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Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer
Abstract
Brain-derived neurotrophic factor (BDNF) was expressed via injection of viral vector into the substantia nigra pars compacta (SNc) to investigate its influence on nigrostriatal dopaminergic activity and locomotor behavior. The recombinant adeno-associated virus (rAAV) vector, pTR-BDNFmyc, incorporated the neuron-specific enolase (NSE) promoter and the internal ribosome entry site (IRES) element driving expression of both epitope-tagged BDNF and green fluorescent protein (GFP) bicistronically. The control vector, pTR-UF4, incorporated NSE promoter-driven GFP expression only. Transgene expression persisted in both vector groups throughout the 9 month course of the study. Partial 6-hydroxydopamine (6-OHDA) lesions were conducted in the SNc ipsilateral to, and 6 months after, transduction with either the pTR-BDNFmyc or the pTR-UF4. Transgenic BDNFmyc had no effect on the number of tyrosine hydroxylase (TH)-labeled neurons in the SNc after 6-OHDA-lesions, but did block the amphetamine-induced, ipsiversive, turning-behavior caused by the lesion in the pTR-UF4 group. The BDNFmyc-transduced group also demonstrated more locomotor activity and rotational activity contralateral to the lesioned side than did the pTR-UF4-transduced group. Long-term, stable expression of BDNF can therefore modulate locomotor activity without significantly affecting nigrostriatal dopaminergic survival.
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“In the vast majority of studies with BDNF administration before induction of parkinsonism, the research results revealed at least partial prevention of neuronal cell loss [89,90,92,93,99,101].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [90]
In the citing paper
“However, the reports are not consistent; some have shown no increase in neuronal survival when BDNF was applied before intoxication with 6-hydroxydopamine (6-OHDA) in PD animal model [90,91].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [90]
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Xiao, X., Li, J., & Samulski, R. J. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.2224-2232.1998 · Cited by 1,381
Kaplitt, M. G., Leone, P., Samulski, R. J., Xiao, X., Pfaff, D. W., O’Malley, K. L., & During, M. J. (1994) · Nature Genetics · doi:10.1038/ng1094-148 · Cited by 1,031
Maisonpierre, P. C., Beau, M. M. L., Espinosa, R., Ip, N. Y., Belluscio, L., de la Monte, S. M., Squinto, S. P., Furth, M. E., & Yancopoulos, G. D. (1991) · Genomics · doi:10.1016/0888-7543(91)90436-i · Cited by 514
McCown, T. J., Xiao, X., Li, J., Breese, G. R., & Samulski, R. J. (1996) · Brain Research · doi:10.1016/0006-8993(95)01488-8 · Cited by 450
Forss‐Petter, S., Danielson, P. E., Catsicas, S., Battenberg, E., Price, J. A., Nerenberg, M. I., & Sutcliffe, G. (1990) · Neuron · doi:10.1016/0896-6273(90)90308-3 · Cited by 368
Mandel, R. J., Spratt, S. K., Snyder, R. O., & Leff, S. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14083 · Cited by 328
Peel, A., Zolotukhin, S., Schrimsher, G. W., Muzyczka, N., & Reier, P. J. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300358 · Cited by 289
Self-citationAltar, C. A., Boylan, C. B., Jackson, C., Hershenson, S., Miller, J., Wiegand, S. J., Lindsay, R. M., & Hyman, C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11347 · Cited by 275
Levivier, M., Przedborski, S., Bencsics, C., & Kang, U. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07810.1995 · Cited by 274
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Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874
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Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U., & Patel, N. K. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.004 · Cited by 820
