Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum
Abstract
The brown seaweed Sargassum stenophyllum biosynthesizes two different sets of fucoidans. One of them is characterized by higher percentages of glucuronic acid and fewer sulfate groups, which are situated on different sugar units. alpha-L-Fucose was the major component but other sugars like beta-D-galactose, beta-D-mannose, alpha-D-glucuronic acid, alpha-D-glucose and beta-D-xylose were also in substantial amounts. Fucoidans from the other set contain small amounts of alpha-D-glucuronic acid and high percentages of sulfate groups, which are concentrated on the fucose residues, with only fucose and galactose as major components. Structural studies of one fucoidan from each set suggest that these products have a general basic structure that has a formal resemblance to that of the fucosylated chondroitin sulfates from the body wall of sea cucumbers, namely, a linear core (formed mainly by (1-->6)-beta-D-galactose and/or (1-->2)-beta-D-mannose units) with branched chains of 'fucans' (formed by (1-->3) and/or (1-->4)-alpha-L-fucose, (1-->4)-alpha-D-glucuronic acid, terminal beta-D-xylose and, sometimes, (1-->4)-alpha-D-glucose). In fucoidans from the second set, the 'core' is reduced to short galactan chains.
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Sargassum stenophyllum has two types of galactofucans composed of a linear core and branched chains of fucans.
“Sargassum stenophyllum was reported to have two types of galactofucans, which resembled the fucosylated chondroitin sulfates from sea cucumbers [23]. They were composed of a linear core and branched chains of fucans.”
From A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent (2022) · cites this paper as [23]
Longer extraction time decreases fucose and sulfate contents, resulting in low-quality fucoidan.
“A longer extraction time decreases the fucose and sulfate contents, resulting in low-quality fucoidan [23,37].”
From A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent (2022) · cites this paper as [23]
These sulfated galactofucans are mainly built of (1→6)-β-d-galactose and/or (1→2)-β-d-mannose units with branching points formed by (1→3) and/or (1→4)-α-l-fucose, (1→4)-α-d-glucuronic acid, terminal β-d-xylose and sometimes (1→4)-α-d-glucose.
“These sulfated galactofucans are mainly built of (1→6)-β-d-galactose and/or (1→2)-β-d-mannose units with branching points formed by (1→3) and/or (1→4)-α-l-fucose, (1→4)-α-d-glucuronic acid, terminal β-d-xylose and sometimes (1→4)-α-d-glucose [18].”
Type I polysaccharides from Sargassum stenophyllum were composed of a linear backbone formed mainly by (1→6)-β-d-galactose and/or (1→2)-β-d-mannose with branching chains formed by (1→3) and/or (1→4)-α-l-fucose, (1→4)-α-d-glucuronic acid, while in the type II polysaccharides the backbone was mainly built of short galactan chains.
“The type I polysaccharides were composed of a linear backbone formed mainly by (1→6)-β-d-galactose and/or (1→2)-β-d-mannose with branching chains formed by (1→3) and/or (1→4)-α-l-fucose, (1→4)-α-d-glucuronic acid, while in the type II polysaccharides the backbone was mainly built of short galactan chains [18].”
FCSPs extracted from Sargassum stenophyllum were grouped into two different types: type I contained a relatively high percentage of α-d-glucuronic acid and relatively few sulfate groups, while type II contained relatively small amounts of α-d-glucuronic acid and a high percentage of sulfate.
“the FCSPs of this type extracted from the brown seaweed Sargassum stenophyllum (Fucales) were grouped into two different types: type I was found to contain a relatively high percentage of α-d-glucuronic acid and relatively few sulfate groups, while type II contained relatively small amounts of α-d-glucuronic acid and a high percentage of sulfate [18].”
Brown seaweed species in the order of Fucales contain very complex FCSPs structures having fucose and galactose in comparable amounts; these structures are generally referred to as sulfated galactofucans and are predominantly found among Sargassum species.
“Brown seaweed species in the order of Fucales have also been reported to contain very complex FCSPs structures having fucose and galactose in comparable amounts; these structures are generally referred to as sulfated galactofucans and are predominantly found among Sargassum species [18,34,35].”
Sulfated pseudo-fucoidan polysaccharides extracted from Sargassum stenophyllum are built mainly of β(1→6)-D-galactose and/or β(1→2)-D-mannose units in the backbone with branching points formed by α(1→3) and/or α(1→4)-L-fucose, α(1→4)-D-glucuronic acid, terminal β-D-xylose, and sometimes α(1→4)-D-glucose.
“In contrast, the sulfated ''pseudo''-fucoidan polysaccharides extracted from some other species in the order Fucales, such as e.g.Sargassum stenophyllum, are built mainly of b(1A6)-D-galactose and/or b(1A2)-D-mannose units in the polysaccharide backbone with branching points formed by a(1A3) and/or a(1A4)-L-fucose, a(1A4)-D-glucuronic acid, terminal b-D-xylose, and sometimes a(1A4)-D-glucose.”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [11]
Sulfate groups on the fucans are typically located at C-4 of an α(1→3)-linked unit or on C-2 of an α(1→4)-linked residue.
