C-reactive protein before and after weight loss in overweight women with and without polycystic ovary syndrome
Abstract
BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with reproductive and metabolic abnormalities. It is unknown whether overweight women with and without PCOS achieve similar benefits from weight loss for cardiovascular risk factors. METHOD: Overweight body mass index-matched women with (n = 15) and without (n = 17) PCOS (weight, 95.3 +/- 17.6 kg; body mass index, 35.6 +/- 5.3 kg/m(2), mean +/- sd) followed an 8-wk weight loss regime. RESULTS: All subjects had similar reductions in weight (3.9 +/- 3.6 kg, 3.8%, vs. 4.5 +/- 4.1 kg, 4.7%, respectively, for PCOS and non-PCOS), waist circumference, fat mass, triglycerides, free testosterone, and fasting and postprandial insulin. At baseline, C-reactive protein (CRP) between groups was not significantly different (5.5 +/- 3.1 mg/liter for PCOS vs. 4.9 +/- 3.0 mg/liter for non-PCOS). There was a significant interaction between PCOS status and CRP (P = 0.016) such that CRP decreased with weight loss for non-PCOS women (-1.2 +/- 1.8 mg/liter; P = 0.025) but not for PCOS women. For all women, the change in CRP correlated with the change in weight (r = 0.560; P = 0.003), fat mass (r = 0.477; P = 0.016), and postprandial insulin (r = 0.402; P = 0.046). Adiponectin, IL-6, and TNF-alpha were not significantly different between groups before or after weight loss. Only subjects with baseline CRP levels below the median (4.52 mg/liter) showed increases in adiponectin (0.98 +/- 1.3 microg/liter) (P = 0.015) and greater reductions in triglycerides (P = 0.001) with weight loss. CONCLUSION: A 4-5% weight loss improved lipid, glucose, and insulin profiles in women with and without PCOS. This degree of weight loss was not effective in lowering CRP concentrations in PCOS women, suggesting that greater weight loss is required in this group to achieve equivalent cardiovascular benefit to non-PCOS women.
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At the end of a meal replacement beverage intervention, significantly more PCOS participants exhibited insulin resistance post-intervention.
“At the end of the meal replacement beverage intervention, significantly more PCOS participants exhibited insulin resistance post-intervention [68]”
From Moving beyond Weight: A Narrative Review of the Dietary and Lifestyle Management for Reducing Cardiometabolic Risk in Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [68]
One study with a diet intervention reported double the number of ovulatory events in women without PCOS compared to women with PCOS, which was statistically significant.
“One study with a diet intervention [34] reported double the number of ovulatory events in women without PCOS compared to women with PCOS, which was statistically significant (Table 3).”
From Weight management interventions in women with and without PCOS: a systematic review (2017) · cites this paper as [34]
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824 · see citing works
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541 · see citing works
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,761 · see citing works
Esposito, K., Pontillo, A., Di Palo, C., Giugliano, G., Masella, M., Marfella, R., & Giugliano, D. (2003) · JAMA · doi:10.1001/jama.289.14.1799 · Cited by 1,511 · see citing works
Cnop, M., Havel, P. J., Utzschneider, K. M., Carr, D. B., Sinha, M. K., Boyko, E. J., Retzlaff, B. M., Knopp, R. H., Brunzell, J. D., & Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-003-1074-z · Cited by 1,483 · see citing works
Ouchi, N., Kihara, S., Arita, Y., Nishida, M., Matsuyama, A., Okamoto, Y., Ishigami, M., Kuriyama, H., Kishida, K., Nishizawa, H., et al. (2001) · Circulation · doi:10.1161/01.cir.103.8.1057 · Cited by 1,275 · see citing works
Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women
Pai, J. K., Pischon, T., Ma, J., Manson, J. E., Hankinson, S. E., JOSHIPURA, K. J., Curhan, G. C., Rifai, N., Cannuscio, C. C., Stampfer, M. J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040967 · Cited by 1,174 · see citing works
Wild, S., Pierpoint, T., McKeigue, P., & Jacobs, H. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01000.x · Cited by 970 · see citing works
A method to assess energy expenditure in children and adults.
