Cited by 320Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

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Age and gender effects on microglia and astrocyte numbers in brains of mice

Mouton, Peter R, Long, Jeffrey M, Lei, De-Liang, Howard, Victor, Jucker, Mathias, Calhoun, Michael E, Ingram, Donald K·2002·Brain Research

DOI 10.1016/s0006-8993(02)03475-3

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Abstract

The morphological changes that occur during normal brain aging are not well understood. This study used modern stereology to assess the effects of age and gender on total numbers of astrocytes and microglia in the hippocampal formation in C57Bl/6NNIA (B6) mice. Astrocytes and microglia were visualized using immunocytochemistry for glial fibrillary acidic protein (GFAP) and complement receptor 3 (Mac-1), respectively, and numbers of each cell type in dentate gyrus (DG) and CA1 regions were estimated using the optical fractionator method. The results reveal significantly greater ( approximately 20%) numbers of microglia and astrocytes in aged females compared to young female B6 mice. We also report that on average female B6 mice have 25-40% more astrocytes and microglia in DG and CA1 regions than age-matched male C57Bl/6J mice. Since astrocytes and microglia are thought to be targets of gonadal hormones, the effects of sex hormones and reproductive aging may be responsible for these findings.

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Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994
Life and Death of Neurons in the Aging Brain
Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344
Cytology & cellular pathology of the nervous system
Penfield, W. G. (1965) · Medical Entomology and Zoology · Cited by 1,035
Genetics of Aging
Finch, C. E., & Tanzi, R. E. (1997) · Science · doi:10.1126/science.278.5337.407 · Cited by 485
Ameboid microglia as effectors of inflammation in the central nervous system
Giulian, D. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180123 · Cited by 482
Interleukin-1 is an astroglial growth factor in the developing brain
Giulian, D., Young, D., Woodward, J., Brown, D. M., & Lachman, L. B. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-02-00709.1988 · Cited by 449
GFAP mRNA increases with age in rat and human brain
Nichols, N. R., Day, J. R., Laping, N. J., Johnson, S. A., & Finch, C. E. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90100-p · Cited by 413
Principles and Practices of Unbiased Stereology: An Introduction for Bioscientists
Mouton, P. R. (2002) · Cited by 404
Self-citation
Altered antigen expression of microglia in the aged rodent CNS
Perry, V. H., Matyszak, M. K., & Fearn, S. (1993) · Glia · doi:10.1002/glia.440070111 · Cited by 364
Age-Related Activation of Microglia and Astrocytes: In Vitro Studies Show Persistent Phenotypes of Aging, Increased Proliferation, and Resistance to Down-Regulation
Rozovsky, I., Finch, C. E., & Morgan, T. E. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00169-3 · Cited by 252