“The sulfate groups on the fucans are typically located at C-4 of a (1A3)-linked unit or on C-2 of a (1A4)-linked residue.11”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [11]
Longer extraction time at higher temperatures led to higher polysaccharide yield with lower amounts of sulfate and a higher proportion of glucuronic acid.
“It has also been shown by others that longer extraction time at higher temperatures led to higher polysaccharide yield with lower amounts of sulfate and a higher proportion of glucuronic acid.11,17”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [11]
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Colorimetric Method for Determination of Sugars and Related Substances
DuBois, M., Gilles, K. A., Hamilton, J. K., Rebers, P. A., & Smith, F. (1956) · Analytical Chemistry · doi:10.1021/ac60111a017 · Cited by 52,269 · see citing works
New method for quantitative determination of uronic acids
Blumenkrantz, N., & Asboe-Hansen, G. (1973) · Analytical Biochemistry · doi:10.1016/0003-2697(73)90377-1 · Cited by 7,140 · see citing works
A simple and rapid method for the permethylation of carbohydrates
Ciucanu, I., & Kerek, F. (1984) · Carbohydrate Research · doi:10.1016/0008-6215(84)85242-8 · Cited by 3,581 · see citing works
A note on the determination of the ester sulphate content of sulphated polysaccharides
Dodgson, K. S., & Price, R. (1962) · Biochemical Journal · doi:10.1042/bj0840106 · Cited by 1,645 · see citing works
Taylor, R., & Conrad, H. E. (1972) · Biochemistry · doi:10.1021/bi00758a009 · Cited by 889 · see citing works
Foxall, C., Watson, S., Dowbenko, D. J., Fennie, C., Lasky, L. A., Kiso, M., Hasegawa, A., Asa, D., & Brandley, B. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.117.4.895 · Cited by 687 · see citing works
Baba, M., Snoeck, R., Pauwels, R., & Clercq, E. D. (1988) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.32.11.1742 · Cited by 545 · see citing works
A revised structure for fucoidan may explain some of its biological activities.
Patankar, M. S., Oehninger, S., Barnett, T., Williams, R. L., & Clark, G. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80609-7 · Cited by 531 · see citing works
Further data on the structure of brown seaweed fucans: relationships with anticoagulant activity
Chevolot, L., Foucault, A., Chaubet, F., Kervarec, N., Sinquin, C., Fisher, A.-M., & Boisson-Vidal, C. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00127-5 · Cited by 330 · see citing works
A study of fucoidan from the brown seaweed Chorda filum
Chizhov, A. O., Dell, A., Morris, H. R., Haslam, S. M., McDowell, R. A., Shashkov, A. S., Nifant’ev, N. E., Khatuntseva, E. A., & Usov, A. I. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00148-2 · Cited by 326 · see citing works
Structure and Anticoagulant Activity of a Fucosylated Chondroitin Sulfate from Echinoderm
Mourão, P. A. S., Pereira, M. S., Pavão, M. S. G., Mulloy, B., Tollefsen, D. M., Mowinckel, M., & Abildgaard, U. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.39.23973 · Cited by 316 · see citing works
Nagasawa, K., Inoue, Y., & Kamata, T. (1977) · Carbohydrate Research · doi:10.1016/s0008-6215(00)83402-3 · Cited by 311 · see citing works
Vieira, R. P., Mulloy, B., & Mourão, P. A. S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92730-4 · Cited by 230 · see citing works
Carlucci, M. J., Pujol, C. A., Ciancia, M., Noseda, M. D., Matulewicz, M. C., Damonte, E. B., & Cerezo, A. S. (1997) · International Journal of Biological Macromolecules · doi:10.1016/s0141-8130(96)01145-2 · Cited by 224 · see citing works
Self-citationInfra-red spectroscopic studies of some polysaccharides
Orr, S. F. D. (1954) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(54)90156-0 · Cited by 215 · see citing works
Mulloy, B., Ribeiro, A.-C., Alves, A.-P., Vieira, R. P., & Mourão, P. A. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31763-5 · Cited by 175 · see citing works
Structural study of fucoidan from Cladosiphon okamuranus tokida
