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Cited by 65Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, Diet

Obesity, free testosterone, and cardiovascular risk factors in adolescents with polycystic ovary syndrome and regularly cycling adolescents

Glueck, Charles J., Morrison, John A., Friedman, Lisa Aronson, Goldenberg, Naila, Stroop, Davis M., Wang, Ping·2006·Metabolism
DOI 10.1016/j.metabol.2005.11.003
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Abstract

Adolescent girls with polycystic ovary syndrome (PCOS) have increased levels of factors constituting the metabolic syndrome: centripetal obesity, hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), and hyperinsulinemia. Given the strong association reported between early, persistent obesity and development of metabolic syndrome 10 years later in girls, we speculated that if adolescent girls without PCOS had obesity measures similar to girls with PCOS, they would exhibit similar metabolic syndrome-cardiovascular disease risk factors. Within this context, we compared 37 adolescent girls with PCOS and 2 samples of normal, regularly cycling adolescent girls (controls) of similar ages, selected from the Cincinnati Clinic of the National Heart, Lung, and Blood Institute Growth and Health Study. The first sample included 157 controls selected using a stratified random sample based on age. As expected, girls with PCOS had higher body mass index (BMI), waist circumference, insulin, systolic blood pressure (SBP) and diastolic blood pressure, triglycerides (TGs), lower HDL-C, and higher low-density lipoprotein cholesterol (LDL-C) and free testosterone (FT) than controls. A second sample consisted of girls matched one to one with girls with PCOS for BMI and age. Comparisons of group differences were not significant for insulin, lipids, or blood pressure; girls with PCOS had a trend toward higher values for waist circumference (median, 92.7 vs 87.5 cm; P = .07) and much higher median FT (4.25 vs 1.42 ng/mL, P = .0001). After matching for BMI and age, by conditional regression analysis, we showed that the groups were not differentiated (P > .15) by insulin, HDL-C, LDL-C, TG, SBP, or diastolic blood pressure, but were differentiated by higher FT (P = .0024) and waist circumference (P = .0024) in PCOS than in controls. Prospective longitudinal analyses of NHGS controls showed that changes in BMI from ages 9 to 10 years to ages 15 to 16 years were positively associated with changes in waist circumference (P < .0001), LDL-C (P = .01), TG (P = .008), and SBP (P = .002). These findings suggest that if adolescent girls achieve adiposity equal to girls with PCOS, they then acquire major components of the metabolic syndrome, and excluding high FT and waist circumference, comparable increased cardiovascular disease risk.

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  • Morning 17-hydroxyprogesterone concentrations greater than 200 ng/dl are more common in women with congenital adrenal hyperplasia (87%), but over 20% of women with polycystic ovary syndrome had elevated morning 17-hydroxyprogesterone values.

    “Although morning 17-OHP concentrations (>200 ng/dl) have been reported as being more common in women with CAH (87%), over 20% of women with PCOS had elevated morning 17-OHP values [110]”

    From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [110]

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Authors
Glueck, C. J., Morrison, J. A., Friedman, L. A., Goldenberg, N., Stroop, D. M., & Wang, P.
Affiliations
  • Cincinnati Children's Hospital Medical Center (US)
  • Maryland Medical Research Institute (US)
Corresponding author
Glueck, Charles J.
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
2006-04
Volume
55
Issue
4
Pages
508-514
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/j.metabol.2005.11.003
OpenAlex
W2123436272
Cited by
65
References
49
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 3
FWCI
4.54
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01hc055025-015)
  • Centers for Disease Control and Prevention
  • National Heart, Lung, and Blood Institute (HC55025, HL 48941, U01HL048941)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
polycystic ovary syndrome, adolescent girls, free testosterone, obesity, metabolic syndrome, cardiovascular risk factors, waist circumference, body mass index, insulin, blood pressure, lipid profile, hypertriglyceridemia, HDL cholesterol, LDL cholesterol, cardiovascular risk, matched controls
MeSH terms
Adolescent, Cardiovascular Diseases, Female, Follow-Up Studies, Humans, Male, Menstrual Cycle, Obesity, Polycystic Ovary Syndrome, Risk Factors, Testosterone, Body Mass Index, Case-Control Studies, Body Fat Distribution

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