Show all 36 references

Research works printed but not linked: 1

Hortega, 1932, Microglia, Vol. 2, 481

Sorted by citations

Items 201–300 of 320

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Shaffery, J., Allard, J. S., Manaye, K., & Roffwarg, H. (2012) · Front. Neur. · doi:10.3389/fneur.2012.00069 · Cited by 16
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Reduction of GFAP induced by long dark rearing is not restricted to visual cortex.
Corvetti, L., Aztiria, E., & Domenici, L. (2006) · Brain Research · doi:10.1016/j.brainres.2005.10.072 · Cited by 17
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Weis, S. N., de Souza, J. M. F., Hoppe, J. B., Firmino, M., Auer, M., Ataii, N. N., da Silva, L. A., Gaelzer, M. M., Klein, C. P., Mól, A. R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-82016-7 · Cited by 14
Sex Differences in Mouse Models of Autism Spectrum Disorders: Their Potential to Uncover the Impact of Brain Sexual Differentiation on Gender Bias
Murta, V., Seiffe, A., & Depino, A. M. (2023) · Sexes · doi:10.3390/sexes4030024 · Cited by 13
Sedentary Life and Reduced Mastication Impair Spatial Learning and Memory and Differentially Affect Dentate Gyrus Astrocyte Subtypes in the Aged Mice
Mendes, F. D. C. C. D. S., da Paixão, L. T. V. B., Diniz, D. G., Anthony, D. C., Brites, D. M. T. O., Diniz, C. W. P., & Sosthenes, M. C. K. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.632216 · Cited by 12
Changes in Glial Fibrillary Acidic Protein Immunoreactivity in the Detate Gyrus and Hippocampus Proper of Adult and Aged Dogs
Hwang, I. K., Choi, J. H., Li, H., Yoo, K., Kim, D. W., Lee, C. H., Yi, S. S., Seong, J. K., Lee, I. S., Yoon, Y. S., et al. (2008) · Journal of Veterinary Medical Science · doi:10.1292/jvms.70.965 · Cited by 12
Selective brain neuronal and glial losses without changes in GFAP immunoreactivity: Young versus mature adult Wistar rats
Diene, L. D., Costa‐Ferro, Z. S. M., Barbosa, S., Milanesi, B. B., Lazzari, G. Z., Neves, L. T., Paz, L. V., Neves, P. F. R., Battisti, V., Martins, L. A., et al. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111128 · Cited by 12
Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse
Benskey, M. J., Panoushek, S., Saito, T., Saido, T. C., Grabinski, T. M., & Kanaan, N. M. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1265151 · Cited by 13
Mutant Murine Hepatitis Virus-Induced Apoptosis in the Hippocampus
Kakizaki, M., Kashiwazaki, H., & Watanabe, R. (2014) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.67.9 · Cited by 11
Exploring the Significance of Microglial Phenotypes and Morphological Diversity in Neuroinflammation and Neurodegenerative Diseases: From Mechanisms to Potential Therapeutic Targets
Anwar, M. M., Pérez‐Martínez, L., & Pedraza‐Alva, G. (2024) · Immunological Investigations · doi:10.1080/08820139.2024.2358446 · Cited by 11
Exploring SERPINA3 as a neuroinflammatory modulator in Alzheimer’s disease with sex and regional brain variations
Sanfilippo, C., Castrogiovanni, P., Imbesi, R., Vecchio, M. M., Sortino, M., Musumeci, G., Vinciguerra, M., & Rosa, M. D. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-024-01523-4 · Cited by 10
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Bortolanza, M., Gobbo, D., Fang, L., Scheller, A., Bai, X., & Kirchhoff, F. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04512-w · Cited by 11
Brain irradiation improves focal cerebral ischemia recovery in aged rats
Titova, E., Ostrowski, R. P., Adami, A., Badaut, J., Lalas, S., Ghosh, N., Vlkolinský, R., Zhang, J. H., & Obenaus, A. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.02.034 · Cited by 11
Region-specific reduction of Gβ4 expression and induction of the phosphorylation of PKB/Akt and ERK1/2 by aging in rat brain
Song, G., Kang, J. S., LEE, S., & Myung, C. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.07.005 · Cited by 10
Age and Environment Influences on Mouse Prion Disease Progression: Behavioral Changes and Morphometry and Stereology of Hippocampal Astrocytes
Bento‐Torres, J., Sobral, L. L., dos Reis, R. R., de Oliveira, R. B., Anthony, D. C., Vasconcelos, P. F. D. C., & Diniz, C. W. P. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4504925 · Cited by 10
Efficient quantitative morphological phenotyping of genetically altered organisms using stereology
Lucocq, J. M. (2006) · Transgenic Research · doi:10.1007/s11248-006-9048-9 · Cited by 10
Microglia reactivity is brain region and sex specific in the context of chronic stress
Zhang, A. Y., Elias, E., White, A. G., Jones, L. G., Hamad, T., & Manners, M. T. (2025) · Scientific Reports · doi:10.1038/s41598-025-18000-2 · Cited by 10
Prenatal choline supplementation attenuates MK-801-induced deficits in memory, motor function, and hippocampal plasticity in adult male rats
Nickerson, C. A., Brown, A. L., Yu, W., Chun, Y., & Glenn, M. J. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.07.071 · Cited by 9
Applications of Unbiased Stereology to Neurodevelopmental Toxicology
Mouton, P. R. (2010) · doi:10.1002/9780470917060.ch4 · Cited by 9
Self-citation
Parental folic acid deficiency delays neurobehavioral development in rat offspring by inhibiting the differentiation of neural stem cells into neurons
