Age and gender effects on microglia and astrocyte numbers in brains of mice

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994

Life and Death of Neurons in the Aging Brain

Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344

Cytology & cellular pathology of the nervous system

Penfield, W. G. (1965) · Medical Entomology and Zoology · Cited by 1,035

Genetics of Aging

Finch, C. E., & Tanzi, R. E. (1997) · Science · doi:10.1126/science.278.5337.407 · Cited by 485

Ameboid microglia as effectors of inflammation in the central nervous system

Giulian, D. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180123 · Cited by 482

Interleukin-1 is an astroglial growth factor in the developing brain

Giulian, D., Young, D., Woodward, J., Brown, D. M., & Lachman, L. B. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-02-00709.1988 · Cited by 449

GFAP mRNA increases with age in rat and human brain

Nichols, N. R., Day, J. R., Laping, N. J., Johnson, S. A., & Finch, C. E. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90100-p · Cited by 413

Principles and Practices of Unbiased Stereology: An Introduction for Bioscientists

Mouton, P. R. (2002) · Cited by 404

Altered antigen expression of microglia in the aged rodent CNS

Perry, V. H., Matyszak, M. K., & Fearn, S. (1993) · Glia · doi:10.1002/glia.440070111 · Cited by 364

Age-Related Activation of Microglia and Astrocytes: In Vitro Studies Show Persistent Phenotypes of Aging, Increased Proliferation, and Resistance to Down-Regulation

Rozovsky, I., Finch, C. E., & Morgan, T. E. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00169-3 · Cited by 252

Diffusion in Brain Extracellular Space

Syková, E., & Nicholson, C. (2008) · Physiological Reviews · doi:10.1152/physrev.00027.2007 · Cited by 1,481

Human Hippocampal Neurogenesis Persists throughout Aging

Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.03.015 · Cited by 1,345

Microglial priming in neurodegenerative disease

Perry, V. H., & Holmes, C. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.38 · Cited by 1,127

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

Encinas, J. M., Michurina, T. V., Peunova, N. I., Park, J.-H., Tordo, J., Peterson, D. A., Fishell, G., Koulakov, A. A., & Enikolopov, G. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.03.010 · Cited by 918

Age-related myelin degradation burdens the clearance function of microglia during aging

Safaiyan, S., Kannaiyan, N., Snaidero, N., Brioschi, S., Biber, K., Yona, S., Edinger, A. L., Jung, S., Rossner, M. J., & Simons, M. (2016) · Nature Neuroscience · doi:10.1038/nn.4325 · Cited by 604

Neocortical glial cell numbers in human brains

Pelvig, D. P., Pakkenberg, H., Stark, A. K., & Pakkenberg, B. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.013 · Cited by 601

Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy

Muzio, L., Viotti, A., & Martino, G. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.742065 · Cited by 581

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

Tay, T. L., Savage, J. C., Hui, C. W., Bisht, K., & Tremblay, M. (2017) · The Journal of Physiology · doi:10.1113/jp272134 · Cited by 562

Retinal microglia: Just bystander or target for therapy?

Karlstetter, M., Scholz, R., Rutar, M., Wong, W. T., Provis, J. M., & Langmann, T. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.11.004 · Cited by 570

TREM2 sustains microglial expansion during aging and response to demyelination

Poliani, P. L., Wang, Y., Fontana, E., Robinette, M. L., Yamanishi, Y., Gilfillan, S., & Colonna, M. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77983 · Cited by 525

Transcriptional and Translational Differences of Microglia from Male and Female Brains

Guneykaya, D., Ivanov, A., Hernandez, D. P., Haage, V., Wojtas, B., Meyer, N., Maricos, M., Jordan, P., Buonfiglioli, A., Gielniewski, B., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.001 · Cited by 477

Astrocytes in Alzheimer's Disease

Verkhratsky, A., Olabarria, M., Noristani, H. N., Yeh, C., & Rodriguez, J. J. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.017 · Cited by 470

Microglial control of neuronal death and synaptic properties

Bessis, A., Béchade, C., Bernard, D., & Roumier, A. (2006) · Glia · doi:10.1002/glia.20459 · Cited by 486

Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

Layé, S., Nadjar, A., Joffre, C., & Bazinet, R. P. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014092 · Cited by 420