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Martin, K. R. G., Quigley, H. A., Zack, D. J., Levkovitch-Verbin, H., Kielczewski, J., Valenta, D., Baumrind, L., Pease, M. E., Klein, R. L., & Hauswirth, W. W. (2003) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.02-1332 · Cited by 362
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Pease, M. E., Zack, D. J., Berlinicke, C., Bloom, K., Cone, F., Wang, Y., Klein, R. L., Hauswirth, W. W., & Quigley, H. A. (2009) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.08-3013 · Cited by 222
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Klein, R. L., King, M. A., Hamby, M. E., & Meyer, E. M. (2002) · Human Gene Therapy · doi:10.1089/10430340252837206 · Cited by 212
Self-citationRecombinant AAV-mediated gene delivery to the central nervous system
Tenenbaum, L., Chtarto, A., Lehtonen, E., Velu, T. J., Brotchi, J., & Levivier, M. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.506 · Cited by 213
Wang, R., & Holsinger, R. M. D. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.10.002 · Cited by 203
Gene Therapy for Parkinson’s Disease, An Update
Axelsen, T. M., & Woldbye, D. P. D. (2018) · Journal of Parkinson s Disease · doi:10.3233/jpd-181331 · Cited by 185
Adeno-associated virus vectors: activity and applications in the CNS
Peel, A. L., & Klein, R. L. (2000) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(00)00183-7 · Cited by 155
Self-citationNeurotrophic factor therapy for Parkinson’s disease
Rangasamy, S. B., Soderstrom, K. E., Bakay, R. A. E., & Kordower, J. H. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)84013-0 · Cited by 155
Sun, M., Kong, L., Wang, X., Lu, X.-G., Gao, Q., & Geller, A. I. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.072 · Cited by 154
Eaton, M. J., Blits, B., Ruitenberg, M. J., Verhaagen, J., & Oudega, M. (2002) · Gene Therapy · doi:10.1038/sj.gt.3301814 · Cited by 146
Spieles-Engemann, A. L., Behbehani, M. M., Collier, T. J., Wohlgenant, S. L., Steece‐Collier, K., Paumier, K. L., Daley, B. F., Gombash, S. E., Madhavan, L., Mandybur, G. T., et al. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.03.009 · Cited by 131
Kang, S. S., Zhang, Z., Liu, X., Manfredsson, F. P., Benskey, M. J., Cao, X., Xu, J., Sun, Y. E., & Ye, K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713969114 · Cited by 131
Park, H., Lim, S., Joo, W. S., Yin, C.-S., Lee, H., Lee, H., Seo, J.-C., Leem, K., Son, Y.-S., Kim, Y.-J., et al. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(02)00031-6 · Cited by 129
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Chiareli, R. A., Carvalho, G. A., Marques, B. L., Mota, L. S., Oliveira‐Lima, O. C., Gomes, R. M., Birbrair, A., Gomez, R. S., Simão, F., Klempin, F., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.665795 · Cited by 130
Seung Taik, L. I. M., Airavaara, M., & Harvey, B. K. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.10.002 · Cited by 128
Murray, T. K., Whalley, K., Robinson, C. S., Ward, M., Hicks, C. A., Lodge, D., Vandergriff, J. L., Baumbarger, P. J., Siuda, E. R., Gates, M. R., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049445 · Cited by 107
Bdnf gene is a downstream target of Nurr1 transcription factor in rat midbrain neurons in vitro
Volpicelli, F., Caiazzo, M., Greco, D., Consales, C., Leone, L., Perrone‐Capano, C., D’Amato, L. C., & di Porzio, U. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04494.x · Cited by 100
Furler, S., Paterna, J. C., Weibel, M., & Büeler, H. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301469 · Cited by 103
Gordon, R., Neal, M. P., Luo, J. D., Langley, M. R., Harischandra, D. S., Panicker, N., Charli, A., Jin, H., Anantharam, V., Woodruff, T. M., et al. (2016) · Nature Communications · doi:10.1038/ncomms12932 · Cited by 102
