Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue1
Abstract
We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord.
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Neuropsin is maximally activated by 380 nm light.
“which is maximally activated by 380 nm light (Tarttelin et al., 2003).”
From Ventral striatum dopamine release encodes unique properties of visual stimuli in mice (2023) · cites this paper as Tarttelin et al., 2003
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- Authors
- Tarttelin, E. E., Bellingham, J., Hankins, M. W., Foster, R. G., & Lucas, R. J.
- Affiliations
- Charing Cross Hospital (GB)
- Corresponding author
- Tarttelin, Emma E
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2003-10-27
- Volume
- 554
- Issue
- 3
- Pages
- 410-416
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2121570154
- Cited by
- 198
- References
- 47
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 15 · 2023: 13 · 2022: 11 · 2021: 15 · 2020: 11 · 2019: 13 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 13 · 2013: 6 · 2012: 7
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- neuropsin, OPN5, retinal-binding proteins, Schiff base, transmembrane domain, gene cloning, gene expression, nervous tissue, eye, brain, testis, spinal cord, mouse chromosome 17
- MeSH terms
- Amino Acid Sequence, Animals, Brain, Exons, Eye, Genes, Humans, Kallikreins, Molecular Sequence Data, Nerve Tissue, Nerve Tissue Proteins, Organ Specificity, Phylogeny, Species Specificity, Sequence Alignment, Genome, Sequence Homology, Amino Acid, Protein Structure, Tertiary, Mice
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