Bouchard, C., Tremblay, A., Leblanc, C., Lortie, G., Savard, R., & Thériault, G. (1983) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/37.3.461 · Cited by 924 · see citing works
Ferrannini, E., Natali, A., Bell, P., Cavallo-Perin, P., Lalic, N., & Mingrone, G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119628 · Cited by 898 · see citing works
Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
Nishizawa, H., Shimomura, I., Kishida, K., Maeda, N., Kuriyama, H., Nagaretani, H., Matsuda, M., Kondo, H., Furuyama, N., Kihara, S., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2734 · Cited by 837 · cited 1× · see citing works
“However, there is a proposed role for androgens in inhibiting adiponectin expression and secretion (48) and IL-6 and TNF- in altering follicular function or gonadotropin secretion (15).”
BackgroundJanssen, I., Heymsfield, S. B., Allison, D. B., Kotler, D. P., & Ross, R. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.4.683 · Cited by 714 · see citing works
Lemieux, I., Pascot, A., Prud’homme, D., Alméras, N., Bogaty, P. M., Nadeau, A., Bergeron, J., & Després, J. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.961 · Cited by 593 · see citing works
C-Reactive Protein: Risk Marker or Mediator in Atherothrombosis?
Jialal, I., Devaraj, S., & Venugopal, S. K. (2004) · Hypertension · doi:10.1161/01.hyp.0000130484.20501.df · Cited by 569 · see citing works
Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes
Faßhauer, M., Kralisch, S., Klier, M., Lössner, U., Blüher, M., Klein, J. C., & Paschke, R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00090-1 · Cited by 534 · see citing works
Moran, L. J., Noakes, M., Clifton, P. M., Tomlinson, L., & Norman, R. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020815 · Cited by 530 · see citing works
Self-citationCoronary Heart Disease Risk Factors in Women With Polycystic Ovary Syndrome
Talbott, E. O., Guzick, D. S., Clerici, A., Berga, S. L., Detre, K. M., Weimer, K., & Kuller, L. H. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.7.821 · Cited by 499 · see citing works
Differentiation Between Obesity and Insulin Resistance in the Association With C-Reactive Protein
McLaughlin, T., Abbasi, F., Lamendola, C. A., Liang, L., Reaven, G. M., Schaaf, P., & Reaven, P. D. (2002) · Circulation · doi:10.1161/01.cir.0000041046.32962.86 · Cited by 374 · see citing works
Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome
Hart, R., Hickey, M., & Franks, S. (2004) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2004.05.001 · Cited by 358 · see citing works
CHEN, M., BERGMAN, R. N., PACINI, G., & PORTE, D. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-1-13 · Cited by 353 · see citing works
Heilbronn, L. K., Noakes, M., & Clifton, P. M. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.21.6.968 · Cited by 331 · see citing works
Self-citationTarkun, İ., ARSLAN, B., Cantürk, Z., Türemen, E., Şahı̇n, T., & Duman, C. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0751 · Cited by 297 · see citing works
Carmina, E., & Løbo, R. A. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.01.041 · Cited by 293 · see citing works
Xydakis, A. M., Case, C. C., Jones, P. H., Hoogeveen, R. C., Liu, M., Smith, E. O., Nelson, K. W., & Ballantyne, C. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031826 · Cited by 284 · see citing works
Changes of Adiponectin Oligomer Composition by Moderate Weight Reduction
Bobbert, T., Rochlitz, H. J., Wegewitz, U. E., Akpulat, S., Mai, K., Weickert, M. O., Möhlig, M., Pfeiffer, A. F. H., & Spranger, J. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2712 · Cited by 271 · see citing works
Talbott, E. O., Zborowski, J. V., Rager, J. R., Boudreaux, M. Y., Edmundowicz, D., & Guzick, D. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032237 · Cited by 269 · see citing works
Huber-Buchholz, M.-M. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.4.1470 · Cited by 269 · see citing works