Zhang, G., Ren, Q., Lin, Y. L., Zhou, D., Huang, L., Li, W., Chang, H., Huang, G., Li, Z., & Yan, J. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109455 · Cited by 8
Neuroprotective role of sialic-acid-binding immunoglobulin-like lectin-11 in humanized transgenic mice
Assale, T. A., Afrang, N., Wißfeld, J., Cuevas-Ríos, G., Klaus, C., Linnartz‐Gerlach, B., & Neumann, H. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1504765 · Cited by 10
Recent developments in understanding brain aging: sex differences, mechanisms, and implications in diseases
Yang, J., Qu, J., & Ma, H. (2022) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2022.03 · Cited by 7
Daytime Light Deficiency Leads to Sex- and Brain Region-Specific Neuroinflammatory Responses in a Diurnal Rodent
Costello, A., Linning‐Duffy, K., Vandenbrook, C., Lonstein, J. S., & Yan, L. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01256-x · Cited by 7
Sex-oriented perspectives in immunopharmacology
Cignarella, A., Vegeto, E., Bolego, C., Trabace, L., Conti, L., & Ortona, E. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106956 · Cited by 7
Exercise and the Aging Brain: Considerations for Sex Differences
Barha, C. K., & Liu-Ambrose, T. Y. L. (2018) · Brain Plasticity · doi:10.3233/bpl-1867 · Cited by 8
Region-specific glial hyperplasia and neuronal stability of rat lateral geniculate nucleus during aging
Fiuza, F. P., de Aquino, A. C. Q., Câmara, D. D. A., Cavalcanti, J. R. L. D. P., do Nascimento, E. S., Lima, R. H., Engelberth, R. C. G. J., & Cavalcante, J. S. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.11.001 · Cited by 8
Perisynaptic Astroglial Response to In Vivo Long-Term Potentiation and Concurrent Long-Term Depression in the Hippocampal Dentate Gyrus
Nam, A. J., Kuwajima, M., Parker, P. H., Bowden, J. B., Abraham, W. C., & Harris, K. M. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0943-25.2025 · Cited by 6
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats
Lee, B. H., Cevizci, M., Lieblich, S. E., & Galea, L. A. M. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00694-8 · Cited by 5
Unraveling the Influence of Litter Size, Maternal Care, Exercise, and Aging on Neurobehavioral Plasticity and Dentate Gyrus Microglia Dynamics in Male Rats
Krejčová, L. V., Bento‐Torres, J., Diniz, D. G., Pereira, A., Hornsby, M. B.-D.-O., Morais, A., Mendes-da-Silva, R. F., Abadie‐Guedes, R., dos Santos, Â. A., de Lima, D. S. C., et al. (2024) · Brain Sciences · doi:10.3390/brainsci14050497 · Cited by 5
Astrocytes phenomics as new druggable targets in healthy aging and Alzheimer’s disease progression
Lana, D., Ugolini, F., Iovino, L., Attorre, S., & Giovannini, M. G. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1512985 · Cited by 6
Hippocampus and dentate gyrus of the Cebus monkey: Architectonic and stereological study
Diniz, C. G., Paz, R. B. D. M., Hamad, M. H. S., Filho, C. S., Martins, A. A. V., Neves, H. B., Cunha, E. D. D. S., Alves, G. C., de Sousa, L. A., Dias, I. A., et al. (2010) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2010.06.002 · Cited by 5
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Shi, J. S. (2020) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2020.25.004160 · Cited by 6
A diet rich in docosahexaenoic acid enhances reactive astrogliosis and ramified microglia morphology in apolipoprotein E epsilon 4-targeted replacement mice
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Shirokova, O. M., Zaborskaya, O., Pchelin, P. V., Kozliaeva, E. V., Pershin, V. I., & Mukhina, I. V. (2023) · Brain Sciences · doi:10.3390/brainsci13020195 · Cited by 5
Magnolia officinalis bark extract improves depressive-like behavior in DSS-induced colitis mice
Kim, M., Kim, J., Lee, K.-I., Kim, H. J., Kim, H., Kim, D., & Park, K.-S. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105775 · Cited by 5
The influence of aging and the microbiome in multiple sclerosis and other neurologic diseases
Fettig, N. M., Pu, A., Osborne, L. C., & Gommerman, J. L. (2024) · Immunological Reviews · doi:10.1111/imr.13361 · Cited by 7
Novel microRNA revealed by systematic analysis of the microRNA transcriptome in dentate gyrus granule cells
Ryan, B., & Williams, J. M. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.09.003 · Cited by 5
Lateral septum microglial changes and behavioral abnormalities of mice exposed to valproic acid during the prenatal period
de Leão, E. R. L. P., de Souza, D. N. C., de Moura, L. V. B., Júnior, A. M. D. S., dos Santos, A. L. G., Diniz, D. G., Diniz, C. W. P., & Sosthenes, M. C. K. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101875 · Cited by 5
Long-term cellular and molecular signatures of pregnancy in the adult and ageing brainPreprint
Duarte‐Guterman, P., Richard, J. E., Lieblich, S. E., Eid, R., Lamers, Y., & Galea, L. A. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.24.529879 · Cited by 5
Intriguing astrocyte responses in CA1 to reduced and rehabilitated masticatory function: Dorsal and ventral distinct perspectives in adult mice
Castro, M. M. L., do Amaral, F. L., Mendes, F. D. C. C. D. S., Anthony, D. C., Brites, D. M. T. O., Diniz, C. W. P., & Sosthenes, M. C. K. (2024) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2024.106097 · Cited by 4
Neuroglia in aging
Semyanov, A. V., & Verkhratsky, A. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19104-6.00002-4 · Cited by 5