Microglia morphophysiological diversity and its implications for the CNS

Vidal-Itriago, A., Radford, R. A. W., Aramideh, J. A., Maurel, C., Scherer, N. M., Don, E. K., Lee, A., Chung, R. S., Graeber, M. B., & Morsch, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.997786 · Cited by 451

Microglia Priming with Aging and Stress

Niraula, A., Sheridan, J. F., & Godbout, J. P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.185 · Cited by 398

Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation

Nair, A., & Bonneau, R. H. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.09.012 · Cited by 392

Neurogenesis, inflammation and behavior

Kohman, R. A., & Rhodes, J. S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.09.003 · Cited by 380

Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?

Fleiss, B., & Gressèns, P. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70058-3 · Cited by 380

Innate immunity and aging

Gómez, C. R., Nomellini, V., Faunce, D. E., & Kovacs, E. J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.05.016 · Cited by 331

Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice

Bondolfi, L., Ermini, F., Long, J. M., Ingram, D. K., & Jucker, M. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00083-6 · Cited by 277

The Neuron-Astrocyte-Microglia Triad in Normal Brain Ageing and in a Model of Neuroinflammation in the Rat Hippocampus

Cerbai, F., Lana, D., Nosi, D., Petkova-Kirova, P., Zecchi, S., Brothers, H. M., Wenk, G. L., & Giovannini, M. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045250 · Cited by 251

Microglia Modulate Hippocampal Neural Precursor Activity in Response to Exercise and Aging

Vukovic, J., Colditz, M. J., Blackmore, D. G., Ruitenberg, M. J., & Bartlett, P. F. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5925-11.2012 · Cited by 241

Age and neuroinflammation: a lifetime of psychoneuroimmune consequences

Godbout, J. P., & Johnson, R. W. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.007 · Cited by 224

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation

Wong, W. T. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00022 · Cited by 241

Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging

Mangold, C. A., Wronowski, B., Du, M., Masser, D. R., Hadad, N., Bixler, G. V., Brucklacher, R. M., Ford, M. M., Sonntag, W. E., & Freeman, W. M. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0920-8 · Cited by 203

Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide

Huang, Y., Henry, C. J., Dantzer, R., Johnson, R. W., & Godbout, J. P. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.012 · Cited by 226

Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan

Tay, T. L., Béchade, C., D’Andrea, I., St‐Pierre, M., Henry, M. S., Roumier, A., & Tremblay, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00421 · Cited by 217

Sex and gender differences in cognitive resilience to aging and Alzheimer's disease

Arenaza‐Urquijo, E. M., Boyle, R., Casaletto, K., Anstey, K. J., Vila‐Castelar, C., Colverson, A., Palpatzis, E., Eissman, J. M., Kheng Siang Ng, T., Raghavan, S., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13844 · Cited by 223

Estrogen, neuroinflammation and neuroprotection in Parkinson’s disease: Glia dictates resistance versus vulnerability to neurodegeneration

Morale, M. C., Serra, P. A., L’Episcopo, F., Tirolo, C., Caniglia, S., Testa, N., Gennuso, F., Giaquinta, G., Rocchitta, G., Desole, M. S., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.060 · Cited by 207

Functional diversity of microglia – how heterogeneous are they to begin with?

Hanisch, U.-K. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00065 · Cited by 195

Opposite effects of early maternal deprivation on neurogenesis in male versus female rats

Oomen, C. A., Girardi, C. E. N., Cahyadi, R., Verbeek, E. C., Krugers, H., Joëls, M., & Lucassen, P. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0003675 · Cited by 190

B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice

Troen, A. M., Shea-Budgell, M. A., Shukitt‐Hale, B., Smith, D. E., Selhub, J., & Rosenberg, I. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805350105 · Cited by 188

Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice

Kohman, R. A., DeYoung, E. K., Bhattacharya, T. K., Peterson, L. N., & Rhodes, J. S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.10.006 · Cited by 176

Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain

Bellinger, F. P., Bellinger, M. T., Seale, L. A., Takemoto, A. S., Raman, A. V., Miki, T., Manning-Bog, A., Berry, M. J., White, L. R., & Ross, G. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-8 · Cited by 173

Stereologic investigation of the posterior part of the hippocampus in schizophrenia