Self-citationPuder, J. J., Varga, S., Kraenzlin, M., Geyter, C. D., Keller, U. B., & Müller-Stich, B. P. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1002 · Cited by 216 · see citing works
The endocrinology of menstruation – a role for the immune system
Critchley, H. O. D., Kelly, R. W., Brenner, R. M., & Baird, D. T. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01432.x · Cited by 203 · see citing works
Endothelial Dysfunction in PCOS: Role of Obesity and Adipose Hormones
Carmina, E., Orio, F., Palomba, S., Longo, R. A., Cascella, T., Colao, A. A. L., Lombardi, G., Rini, G. B., & Løbo, R. A. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.10.059 · Cited by 199 · see citing works
Kopp, H., Krzyżanowska, K., Möhlig, M., Spranger, J., Pfeiffer, A. F. H., & Schernthaner, G.-H. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802983 · Cited by 189 · see citing works
The polycystic ovary syndrome per se is not associated with increased chronic inflammation
Möhlig, M., Spranger, J., Osterhoff, M., Ristow, M., Pfeiffer, A. F. H., Schill, T., Schlößer, H. W., Brabant, G. E., & Schöfl, C. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500525 · Cited by 182 · see citing works
Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles
Amato, G. (2003) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(03)00233-3 · Cited by 171 · see citing works
Shin, M.-J., Hyun, Y. J., Kim, O. Y., Kim, J., Jang, Y., & Lee, J. H. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803304 · Cited by 170 · see citing works
Acién, P., Quereda, F., Matallı́n, P., Villarroya, E., López-Fernández, J. A., Acién, M., Mauri, M., & Alfayate, R. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00184-3 · Cited by 170 · see citing works
Moran, L., Noakes, M., Clifton, P. M., Wittert, G., Tomlinson, L., Galletly, C. A., Luscombe‐Marsh, N. D., & Norman, R. J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031583 · Cited by 170 · see citing works
Self-citationMarfella, R., Esposito, K., Siniscalchi, M., Cacciapuoti, F., Giugliano, F., Labriola, D., Ciotola, M., Di Palo, C., Misso, L., & Giugliano, D. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.47 · Cited by 170 · see citing works
Plasma adiponectin and insulin resistance in women with polycystic ovary syndrome
Ardawi, M. S. M., & Rouzi, A. A. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.11.077 · Cited by 165 · see citing works
C-reactive protein: a new risk assessment tool for cardiovascular disease.
Clearfield, M. B. (2005) · PubMed · Cited by 163 · see citing works
Noakes, M., Foster, P., Keogh, J. B., & Clifton, P. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.8.1894 · Cited by 152 · see citing works
Self-citationChanges in Insulin Sensitivity, Secretion and Glucose Effectiveness During Menstrual Cycle
Pulido, J. M. E., & Salazar, M. A. (1999) · Archives of Medical Research · doi:10.1016/s0188-0128(98)00008-6 · Cited by 144 · see citing works
Escobar-Morreale, H. F., Villuendas, G., Botella-Carretero, J. I., Sancho, J., & Millán, J. L. S. (2003) · Diabetologia · doi:10.1007/s00125-003-1090-z · Cited by 143 · see citing works
Moran, L. J., Noakes, M., Clifton, P. M., Wittert, G. A., Williams, G., & Norman, R. J. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.77 · Cited by 141 · see citing works
Self-citationPirro, M. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.20.2474 · Cited by 127 · see citing works
Body Fat Distribution in Healthy Young and Older Men
Schwartz, R. S., Shuman, W. P., Bradbury, V. L., Cain, K. C., Fellingham, G. W., Beard, J. C., Kahn, S. E., Stratton, J. R., Cerqueira, M. D., & Abrass, I. B. (1990) · Journal of Gerontology · doi:10.1093/geronj/45.6.m181 · Cited by 122 · see citing works
Vgontzas, A. N., Trakada, G., Bixler, E. O., Lin, H.-M., Pejovic, S., Zoumakis, E., Chrousos, G. P., & Legro, R. S. (2006) · Metabolism · doi:10.1016/j.metabol.2006.04.002 · Cited by 114 · see citing works
