The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
Open accessAbstract
beta-Catenin is an essential component of the canonical Wnt signaling system that controls decisive steps in development. We employed here two conditional beta-catenin mutant alleles to alter beta-catenin signaling in the central nervous system of mice: one allele to ablate beta-catenin and the second allele to express a constitutively active beta-catenin. The tissue mass of the spinal cord and brain is reduced after ablation of beta-catenin, and the neuronal precursor population is not maintained. In contrast, the spinal cord and brain of mice that express activated beta-catenin is much enlarged in mass, and the neuronal precursor population is increased in size. beta-Catenin signals are thus essential for the maintenance of proliferation of neuronal progenitors, controlling the size of the progenitor pool, and impinging on the decision of neuronal progenitors to proliferate or to differentiate.
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Cites
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Self-citationNeuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Thomas, K. R., & Capecchi, M. R. (1990) · Nature · doi:10.1038/346847a0 · Cited by 896
The bHLH Gene Hes1 as a Repressor of the Neuronal Commitment of CNS Stem Cells
Nakamura, Y., Sakakibara, S.-I., Miyata, T., Ogawa, M., Shimazaki, T., Weiss, S., Kageyama, R., & Okano, H. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00283.2000 · Cited by 316 · cited 2×
“Ablation of Notch or of the main effectors of Notch signals, Hes1 and Hes5, causes precocious neuronal differentiation (de la Pompa et al., 1997; Lutolf et al., 2002; Nakamura et al., 2000; Ohtsuka et al., 1999).”
BackgroundGenetic mechanisms of early neurogenesis inDrosophila melanogaster
Campos-Ortega, J. A. (1995) · Molecular Neurobiology · doi:10.1007/bf02740668 · Cited by 137
Cited by
Wnt signalling in stem cells and cancer
Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
Mao, Y., Ge, X., Frank, C. L., Madison, J. M., Koehler, A. N., Doud, M. K., Tassa, C., Berry, E. M., Soda, T., Singh, K. K., et al. (2009) · Cell · doi:10.1016/j.cell.2008.12.044 · Cited by 774
The Wnt/β-catenin pathway directs neuronal differentiation of cortical neural precursor cells
Hirabayashi, Y., Itoh, Y., Tabata, H., Nakajima, K., Akiyama, T., Masuyama, N., & Gotoh, Y. (2004) · Development · doi:10.1242/dev.01165 · Cited by 600
WNTS in the vertebrate nervous system: from patterning to neuronal connectivity
Ciani, L., & Salinas, P. C. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1665 · Cited by 543
Metadata
- Authors
- Zechner, D., Fujita, Y., Hülsken, J., Müller, T., Walther, I., Taketo, M. M., Bryan Crenshaw, E., Birchmeier, W., & Birchmeier, C.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 258
- Issue
- 2
- Pages
- 406-418
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W1996484852
- Cited by
- 483
- References
- 6
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zechner, D., Fujita, Y., Hülsken, J., Müller, T., Walther, I., Taketo, M. M., Bryan Crenshaw, E., Birchmeier, W., & Birchmeier, C. (2003). β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Developmental Biology. https://doi.org/10.1016/s0012-1606(03)00123-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