Schmitt, A., Steyskal, C., Bernstein, H., Schneider-Axmann, T., Parlapani, E., Schaeffer, E. L., Gattaz, W. F., Bogerts, B., Schmitz, C., & Falkai, P. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0430-y · Cited by 167

Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis

Okamoto, M., Inoue, K., Iwamura, H., Terashima, K., Soya, H., Asashima, M., & Kuwabara, T. (2011) · The FASEB Journal · doi:10.1096/fj.11-184697 · Cited by 172

Inflammatory processes in the aging mouse brain: Participation of dendritic cells and T-cells

Stichel, C. C., & Luebbert, H. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.07.022 · Cited by 151

Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms

Denis, I., Potier, B., Vancassel, S., Heberden, C., & Lavialle, M. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.007 · Cited by 150

Cerebral Ischemic Stroke: is Gender Important?

Gibson, C. L. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.102 · Cited by 154

Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine

Lynch, M. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.868448 · Cited by 146

Exercise reduces activation of microglia isolated from hippocampus and brain of aged mice

Kohman, R. A., Bhattacharya, T. K., Wojcik, E., & Rhodes, J. S. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-114 · Cited by 155

Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System

Bollaerts, I., houcke, J. V., Andries, L., Groef, L. D., & Moons, L. (2017) · Mediators of Inflammation · doi:10.1155/2017/9478542 · Cited by 138

Insulin-like growth factor-1 in CNS and cerebrovascular aging

Sonntag, W. E., Deák, F., Ashpole, N. M., Tóth, P., Csiszár, A., Freeman, W. M., & Ungvari, Z. I. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00027 · Cited by 139

Sexual differentiation of microglia

Villa, A. M., Torre, S. D., & Maggi, A. C. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.11.003 · Cited by 135

Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review

Edler, M. K., Mhatre-Winters, I., & Richardson, J. R. (2021) · Cells · doi:10.3390/cells10051138 · Cited by 126

Implication of cerebral astrocytes in major depression: A review of fine neuroanatomical evidence in humans

O’Leary, L. A., & Mechawar, N. (2021) · Glia · doi:10.1002/glia.23994 · Cited by 126

Female mice are protected from space radiation-induced maladaptive responses

Krukowski, K., Grue, K. A., Frias, E. S., Pietrykowski, J., Jones, T., Nelson, G. A., & Rosi, S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.08.008 · Cited by 126

Mechanisms of Hippocampal Aging and the Potential for Rejuvenation

Fan, X., Wheatley, E., & Villeda, S. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031357 · Cited by 132

Resveratrol Protects Against Neurotoxicity Induced by Kainic Acid

Wang, Q., Yu, S. O., Simonyi, Á., Rottinghaus, G. E., Sun, G. Y., & Sun, A. Y. (2004) · Neurochemical Research · doi:10.1007/s11064-004-6883-z · Cited by 123

Changes in extracellular space size and geometry in APP23 transgenic mice: A model of Alzheimer's disease

Syková, E., Voříšek, I., Antonova, T., Mazel, T., Meyer-Luehmann, M., Jucker, M., Hájek, M., Or, M., & Bureš, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408235102 · Cited by 121

Age and Neuroinflammation: A Lifetime of Psychoneuroimmune Consequences

Godbout, J. P., & Johnson, R. W. (2006) · Neurologic Clinics · doi:10.1016/j.ncl.2006.03.010 · Cited by 123

Glucocorticoid Hormones Decrease Proliferation of Embryonic Neural Stem Cells through Ubiquitin-Mediated Degradation of Cyclin D1

Sundberg, M., Savola, S. P., Hienola, A., Korhonen, L., & Lindholm, D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4906-05.2006 · Cited by 120

APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice

Stephen, T. L., Cacciottolo, M., Balu, D., Morgan, T. E., LaDu, M. J., Finch, C. E., & Pike, C. J. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0729-z · Cited by 115

Exercise and the Aging Brain: Considerations for Sex Differences

Barha, C. K., & Liu-Ambrose, T. Y. L. (2018) · Brain Plasticity · doi:10.3233/bpl-180067 · Cited by 126

Estrogen provides neuroprotection against activated microglia‐induced dopaminergic neuronal injury through both estrogen receptor‐α and estrogen receptor‐β in microglia

Liu, X., Fan, X., Zhao, Y. G., Luo, G., Li, X., Li, R., & Le, W. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20583 · Cited by 112

Sexual Dimorphism in Ischemic Stroke: Lessons from the Laboratory

Manwani, B., & McCullough, L. D. (2011) · Women s Health · doi:10.2217/whe.11.22 · Cited by 113

Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain

Verkhratsky, A., Augusto‐Oliveira, M., Pivoriūnas, A., Popov, A., Brazhe, A., & Semyanov, A. V. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02465-3 · Cited by 110

Age-associated increase in BMP signaling inhibits hippocampal neurogenesis.

