Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and Alzheimer's dementia
Open accessAbstract
Neuropsychiatric symptoms (NPS) occur frequently in mild cognitive impairment (MCI) and Alzheimer's dementia (AD). The authors examined the relationship between NPS and white-matter integrity in these conditions. Twenty-two individuals with MCI and 23 with mild AD underwent clinical assessments including the Neuropsychiatric Inventory Questionnaire and 3.0-tesla magnetic resonance scans. Fractional anisotropy (FA) was measured in the following manually-drawn regions of interest (ROI): fornix, cingulum bundle, splenium, and cerebral peduncles (control region). The probability of having NPS by tertile of ROI FA was assessed by logistic regression. Because associations were similar within MCI and AD groups, the two groups were combined. Compared with those in the highest tertile, participants within the lowest anterior cingulum (AC) FA tertile were more likely to exhibit irritability, agitation, dysphoria, apathy, and nighttime behavioral disturbances. After adjusting for Mini-Mental State Exam status, participants in the lowest versus highest tertile of AC FA were more likely to report irritability. Using DTI, low AC FA was associated with increased odds of irritability in mild AD and MCI participants. Further imaging studies are necessary to elucidate the role of the AC in the pathophysiology of neuropsychiatric symptoms in AD and MCI.
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NPI Irritability, but not Agitation/Aggression, is associated with lower fractional anisotropy in anterior cingulate cortex in Alzheimer's disease.
“In a study using DTI Tighe et al. (2012) reported that NPI Irritability (but not Agitation/Aggression) was associated with lower fractional anisotropy (FA) (suggesting decreased WM integrity) in ACC.”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Tighe et al., 2012
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- Authors
- Tighe, S. K., Oishi, K., Mori, S., Smith, G. S., Albert, M., Lyketsos, C. G., & Mielke, M. M.
- Affiliations
- Johns Hopkins University (US)
- Kennedy Krieger Institute (US)
- ORCID
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2012-10
- Volume
- 24
- Issue
- 4
- Pages
- 484-488
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- PMC
- PMC3533244
- OpenAlex
- W1990121449
- Cited by
- 77
- References
- 16
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 11 · 2022: 4 · 2021: 8 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 9 · 2016: 10 · 2015: 8 · 2014: 4 · 2013: 7
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P50‐AG021334, R01AG041633, R01AG038893, R21AG033774, P50AG005146, T32AG027668, P30AG021334)
- National Center for Research Resources (P41RR15241, P41RR015241)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- neuropsychiatric symptoms, mild cognitive impairment, Alzheimer's disease, white matter integrity, anterior cingulum, fractional anisotropy, irritability, agitation, apathy, dysphoria, fornix, splenium, cerebral peduncle
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Anxiety, Brain, Female, Humans, Image Processing, Computer-Assisted, Irritable Mood, Male, Middle Aged, Neuropsychological Tests, Surveys and Questionnaires, Anisotropy, Diffusion Tensor Imaging, Apathy, Cognitive Dysfunction
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