Klein, R. L., Hirko, A. C., Meyers, C., Grimes, J. R., Muzyczka, N., & Meyer, E. M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02634-2 · Cited by 84
Self-citationRuitenberg, M. J., Blits, B., Dijkhuizen, P. A., Beek, E. T. T., Bakker, A., van Heerikhuize, J. J., Pool, C. W., Hermens, W. T. J., Boer, G. J., & Verhaagen, J. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.11.018 · Cited by 80
Visanji, N. P., Orsi, A., Johnston, T. H., Howson, P. A., Dixon, K., Callizot, N., Brotchie, J. M., & Rees, D. D. (2008) · The FASEB Journal · doi:10.1096/fj.07-095398 · Cited by 78
Halbach, O. V. B. U., Minichiello, L., & Unsicker, K. (2005) · The FASEB Journal · doi:10.1096/fj.05-3845fje · Cited by 79
Hernandez-Chan, N. G., Bannon, M. J., Orozco-Barrios, C. E., Escobedo, L., Zamudio, S., De la Cruz, F., Gongora-Alfaro, J. L., Armendáriz-Borunda, J., Reyes-Corona, D., Espadas-Alvarez, A. J., et al. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-015-0166-7 · Cited by 73
Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging
Ryu, Y., Go, J., Park, H., Choi, Y., Seo, Y. J., Choi, J. H., Rhee, M., Lee, T. G., Lee, C., & Kim, K. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108173 · Cited by 74
Ruitenberg, M. J., Eggers, R., Boer, G. J., & Verhaagen, J. (2002) · Methods · doi:10.1016/s1046-2023(02)00222-0 · Cited by 75
Cerri, S., Greco, R., Levandis, G., Ghezzi, C., Mangione, A. S., Armentero, M., Bonizzi, A., Avanzini, M. A., Maccario, R., & Blandini, F. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0023 · Cited by 72
Manfredsson, F. P., Bürger, C., Sullivan, L. F., Muzyczka, N., Lewin, A. S., & Mandel, R. J. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.06.019 · Cited by 70
Self-citationElectrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease
Yadav, A. P., & Nicolelis, M. A. L. (2017) · Movement Disorders · doi:10.1002/mds.27033 · Cited by 69
Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases
Cai, J., Hua, F., Yuan, L., Tang, W., Lu, J., Yu, S., Wang, X., & Hu, Y. (2014) · BioMed Research International · doi:10.1155/2014/601084 · Cited by 66
Nie, S., Yan, X., Chen, G., Ma, K., Han, C., Guo, Z., Zhang, Z., Ye, K., & Cao, X. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.016 · Cited by 65
GDNF therapy for Parkinson’s disease
Hong, M. G. L., Mukhida, K., & Mendez, I. M. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.7.1125 · Cited by 64
Pröschel, C., Stripay, J. L., Shih, C., Munger, J. C., & Noble, M. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201302878 · Cited by 65
O’Neill, M. J., Murray, T. K., Whalley, K., Ward, M., Hicks, C. A., Woodhouse, S., Osborne, D. J., & Skolnick, P. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.12.023 · Cited by 62
Gene transfer of trophic factors and stem cell grafting as treatments for Parkinson’s disease
Dass, B., Olanow, C. W., & Kordower, J. H. (2006) · Neurology · doi:10.1212/wnl.66.10_suppl_4.s89 · Cited by 62
Ren, R., Li, Y., Liu, Z., Liu, K., & He, S. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8484 · Cited by 60
Stahl, K., Mylonakou, M. N., Skare, Ø., Amiry-Moghaddam, M. R., & Torp, R. (2011) · Brain Research · doi:10.1016/j.brainres.2010.12.090 · Cited by 63
Autotransplantation of Bone Marrow-Derived Stem Cells as a Therapy for Neurodegenerative Diseases
Kan, I., Melamed, E., & Offen, D. (2007) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-68976-8_10 · Cited by 60
Baker, S. A., Stanford, L. E., Brown, R. E., & Hagg, T. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.052 · Cited by 55
Nosheny, R. L., Ahmed, F. A. K. M., Yakovlev, A. G., Meyer, E. M., Ren, K., Tessarollo, L., & Mocchetti, I. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05506.x · Cited by 53