Nagaoka, M., Shibata, H., Kimura-Takagi, I., Hashimoto, S., Kimura, K., Makino, T., Aiyama, R., Ueyama, S., & Yokokura, T. (1999) · Glycoconjugate Journal · doi:10.1023/a:1006945618657 · Cited by 173 · see citing works
Andersson, L.-O., Barrowcliffe, T. W., Holmer, E., Johnson, E. A., & Soderstrom, G. F. (1979) · Thrombosis Research · doi:10.1016/0049-3848(79)90159-2 · Cited by 172 · see citing works
Conformational changes and anticoagulant activity of chondroitin sulfate following its O-sulfonation
Maruyama, T., Toida, T., Imanari, T., Yu, G., & Linhardt, R. J. (1998) · Carbohydrate Research · doi:10.1016/s0008-6215(97)10060-x · Cited by 158 · see citing works
Nishino, T., Nishioka, C., Ura, H., & Nagumo, T. (1994) · Carbohydrate Research · doi:10.1016/s0008-6215(00)90980-7 · Cited by 157 · see citing works
Nishino, T., Yokoyama, G., Dobashi, K., Fujihara, M., & Nagumo, T. (1989) · Carbohydrate Research · doi:10.1016/0008-6215(89)84010-8 · Cited by 132 · see citing works
Anticoagulant and antithrombin activities of oversulfated fucans
Nishino, T., & Nagumo, T. (1992) · Carbohydrate Research · doi:10.1016/s0008-6215(00)90581-0 · Cited by 122 · see citing works
Nishino, T., Nagumo, T., Kiyohara, H., & Yamada, H. (1991) · Carbohydrate Research · doi:10.1016/0008-6215(91)84147-7 · Cited by 116 · see citing works
The role of carbohydrates in sperm-egg interaction in rats
Shalgi, R. (1986) · Biology of Reproduction · doi:10.1095/biolreprod34.3.446 · Cited by 105 · see citing works
Kariya, Y., Watabe, S., Kyogashima, M., Ishihara, M., & Ishii, T. (1997) · Carbohydrate Research · doi:10.1016/s0008-6215(96)00258-3 · Cited by 92 · see citing works
Larsen, B. A., Haug, A., Painter, T. J., Marøy, K., Brünvoll, J., Bunnenberg, E., Djerassi, C., & Records, R. (1966) · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · doi:10.3891/acta.chem.scand.20-0219 · Cited by 85 · see citing works
Kariya, Y., Watabe, S., HASHIMOTO, K., & Yoshida, K. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)34087-6 · Cited by 84 · see citing works
Oehninger, S., Clark, G. F., Acosta, A. A., & Hodgen, G. D. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54077-1 · Cited by 69 · see citing works
Stortz, C. A., & Cerezo, A. S. (1993) · Carbohydrate Research · doi:10.1016/0008-6215(93)80036-e · Cited by 66 · see citing works
Self-citationGlucuronoxylofucan, a cell-wall component of ascophyllum nodosum. Part I
Percival, E. E. (1968) · Carbohydrate Research · doi:10.1016/s0008-6215(00)81200-8 · Cited by 65 · see citing works
Carbohydrates of the brown seaweeds himanthalia lorea and bifurcaria bifurcata
Mian, A. J., & Percival, E. (1973) · Carbohydrate Research · doi:10.1016/s0008-6215(00)85031-4 · Cited by 50 · see citing works
An anticoagulant fucoidan from the brown seaweed Ecklonia kurome
Nishino, T., Kiyohara, H., Yamada, H., & Nagumo, T. (1991) · Phytochemistry · doi:10.1016/0031-9422(91)83722-w · Cited by 49 · see citing works
Abdel-Fattah, A. F., Hussein, M. M.-D., & Salem, H. M. (1974) · Carbohydrate Research · doi:10.1016/s0008-6215(00)82935-3 · Cited by 48 · see citing works
A radiochemical approach to the determination of carboxylic acid groups in polysaccharides
Anderson, M. A., & Stone, B. A. (1985) · Carbohydrate Polymers · doi:10.1016/0144-8617(85)90029-3 · Cited by 41 · see citing works
Nishino, T., Takabe, Y., & Nagumo, T. (1994) · Carbohydrate Polymers · doi:10.1016/0144-8617(94)90099-x · Cited by 31 · see citing works
Matulewicz, M. C., & Cerezo, A. S. (1987) · Carbohydrate Polymers · doi:10.1016/0144-8617(87)90054-3 · Cited by 30 · see citing works
Self-citationCarbohydrates of the brown seaweeds
Percival, E. E., & Young, M. (1974) · Carbohydrate Research · doi:10.1016/s0008-6215(00)82097-2 · Cited by 29 · see citing works
Structural features of a novel glucuronogalactofucan from ascophyllum nodosum
Medcalf, D. G., Schneider, T. L., & Barnett, R. W. (1978) · Carbohydrate Research · doi:10.1016/s0008-6215(00)83249-8 · Cited by 20 · see citing works
Low-molecular Carbohydrates in Algae. VII. Investigation of Fucus spiralis and Desmarestia aculeata.
