Melatonin mediates two distinct responses in vascular smooth muscle
Abstract
The pineal hormone melatonin was found to produce two distinct contractile responses in vascular smooth muscle. In isolated rat caudal artery segments, denuded of endothelium, melatonin (10(-10)-10(-7) M) potentiated phenylephrine-induced contractions in a concentration-dependent manner. At higher melatonin concentrations (10(-7)-10(-5) M), however, the potentiating effect was attenuated. In the presence of the melatonin MT2 receptor antagonist, 4-phenyl-2-acetamidotetraline (4P-ADOT), the attenuated constrictor responses were selectively enhanced. These results are consistent with the hypothesis that melatonin activates two receptor subtypes in vascular smooth muscle; MT2 receptors may induce relaxation, while a second receptor subtype mediates vasoconstriction.
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Two different melatonin receptors have been identified with opposite vascular effects: MT1 receptors mediate vasoconstriction and MT2 receptors mediate vasodilatation.
“In addition, two different melatonin receptors have been identified with opposite vascular effects: MT1 receptors mediate vasoconstriction and MT2 receptors mediate vasodilatation (Doolen et al. 1998).”
From Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans (2003) · cites this paper as Doolen et al. 1998
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- Authors
- Doolen, S., Krause, D. N., Dubocovich, M. L., & Duckles, S. P.
- Affiliations
- University of California, Irvine (US)
- Northwestern University (US)
- Corresponding author
- Duckles, Sue P
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 345
- Issue
- 1
- Pages
- 67-69
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W1993651993
- Cited by
- 229
- References
- 0
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 10 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL50775, R01HL050775)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- melatonin, vascular smooth muscle, vasoconstriction, vasorelaxation, MT2 receptor, phenylephrine-induced contraction, receptor subtypes, pineal hormone, caudal artery
- MeSH terms
- Adrenergic alpha-Agonists, Animals, Drug Synergism, Male, Melatonin, Muscle Contraction, Muscle Relaxation, Muscle, Smooth, Vascular, Phenylephrine, Rats, Inbred F344, Receptors, Cell Surface, Tetrahydronaphthalenes, Vasoconstriction, Receptors, Cytoplasmic and Nuclear, Receptors, Melatonin, Rats, In Vitro Techniques
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