Brain-Derived Neurotrophic Factor in Plasma of Women with Endometriosis
Abstract
Purpose: Endometriosis is one of the most common benign gynecological diseases affecting women of reproductive age; it is characterized by the presence and growth of ectopic endometrial tissue outside the endometrial cavity. This complex disease is frequently associated with infertility and pelvic pain. Given the relationship and the apparent importance of the role that neurotrophins play in the reproductive system, and in particular brain-derived neurotrophic factor (BDNF) which is involved in both the central and peripheral pain pathways, we were interested in determining whether the presence of endometriosis is associated and correlated with plasma and follicular fluid variation of BDNF. Methods: We determined BDNF level in plasma and in follicular fluid from infertile women with endometriosis and fertile women without the disease. Results: BDNF plasma levels were significantly higher in endometriotic patients than in control women (p<0.001). After surgery this level decreased significantly (p<0.001), ranging within the values of control women in follicular phase. In follicular fluid, BDNF values were significantly lower in infertile women for endometriosis than in infertile women for male factors (p<0.001). Conclusion: These data raise the possibility that neuroinflammatory reactions in endometriosis could have a neuroprotective effect and support the hypothesis that BDNF represents an important link in the networks of human homeostasis, thus providing an early marker for patients affected by endometriosis. Moreover, low BDNF levels in follicular fluid may refect an altered ovary production and may be a marker of poor oocyte quality and poor fertility in women suffering from endometriosis.
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Ectopic and eutopic endometrium produce neurotrophic factors, some of which are differentially expressed in cases of endometriosis and could serve as minimally invasive endometriosis biomarkers.
“Not surprisingly, ectopic and eutopic endometrium produce neurotrophic factors, 83 some of which are differentially expressed in cases of endometrioisis 84 and could serve as minimally invasive endometriosis biomarkers.85”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [85]
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- Authors
- Giannini, A., Bucci, F., Luisi, S., Cela, V., Pluchino, N., Merlini, S., Casarosa, E., Russo, M., Cubeddu, A., Daino, D., Artini, P. G., & Genazzani, A. R.
- Affiliations
- University of Pisa (IT)
- University of Siena (IT)
- Corresponding author
- Giannini, Andrea
- Venue
- Journal of Endometriosis
- Publisher
- SAGE Publications
- Published
- 2010-07
- Volume
- 2
- Issue
- 3
- Pages
- 144-150
- ISSN
- 2035-9969 (ISSN-L)
- 2036-282X
- OpenAlex
- W4241740112
- Cited by
- 27
- References
- 30
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 6 · 2022: 2 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Endometriosis and Pelvic Pain Disorders (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Journal of Endometriosis and Pelvic Pain Disorders
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- endometriosis, brain-derived neurotrophic factor, plasma BDNF, follicular fluid, infertility, neuroinflammation, neuroprotection, oocyte quality, biomarkers, pelvic pain
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