Bouveng, H. O., Lindberg, B., Burris, R. H., & Lamm, O. (1955) · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · doi:10.3891/acta.chem.scand.09-0168 · Cited by 19 · see citing works
Some structural features of sargassan, a sulphated heteropolysaccharide from Sargassum linifolium
ABDEL-FATTAH, A. F., Hussein, M. M.-D., & Salem, H. M. (1974) · Carbohydrate Research · doi:10.1016/s0008-6215(00)82936-5 · Cited by 18 · see citing works
Methanolysis of Fucoidan. II. The Presence of Sugars Other Than L-Fucose
Schweiger, R. G. (1962) · The Journal of Organic Chemistry · doi:10.1021/jo01059a034 · Cited by 16 · see citing works
Two new polysaccharides from Colpomenia sinuosa
Hussein, M. M.-D. (1975) · Phytochemistry · doi:10.1016/0031-9422(75)85313-1 · Cited by 9 · see citing works
The Determination of Fucose in Complex Natural Products
Tortorella, H., Mazzini, M. N., & Cerezo, A. S. (1988) · Analytical Letters · doi:10.1080/00032718808059902 · Cited by 1 · see citing works
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Seaweed extracts as biostimulants of plant growth and development
Khan, W., Rayirath, U. P., Subramanian, S., Jithesh, M. N., Rayorath, P., Hodges, D. M., Critchley, A. T., Craigie, J. S., Norrie, J., & Prithiviraj, B. (2009) · Journal of Plant Growth Regulation · doi:10.1007/s00344-009-9103-x · Cited by 1,740 · see citing works
Fucoidan: Structure and bioactivity
Li, B., Lu, F., Wei, X., & Zhao, R. (2008) · Molecules · doi:10.3390/molecules13081671 · Cited by 1,383 · see citing works
Chemical structures and bioactivities of sulfated polysaccharides from marine algae
Jiao, G., Yu, G., Zhang, J., & Ewart, H. S. (2011) · Marine Drugs · doi:10.3390/md9020196 · Cited by 1,054 · see citing works
Ale, M. T., Mikkelsen, J. D., & Meyer, A. S. (2011) · Marine Drugs · doi:10.3390/md9102106 · Cited by 779 · see citing works
Berteau, O. (2003) · Glycobiology · doi:10.1093/glycob/cwg058 · Cited by 769 · see citing works
Marine Polysaccharides from Algae with Potential Biomedical Applications
Raposo, M. F. D. J., Morais, A. M. M. B., & Morais, R. M. S. C. (2015) · Marine Drugs · doi:10.3390/md13052967 · Cited by 693 · see citing works
Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications
Cunha, L., & Grenha, A. (2016) · Marine Drugs · doi:10.3390/md14030042 · Cited by 619 · see citing works
Characterization of polysaccharides extracted from brown seaweeds
Rioux, L.-E., Turgeon, S. L., & Beaulieu, M. (2007) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2007.01.009 · Cited by 604 · see citing works
Screening for bioactive compounds from algae
Plaza, M., Santoyo, S., Jaime, L., Reina, G. G.-B., Herrero, M., Señoráns, F. J., & Ibáñez, E. (2009) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2009.03.016 · Cited by 493 · see citing works
Potentials of macroalgae as feedstocks for biorefinery
Jung, K. A., Lim, S.-R., Kim, Y., & Park, J. M. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2012.10.025 · Cited by 487 · see citing works
Ponce, N. M. A., Pujol, C. A., Damonte, E. B., Flores, M. L., & Stortz, C. A. (2003) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00403-2 · Cited by 484 · see citing works
Microwave-assisted extraction of sulfated polysaccharides (fucoidan) from brown seaweed
Rodriguez-Jasso, R. M., Mussatto, S. I., Pastrana, L., Aguilar, C. N., & Teixeira, J. A. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.06.006 · Cited by 434 · see citing works
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Bilan, M. I., Grachev, A. A., Ustuzhanina, N. E., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I. (2002) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00053-8 · Cited by 412 · see citing works
Ale, M. T., & Meyer, A. S. (2013) · RSC Adv. · doi:10.1039/c3ra23373a · Cited by 381 · see citing works
Ye, H., Wang, K., Zhou, C., Liu, J., & Zeng, X. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.04.012 · Cited by 372 · see citing works
Yuan, Y., & Macquarrie, D. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.04.057 · Cited by 371 · see citing works
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Senthilkumar, K., Manivasagan, P., Venkatesan, J., & Kim, S.-K. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.06.030 · Cited by 340 · see citing works
Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms
van Weelden, G. H., Bobiński, M. S., Okła, K., van Weelden, W. J., Romano, A., & Pijnenborg, J. M. A. (2019) · Marine Drugs · doi:10.3390/md17010032 · Cited by 336 · see citing works
Dore, C. M. P. G., Faustino Alves, M. G. D. C., Pofírio Will, L. S. E., Costa, T. G., Sabry, D. A., de Souza Rêgo, L. A. R., Accardo, C. M., Rocha, H. A. O., Filgueira, L. G. A., & Leite, E. L. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.07.075 · Cited by 286 · see citing works
Fenoradosoa, T. A., Ali, G., Delattre, C., Laroche, C., Petit, E., Wadouachi, A., & Michaud, P. (2009) · Journal of Applied Phycology · doi:10.1007/s10811-009-9432-y · Cited by 288 · see citing works
Chen, S., Xue, C., Yin, L., Tang, Q., Yu, G., & Chai, W. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.08.040 · Cited by 268 · see citing works
Vishchuk, O. S., Ermakova, S. P., & Zvyagintseva, T. N. (2011) · Carbohydrate Research · doi:10.1016/j.carres.2011.09.034 · Cited by 267 · see citing works
A highly regular fraction of a fucoidan from the brown seaweed Fucus distichus L.