Dvořáková-Lorenzová, A., Suchánek, P., Havel, P. J., Stávek, P., Karasová, L., Valenta, Z., Tintěra, J., & Poledne, R. (2006) · Metabolism · doi:10.1016/j.metabol.2005.09.010 · Cited by 98 · see citing works
Siemińśka, L., Marek, B., Kos‐Kudła, B., Niedziolka, D., Kajdaniuk, D., Nowak, M., & Głogowska-Szeląg, J. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03347474 · Cited by 85 · see citing works
Yuan, G., Zhou, L., Tang, J., Yang, Y., Gu, W., Li, F., Hong, J., Gu, Y., Li, X., Ning, G., et al. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2005.10.025 · Cited by 78 · see citing works
CRP reduction following gastric bypass surgery is most pronounced in insulin-sensitive subjects
Holdstock, C., Lind, L., Engstrom, B. E., Ohrvall, M., Sundbom, M., Larsson, A., & Karlsson, F. A. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803000 · Cited by 73 · see citing works
Brochu, M., Tchernof, A., Turner, A. N., Ades, P. A., & Poehlman, É. T. (2003) · Metabolism · doi:10.1053/meta.2003.50095 · Cited by 69 · see citing works
Serum and Follicular Fluid Cytokines in Polycystic Ovary Syndrome During Stimulated Cycles
Amato, G., Conte, M. L., Mazziotti, G., et al. (2003) · Obstetrics and Gynecology · doi:10.1097/00006250-200306000-00009 · Cited by 59 · see citing works
Polycystic ovary syndrome, diabetes and cardiovascular disease: risks and risk factors
Lakhani, K., Prelević, G. M., Seifalian, A. M., Atiomo, W., & Hardiman, P. J. (2004) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443610400007810 · Cited by 53 · see citing works
Determinants of Circulating Adiponectin in Women with Polycystic Ovary Syndrome
Vrbíková, J., Dvořáková, K., Hill, M., Včelák, J., Stanická, S., Vaňková, M., Vejražková, D., Vondra, K., Bendlová, B., & Stárka, L. (2005) · Gynecologic and Obstetric Investigation · doi:10.1159/000086273 · Cited by 24 · see citing works
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Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis
Escobar-Morreale, H. F., Luque‐Ramírez, M., & González, F. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.11.036 · Cited by 522 · see citing works
Stener-Victorin, E., Teede, H., Norman, R. J., Legro, R., Goodarzi, M. O., Dokras, A., Laven, J., Hoeger, K., & Piltonen, T. T. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00511-3 · Cited by 495 · see citing works
Self-citationMoran, L. J., Pasquali, R., Teede, H. J., Hoeger, K. M., & Norman, R. J. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.018 · Cited by 444 · see citing works
Self-citationAssessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline
Teede, H. J., Misso, M. L., Deeks, A. A., Moran, L. J., Stuckey, B. G. A., Wong, J. L. A., Norman, R. J., Costello, M. F., & Groups, O. B. O. T. G. D. (2011) · Medical Journal of Australia · doi:10.5694/mja11.10915 · Cited by 379 · see citing works
Self-citationElkind-Hirsch, K., Marrioneaux, O., Bhushan, M., Vernor, D., & Bhushan, R. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0115 · Cited by 276 · see citing works
Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis
Toulis, K. A., Goulis, D. G., Farmakiotis, D., Georgopoulos, N. A., Katsikis, I., Tarlatzis, B. C., Papadimas, I., & Panidis, D. (2009) · Human Reproduction Update · doi:10.1093/humupd/dmp006 · Cited by 262 · see citing works
Aboeldalyl, S., James, C., Seyam, E., Ibrahim, E. M., Shawki, H., & Amer, S. A. K. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052734 · Cited by 251 · see citing works
Meta-analysis of cardiovascular disease risk markers in women with polycystic ovary syndrome
Toulis, K. A., Goulis, D. G., Mintziori, G., Kintiraki, E., Eukarpidis, E., Mouratoglou, S., Pavlaki, A., Stergianos, S., Poulasouchidou, M., Tzellos, T., et al. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmr025 · Cited by 229 · see citing works
Mehrabani, H. H., Salehpour, S., Amiri, Z., Farahani, S. J., Meyer, B. J., & Tahbaz, F. (2012) · Journal of the American College of Nutrition · doi:10.1080/07315724.2012.10720017 · Cited by 141 · see citing works