Self-citationNezhadi, A., Sheibani, V., Esmaeilpour, K., Shabani, M., & Esmaeili‐Mahani, S. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.019 · Cited by 52
Dass, B., Iravani, M. M., Jackson, M. J., Engber, T. M., Galdes, A., & Jenner, P. G. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00214-2 · Cited by 52
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Wang, Z.-H., Wu, W., Kang, S. S., Liu, X., Wu, Z., Peng, J., Yu, S. P., Manfredsson, F. P., Sandoval, I. M., Liu, X., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99007 · Cited by 52
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Cao, Q., Zou, Q., Zhao, X. Y., Zhang, Y., Qu, Y., Wang, N., Murayama, S., Qi, Q., Hashimoto, K., Lin, S., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01063-9 · Cited by 47
Chen, L.-W., Zhang, J., Shum, D. K., & Chan, Y. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21014 · Cited by 47
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Yadav, A. P., Fuentes, R., Zhang, H., Vinholo, T., Wang, C.-H., Freire, M., & Nicolelis, M. (2014) · Scientific Reports · doi:10.1038/srep03839 · Cited by 43
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Shaimardanova, A. A., Chulpanova, D. S., Kitaeva, K. V., Abdrakhmanova, I. I., Chernov, V. M., Rutland, C. S., Rizvanov, A. A., & Solovyeva, V. V. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11110580 · Cited by 45
Kang, S. S., Wu, Z., Liu, X., Edgington‐Mitchell, L. E., & Ye, K. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01248-1 · Cited by 45
Fenner, M. E., Achim, C. L., & Fenner, B. M. (2013) · Journal of Molecular Histology · doi:10.1007/s10735-013-9562-z · Cited by 42
Adeno‐associated virus‐mediated gene delivery approaches for the treatment of CNS disorders
Terzi, D., & Zachariou, V. (2008) · Biotechnology Journal · doi:10.1002/biot.200800284 · Cited by 43
Nosheny, R. L., Mocchetti, I., & Bachis, A. (2005) · Neurotoxicity Research · doi:10.1007/bf03033829 · Cited by 41
Álvarez-Maya, I., Navarro-Quiroga, I., Meraz‐Ríos, M. A., Aceves, J., & Martínez‐Fong, D. (2001) · Molecular Medicine · doi:10.1007/bf03401952 · Cited by 41
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Neuroprotective effect of BDNF in young and aged 6-OHDA treated rat model of Parkinson disease.
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Park, H., & Chang, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218129 · Cited by 34
Clarke, E., Stocki, P., Sinclair, E. H., Gauhar, A., Fletcher, E. J. R., Krawczun-Rygmaczewska, A., Duty, S., Walsh, F. S., Doherty, P., & Rutkowski, J. L. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071335 · Cited by 32
Chen, L.-W., Hu, H., Liu, L., Yung, K. K. L., & Chan, Y. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.04.020 · Cited by 31
Gene Therapy for Parkinson's Disease
Denyer, R., & Douglas, M. R. (2012) · Parkinson s Disease · doi:10.1155/2012/757305 · Cited by 31
Mocchetti, I., Nosheny, R. L., Tanda, G., Ren, K., & Meyer, E. M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1403.010 · Cited by 30
Self-citationDickerson, J. W., Hemmerle, A. M., Numan, S., Lundgren, K. H., & Seroogy, K. B. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.06.008 · Cited by 29
Live Attenuated Vaccine Based on Duck Enteritis Virus against Duck Hepatitis A Virus Types 1 and 3
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Recombinant adeno-associated virus vector design and gene expression in the mammalian brain
Paterna, J., & Büeler, H. (2002) · Methods · doi:10.1016/s1046-2023(02)00225-6 · Cited by 29
Electro-Acupuncture Ameliorated MPTP-Induced Parkinsonism in Mice via TrkB Neurotrophic Signaling
Zhao, Y., Luo, D., Ning, Z., Rong, J., & Lao, L. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00496 · Cited by 27
Chemokine receptors and neurotrophic factors: Potential therapy against aids dementia?