Bilan, M. I., Grachev, A. A., Ustuzhanina, N. E., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I. (2004) · Carbohydrate Research · doi:10.1016/j.carres.2003.10.028 · Cited by 255 · see citing works
Yang, C., Chung, D., Shin, I.-S., Lee, H., Kim, J., Lee, Y., & You, S. (2008) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2008.08.006 · Cited by 254 · see citing works
Talarico, L. B., Zibetti, R. G. M., de Faria, P. A. C., Scolaro, L. A., Duarte, M. E. R., Noseda, M. D., Pujol, C. A., & Damonte, E. B. (2004) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2004.03.002 · Cited by 251 · see citing works
Self-citationFucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties
Zayed, A., El‐Aasr, M., Ibrahim, A.-R. S., & Ulber, R. (2020) · Marine Drugs · doi:10.3390/md18110571 · Cited by 245 · see citing works
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Vo, T., & Kim, S. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.08.007 · Cited by 237 · see citing works
Stiger‐Pouvreau, V., Bourgougnon, N., & Deslandes, É. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802772-1.00008-7 · Cited by 226 · see citing works
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Liu, M., Liu, Y., Cao, M., Liu, G., Chen, Q., Sun, L., & Chen, H. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.05.060 · Cited by 221 · see citing works
Hifney, A. F., Fawzy, M. A., Abdel-Gawad, K. M., & Gomaa, M. (2016) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2015.09.022 · Cited by 216 · see citing works
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Morya, V. K., Kim, J.-E., & Kim, E.-K. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3666-8 · Cited by 208 · see citing works
Mandal, P., Mateu, C. G., Chattopadhyay, K., Pujol, C. A., Damonte, E. B., & Ray, B. (2007) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020701800305 · Cited by 205 · see citing works
Zhu, B., Ni, F., Xiong, Q., & Yao, Z. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1716207 · Cited by 202 · see citing works
Otero, P., Carpena, M., Garcia‐Oliveira, P., Echave, J., Soria-López, A., García-Pérez, P., Fraga‐Corral, M., Cao, H., Nie, S., Xiao, J., et al. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1969534 · Cited by 203 · see citing works
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Manivasagan, P., Bharathiraja, S., Bui, N. Q., Jang, B., Oh, Y., Lim, I. G., & Oh, J. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.06.007 · Cited by 192 · see citing works
Hwang, P., Chien, S.-Y., Chan, Y.-L., Lu, M.-K., Wu, C.-H., Kong, Z.-L., & Wu, C.-J. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf1043647 · Cited by 184 · see citing works
Characterization of alginates from Ghanaian brown seaweeds: Sargassum spp. and Padina spp.
Rhein‐Knudsen, N., Ale, M. T., Ajalloueian, F., & Meyer, A. S. (2017) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2017.05.016 · Cited by 186 · see citing works
Marine algal carbohydrates as carbon sources for the production of biochemicals and biomaterials
Cesário, M. T., da Fonseca, M. M. R., Marques, M. M., & de Almeida, M. C. M. D. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.02.006 · Cited by 186 · see citing works
Immanuel, G., Madasamy, S., Marudhupandi, T., Radhakrishnan, S., & Palavesam, A. (2012) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2012.01.003 · Cited by 181 · see citing works
Holtkamp, A. D., Kelly, S., Ulber, R., & Lang, S. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1790-x · Cited by 175 · see citing works