Lifestyle and Behavioral Management of Polycystic Ovary Syndrome
Brennan, L., Teede, H. J., Skouteris, H., Linardon, J., Hill, B., & Moran, L. (2017) · Journal of Women s Health · doi:10.1089/jwh.2016.5792 · Cited by 114 · see citing works
Self-citationGiallauria, F., Palomba, S., Maresca, L., Vuolo, L., Tafuri, D., Lombardi, G., Colao, A., Vigorito, C., & Orio, F. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03305.x · Cited by 111 · see citing works
The usefulness of circulating adipokine levels for the assessment of obesity-related health problems
Inadera, H. (2008) · International Journal of Medical Sciences · doi:10.7150/ijms.5.248 · Cited by 108 · see citing works
Bahadır, A., Baltacı, D., Türker, Y., Türker, Y., Iliev, D., Öztürk, S., Deler, M. H., & Sarıgüzel, Y. C. (2014) · The Anatolian Journal of Cardiology · doi:10.5152/akd.2014.5787 · Cited by 104 · see citing works
The Role of Obesity in the Development of Polycystic Ovary Syndrome
Motta, A. B. (2012) · Current Pharmaceutical Design · doi:10.2174/13816128112092482 · Cited by 103 · see citing works
Interleukin-6 Levels in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Peng, Z., Sun, Y., Lv, X., Zhang, H., Liu, C., & Dai, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148531 · Cited by 102 · see citing works
Gao, L., Gu, Y., & Yin, X. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164021 · Cited by 95 · see citing works
Adipose tissue and reproduction in women
BOHLER, H. C. L., Mokshagundam, S. L., & Winters, S. J. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.03.079 · Cited by 94 · see citing works
Testosterone, SHBG and cardiovascular health in postmenopausal women
Brand, J. S., & van der Schouw, Y. T. (2010) · International Journal of Impotence Research · doi:10.1038/ijir.2009.64 · Cited by 73 · see citing works
Adolescent-Onset Depression: Are Obesity and Inflammation Developmental Mechanisms or Outcomes?
Byrne, M. L., O’brien-simpson, N. M., Mitchell, S., & Allen, N. B. (2015) · Child Psychiatry & Human Development · doi:10.1007/s10578-014-0524-9 · Cited by 66 · see citing works
Yang, C., Li, C.-I., Lin, C., Liu, C.-S., Lin, C., Lin, C., & Lin, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132908 · Cited by 65 · see citing works
Gouveia-Figueira, S. C., Späth, J., Zivkovic, A. M., & Nording, M. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132042 · Cited by 63 · see citing works
Thomson, R. L., Buckley, J. D., Moran, L., Noakes, M., Clifton, P. M., Norman, R. J., & Brinkworth, G. D. (2009) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2009.02177.x · Cited by 59 · see citing works
Self-citationLow Circulating Adiponectin Levels in Women with Polycystic Ovary Syndrome: An Updated Meta-Analysis
Li, S., Huang, X., Zhong, H., Peng, Q., Chen, S., Xie, Y., Qin, X., & Qin, A. (2014) · Tumor Biology · doi:10.1007/s13277-013-1595-0 · Cited by 58 · see citing works
Weight management interventions in women with and without PCOS: a systematic review
Kataoka, J., Tassone, E., Misso, M., Joham, A., Stener-Victorin, E., Teede, H., & Moran, L. (2017) · Nutrients · doi:10.3390/nu9090996 · Cited by 58 · see citing works
Self-citationMoran, L. J., Noakes, M., Clifton, P., Buckley, J., Brinkworth, G., Thomson, R., & Norman, R. J. (2019) · Nutrients · doi:10.3390/nu11030492 · Cited by 57 · see citing works
Self-citationHu, W., Qiao, J., Yan, Y., Wang, L., & Li, R. (2011) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2011.03.015 · Cited by 56 · see citing works
Tosi, F., Dorizzi, R. M., Castello, R., Maffeis, C., Spiazzi, G., Zoppini, G., Muggeo, M., & Moghetti, P. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0379 · Cited by 56 · see citing works
Redman, L. M., Elkind-Hirsch, K., & Ravussin, E. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.01.137 · Cited by 44 · see citing works
Moran, L., Noakes, M., Clifton, P. M., Norman, R. J., & Fenech, M. F. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.11.007 · Cited by 48 · see citing works