The Masticatory Activity Interference in Quantitative Estimation of CA1, CA3 and Dentate Gyrus Hippocampal Astrocytes of Aged Murine Models and under Environmental Stimulation
Leal, M. D. C. F., do Amaral, F. L., Arruda, B. F. D. S., Kurosawa, J. A. A., Vieira, A. A., Maia, J. C. C., Scalfoni, V. V. B., da Silveira, A. M., Feijó, M. O., de Albuquerque, F. B. A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076529 · Cited by 4
Acute exposure to paraquat affects the phenotypic differentiation of substantia nigra microglia in rats
Zhang, W., Fan, X., Fan, Z., Wu, B., Wang, M., Duan, W., & Song, B. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-17262-3 · Cited by 4
Female and male microglia are not different in the dentate gyrus of postnatal day 10 mice
Guez‐Barber, D., Colón, L. M., Raphael, D., Wragan, M., Yun, S., & Eisch, A. J. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137171 · Cited by 4
Blocking interleukin-1 signalling in the brain - structural and functional outcomes
Spulber, S. D. (2008) · Figshare · Cited by 4
Laminaria japonica fucoidan ameliorates D-galactose-induced cognitive impairment via the regulation of tryptophan metabolism along the gut-brain axis
Wang, L., Lu, C., Li, S., Wu, T., Ren, X., Song, S., & Ai, C. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.150151 · Cited by 3
Sex differences of synaptic plasticity and microglial remodeling in the dorsal hippocampus following trigeminal nerve injury in mice
Tiwari, M. N., Paik, L., Fiorin, F. D. S., & Chung, M. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107097 · Cited by 3
[Not Available].
Torabi-Nami, M., Nasehi, M., & Zarrindast, M. (2013) · PubMed · Cited by 3
Neuroglial cells: morphological changes during normal aging
Pannese, E. (2012) · RENDICONTI LINCEI · doi:10.1007/s12210-012-0218-9 · Cited by 3
The Ageless Question--What Accounts for Age-Related Cognitive Decline?
Nagahara, A. H., & Tuszynski, M. H. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.19.pe20 · Cited by 3
Changes in hippocampal astrocyte morphology of Ruddy turnstone (Arenaria interpres) during the wintering period at the mangroves of Amazon River estuary
da Costa, E. R., Henrique, E. P., da Silva, J. B., Pereira, P. D. C., de Abreu, C. C., Fernandes, T. N., Magalhães, N. G. D. M., da Silva, A. D. J. F., Guerreiro, L. C. F., Diniz, C. G., et al. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101805 · Cited by 3
Astrocytic responses to binge ethanol in male and female mice: An examination of astrocytic glutamate transporters and density changes in the dorsal hippocampus
Swepson, C., Mebane, D. R., Correia, D., Imafidon, E. H., Trevisani, C. P., Nelson, J., & Marshall, S. A. (2026) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.70224 · Cited by 2
Sex differences in neurobehavior and the adult hippocampal neurogenic niche: influence of traumatic brain injury and CLIP antagonism
Iannucci, J., Venkatasamy, L., Davis, M., Nguyen, T.-A., Yadav, G. S., Nugeness, V., Dominy, R., Arisi, G. M., Newell‐Rogers, M. K., & Shapiro, L. A. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1768730 · Cited by 2
Prolonged social isolation promotes depressive-like behavior in male and female mice, with sex-related differences in the stress response
Cepeda, Y., Tobar, C., Jara, N., Pardo, C. C., Villarroel, A., Lagos, R., Recabal, A., Nova-Lamperti, E., Obregón-Rivas, A. M., Vidal, P. M., et al. (2026) · Biology of Sex Differences · doi:10.1186/s13293-026-00874-0 · Cited by 3
Quantitative Morphological Analyses of the Striatum and Cerebellum of Tenascin-R deficient mice
Steen, A.-B. (2006) · Cited by 2
Roles of Innate Immunity and Inflammation in the Aging Brain
Okun, E., Chen, X., Bašta, M., & Mattson, M. P. (2011) · Oxidative stress and disease · doi:10.1201/b11014-2 · Cited by 2
The Impact of Aging on Ischemic Stroke
Sohrabji, F. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_6 · Cited by 3
Neuroprotection in Perimenopausal Women
Russu, M. C., & Antonescu, A. C. (2018) · InTech eBooks · doi:10.5772/intechopen.74330 · Cited by 3
Sex differences in microglia as a risk factor for Alzheimer’s disease
Delage, C. I., Rendina, D. N., Malacon, K. E., Tremblay, M., & Bilbo, S. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819344-0.00008-9 · Cited by 2
Comparison of Methods for Counting Neurons and Neuron Profiles in Brain Sections
Denham, G., Alahmari, S. S., Anderson, A. S., Sanchez, K., Dag, D., Delgado, P. A., Hall, L., Goldgof, D. B., & Mouton, P. R. (2024) · Neuromethods · doi:10.1007/978-1-0716-3977-1_8 · Cited by 1
Self-citation
Proactive M2 blockade prevents cognitive decline in GRK5-deficient APP transgenic mice via enhancing cholinergic neuronal resilience
Zhang, Q., Singh, P., Peng, D. W., Peng, E. Y., Burns, J. M., Swerdlow, R. H., & Suo, W. Z. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107619 · Cited by 1
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Farooqui, A. A. (2014) · Springer eBooks · doi:10.1007/978-3-319-04111-7_2 · Cited by 1
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Henry, C. J. (2011) · OhioLink ETD Center (Ohio Library and Information Network)
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Lana, D. (2016) · Premio Tesi dottorato/Premio Tesi di dottorato · doi:10.36253/978-88-6655-941-2