Hentati, F., Delattre, C., Ursu, A.-V., Desbrières, J., Cerf, D. L., Gardarin, C., Abdelkafi, S., Michaud, P., & Pierre, G. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.06.098 · Cited by 171 · see citing works
Hemmingson, J. A., Falshaw, R., Furneaux, R. H., & Thompson, K. (2006) · Journal of Applied Phycology · doi:10.1007/s10811-006-9096-9 · Cited by 171 · see citing works
In vitro and in vivo hypoglycemic effects of brown algal fucoidans
Shan, X., Liu, X., Hao, J., Cai, C., Fan, F., Dun, Y., Zhao, X., Liu, X., Li, C., & Yu, G. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.11.036 · Cited by 166 · see citing works
Rioux, L., & Turgeon, S. L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418697-2.00007-6 · Cited by 162 · see citing works
Antioxidant and antiproliferative activities of heterofucans from the seaweed Sargassum filipendula
Costa, L. S., Fidelis, G. P., Telles, C. B. S., Dantas-Santos, N., Camara, R. B. G., Cordeiro, S. L., Costa, M. S. S. P., Almeida-Lima, J., Melo-Silveira, R. F., Oliveira, R. M., et al. (2011) · Marine Drugs · doi:10.3390/md9060952 · Cited by 155 · see citing works
Lee, S., Ko, C., Ahn, G., You, S., Kim, J., Heu, M. S., Kim, J., Jee, Y., & Jeon, Y. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.03.056 · Cited by 160 · see citing works
Wang, J., Zhang, Q., Zhang, Z., Zhang, H., & Niu, X. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2010.05.010 · Cited by 159 · see citing works
Ammar, H. H., Lajili, S., Said, R. B., Cerf, D. L., Bouraoui, A., & Majdoub, H. (2015) · DARU Journal of Pharmaceutical Sciences · doi:10.1186/s40199-015-0089-6 · Cited by 158 · see citing works
Cong, Q., Chen, H., Liao, W., Xiao, F., Wang, P., Qin, Y., Dong, Q., & Ding, K. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.09.087 · Cited by 156 · see citing works
Silva, T. M. A., Alves, L. G., Queiroz, K. C. S., Santos, M. G. L., Marques, C. T., Chavante, S. F., Rocha, H. A. O., & Leite, E. L. (2005) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2005000400005 · Cited by 157 · see citing works
Rocha, H. A. O., Moraes, F. A., Trindade, E. D. S., Franco, C. R. C., Torquato, R. J. S., Veiga, S. S., Valente, A. P., Mourão, P. A. S., Leite, E. L., Nader, H. B., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501124200 · Cited by 156 · see citing works
Ale, M. T., Maruyama, H., Tamauchi, H., Mikkelsen, J. D., & Meyer, A. S. (2011) · Marine Drugs · doi:10.3390/md9122605 · Cited by 151 · see citing works
Kariya, Y., Mulloy, B., Imai, K., Tominaga, A., Kaneko, T., Asari, A., Suzuki, K., Masuda, H., Kyogashima, M., & Ishii, T. (2004) · Carbohydrate Research · doi:10.1016/j.carres.2004.02.025 · Cited by 147 · see citing works
A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent
Jayawardena, T. U., Nagahawatta, D. P., Fernando, I. P. S., Kim, Y.-T., Kim, J.-S., Kim, W.-S., Lee, J. S., & Jeon, Y.-J. (2022) · Marine Drugs · doi:10.3390/md20120755 · Cited by 149 · see citing works
A Comprehensive and Comparative Analysis of the Fucoidan Compositional Data Across the Phaeophyceae
Ponce, N. M. A., & Stortz, C. A. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.556312 · Cited by 148 · see citing works
Foley, S. A., Szegezdi, E., Mulloy, B., Samali, A., & Tuohy, M. G. (2011) · Journal of Natural Products · doi:10.1021/np200124m · Cited by 142 · see citing works
Pradhan, B., Patra, S., Nayak, R., Behera, C., Dash, S. R., Nayak, S., Sahu, B. B., Bhutia, S. K., & Jena, M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.09.019 · Cited by 142 · see citing works
In vitro model to estimate gut inflammation using co-cultured Caco-2 and RAW264.7 cells.
