Evidence of white matter tract disruption in MRI hyperintensities
Abstract
Background Diffusion tensor imaging (DTI) of brain tissue measures the apparent diffusion coefficient (ADC), or isotropic diffusion, and anisotropy, or diffusion as influenced by tissue structure. We hypothesized that hyperintensities, when compared with normal tissue by DTI, would show evidence of damage through an increased ADC and decreased anisotropy. We also hypothesized that DTI changes in hyperintensities would be similar between depressed subjects and control subjects.Methods Fourteen depressed geriatric patients and nineteen control subjects received DTI. The ADC and aniso-tropy of normal tissue from standard regions were compared with hyperintensities from these regions. The Students' t test compared individual regions and averaged white matter results.Results Hyperintensities showed higher ADC and lower anisotropy than normal regions. Gray matter exhibited similar trends. There was no significant difference in diffusion characteristics of hyperintensities between subjects and control subjects.Conclusions Hyperintensities damage the structure of brain tissue, and do so comparably in depressed subjects and control subjects.
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Major fibre tracts such as the forceps major and forceps minor, inferior fronto-occipital fasciculus as well as the posterior cingulum show white matter alterations in Alzheimer's disease dementia.
“In particular, major fibre tracts such as the forceps major and forceps minor, inferior fronto-occipital fasciculus as well as the posterior cingulum show white matter alterations in Alzheimer’s disease dementia (Taylor et al., 2001; Teipel et al., 2002; Douaud et al., 2011; Mito et al., 2018).”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Taylor et al., 2001
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- Authors
- Taylor, W. D., Payne, M. E., Krishnan, K. R. R., Wagner, H. R., Provenzale, J. M., Steffens, D. C., & MacFall, J. R.
- Affiliations
- Duke University (US)
- Corresponding author
- Taylor, Warren D
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 50
- Issue
- 3
- Pages
- 179-183
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2039717395
- Cited by
- 134
- References
- 24
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 10
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01 MH-54846, P30MH040159, P30 MH 40159, R01MH054846)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Keywords
- white matter hyperintensities, diffusion tensor imaging, apparent diffusion coefficient, anisotropy, brain tissue damage, depression, geriatric depression, gray matter
- MeSH terms
- Aged, Brain, Depressive Disorder, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Severity of Illness Index, Anisotropy
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