Self-citationRondanelli, M., Perna, S., Faliva, M. A., Monteferrario, F., Repaci, E., & Allieri, F. (2014) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-014-3433-z · Cited by 39 · see citing works
Chen, M., Chen, H., Chen, S., Ho, H., Yang, Y., & Yang, W. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.06.009 · Cited by 38 · see citing works
Kılıç, S., Yılmaz, N., Zülfikaroğlu, E., Erdoğan, G., Aydın, M., & Batıoğlu, S. (2010) · Gynecological Endocrinology · doi:10.3109/09513590.2010.530706 · Cited by 35 · see citing works
Esteghamati, A., Morteza, A., Khalilzadeh, O., Anvari, M., Noshad, S., Zandieh, A., & Nakhjavani, M. (2012) · Journal of Health Population and Nutrition · doi:10.3329/jhpn.v30i1.11278 · Cited by 33 · see citing works
Olszanecka, A., Kawecka−Jaszcz, K., & Czarnecka, D. (2016) · Archives of Medical Science · doi:10.5114/aoms.2016.59925 · Cited by 33 · see citing works
Bilgir, O., Kebapçılar, L., Taner, C. E., Bilgir, F., Kebapçılar, A. G., Bozkaya, G., Yıldız, Y., Yüksel, A., & Sarı, İ. (2009) · Internal Medicine · doi:10.2169/internalmedicine.48.2177 · Cited by 31 · see citing works
Impact of hypocaloric dietary intervention on ovulation in obese women with PCOS
Jarrett, B. Y., & Lujan, M. E. (2016) · Reproduction · doi:10.1530/rep-16-0385 · Cited by 29 · see citing works
Spanos, N., Τζιόμαλος, Κ., Μacut, D., Koiou, E., Kandaraki, E., Delkos, D., Tsourdi, E. A., & Panidis, D. (2012) · Obesity Facts · doi:10.1159/000341579 · Cited by 28 · see citing works
Polycystic Ovary Syndrome and Chronic Inflammation: Pharmacotherapeutic Implications
Sirmans, S. M., Weidman-Evans, E., Everton, V., & Thompson, D. (2012) · Annals of Pharmacotherapy · doi:10.1345/aph.1q514 · Cited by 24 · see citing works
Costa, L. O. B. F., dos Santos, M. P., de Oliveira, M., & Viana, A. D. O. R. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.04.005 · Cited by 22 · see citing works
Salehidoost, R., Boroujeni, G. T., Feizi, A., Aminorroaya, A., & Amini, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-20277-6 · Cited by 21 · see citing works
Predictors of pregnancy after intrauterine insemination in women with polycystic ovary syndrome
Guan, H., Pan, L., Song, H. S., Tang, H., & Tang, L.-S. (2021) · Journal of International Medical Research · doi:10.1177/03000605211018600 · Cited by 21 · see citing works
Jeemon, P., Prabhakaran, D., Ramakrishnan, L., Gupta, R., Ahmed, F., Thankappan, K. R., Kartha, C. S., Chaturvedi, V., Reddy, K. S., & the Sentinel Surveillance in Industrial Populations Study Group (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-19 · Cited by 19 · see citing works
Ilie, I. R. P., Marian, I., Mocan, T., Ilie, R., MOCAN, L. C., Duncea, I., & Pepene, C. E. (2012) · BMC Endocrine Disorders · doi:10.1186/1472-6823-12-9 · Cited by 19 · see citing works
Moran, L., Meyer, C., Hutchison, S. K., Zoungas, S., & Teede, H. J. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03345790 · Cited by 19 · see citing works
Self-citationAubuchon, M., Liu, Y., Petroski, G. F., Thomas, T. R., & Polotsky, A. J. (2016) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2016.1177619 · Cited by 18 · see citing works
Jorgensen, J. M., Yang, Z., Lönnerdal, B. L., Chantry, C. J., & Dewey, K. G. (2016) · Maternal and Child Nutrition · doi:10.1111/mcn.12394 · Cited by 17 · see citing works
Alenezi, S. A., Elkmeshi, N., Alanazi, A., Alanazi, S. T. A., Khan, R. N., & Amer, S. A. K. S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13164934 · Cited by 16 · see citing works
Herbert, S., & Woolf, K. (2023) · Nutrients · doi:10.3390/nu15245069 · Cited by 15 · see citing works
“While the researchers stated that reductions in insulin resistance might rely on reduction in a certain level of abdominal fat, there were no significant differences in total fat mass nor total fat-free mass markers between PCOS and non-PCOS participants in the study [68].”
BackgroundMethodInfluentialIncreased serum C-reactive protein levels in normal weight women with polycystic ovary syndrome.