Tanoue, T., Nishitani, Y., Kanazawa, K., Hashimoto, T., & Mizuno, M. (2008) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2008.07.063 · Cited by 141 · see citing works
Câmara, R. B. G., Costa, L. S., Fidelis, G. P., Nobre, L. T. D. B., Dantas-Santos, N., Cordeiro, S. L., Costa, M. S. S. P., Alves, L. G., & Rocha, H. A. O. (2011) · Marine Drugs · doi:10.3390/md9010124 · Cited by 137 · see citing works
Palanisamy, S., Vinosha, M., Marudhupandi, T., Rajasekar, P., & Prabhu, N. M. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.04.085 · Cited by 133 · see citing works
Liu, J., Wu, S., Chen, L., Li, Q., Shen, Y.-Z., Li, J., Zhang, X., Chen, P., Wu, M., Choi, J., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.113 · Cited by 131 · see citing works
Thinh, P. D., Menshova, R. V., Ermakova, S. P., Anastyuk, S. D., Ly, B., & Николаевна, З. Т. (2013) · Marine Drugs · doi:10.3390/md11051456 · Cited by 129 · see citing works
Hu, P., Li, Z., Chen, M., Sun, Z., Ling, Y., Jiang, J., & Huang, C. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.12.019 · Cited by 128 · see citing works
Ni, L., Wang, L., Fu, X.-T., Duan, D., Jeon, Y., Xu, J.-C., & Gao, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.04.012 · Cited by 116 · see citing works
Veeraperumal, S., Senthilkumar, N., Thangam, R., Rajkumar, M., Anbazhagan, C., Rengasamy, R., Gunasekaran, P., Kannan, S., & Perumal, P. (2013) · Process Biochemistry · doi:10.1016/j.procbio.2012.12.014 · Cited by 126 · see citing works
Anisha, G. S., Padmakumari, S., Patel, A. K., Pandey, A., & Singhania, R. R. (2022) · Bioengineering · doi:10.3390/bioengineering9090472 · Cited by 121 · see citing works
Rabanal, M., Ponce, N. M. A., Navarro, D. A., Gomez, R. M., & Stortz, C. A. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.10.019 · Cited by 117 · see citing works
Vishchuk, O. S., Ermakova, S. P., & Zvyagintseva, T. N. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.03.065 · Cited by 117 · see citing works
Abdel‐Latif, H. M. R., Dawood, M. A. O., Alagawany, M. M., Faggio, C., Nowosad, J., & Kucharczyk, D. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.01.039 · Cited by 118 · see citing works
Heterofucans from Dictyota menstrualis have anticoagulant activity
Albuquerque, I. R. L., Queiroz, K. C. S., Alves, L. G., dos Santos, E. A., Leite, E. L., & Rocha, H. A. O. (2004) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2004000200002 · Cited by 116 · see citing works
Ale, M. T., Mikkelsen, J. D., & Meyer, A. S. (2012) · Journal of Applied Phycology · doi:10.1007/s10811-011-9690-3 · Cited by 113 · see citing works
Fucoidans: Pro- or antiangiogenic agents?
Ustyuzhanina, N. E., Bilan, M. I., Ушакова, Н. А., Usov, A. I., Kiselevskiy, M. V., & Nifantiev, N. E. (2014) · Glycobiology · doi:10.1093/glycob/cwu063 · Cited by 113 · see citing works
Ultrasound-assisted extraction of fucoidan from Sargassum muticum
Flórez-Fernández, N., López-García, M., González‐Muñoz, M. J., Vilariño, J. M. L., & Domı́nguez, H. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-016-1043-9 · Cited by 114 · see citing works
Green synthesis of silver nanoparticles using biopolymers, carboxymethylated-curdlan and fucoidan
Leung, T. C.-Y., Wong, C. K., & Xie, Y. (2010) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2010.02.026 · Cited by 109 · see citing works
Simultaneous Extraction and Depolymerization of Fucoidan from Sargassum muticum in Aqueous Media
Balboa, E. M., Rivas, S., Moure, A., Domı́nguez, H., & Parajó, J. C. (2013) · Marine Drugs · doi:10.3390/md11114612 · Cited by 107 · see citing works
Mou, J., Li, Q., Qi, X., & Yang, J. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.01.017 · Cited by 108 · see citing works
Potential of intensification techniques for the extraction and depolymerization of fucoidan
Flórez-Fernández, N., Torres, M. D., González‐Muñoz, M. J., & Domı́nguez, H. (2018) · Algal Research · doi:10.1016/j.algal.2018.01.002 · Cited by 107 · see citing works
Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis
Trinchero, J., Ponce, N. M. A., Córdoba, O. L., Flores, M. L., Pampuro, S. E., Stortz, C. A., Salomón, H., & Turk, G. (2008) · Phytotherapy Research · doi:10.1002/ptr.2723 · Cited by 106 · see citing works
Challenges and Opportunities in Relation to Sargassum Events Along the Caribbean Sea
Robledo, D., Vázquez-Delfín, E. F., Freile‐Pelegrín, Y., Vásquez‐Elizondo, R. M., Qui‐Minet, Z. N., & Salazar-Garibay, A. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.699664 · Cited by 104 · see citing works
Beneficial effects of fucoidan on osteoblastic MG-63 cell differentiation
Cho, Y.-S., Jung, W., Kim, J., Choi, I., & Kim, S. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.03.051 · Cited by 104 · see citing works
Structures and antiviral activities of polysaccharides from Sargassum trichophyllum
Lee, J., Takeshita, A., Hayashi, K., & Hayashi, T. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.05.059 · Cited by 104 · see citing works
Silchenko, A. S., Rasin, A. B., Игоревич, К. М., Kalinovsky, A. I., Miansong, Z., Changheng, L., Malyarenko, O. S., Zueva, A. O., Николаевна, З. Т., & Ermakova, S. P. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.08.043 · Cited by 102 · see citing works
Structure and Biological Activity Analysis of Fucoidan Isolated from Sargassum siliquosum
Wang, S.-H., Huang, C., Chen, C., Chang, C., Huang, C.-Y., Dong, C., & Chang, J. (2020) · ACS Omega · doi:10.1021/acsomega.0c04591 · Cited by 102 · see citing works
Pandian, V., Vaseela, N., & Thirumaran, G. (2012) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(12)60082-x · Cited by 100 · see citing works
Dias, P. F., Siqueira, J. M., Vendruscolo, L. F., Neiva, T. D. J. C., Gagliardi, A. R. D. T., Maraschin, M., & Ribeiro‐do‐Valle, R. M. (2005) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-004-0995-7 · Cited by 99 · see citing works
Polysaccharides composition from tropical brown seaweeds
García‐Ríos, V., Ríos‐Leal, E., Robledo, D., & Freile‐Pelegrín, Y. (2012) · Phycological Research · doi:10.1111/j.1440-1835.2012.00661.x · Cited by 99 · see citing works
Magalhaes, K. D., Costa, L. S., Fidelis, G. P., Oliveira, R. M., Nobre, L. T. D. B., Dantas-Santos, N., Camara, R. B. G., Albuquerque, I. R. L., Cordeiro, S. L., Sabry, D. A., et al. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12053352 · Cited by 97 · see citing works
Isolation and characterization of poly- and oligosaccharides from the red microalga Porphyridium sp.
