Impact of sperm characteristics on time‐lapse embryo morphokinetic parameters and clinical outcome of conventional in vitro fertilization
Open accessAbstract
Background: Sperm abnormalities may negatively affect embryo development. Objectives: To determine the influence of sperm abnormalities (morphology, motility, DNA fragmentation) on embryo morphokinetic variables and clinical outcome of conventional IVF. Materials and methods: Participants were 86 couples undergoing in vitro fertilization (IVF). Sperm morphology was evaluated according to the strict criteria proposed by Kruger/Tygerberg. CASA system was applied for sperm motility assessment. Sperm DNA fragmentation was assessed by the chromatin structure assay (SCSA). Morphokinetic parameters were determined in 223 embryos obtained from conventional IVF only and cultured in a single‐step medium using time‐lapse imaging technology. Results: Time‐lapse variables from the initial embryo development, such as time of pronuclei fading (tPNf) and time for two cells (t2), were those more strongly related with abnormalities of sperm motility, morphology, and DNA fragmentation. Sperm morphological abnormalities rather than sperm motility were more closely associated with embryo morphokinetics. Sperm head defects were mainly correlated with the last stages of embryonic development (t9 to tHB), sperm midpiece defects with intermediate cleaving embryos (t5‐t9), and sperm tail defects with the initial stages of embryonic development (tPNa‐t4). Excess residual cytoplasm was positively correlated with all embryo morphokinetic parameters except t2 and tM. Absence of acrosomes, pinheads, coiled tails, and multiple sperm morphological defects correlated negatively with time‐lapse embryo morphokinetic variables. Discussion: A large number of sperm‐related variables, including frequency of specific morphological defects, morphological indexes, DNA fragmentation and motility, and time‐lapse embryo variables, such as time intervals based mainly of 15 time points were recorded. Conclusion: There were strong associations between specific sperm defects of the head, midpiece, and tail with certain stages of embryonic development from observation of pronuclei to the hatched blastocyst. Coiled tail, cumulative head defects, and multiple abnormalities index (MAI) were associated both with embryo morphokinetics and the implantation success.
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Nikolova et al. examined implantation rate after single embryo transfer in 86 couples and found that abnormalities of the head or the flagellum or high MAI appeared to be predictive of a lower success rate.
“Nikolova et al. [27] examined the implantation rate after single embryo transfer in 86 couples (42 successful vs. 44 unsuccessful implantations). Abnormalities of the head (vacuoles, wide acrosome) or the flagellum (coiled tail) or high MAI appeared to be predictive of a lower success rate.”
From Recommendations for Human Sperm Morphology Assessment in 2025: An Expert Review From the French BLEFCO Group (2026) · cites this paper as [27]
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- Authors
- Nikolova, S., Parvanov, D., Georgieva, V., Ivanova, I., Ganeva, R., & Stamenov, G.
- Affiliations
- Embryology Department Nadezhda Women’s Health Hospital Sofia Bulgaria
- Research Department Nadezhda Women’s Health Hospital Sofia Bulgaria
- Andrology Department Nadezhda Women’s Health Hospital Sofia Bulgaria
- Obsterics and Gynecology Department Nadezhda Women’s Health Hospital Sofia Bulgaria
- Corresponding author
- Parvanov, Dimitar
- Venue
- Andrology
- Publisher
- Wiley
- Published
- 2020-03-30
- Volume
- 8
- Issue
- 5
- Pages
- 1107-1116
- ISSN
- 2047-2919 (ISSN-L)
- 2047-2927
- OpenAlex
- W3010135326
- Cited by
- 24
- References
- 56
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Andrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- sperm abnormalities, sperm morphology, sperm motility, sperm DNA fragmentation, embryo morphokinetics, time-lapse embryo imaging, IVF outcomes, implantation success, acrosome defects, blastocyst development
- MeSH terms
- Adult, Embryo, Mammalian, Female, Fertilization in Vitro, Humans, Male, Embryo Implantation, Pregnancy, Sperm Motility, Spermatozoa, Treatment Outcome, Embryonic Development, DNA Fragmentation, Time-Lapse Imaging
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