The effect of ethinyl estradiol on endometrial thickness and uterine volume during ovulation induction by clomiphene citrate

Yagel, Simcha; Ben-Chetrit, Avraham; Anteby, Eyal; Zacut, David; Hochner-Celnikier, Drorit; Ron, Moshe

doi:10.1016/s0015-0282(16)54772-4

Cited by 97Reproductive Health and TechnologiesOvarian function and disordersReproductive Biology and Fertility

The effect of ethinyl estradiol on endometrial thickness and uterine volume during ovulation induction by clomiphene citrate

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Yagel, Simcha, Ben-Chetrit, Avraham, Anteby, Eyal, Zacut, David, Hochner-Celnikier, Drorit, Ron, Moshe·1992·Fertility and Sterility

DOI 10.1016/s0015-0282(16)54772-4

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Abstract

Objective To assess the deleterious effect of clomiphene citrate (CC) on the development of the endometrium and its improvement by the addition of ethinyl estradiol (E2). PARTICIPATING PATIENTS: Infertility-treated patients, monitored for induction of ovulation or timing of insemination (control group).Design We studied four groups of women during an ovulatory cycle with various treatment schedules. Group 1: untreated patients; group 2: patients treated by CC; group 3: patients treated by CC + ethinyl E2; group 4: patients treated by human menopausal gonadotropin. Follow-up of the patients was done by vaginal ultrasonography and measurements of blood E2.Results In the group treated by CC, both endometrial thickness and uterine volume growth during the follicular phase were lower as compared with untreated controls and menotropin-treated patients. The addition of ethinyl E2 to these patients reversed this deleterious effect of CC without interfering with ovulation.Conclusion Ethinyl E2 may reverse the deleterious effect of CC on endometrial development during the follicular phase.

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Unlike CC, aromatase inhibitors do not carry an antiestrogenic effect on the endometrium.
“Unlike CC, they do not carry an antiestrogenic effect on the endometrium.”
From A new era in ovulation induction (2006) · cites this paper as [11]
The disappointing pregnancy rates with clomiphene citrate have been attributed to its peripheral antiestrogenic effects, mainly on the endometrium and the cervical mucus.
“This has been attributed to its peripheral antiestrogenic effects, mainly on the endometrium and the cervical mucus (8 -13).”
From A new era in ovulation induction (2006) · cites this paper as [11]
Clomiphene citrate use is associated with endometrial thinning in 15%-50% of patients.
“The use of CC is associated with endometrial thinning in 15%-50% of patients (10 -12).”
From A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation (2004) · cites this paper as [11]
Endometrial thinning has been observed in 15%-50% of patients on clomiphene.
“This endometrial thinning has been observed in 15%-50% patients on clomiphene (10,13,14).”
From A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal women (2002) · cites this paper as [13]

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PENAMBAHAN ETINIL ESTRADIOL PADAINDUKSI OVULASI MENGGUNAKANKLOMIFEN SITRATPENGARUH TERHADAP NILAI RHEOLOGI LENDIR SERVIKSDAN KETEBALAN ENDOMETRIUM
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Authors: Yagel, S., Ben-Chetrit, A., Anteby, E., Zacut, D., Hochner-Celnikier, D., & Ron, M.
Affiliations: Hadassah Medical Center (IL)
ORCID: Yagel, Simcha
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 1992-01
Volume: 57
Issue: 1
Pages: 33-36
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/s0015-0282(16)54772-4
OpenAlex: W81464224
Cited by: 97
References: 10
Citations by year: 2026: 1 · 2024: 1 · 2022: 1 · 2020: 3 · 2019: 2 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 8
FWCI: 1.93
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 11104 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords: ethinyl estradiol, clomiphene citrate, ovulation induction, endometrial thickness, uterine volume, endometrial development, follicular phase, infertility, human menopausal gonadotropin, insemination timing, vaginal ultrasonography
MeSH terms: Adult, Clomiphene, Drug Therapy, Combination, Endometrium, Estradiol, Ethinyl Estradiol, Female, Humans, Infertility, Female, Menotropins, Ovulation, Ovulation Induction, Uterus

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The effect of ethinyl estradiol on endometrial thickness and uterine volume during ovulation induction by clomiphene citrate

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