Yousef, H., Morgenthaler, A., Schlesinger, C., Bugaj, L., Conboy, I. M., & Schaffer, D. V. (2015) · Stem Cells · doi:10.1002/stem.1943 · Cited by 109

Effects of estrogen and raloxifene on neuroglia number and morphology in the hippocampus of aged female mice

Lei, D.-L., Long, J. M., Hengemihle, J. M., O'Neill, J., Manaye, K. F., Ingram, D. K., & Mouton, P. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00245-8 · Cited by 106

Sex, stroke, and inflammation: The potential for estrogen-mediated immunoprotection in stroke

Ritzel, R. M., Capozzi, L. A., & McCullough, L. D. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.04.007 · Cited by 110

Stereological analysis of the hypothalamic hypocretin/orexin neurons in an animal model of depression

Allard, J. S., Tizabi, Y., Shaffery, J. P., Trouth, C. O., & Manaye, K. F. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.06.004 · Cited by 107

Neuroinflammation in preterm babies and autism spectrum disorders

Bokobza, C., Steenwinckel, J. V., Mani, S., Mezger, V., Fleiss, B., & Gressèns, P. (2018) · Pediatric Research · doi:10.1038/s41390-018-0208-4 · Cited by 112

Neural stem cell deforestation as the main force driving the age-related decline in adult hippocampal neurogenesis

Encinas, J. M., & Sierra, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.010 · Cited by 107

Phenotypic and gene expression modification with normal brain aging in GFAP-positive astrocytes and neural stem cells

Bernal, G. M., & Peterson, D. A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00694.x · Cited by 109

Age-related changes of astorocytes, oligodendrocytes and microglia in the mouse hippocampal CA1 sector

Hayakawa, N., Kato, H., & Araki, T. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.01.005 · Cited by 104

Advancing the Study of Stroke in Women

Bushnell, C., Hurn, P. D., Colton, C. A., Miller, V. M., del Zoppo, G., Elkind, M. S. V., Stern, B. J., Herrington, D. M., Ford-Lynch, G., Gorelick, P. B., et al. (2006) · Stroke · doi:10.1161/01.str.0000236053.37695.15 · Cited by 102

Evolution of microglial activation in ischaemic core and peri-infarct regions after stroke: A PET study with the TSPO molecular imaging biomarker [ C]vinpocetine

Gulyás, B. Z., Tóth, M., Schain, M., Airaksinen, A. J., Vas, Á., Kostulas, K., Lindström, P., Hillert, J. A., & Halldin, C. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.06.026 · Cited by 100

In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with18F-PBR111 PET

Colasanti, A., Guo, Q., Muhlert, N., Giannetti, P., Onega, M., Newbould, R. D., Ciccarelli, O., Rison, S., Thomas, C., Nicholas, R., et al. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.135129 · Cited by 100

Chronic gliosis and behavioral deficits in mice following repetitive mild traumatic brain injury

Mannix, R., Berglass, J., Berkner, J., Moleus, P., Qiu, J., Andrews, N., Gunner, G., Berglass, L., Jantzie, L. L., Robinson, S., et al. (2014) · Journal of neurosurgery · doi:10.3171/2014.7.jns14272 · Cited by 100

Evaluation of age-related changes in translocator protein (TSPO) in human brain using 11C-[R]-PK11195 PET

Kumar, A., Muzik, O., Shandal, V., Chugani, D. C., Chakraborty, P. K., & Chugani, H. T. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-232 · Cited by 98

Do microglia play a role in sex differences in TBI?