Authors: Mouton, P. R., Long, J. M., Lei, D.-L., Howard, V., Jucker, M., Calhoun, M. E., & Ingram, D. K.
Affiliations: National Institutes of Health (US)
Icahn School of Medicine at Mount Sinai (US)
University of Basel (CH)
Corresponding author: Mouton, Peter R
ORCID: Mouton, Peter R
Jucker, Mathias
Calhoun, Michael E
Ingram, Donald K
Venue: Brain Research
Publisher: Elsevier BV
Published: 2002-11
Volume: 956
Issue: 1
Pages: 30-35
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/s0006-8993(02)03475-3
OpenAlex: W2059109913
Cited by: 320
References: 36
Citations by year: 2026: 12 · 2025: 13 · 2024: 16 · 2023: 17 · 2022: 15 · 2021: 21 · 2020: 23 · 2019: 13 · 2018: 17 · 2017: 13 · 2016: 14 · 2015: 6 · 2014: 16 · 2013: 15 · 2012: 20
FWCI: 4.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: brain aging, microglia, astrocytes, sex differences, age effects, hippocampus, dentate gyrus, CA1 region, glial fibrillary acidic protein, complement receptor 3, gonadal hormones, reproductive aging, C57BL/6 mice
MeSH terms: Age Factors, Aging, Animals, Astrocytes, Cell Count, Female, Glial Fibrillary Acidic Protein, Hippocampus, Male, Sex Factors, Macrophage-1 Antigen, Microglia, Mice

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Age and gender effects on microglia and astrocyte numbers in brains of mice

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