Makedos, A., Goulis, D. G., Arvanitidou, M., Mintziori, G., Papanikolaou, A., Makedou, A., & Panidis, D. (2011) · PubMed Central · Cited by 13 · see citing works
Makedos, A., Goulis, D. G., Papanikolaou, A., & Panidis, D. (2010) · Angiology · doi:10.1177/0003319709361198 · Cited by 13 · see citing works
Whitaker, K. (2011) · Journal of pharmacy and practice · doi:10.1177/0897190010384632 · Cited by 9 · see citing works
Kalyan, S., Hitchcock, C. L., Sirrs, S. M., Pudek, M. R., & Prior, J. C. (2010) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.30.5.442 · Cited by 12 · see citing works
Choi, Y.-J., Kang, K., Je, M., Lee, Y., & Kim, Y. (2025) · Nutrients · doi:10.3390/nu17040674 · Cited by 12 · see citing works
Nguo, K., McGowan, M., Cowan, S., Davidson, Z. E., Pirotta, S., Dordevic, A. L., Teede, H. J., Hajishafiee, M., Carmichael, M. A., & Moran, L. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad169 · Cited by 9 · see citing works
Self-citationMoran, L., Noakes, M., Wittert, G., Clifton, P. M., & Norman, R. J. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.07.013 · Cited by 8 · see citing works
Self-citationCasula, M., Tragni, E., Zambon, A., Filippi, A., Brignoli, O., Cricelli, C. A., Poli, A., & Catapano, A. L. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.09.010 · Cited by 6 · see citing works
Oldfield, A. L., Carter, F. E., Reeves, R. E., Jarrett, B. Y., Brink, H. V., & Lujan, M. E. (2024) · Human Reproduction · doi:10.1093/humrep/deae017 · Cited by 5 · see citing works
Moran, L., Lombard, C. B., & Noakes, M. (2009) · Nutrition & Dietetics · doi:10.1111/j.1747-0080.2009.01379.x · Cited by 4 · see citing works
Self-citationYavuz, A., Uğur, K., Karagöz, Z. K., Ayan, D., & Aydın, S. (2022) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/j.ceog4904087 · Cited by 2 · see citing works
PALLAVI, K., & Harshitha, K. S. (2024) · International Journal of Current Pharmaceutical Research · doi:10.22159/ijcpr.2024v16i4.5003 · Cited by 1 · see citing works
Pattnaik, S., Gupta, S., Saxena, U., Matlani, M., & Kapoor, R. (2021) · Indian Journal of Physiology and Pharmacology · doi:10.25259/ijpp_72_2020 · Cited by 1 · see citing works
Renke, M. (2009)
Marsh, K. A. (2009) · Springer eBooks · doi:10.1007/978-0-387-09718-3_16 · Cited by 2 · see citing works
Zhang, J., Kim, J. Y., Levine, R., Cho, C., Lee, H., Thoma, E., Carter, F. E., Jarrett, B. Y., Smith, B., Brink, H. V., et al. (2026) · Nutrients · doi:10.3390/nu18040654
- Authors
- Moran, L. J., Noakes, M., Clifton, P. M., Wittert, G. A., Belobrajdic, D. P., & Norman, R. J.
- Affiliations
- Commonwealth Scientific and Industrial Research Organisation (AU)
- The University of Adelaide (AU)
- Corresponding author
- Norman, Robert J.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2007-08-01
- Volume
- 92
- Issue
- 8
- Pages
- 2944-2951
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2062737331
- Cited by
- 66
- References
- 56
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 4 · 2019: 1 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 3 · 2012: 8
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Sanofi
- Commonwealth Scientific and Industrial Research Organisation
- Meat and Livestock Australia
- University of Adelaide
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- polycystic ovary syndrome, C-reactive protein, weight loss, overweight women, cardiovascular risk factors, insulin resistance, adiponectin, inflammatory cytokines, triglycerides, free testosterone, waist circumference, fat mass, adipose tissue inflammation, lifestyle intervention, insulin sensitivity, dyslipidemia, hyperandrogenism
- MeSH terms
- Adult, Anthropometry, Body Composition, C-Reactive Protein, Eating, Female, Humans, Menstruation, Middle Aged, Motor Activity, Obesity, Polycystic Ovary Syndrome, Gonadal Steroid Hormones, Smoking, Tumor Necrosis Factor-alpha, Weight Loss, Interleukin-6, Body Mass Index, Diet, Carbohydrate-Restricted, Adiponectin
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