Caplan, H. W., Cox, C. S., & Bedi, S. S. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23854 · Cited by 100

Brain Response to Injuries: When Microglia Go Sexist

Rahimian, R., Cordeau, P., & Križ, J. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.048 · Cited by 101

Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine

Gulyás, B., Vas, Á., Tóth, M., Takano, A., Varrone, A., Cselényi, Z., Schain, M., Mattsson, P., & Halldin, C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.02.020 · Cited by 94

Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease

Ma, W., & Wong, W. T. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-17121-0_11 · Cited by 93

Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes

Diniz, D. G., Fôro, C. A. R., Rego, C. M. D., Gloria, D. A., Oliveira, F. R. R. D., Paes, J. M. P., de Sousa, A. A., Tokuhashi, T. P., Trindade, L. S., Turiel, M., et al. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07296.x · Cited by 92

Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury

Fleiss, B., Nilsson, M. K. L., Blomgren, K., & Mallard, C. E. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-70 · Cited by 88

Cognitive and Behavioral Consequences of Impaired Immunoregulation in Aging

Corona, A. W., Fenn, A. M., & Godbout, J. P. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9313-4 · Cited by 87

Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain

L’Episcopo, F., Tirolo, C., Serapide, M. F., Caniglia, S., Testa, N., Leggio, L., Vivarelli, S., Iraci, N., Pluchino, S., & Marchetti, B. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00012 · Cited by 85

Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging

Chowen, J. A., & García‐Segura, L. M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111473 · Cited by 92

The neuroglial population in the primary visual cortex of the aging rhesus monkey

Peters, A., Verderosa, A., & Sethares, C. (2008) · Glia · doi:10.1002/glia.20686 · Cited by 87

The aging rat retina: from function to anatomy

Nadal-Nicolás, F. M., Vidal‐Sanz, M., & Agudo‐Barriuso, M. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.021 · Cited by 83

Postnatal Erythropoietin Mitigates Impaired Cerebral Cortical Development Following Subplate Loss from Prenatal Hypoxia–Ischemia

Jantzie, L. L., Corbett, C. J., Firl, D. J., & Robinson, S. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu066 · Cited by 81

Microglia transcriptional states and their functional significance: Context drives diversity

Depp, C., Doman, J. L., Hingerl, M., Xia, J., & Stevens, B. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.009 · Cited by 84

SeXX Matters in Multiple Sclerosis

Gilli, F., DiSano, K. D., & Pachner, A. R. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00616 · Cited by 79

Changes in Selenoprotein P in Substantia Nigra and Putamen in Parkinson's Disease

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Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic mouse model of Alzheimer’s disease

Touma, C., Ambrée, O., Goertz, N., Keyvani, K., Lewejohann, L., Palme, R., Paulus, W., Schwarze-Eicker, K., & Sachser, N. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.004 · Cited by 78

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Nissen, J. C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030561 · Cited by 83

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Rahimian, R., Belliveau, C., Chen, R., & Mechawar, N. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.871997 · Cited by 77

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O’Neil, J. N., Mouton, P. R., Tizabi, Y., Ottinger, M. A., Lei, D.-L., Ingram, D. K., & Manaye, K. F. (2007) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2007.05.008 · Cited by 68

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Tariq, M. B., Lee, J., & McCullough, L. D. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00969-x · Cited by 72

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Zareen, N., Shinozaki, M., Ryan, D., Alexander, H., Amer, A., Truong, D. Q., Khadka, N., Sarkar, A. D., Naeem, S., Bikson, M., et al. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.08.004 · Cited by 72

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Fu, Y., Rusznák, Z., Herculano‐Houzel, S., WATSON, C. R. R., & Paxinos, G. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0462-x · Cited by 71

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Long, J. M., Kalehua, A. N., Muth, N. J., Calhoun, M. E., Jucker, M., Hengemihle, J. M., Ingram, D. K., & Mouton, P. R. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00088-8 · Cited by 163

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Conejo, N. M., González‐Pardo, H., Cimadevilla, J. M., Vallejo, G., & Árias, J. L. (2003) · Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) · Cited by 4

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Unger, J. W. (1998) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19981001)43:1 · Cited by 103

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Conejo, N. M., González‐Pardo, H., Arias, J. L., Cimadevilla, J. M., & Vallejo, G. (2003) · Redalyc (Universidad Autónoma del Estado de México)

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