Cited by 170Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGestational Diabetes Research and Management

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Insulin, androgens, and obesity in women with and without polycystic ovary syndrome: a heterogeneous group of disorders

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Acién, Pedro, Quereda, Francisco, Matallı́n, Pilar, Villarroya, Encarnación, López-Fernández, Jose A, Acién, Maribel, Mauri, Monserrat, Alfayate, Rocı́o·1999·Fertility and Sterility

DOI 10.1016/s0015-0282(99)00184-3

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Abstract

Objective To analyze the correlations among insulin, androgens, body mass index (BMI), and other related metabolic anomalies in women with and without polycystic ovary syndrome (PCOS).Design Retrospective study of normal and obese women with and without PCOS.Setting Gynecologic endocrinology units of Elche, San Juan, and Alicante Hospitals and Hormone Laboratory at Alicante University Hospital ("Miguel Hernández" University).Patient(s) A total of 212 women were studied: 137 with PCOS and 75 without PCOS.Intervention(s) BMI, gonadotropins, insulin, androgens (T, androstenedione, DHEAS), 17alpha-hydroxyprogesterone, sex hormone-binding globulin, and triglycerides were studied. Glycemia and insulin response to the tolerance test (GTT) with a 100-g oral glucose load were also assessed in 103 women.Result(s) A good correlation between insulin and BMI was found in normal and obese women without hormonal dysfunction and in patients with or without PCOS. Good correlations, although lower, between insulin and T, and BMI, insulin, and T with triglycerides were also found in patients with PCOS. These patients fell into clearly distinct categories: with or without insulin resistance and with or without obesity, but slim women with PCOS had insulin and metabolic variables similar to those without PCOS, and most obese women with PCOS were insulin-resistant and more hyperandrogenic and hypertriglyceridemic.Conclusion(s) Insulin, androgens, and BMI are related in women both with PCOS and without PCOS, especially in obese ones. Insulin and metabolic indices are similar in lean women with PCOS and those without PCOS, but obese women with PCOS are more insulin-resistant, hyperandrogenic, and hypertriglyceridemic. Three types of disorders can be distinguished: simple nonhyperandrogenic obesity, typical nonhyperinsulinemic PCOS, and insulin-resistant PCOS.

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Authors: Acién, P., Quereda, F., Matallı́n, P., Villarroya, E., López-Fernández, J. A., Acién, M., Mauri, M., & Alfayate, R.
Affiliations: Universitat de Miguel Hernández d'Elx (ES)
Corresponding author: Acién, Pedro
ORCID: Acién, Pedro
Quereda, Francisco
Acién, Maribel
Alfayate, Rocı́o
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 1999-07
Volume: 72
Issue: 1
Pages: 32-40
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/s0015-0282(99)00184-3
OpenAlex: W2012212806
Cited by: 170
References: 23
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 12
FWCI: 7.13
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 8366 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords: polycystic ovary syndrome, insulin resistance, hyperandrogenism, obesity, body mass index, insulin, androgens, testosterone, androstenedione, dehydroepiandrosterone, sex hormone-binding globulin, hypertriglyceridemia, insulin tolerance test, metabolic heterogeneity, lean PCOS
MeSH terms: Adolescent, Adult, Androgens, Androstenedione, Blood Glucose, Female, Humans, Insulin, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Retrospective Studies, Sex Hormone-Binding Globulin, Testosterone, Triglycerides, Body Mass Index, 17-alpha-Hydroxyprogesterone

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Insulin, androgens, and obesity in women with and without polycystic ovary syndrome: a heterogeneous group of disorders

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