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Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum
Abstract
The brown seaweed Sargassum stenophyllum biosynthesizes two different sets of fucoidans. One of them is characterized by higher percentages of glucuronic acid and fewer sulfate groups, which are situated on different sugar units. alpha-L-Fucose was the major component but other sugars like beta-D-galactose, beta-D-mannose, alpha-D-glucuronic acid, alpha-D-glucose and beta-D-xylose were also in substantial amounts. Fucoidans from the other set contain small amounts of alpha-D-glucuronic acid and high percentages of sulfate groups, which are concentrated on the fucose residues, with only fucose and galactose as major components. Structural studies of one fucoidan from each set suggest that these products have a general basic structure that has a formal resemblance to that of the fucosylated chondroitin sulfates from the body wall of sea cucumbers, namely, a linear core (formed mainly by (1-->6)-beta-D-galactose and/or (1-->2)-beta-D-mannose units) with branched chains of 'fucans' (formed by (1-->3) and/or (1-->4)-alpha-L-fucose, (1-->4)-alpha-D-glucuronic acid, terminal beta-D-xylose and, sometimes, (1-->4)-alpha-D-glucose). In fucoidans from the second set, the 'core' is reduced to short galactan chains.
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In the citing paper
“Sargassum stenophyllum was reported to have two types of galactofucans, which resembled the fucosylated chondroitin sulfates from sea cucumbers [23]. They were composed of a linear core and branched chains of fucans.”
From A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent (2022) · cites this paper as [23]
In the citing paper
“A longer extraction time decreases the fucose and sulfate contents, resulting in low-quality fucoidan [23,37].”
From A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent (2022) · cites this paper as [23]
In the citing paper
“These sulfated galactofucans are mainly built of (1→6)-β-d-galactose and/or (1→2)-β-d-mannose units with branching points formed by (1→3) and/or (1→4)-α-l-fucose, (1→4)-α-d-glucuronic acid, terminal β-d-xylose and sometimes (1→4)-α-d-glucose [18].”
In the citing paper
“The type I polysaccharides were composed of a linear backbone formed mainly by (1→6)-β-d-galactose and/or (1→2)-β-d-mannose with branching chains formed by (1→3) and/or (1→4)-α-l-fucose, (1→4)-α-d-glucuronic acid, while in the type II polysaccharides the backbone was mainly built of short galactan chains [18].”
In the citing paper
“the FCSPs of this type extracted from the brown seaweed Sargassum stenophyllum (Fucales) were grouped into two different types: type I was found to contain a relatively high percentage of α-d-glucuronic acid and relatively few sulfate groups, while type II contained relatively small amounts of α-d-glucuronic acid and a high percentage of sulfate [18].”
In the citing paper
“Brown seaweed species in the order of Fucales have also been reported to contain very complex FCSPs structures having fucose and galactose in comparable amounts; these structures are generally referred to as sulfated galactofucans and are predominantly found among Sargassum species [18,34,35].”
In the citing paper
“In contrast, the sulfated ''pseudo''-fucoidan polysaccharides extracted from some other species in the order Fucales, such as e.g.Sargassum stenophyllum, are built mainly of b(1A6)-D-galactose and/or b(1A2)-D-mannose units in the polysaccharide backbone with branching points formed by a(1A3) and/or a(1A4)-L-fucose, a(1A4)-D-glucuronic acid, terminal b-D-xylose, and sometimes a(1A4)-D-glucose.”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [11]
In the citing paper
“The sulfate groups on the fucans are typically located at C-4 of a (1A3)-linked unit or on C-2 of a (1A4)-linked residue.11”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [11]
In the citing paper
“It has also been shown by others that longer extraction time at higher temperatures led to higher polysaccharide yield with lower amounts of sulfate and a higher proportion of glucuronic acid.11,17”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [11]
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Metadata
- Authors
- Duarte, M. E. R., Cardoso, M. A., Noseda, M. D., & Cerezo, A. S.
- Affiliations
- Universidade Federal do Paraná (BR)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Cerezo, Alberto S
- Venue
- Carbohydrate Research
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 333
- Issue
- 4
- Pages
- 281-293
- ISSN
- 0008-6215 (ISSN-L)
- OpenAlex
- W2056705583
- Cited by
- 319
- References
- 44
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 14 · 2023: 14 · 2022: 19 · 2021: 18 · 2020: 24 · 2019: 17 · 2018: 12 · 2017: 20 · 2016: 11 · 2015: 22 · 2014: 19 · 2013: 20 · 2012: 21
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- fucoidan, brown seaweed polysaccharides, sulfated polysaccharides, glucuronic acid, fucose, galactose, mannose, xylose, polysaccharide structure, galactan, fucan
- MeSH terms
- Anticoagulants, Blood Coagulation, Humans, Monosaccharides, Optical Rotation, Partial Thromboplastin Time, Polysaccharides, Seaweed, Thrombin Time, Nuclear Magnetic Resonance, Biomolecular
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