Cited by 198Photoreceptor and optogenetics researchRetinal Development and DisordersReceptor Mechanisms and Signaling

Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue1

Tarttelin, Emma E, Bellingham, James, Hankins, Mark W, Foster, Russell G, Lucas, Robert J·2003·FEBS Letters

Abstract

We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord.

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Crossref · 10.1016/s0014-5793(03)01212-2

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47 of 47 references verified0 citation errors · 0 not checkable

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Authors
Tarttelin, E. E., Bellingham, J., Hankins, M. W., Foster, R. G., & Lucas, R. J.
Affiliations
Charing Cross Hospital (GB)
Corresponding author
Tarttelin, Emma E
Venue
FEBS Letters
Publisher
Wiley
Published
2003-10-27
Volume
554
Issue
3
Pages
410-416
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2121570154
Cited by
198
References
47
Citations by year
2026: 9 · 2025: 19 · 2024: 15 · 2023: 13 · 2022: 11 · 2021: 15 · 2020: 11 · 2019: 13 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 13 · 2013: 6 · 2012: 7
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
neuropsin, OPN5, retinal-binding proteins, Schiff base, transmembrane domain, gene cloning, gene expression, nervous tissue, eye, brain, testis, spinal cord, mouse chromosome 17
MeSH terms
Amino Acid Sequence, Animals, Brain, Exons, Eye, Genes, Humans, Kallikreins, Molecular Sequence Data, Nerve Tissue, Nerve Tissue Proteins, Organ Specificity, Phylogeny, Species Specificity, Sequence Alignment, Genome, Sequence Homology, Amino Acid, Protein Structure, Tertiary, Mice

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