Mocchetti, I., Bachis, A., & Masliah, E. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21492 · Cited by 27
Dass, B., Iravani, M. M., Huang, C.-S., Barsoum, J., Engber, T. M., Galdes, A., & Jenner, P. G. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0227-7 · Cited by 26
Developmental Expression of Neurotrophins and Their Receptors in Postnatal Rat Ventral Midbrain
Numan, S., Gall, C. M., & Seroogy, K. B. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:27:2:245 · Cited by 25
Prospects for the treatment of Parkinson’s disease using neurotrophic factors
Hurelbrink, C. B., & Barker, R. A. (2001) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2.10.1531 · Cited by 25
Fu, A., Zhang, M., Gao, F., Xu, X., & Chen, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059642 · Cited by 28
Neurotrophins as Therapeutic Agents for Parkinson’s Disease; New Chances From Focused Ultrasound?
Stefani, A., Pierantozzi, M., Cardarelli, S., Stefani, L., Cerroni, R., Conti, M., Garasto, E., Mercuri, N. B., Marini, C., & Sucapane, P. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.846681 · Cited by 23
Komnig, D., Dagli, T. C., Habib, P., Zeyen, T., Schulz, J. B., & Falkenburger, B. H. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14575 · Cited by 24
Mocchetti, I., Bachis, A., Nosheny, R. L., & Tanda, G. (2007) · Neurotoxicity Research · doi:10.1007/bf03033922 · Cited by 25
Mocchetti, I., Bachis, A., Campbell, L. A., & Avdoshina, V. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9488-y · Cited by 23
Enna, S. J., Reisman, S. A., & Stanford, J. A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.07.004 · Cited by 21
Neurotrophic factors for the treatment of Parkinson's disease
Chiocco, M. J., Harvey, B. K., Wang, Y., & Hoffer, B. J. (2007) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(08)70024-5 · Cited by 20
Gene delivery with viral vectors for cerebrovascular diseases
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Peng, Z., Hou, T., Yang, K., Zhang, J., Mao, Y.-H., & Hou, X. (2025) · Nutrients · doi:10.3390/nu17111769 · Cited by 21
Expression of BDNF-Associated lncRNAs in Parkinson’s disease
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Preclinical development of gene therapy for Parkinson's disease
Porras, G., & Bézard, E. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.08.003 · Cited by 19
Gene therapy for Parkinson's disease
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Are growth factors the answer?
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Pietropaolo, S., Paterna, J., Büeler, H., Feldon, J., & Yee, B. K. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282da0bf6 · Cited by 15
Neurotrophic Support of Midbrain Dopaminergic Neurons
Halbach, O. V. B. U., & Unsicker, K. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-0322-8_7 · Cited by 15
Er, Ş., & Airavaara, M. (2023) · Biochemical Society Transactions · doi:10.1042/bst20220770 · Cited by 14
Gene therapy in Parkinson?s disease
Eberhardt, O., & Schulz, J. B. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0947-x · Cited by 14
Pre- and post-synaptic modification by neurotrophins
Kojima, M., Klein, R. L., & Hatanaka, H. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00034-2 · Cited by 13
Self-citationGene therapy approaches for the treatment of Parkinson's disease
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Metadata
- Authors
- Klein, R. L., Lewis, M. H., Muzyczka, N., & Meyer, E. M.
- Affiliations
- University of Florida (US)
- Corresponding author
- Klein, Ronald L.
- ORCID
- Lewis, Mark H.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 847
- Issue
- 2
- Pages
- 314-320
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1987647111
- Cited by
- 128
- References
- 22
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 6
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- National Institutes of Health (2r01gm035723-15)
- National Heart, Lung, and Blood Institute (HL 53665, HL/DK 50257, R01HL053665)
- National Institute of General Medical Sciences (GM35723)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK050257)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- brain-derived neurotrophic factor, 6-hydroxydopamine lesion, substantia nigra pars compacta, gene transfer, adeno-associated virus vectors, neuron-specific enolase promoter, internal ribosome entry site, amphetamine-induced rotation, locomotor activity, dopaminergic neuron survival, tyrosine hydroxylase, neuroprotection
- MeSH terms
- Amphetamine, Central Nervous System Stimulants, Animals, Genetic Vectors, Humans, Motor Activity, Parkinson Disease, Substantia Nigra, Oxidopamine, Rats, Sprague-Dawley, Gene Transfer Techniques, Adrenergic Agents, Brain-Derived Neurotrophic Factor, Rats
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