Geresh, S., Arad, S. M., Levy‐Ontman, O., Zhang, W., Tekoah, Y., & Glaser, R. (2008) · Carbohydrate Research · doi:10.1016/j.carres.2008.11.012 · Cited by 94 · see citing works
Cui, Y., Liu, X. B., Li, S., Hao, L., Du, J., Gao, D., Kang, Q., & Lu, J. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.05.134 · Cited by 92 · see citing works
Madasamy, S., Thaddaeus, B. J., Palavesam, A., & Immanuel, G. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.05.037 · Cited by 92 · see citing works
Antioxidant Activity of Sulfated Polysaccharides Isolated from Sargassum fulvellum
Kim, S., Choi, D., Athukorala, Y., Jeon, Y., Senevirathne, M., & Rha, C. (2007) · Preventive Nutrition and Food Science · doi:10.3746/jfn.2007.12.2.065 · Cited by 89 · see citing works
Yin and Yang: complement activation and regulation in Alzheimer’s disease
Shen, Y., & Meri, S. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.08.001 · Cited by 89 · see citing works
Dalal, S. R., Hussein, M. H., El‐Naggar, N. E., Mostafa, S. I., & Shaaban-Dessouki, S. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-96202-0 · Cited by 88 · see citing works
Zhu, Y., Liu, L., Sun, Z., Ji, Y., Wang, D., Mei, L., Shen, P., Li, Z., Tang, S., Zhang, H., et al. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.03.065 · Cited by 87 · see citing works
Rheological characterisation of polysaccharides extracted from brown seaweeds
Rioux, L., Turgeon, S. L., & Beaulieu, M. (2007) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2829 · Cited by 87 · see citing works
Borazjani, N. J., Tabarsa, M., You, S., & Rezaei, M. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.11.059 · Cited by 87 · see citing works
Anastyuk, S. D., Imbs, T. I., Шевченко, Н. М., Dmitrenok, P. S., & Николаевна, З. Т. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.06.033 · Cited by 85 · see citing works
Ficko‐Blean, E., Hervé, C., & Michel, G. (2015) · Perspectives in Phycology · doi:10.1127/pip/2015/0028 · Cited by 86 · see citing works
Imbs, T. I., Ermakova, S. P., Malyarenko (Vishchuk), O. S., Isakov, V. V., & Zvyagintseva, T. N. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.08.062 · Cited by 84 · see citing works
Extraction of sulfated polysaccharides by autohydrolysis of brown seaweed Fucus vesiculosus
Rodríguez-Jasso, R. M., Mussatto, S. I., Pastrana, L., Aguilar, C. N., & Teixeira, J. A. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-012-9834-0 · Cited by 83 · see citing works
- Authors
- Duarte, M. E. R., Cardoso, M. A., Noseda, M. D., & Cerezo, A. S.
- Affiliations
- Universidade Federal do Paraná (BR)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Cerezo, Alberto S
- Venue
- Carbohydrate Research
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 333
- Issue
- 4
- Pages
- 281-293
- ISSN
- 0008-6215 (ISSN-L)
- OpenAlex
- W2056705583
- Cited by
- 319
- References
- 44
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 14 · 2023: 14 · 2022: 19 · 2021: 18 · 2020: 24 · 2019: 17 · 2018: 12 · 2017: 20 · 2016: 11 · 2015: 22 · 2014: 19 · 2013: 20 · 2012: 21
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- fucoidan, brown seaweed polysaccharides, sulfated polysaccharides, glucuronic acid, fucose, galactose, mannose, xylose, polysaccharide structure, galactan, fucan
- MeSH terms
- Anticoagulants, Blood Coagulation, Humans, Monosaccharides, Optical Rotation, Partial Thromboplastin Time, Polysaccharides, Seaweed, Thrombin Time, Nuclear Magnetic Resonance, Biomolecular
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