Transient versus sustained visual channels in the visual backward masking deficits of schizophrenia patients
Abstract
Background Schizophrenia patients have information-processing deficits that can be quantified using visual backward masking. The visual information processing system is divided functionally and structurally into transient and sustained visual channels. When visual stimuli are presented to a subject, the transient pathway detects the presence and location of the stimulus while the sustained pathway is involved in fine discrimination and identification of the stimulus. While independent subcortically, the transient and sustained visual channels converge cortically into the dorsal and ventral processing streams that assess spatial relationships and object recognition respectively.Methods To better understand the underlying mechanisms of the visual backward masking deficits, 16 schizophrenia patients and 17 comparison subjects were tested on two different visual backward masking paradigms that required either locating or identifying a target letter.Results Schizophrenia patients had visual backward masking deficits in a task that involved locating a target letter while there were no deficits in the task that involved identification of a target letter.Conclusions The visual backward masking deficits of schizophrenia patients suggest impairment in the processing of spatial information. These deficits are discussed in the context of our current knowledge of visual information processing and the neuropathophysiology of schizophrenia.
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Patients with schizophrenia show preferential M-pathway dysfunction, although deficits have also been observed in parvocellular processing.
“Patients with schizophrenia show preferential M-pathway dysfunction (21,22,28,35–38), although deficits have also been observed in parvocellular processing (19,20).”
From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [35]
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- Authors
- Cadenhead, K. S., Serper, Y., & Braff, D. L.
- Affiliations
- University of California San Diego (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 43
- Issue
- 2
- Pages
- 132-138
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1968242769
- Cited by
- 143
- References
- 32
- Citations by year
- 2024: 1 · 2023: 6 · 2022: 7 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K37MH42228, K20MH001124, K20MH01124)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- schizophrenia, visual backward masking, visual processing, spatial data processing, dorsal stream, ventral stream, object recognition, target localization, target identification
- MeSH terms
- Adult, Energy Metabolism, Female, Humans, Male, Mental Processes, Photic Stimulation, Schizophrenic Psychology, Visual Perception
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