51
Renal Toxicity of Non-Steroidal Anti-Inflammatory Drugs
Black, H. E. (1986) · Toxicologic Pathology · doi:10.1177/019262338601400110 · Cited by 51
Editorial: Sounding the Alarm—Does Induction of Prostaglandin Endoperoxide Synthase-2 Control the Mammalian Ovulatory Clock?1
Richards, J. S. (1997) · Endocrinology · doi:10.1210/endo.138.10.5515 · Cited by 50
Renal Effects of Over‐the‐Counter Analgesics
Whelton, A. (1995) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1995.tb04088.x · Cited by 47
Biosynthesis and Role of the Endothelium‐Derived Vasodilator, Nitric Oxide, in the Gastric Mucosa
Whittle, B. J. R., Boughton-Smith, N. K., & Moncada, S. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb39755.x · Cited by 45
Bleeding disorder due to platelet prostaglandin H synthase‐1 (PGHS‐1) deficiency
Matijevic‐Aleksic, N., McPhedran, P., & Wu, K. K. (1996) · British Journal of Haematology · doi:10.1046/j.1365-2141.1996.279813.x · Cited by 33
Characteristic Morphology of the Constricted Fetal Ductus Arteriosus following Maternal Administration of Indomethacin
Momma, K., Konish, T., & Hagiwara, H. (1985) · Pediatric Research · doi:10.1203/00006450-198505000-00017 · Cited by 32
Pharmacology of interleukin-1-induced neutrophil migration
Perretti, M., Appleton, I., Parente, L., & Flower, R. J. (1993) · Inflammation Research · doi:10.1007/bf01991139 · Cited by 28
Prostaglandins and reproduction—what do knockouts really tell us?
Challis, J. R. G. (1997) · Nature Medicine · doi:10.1038/nm1297-1326 · Cited by 26
Disruption of Cyclooxygenase Genes in Mice
Mahler, J. F., Davis, B. J., Morham, S. G., & Langenbach, R. I. (1996) · Toxicologic Pathology · doi:10.1177/019262339602400607 · Cited by 14
Self-citation
Prostaglandin-Endoperoxide Synthase
Choi, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_103086 · Cited by 8
Importance of gastric acid in gastric ulcer formation in rabbits with antibody-induced prostaglandin deficiency
Lee, M., Aldred, K., Lee, E. W., Prince, M. D., & Feldman, M. L. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91166-2 · Cited by 4

Research works printed but not linked: 4

Wechter, 1997, R-Flurbiprofen chemoprevention and treatment of intestinal adenomas in the APCMin/+ mouse model, Cancer Res, 57, 4316
Chulada, 1998, Cyclooxygenase-1 and -2 deficiency decrease spontaneous intestinal adenomas in the Min mouse, Proc Am Assoc Cancer Res, 39, 195
Shoemaker, 1997, Studies of neoplasia in the Min mouse, Biochim Biophys Acta, 1332, F25
Tiano, 1998, Effects of cyclooxygenase deficiency on inflammation and papilloma formation in mouse skin, Proc Am Assoc Cancer Res, 38, 257

Sorted by citations

Prostaglandins and Inflammation
Ricciotti, E., & FitzGerald, G. A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207449 · Cited by 4,035
Cyclooxygenases: Structural, cellular, and molecular biology
Smith, W. L., DeWitt, D. L., & Garavito, R. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.145 · Cited by 2,925
Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
Simmons, D. L., Botting, R. M., & Hla, T. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.3.3 · Cited by 1,718
Nonsteroidal Anti-inflammatory Drugs as Anticancer Agents: Mechanistic, Pharmacologic, and Clinical Issues
Thun, M. J., Henley, S. J., & Patrono, C. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.4.252 · Cited by 1,430
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
North, T. E., Goessling, W., Walkley, C. R., Lengerke, C., Kopani, K. R., Lord, A. M., Weber, G. J., Bowman, T. V., Jang, I. H., Großer, T., et al. (2007) · Nature · doi:10.1038/nature05883 · Cited by 1,095

See all 230

Authors: Langenbach, R., Loftin, C., Lee, C., & Tiano, H.
Affiliations: National Institutes of Health (US)
National Institute of Environmental Health Sciences (US)
Corresponding author: Langenbach, Robert
ORCID: Lee, Christopher
Venue: Biochemical Pharmacology
Publisher: Elsevier BV
Published: 1999-10
Volume: 58
Issue: 8
Pages: 1237-1246
ISSN: 0006-2952 (ISSN-L)
DOI: 10.1016/s0006-2952(99)00158-6
OpenAlex: W113612665
Cited by: 230
References: 115
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 2 · 2015: 13 · 2014: 5 · 2013: 7 · 2012: 9
FWCI: 12.40
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: cyclooxygenase, cyclooxygenase-1, cyclooxygenase-2, prostaglandins, cancer susceptibility, inflammation, gastric ulcer, nonsteroidal anti-inflammatory drugs, cyclooxygenase inhibition, gene ablation
MeSH terms: Animals, Cell Transformation, Neoplastic, Female, Humans, Inflammation, Isoenzymes, Membrane Proteins, Phenotype, Prostaglandin-Endoperoxide Synthases, Reproduction, Stomach Ulcer, Mice, Knockout, Mice, Cyclooxygenase 1, Cyclooxygenase 2

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